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Phthalanilic Acid

    • Product Name Phthalanilic Acid
    • Alias N-Phenylphthalamic acid
    • Einecs 217-879-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    661761

    CAS_Number 524-92-5
    Molecular_Formula C8H7NO3
    Molecular_Weight 165.15 g/mol
    IUPAC_Name 2-(phenylamino)benzoic acid
    Appearance White to light beige solid
    Melting_Point 135-139°C
    Boiling_Point Unavailable
    Solubility_in_Water Slightly soluble
    Density Unavailable
    PubChem_CID 10226
    SMILES C1=CC=CC=C1NC2=CC=CC=C2C(=O)O
    InChI InChI=1S/C8H7NO3/c10-8(11)6-4-2-1-3-5(6)9-7-5/h1-4,9H,(H,10,11)
    Synonyms N-Phenylanthranilic acid
    Storage_Conditions Store in a cool, dry place

    As an accredited Phthalanilic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phthalanilic Acid, 100g, is packaged in a sturdy amber glass bottle with a tight-sealing screw cap and clear labeling.
    Shipping Phthalanilic Acid is typically shipped in tightly sealed containers, protected from moisture, heat, and incompatible substances. Packaging complies with standard chemical safety regulations, using fiber drums or high-density polyethylene containers. Proper labeling and documentation ensure safe and legal transport. Handling precautions are crucial to avoid spills or exposure during transit.
    Storage Phthalanilic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture, heat sources, and incompatible materials such as strong oxidizing agents. Proper labeling and secure storage minimize the risk of contamination or accidental release. Use suitable protective equipment when handling, and follow regulatory guidelines for chemical storage and disposal.
    Application of Phthalanilic Acid

    Applications of Phthalanilic Acid in Industrial Manufacturing

    Phthalanilic Acid supports a defined set of commercial chemical processes, contributing to the production of high-grade intermediate compounds and specialized end-user materials. Our expertise as a direct manufacturer enables us to ensure tight process control, supply consistency, and technical support for demanding downstream industries. Below we provide an in-depth view of recognized industrial use scenarios for this compound, focusing on compliance, technical integration, and finished product profiles.

    1. Synthesis of Azo Dyes for the Textile Sector

    Phthalanilic Acid acts as a crucial coupling agent in the diazotization and coupling stages of synthesizing mono-azo and disazo dyes, primarily for polyester, cotton, and polyamide fibers. The raw material facilitates the formation of intense, wash-fast hues required in high-performance textile coloration. We provide technical support for adjusting dosage to achieve shade accuracy and colorfastness according to customer requirements.

    Industry compliance standards

    • Oeko-Tex Standard 100 (dyestuff residue limits, banned amines)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • EU REACH Annex XVII (Azo colorant restrictions)
    • ISO 105 series (Textile color fastness; relevant for downstream goods)

    Typical usage ratio

    • Ranges from 0.15 to 0.45 mol per 1.0 mol diazonium salt, depending on targeted dye molecular structure and intensity; formulators set the dosage based on coupling efficiency and substrate requirements.

    Downstream process integration

    • Added directly after in-situ diazonium salt preparation during dye synthesis; completed in aqueous or mixed solvent coupling reactions, followed by isolation and purification of finished dye intermediates.

    Final product types

    • Acid dyes for wool and nylon
    • Dispersed dyes for synthetic fibers
    • Direct dyes for cellulosics and blended textiles
    • Textile printing pastes based on custom dye recipes

    2. Intermediate for Pharmaceutical API Manufacturing

    Our product serves as a building block for synthesizing select active pharmaceutical ingredients—especially nonsteroidal anti-inflammatory drugs (NSAIDs) belonging to the anthranilic acid derivative family. Its chemical structure allows targeting reactions with substituted acyl groups, offering a reliable starting material for further derivatization under GMP-compliant conditions.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • European Pharmacopoeia (Ph.Eur.) specifications for intermediates
    • 21 CFR Part 210/211 (US FDA GMP guidelines)
    • USP General Chapters <467> & <231> (Residual solvents, heavy metals monitoring)

    Typical usage ratio

    • Usually between 0.9 and 1.2 equivalents per target API precursor; process engineers fine-tune exact charge based on required yield versus cost of goods and impurity control.

    Downstream process integration

    • Introduced in early step of multistage synthesis, reacting via nucleophilic substitution or amide formation, followed by downstream purification and conversion into final API structures under validated protocols.

    Final product types

    • Mefenamic acid tablets and suspensions
    • Anthranilic acid anti-inflammatory agents
    • API intermediates for pain relief compounds
    • Modified NSAID analogs in clinical development

    3. Polymer Additive for Engineering Plastics

    Manufacturers incorporate phthalanilic acid as a chain-stopping or functional modification agent in specialty polyamide and polyester resins. Its aromatic and carboxylic functionalities help tune hydrolytic stability and surface polarity, driving applications in electronics and automotive engineering-grade plastics with specialized end-use profiles.

    Industry compliance standards

    • UL 94 (Flammability standard for plastic materials)
    • RoHS Directive 2011/65/EU (Heavy metal and hazardous substance limitations)
    • ISO 9001:2015 (Quality management system for industrial production)
    • EN ISO 1043 (Polymer identification codes, relevant for traceability)

    Typical usage ratio

    • Generally 0.05% to 0.5% by weight of polymer feed; the exact loading is determined by molecular weight aiming, desired product performance, and required certification margins.

    Downstream process integration

    • Metered into melt compounding stage or pre-polymerization batch; either reacts directly into polymer backbone or imparts chain-end modifications, followed by extrusion or molding to shape resins into pellets or profiles.

    Final product types

    • Heat-stable polyamide compounds (PA6, PA66 special grades)
    • Modified polyethylene terephthalate (PET) chips for films
    • Injection-molded automotive components
    • Non-halogenated flame-retardant cable insulation and connectors

    4. Chemical Precursor for Agrochemical Synthesis

    This compound supports the production of several crop protection agents—specifically as an intermediate in constructing herbicides and select plant growth regulator scaffolds. The amino- and carboxy-functional groups provide a stable foundation for substitution reactions during active ingredient synthesis in chemical crop protection.

    Industry compliance standards

    • FAO/WHO Guidelines on Good Laboratory Practice for Pesticide Residue Analysis
    • ISO 17025 (Testing and calibration competence for agrochemical analysis)
    • EU Regulation (EC) No 1107/2009 (Approval of plant protection products in the EU)
    • China GB 2763 Maximum Residue Limits for pesticides

    Typical usage ratio

    • Ranges from 0.8–1.3 mol per intermediate step, tailored to the specific agrochemical active structure and the efficiency of conversion pathways in pilot and industrial-scale runs.

    Downstream process integration

    • Charged into core reaction vessels during synthesis of target molecules; involves acylation, chlorination, or sulfonation stages before purification to yield technical grade active substances for formulation.

    Final product types

    • Herbicide actives for rice and wheat cultivation
    • Selective plant growth regulators for fruit crops
    • Pre-mix technical powders for pesticide formulations
    • Active ingredient intermediates for further chemical derivatization

    5. Raw Material for Analytical Reference Compounds

    Certified reference material producers and specialty chemical laboratories use phthalanilic acid as a calibration standard and a precursor in the synthesis of analytical markers. Its defined molecular structure and high purity enable repeatable chromatographic detection and quantification required by laboratory quality control systems.

    Industry compliance standards

    • ISO 17034 (General requirements for the competence of reference material producers)
    • ISO/IEC 17025 (General requirements for testing and calibration laboratories)
    • USP–NF Reference Standard Guidelines
    • USP General Chapter <621> (Chromatography)

    Typical usage ratio

    • Prepared as 0.01%–0.10% (w/v) calibration solutions, or matched to molar equivalent of target analysis reagents in standard preparation protocols; adjustment based on LC/UV calibration curve requirements.

    Downstream process integration

    • Dissolved or derivatized into secondary standards, then incorporated into laboratory validation runs, traceability checks, or batch-release purity assessments.

    Final product types

    • Certified calibration solutions for HPLC/UV or LC-MS
    • Purity reference substances for regulatory audits
    • Analytical marker compounds for method validation
    • Control standards for chemical QC in industrial labs
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    Certification & Compliance
    More Introduction

    Phthalanilic Acid: Reliable Quality For Advanced Applications

    Direct From The Manufacturer: A Close Look At Our Phthalanilic Acid

    With years in specialty chemical production, we approach new product introductions with careful attention to detail and transparency. Phthalanilic acid, bearing the molecular formula C8H7NO3, stands as one of our key aromatic intermediates. As a company focused on core competence and technical know-how, we believe our phthalanilic acid meets the changing demands of the fine chemicals sector.

    Model and Specifications

    Within our production line, phthalanilic acid carries the CAS number 118-29-6. Most requests cover the acid in white crystalline powder form, suitable for downstream synthesis. Our batches consistently reach purity levels above 99% (by HPLC), keeping inorganic impurities below trace detection limits. Water content remains below 0.5%, and each lot undergoes strict GC and melting point analysis. This accuracy reflects both our strict raw material screening and in-process controls. We use a dedicated reaction train to reduce the risk of cross-contamination, giving us greater command over the final purity.

    Raw Material Sourcing: Foundation Of Quality

    Our phthalanilic acid process starts with locally sourced phthalic anhydride and high-purity aniline. These foundational ingredients come from long-term partners whose audits pass our environmental, regulatory, and technical checks. Direct sourcing for phthalic anhydride cuts down on logistics risks and ensures feedstock freshness, which matters for reactivity and color. Each phthalic anhydride lot gets tested for ortho- and para-isomer content before synthesis, tightening our product quality.

    Manufacturing Process Insights

    We employ an aqueous-phase amidation route, avoiding harsh solvents and optimizing reaction temperature for yield and safety. Routine checks across several synthesis steps let us control potential side reactions, keeping structural byproducts well below acceptance limits. By investing in advanced reaction monitoring and NMR verification, we flag off-spec material early and eliminate unnecessary waste. Every batch receives spectral confirmation to meet accepted assignments for phthalanilic acid, and each lot number supports full process traceability.

    Phthalanilic Acid Usage: From Dyes To Agrochemicals

    Much of our production ends up supporting dye intermediates and pigment manufacturers. The amidic structure serves as an anchoring block for certain azo dye syntheses, enabling colorfastness and heat stability. In crop protection, phthalanilic acid operates as a scaffold for plant growth regulators and some newer-generation herbicides. Research groups often turn to phthalanilic acid for small-scale organic synthesis or as a testing molecule in reactivity studies. Our supply efforts guarantee uninterrupted access for both routine industrial users and advanced R&D teams.

    Why Purity And Batch Stability Matter

    For dye houses and agrochemical users, batch-to-batch stability of phthalanilic acid makes the difference between success and costly troubleshooting. We see firsthand how minute changes in impurity profiles can trigger off-color batches in pigment plants or cause poor yields in downstream coupling reactions. Our approach keeps trace organics and residual metal ions at unnoticeable levels, using both filtration and chelation during work-up. Customers report reduced need for downstream purification, which trims production costs—an advantage that comes directly from handling material at the source.

    Quality Beyond The Certificate Of Analysis

    A specification sheet cannot always speak for how a chemical will behave in application. Our technical team keeps in close conversation with repeat buyers, tracking how our phthalanilic acid performs in varying environments. By recording their production challenges—such as unforeseen solubility shifts or unexpected side reactions—we adjust our internal parameters accordingly. For instance, we shifted our drying technology to reduce particle agglomeration, responding to a dye customer’s request for improved flow properties.

    Distinctions From Other Aromatic Acids

    Phthalanilic acid sits within a family of aromatic intermediates, yet it solves different problems than phthalic acid, terephthalic acid, or simple benzoic acid. The attached aniline moiety not only changes the reactivity but also enables selectivity in coupling chemistry. Phthalic acid primarily operates in bulk polyester production, whereas phthalanilic acid provides unique nucleophilicity and anchoring points in custom synthesis. In direct comparison with phthalamic acid, our product introduces added synthetic flexibility for constructing more complex organic molecules.

    Consistency, Scalability, And Customer Feedback

    As plant-scale chemists, we maintain focus on consistency from one drum to the next, with targeted weekly reviews of historical QC data and scheduled maintenance of our reactors and filtration lines. Equipment is inspected and validated for material compatibility so that customers receive nearly identical lots year-round. Scale-up of production remains straightforward due to our modular batch reactors and flexible output schedules. Regular feedback from customers—ranging from pigment plants to university researchers—lets us see real-world results and calibrate both physical and chemical properties accordingly.

    Logistics And Packaging: Handling With Care

    Bulk phthalanilic acid ships in high-density PE drums lined with food-grade foil, reducing moisture pick-up and oxidation during transit. By managing our own filling operation, we remove the risk of contamination—a commitment large traders often struggle to honor. Middlemen often sidestep protection measures, leading to caked, discolored material. Every outgoing shipment is weather-sealed, batch-coded, and tracked from our main plant docks to customer loading bays. Documentation follows right behind, supporting customs needs and ensuring full chain-of-custody.

    Safe Handling And Responsible Manufacturing

    As original producers, we take chemical safety seriously from starting material to finished acid. Our operators work in ventilated environments under active monitoring, and residual solvents test well below regulatory thresholds. Environmental impact matters: Effluent streams from phthalanilic acid synthesis route through dedicated neutralization and filtration systems, so no untreated organics reach the environment. We undergo government safety inspections and maintain a clean record—adding assurance for companies that evaluate raw material risks closely.

    Solving Supply Issues In Changing Markets

    In the past decade, global demand for specialty aromatic acids fluctuated with regulatory changes and end-use market cycles. Larger intermediates, once imported through multiple agents, faced inconsistent supply and inflated costs. Rather than depend on a volatile import network, we invested in local synthesis and raw material partnerships to control costs and avoid last-minute shortages. During trade disruptions, our domestic customers found our direct approach more reliable, with faster lead times and stable pricing structures.

    Sustainability And Future Development

    We have shifted part of our energy sourcing to renewables and improved our water recycling efficiency, decreasing the environmental load from phthalanilic acid runs. Product development here blends operator experience with input from sustainability officers and purchasing managers along the value chain. For future upgrades, we pursue greener synthesis routes, including enzyme-catalyzed options under discussion at our lab bench. Our willingness to invest in incremental improvements supports customers’ own sustainability compliance targets.

    Knowledge Sharing And Industry Support

    We don’t just ship barrels. Over the years, we have published process notes and technical bulletins highlighting observed handling tips, such as dissolving phthalanilic acid at controlled pH or using specific buffers in pigment applications. Long-time customers depend on these insights to avoid plant downtime, reduce batch waste, and clarify production methods for regulatory inspections. Open dialogue with application chemists informs our troubleshooting tools, keeping technical support both responsive and practical.

    User-Centric Improvements

    Direct user feedback drove our development of low-dust formulations in phthalanilic acid to minimize inhalation risk during manual charging. A handful of inquiries led us to change drum sizes for certain high-throughput customers, tailoring batch volume to avoid storage bottlenecks. By regularly engaging with labs who prototype innovative uses for phthalanilic acid, we refine filtering and drying methods that reduce manual handling and boost downstream productivity.

    Phthalanilic Acid Versatility In Synthesis

    Versatility in organic synthesis cannot be separated from the source and nature of the starting materials. Phthalanilic acid’s structure, an ortho-carboxyanilide, positions it as more than just a stepping stone for specialty dyes. The nucleophilicity linked to its amide moiety supports condensation and ring-closure processes, building out heterocycles for pharmaceuticals and advanced materials. We work with customers to supply targeted impurity profiles when they demand high selectivity for research or pilot-scale projects.

    Comparative Performance: Direct User Experience

    Over the years, we’ve run side-by-side comparisons of our phthalanilic acid with alternatives sourced from international producers. One dye manufacturer reported smoother dispersibility and fewer undissolved particles using our product, attributing it to low-level, but consistent, control of micron-sized inclusions. In another case, a university research group avoided multiple recystallizations when switching from imported acid to ours, shaving days off their workflow. These examples ground our claim for quality performance instead of just certificate numbers.

    Addressing Challenges In Phthalanilic Acid Use

    Some pigment makers struggle with partial hydrolysis and color changes during storage—a result of hidden trace chloro- or nitro- impurities. Tackling this pain point, we enforce simplified work-up paths, double-polish our acid, and apply fresh-pack protocols to extend sitting time in warehouses. For agricultural users, shelf life and easy dispersion drive ordering decisions. Keeping particle size uniform, and maintaining a dryness profile, means less clogging of process feeders and higher repeatability in blending.

    Looking Ahead: Meeting Tomorrow’s Needs

    Customers approach us not only for product supply but also for application experimentation. We maintain lab-scale reactors for collaborative trials, ready to fine-tune reaction parameters based on feedback or new end-use goals. If a new pigment line requires tighter control on ortho/para by-products, we explore process tweaks without long lead times. Our technical sales staff participate in dialogue, sharing practical stories from the factory floor to help buyers navigate day-to-day challenges or regulatory hurdles.

    Regulatory Compliance And Documentation

    Our documentation supports audits and regulatory registration in different jurisdictions. Each batch ships with a full certificate of analysis and traceability statement. To meet the rising requirements of downstream users, especially in pharma and agriculture, we update toxicology dossiers and provide full REACH and SDS coverage reflecting current law. This focus comes from handling annual inspections and demands for customer transparency, which has become part of our business culture.

    Continuous Improvement Rooted In Experience

    Every few months, our technical team re-examines process efficiency, watching for areas to improve yield or waste treatment. Small changes—tweaked filtration speeds, alternative crystal seeding—translate to smoother operations both in our plant and for our customers’ processes. Staying in touch with both the science and the people who use phthalanilic acid keeps our product relevant year after year.

    Choosing The Right Supplier: Build On Direct Manufacturer Value

    Markets flooded by traders and resellers sometimes blur the value of buying direct from a manufacturing partner. By focusing on direct technical communication, consistent raw material control, and real feedback loops, our phthalanilic acid stands out—not just for its analytic numbers, but for its reliability in the wide variety of chemistries our users pursue. We remain invested in both technology and relationships to keep improving, batch after batch, in a quickly evolving chemical landscape.