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C6 Ceramide

    • Product Name C6 Ceramide
    • Alias N-hexanoyl-D-erythro-sphingosine
    • Einecs 206-018-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    761101

    Chemical Name N-Hexanoyl-D-erythro-sphingosine
    Common Name C6 Ceramide
    Molecular Formula C24H47NO3
    Molecular Weight 397.64 g/mol
    CAS Number 112163-59-4
    Appearance White to off-white solid
    Solubility Soluble in DMSO, ethanol, and chloroform
    Purity Typically ≥98%
    Storage Temperature -20°C (dry and protected from light)
    Biological Activity Induces apoptosis and regulates cell signaling
    Synonyms N-Hexanoylsphingosine, C6-D-erythro-Ceramide
    Melting Point Approx. 67-69°C

    As an accredited C6 Ceramide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing C6 Ceramide is typically supplied in a 25 mg amber glass vial, sealed for light protection, and clearly labeled with product details.
    Shipping C6 Ceramide is shipped in tightly sealed, amber vials to protect from light and moisture. The chemical is packed with cold packs or on dry ice to maintain stability during transit. All containers comply with safety regulations for hazardous materials and are accompanied by a material safety data sheet (MSDS) for handling instructions.
    Storage C6 Ceramide should be stored at -20°C, protected from light and moisture. It should be kept in tightly sealed containers to prevent degradation. Avoid repeated freeze-thaw cycles to maintain stability. For best results, dissolve in appropriate solvents—such as DMSO or ethanol—immediately before use. Always follow manufacturer-specific guidelines for storage and handling to ensure product integrity.
    Application of C6 Ceramide

    Applications of C6 Ceramide in Industrial Manufacturing

    C6 Ceramide plays a vital role as a functional ingredient across several specialized industrial sectors. As a manufacturer with deep process expertise, we supply high-purity C6 Ceramide for advanced formulation needs, ensuring traceable compliance at every level of the value chain. Below are the major downstream segments where this raw material delivers process-specific advantages.

    1. Advanced Skincare Formulation

    Major cosmetic manufacturers incorporate C6 Ceramide during the emulsion phase of premium skin creams, facial serums, and barrier repair lotions. Our technical service teams advise on micro-encapsulation and co-solubilization to prevent crystallization and maintain stability under variable temperature and humidity, especially in anhydrous and emulsified bases. Customers benefit from our product’s batch-to-batch lipid profile consistency, supporting product claims on moisture retention and skin barrier reinforcement by direct metabolic integration into stratum corneum lipid matrices. We enable documentation for formulation transparency demanded by global prestige skincare brands.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 for Cosmetic Products (Annex II/VI substance lists)
    • U.S. FDA Title 21 CFR Part 700–740 (cosmetics ingredient regulations)
    • ISO 22716:2007 (Cosmetics GMP)
    • China NMPA inventory compliance (IECIC/IECSC)

    Typical usage ratio

    • 0.05–2.5% w/w in creams; 0.1–1.5% in facial serums; selection based on desired occlusivity and skin type

    Downstream process integration

    • Added during controlled heating/cooling and high-shear mixing in emulsification
    • Pre-dispersion in solvents or oils to enhance dissolution, before final blending
    • Integrated into critical quality attribute (CQA) testing workflows for product release

    Final product types

    • Barrier repair creams
    • Moisturizing serums
    • Sensitive-skin cleansers
    • Soothing masks and overnight treatments

    2. Pharmaceutical Topical Development

    Pharmaceutical laboratories use C6 Ceramide as a penetration enhancer and structural lipid in the formulation of prescription-grade topical products. In these settings, our raw material integrates with active pharmaceutical ingredients (APIs) in semi-solid bases such as ointments and gels, supporting lipid layer formation for controlled dermal delivery. We supply full impurity profiling and traceability to help our clients meet stringent dossier expectations for new drug applications and lifecycle management. Compared to longer-chain ceramides, the C6 type enables enhanced skin absorption, especially in treatments targeting compromised or atopic skin.

    Industry compliance standards

    • European Pharmacopoeia monographs and EMA guidelines (topical excipient)
    • U.S. FDA 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)
    • ICH Q3A/B (Impurity profile and residual solvents standards)
    • Japanese Pharmacopoeia (where ceramide excipients are specified)

    Typical usage ratio

    • 0.01–2% w/w depending on API load, viscosity targets, and delivery profile

    Downstream process integration

    • Incorporated in main batch blending, alongside emulsifiers and humectants
    • Dosed following high shear homogenization of principal excipients to ensure even lipid distribution
    • In-process controls (HPLC, NMR) to quantify actual ceramide content in finished product

    Final product types

    • Prescription barrier repair ointments for atopic dermatitis
    • Transdermal delivery gels
    • Corticosteroid or immunomodulating creams containing ceramide

    3. Functional Hair Care Ingredient Manufacturing

    Hair care brands demand C6 Ceramide for integration into conditioning agents, leave-in treatments, and salon-grade masks. Our production supports technical requirements for micro-dispersion in aqueous or alcohol-based bases, allowing lipid replenishment on damaged keratin fibers. We supply COA-backed lots produced under cosmetic GMP, facilitating audits and third-party verification for branded retail products. This ingredient provides structural reinforcement, improved tress smoothness, and reduction of split ends when processed in combination with cationic polymers or silicone alternatives. We support panel test data and performance benchmarking for our direct customers.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009 labeling and safety rules
    • ISO 16128 (Guidelines on natural and organic cosmetic ingredients)
    • U.S. California Safe Cosmetics Act (where applicable)

    Typical usage ratio

    • 0.01–0.5% in rinse-off products
    • 0.05–1.0% in leave-in treatments

    Downstream process integration

    • Pre-mixed during aqueous phase with surfactants and lipid co-emulsifiers
    • Heat-stable blending for cream masks or cold addition for clear serums
    • Quality control checks for dispersion consistency and finished product viscosity

    Final product types

    • Conditioning shampoos
    • Leave-in conditioners
    • Salon hair repair masks
    • Cuticle repair sprays

    4. Biomedical Membrane Fabrication

    Device manufacturers deploy C6 Ceramide in the engineering of biomimetic lipid membranes for medical and biotechnology applications, such as transdermal patches and skin models. Our advanced purification and tight control of fatty acid chirality enables reproducible membrane architectures. Downstream clients use our product for model testing of pharmaceutical diffusion, barrier function research, and controlled release device prototyping. We support validation packages for material compatibility and documentation for laboratory and preclinical workflows.

    Industry compliance standards

    • ISO 10993-1:2021 (Biological evaluation of medical devices)
    • USP <1031> The Biocompatibility of Materials Used in Drug Containers, Medical Devices, and Implants
    • CFR Title 21, Part 820 (QSR for medical device manufacturing)

    Typical usage ratio

    • 5–20% w/w in synthetic lipid membranes or engineered tissue scaffolds, tailored to research protocol

    Downstream process integration

    • Blended during thin film casting, freeze-thaw cycling, or solvent evaporation steps
    • Directly weighed and added with other sphingolipids or phospholipids in bilayer construction
    • Quality checks for lamellar phase purity, crystallinity, and biocompatibility

    Final product types

    • Transdermal drug delivery systems
    • Artificial skin models for in vitro testing
    • Research-grade biomembrane kits

    5. Nutraceutical and Functional Food Additive Manufacturing

    Food industry manufacturers utilize C6 Ceramide as a functional additive in innovative nutraceutical blends and specialized food matrices, focusing on metabolic and barrier health properties. Our units maintain full traceability with allergen and contaminant screening suitable for food contact. We fulfill requirements on batch analysis and technical documentation for export to regulated markets. Applications include fortification of dairy-alternative drinks, ready-to-eat nutritional bars, and encapsulated powders for dietary supplementation, with special focus on formulation clarity and taste masking using lipid microencapsulation technologies.

    Industry compliance standards

    • EU Novel Food Regulation (EU) 2015/2283, regulatory dossier support required
    • U.S. FDA GRAS status (self-affirmed or notified depending on jurisdiction)
    • GB 2760-2022 (National Food Safety Standard for Use of Food Additives, China)
    • FSSC 22000, ISO 22000:2018 (Food safety management systems)

    Typical usage ratio

    • 0.01–0.5% w/w in fortified beverages and powder blends; dosage adjusted based on taste and solubility profiles

    Downstream process integration

    • Microencapsulated or directly dispersed into liquid or powder pre-mixes during batch blending
    • Integrated before final homogenization or spray-drying for even ingredient distribution
    • Sensory and stability trials during pilot runs to optimize mouthfeel and shelf life

    Final product types

    • Functional sports beverages
    • Dairy-free nutritional drinks
    • Wellness supplement powders
    • Food bars and meal replacements
    Free Quote

    Competitive C6 Ceramide prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing C6 Ceramide: The Value of Pure, Traceable Production

    From our perspective as a chemical manufacturer with decades of hands-on experience, every molecule of C6 Ceramide reflects a direct response to what research scientists, formulation experts, and industrial partners have requested from us over the years. Instead of chasing trends, we’ve always preferred to listen to practical needs voiced on the ground. Most of our partners use ceramides not because marketing teams say so but because carefully selected ceramides bring measurable advantages to their products. We manufacture C6 Ceramide not as an anonymous ingredient, but as a precise tool shaped for real-world results.

    Our C6 Ceramide: Model Consistency, Reliable Purity

    When a laboratory or production facility chooses C6 Ceramide, it’s not just about buying a chemical—it’s about buying peace of mind. We designed our manufacturing line to handle small and large runs with strict attention to batch consistency. Each C6 Ceramide lot delivers narrow purity specifications, typically exceeding 98% (HPLC), which we confirm with rigorous, traceable testing. This kind of control proves essential since minor impurities, often ignored by less careful producers, can ruin cell culture studies, clog reactors, or disrupt downstream processing. Our regular feedback loop with end-users pushes us to keep improving both the quality controls and the documentation we offer with every shipment.

    What Sets C6 Ceramide Apart

    In everyday work, C6 Ceramide’s shorter chain length—six carbon atoms—translates to distinct handling properties and biological effects compared to other ceramides. Technicians notice faster solubility and easier dispersion in aqueous-organic systems. For researchers focused on cellular signaling, C6 Ceramide’s increased membrane permeability changes how experiments behave, often allowing more precise, rapid modulation of apoptosis or stress responses. In product formulations, this type has found its place in both investigative and commercial settings, especially where molecular size creates process or performance advantages. Since many ceramides possess long acyl chains, they tend to be highly hydrophobic and difficult to work with. By contrast, C6 Ceramide’s intermediate polarity accommodates a wider variety of solvents and matrix materials.

    Real-World Applications Driven by End-User Feedback

    Over the years, we’ve worked with cellular biologists, pharmaceutical developers, cosmetic scientists, and specialty material researchers who all sought consistent performance and tailored support for their work. For cancer biology labs, C6 Ceramide became a benchmark tool for investigating sphingolipid pathways involved in apoptosis and cell fate. Unlike longer-chain ceramides, C6 offers reproducible responses even with subtle dosing changes, supporting sharp, reliable endpoints in tissue models. For cosmetic companies, C6 Ceramide serves as a testbed for understanding epidermal barrier restoration and skin hydration at a mechanistic level. Its lower hydrophobicity means it won’t challenge emulsification or blending as severely as C16 or C24 derivatives.

    With each new request, we refined our production and supply chain. For pharmaceutical developers, C6 Ceramide’s consistent lot analysis, absence of extraneous solvents, and demonstrated stability create the foundation for pre-clinical studies and regulated filings. When complications arise—whether cloudiness in intermediate steps, assay interference, or handling issues in high-throughput screening—we have traced these issues back to minute variations in ceramide composition. We address them directly by communicating with users, adapting our purification steps, and updating raw material sourcing. This cycle of active listening and direct problem-solving is what separates a real manufacturer from a reseller.

    Production Built for Transparency—No Guesswork Involved

    In our years of manufacturing specialty sphingolipids, transparency in both process and documentation prevents unnecessary headaches. By keeping our workflow reproducible, with full batch records and open access to impurity profiles, end-users can focus on research, not troubleshooting supply chain mysteries. For example, we use validated HPLC and MS protocols for every production run, offering product-specific CoAs with actual test data instead of boilerplate statements. Our willingness to share process details—such as extraction solvents, synthetic precursors, and storage conditions—lets customers trust that every gram of C6 Ceramide supports both scientific and regulatory scrutiny.

    Logistics for such sensitive products involves more than a well-sealed container. With C6 Ceramide, maintaining non-reactive packaging and environmental controls at every stage of transport prevents spoilage. For researchers needing repeat experiments months apart, product stability—and detailed expiration tracking—carries huge weight. We maintain strict cold chain and desiccation protocols, matched with lot tracking systems, so scientists reordering for a multi-year project get the same high-quality material as their first shipment. This degree of attention simply doesn’t occur when bulk traders act as middlemen.

    Why Chain Length and Purity Matter in Practice

    Chemists and biologists repeatedly show us that even small shifts in ceramide chain length, unsaturation, and side-group composition create clear differences in bioactivity. C6 Ceramide, with its six-carbon fatty acid, bridges the gap between basic cell-permeable probes and structurally robust, longer ceramides. In pharmacological studies, this chain length promotes rapid uptake and distinct intracellular localization. Rather than clinging to cellular membranes and lingering, C6 Ceramide interacts quickly and reversibly with intended targets. That means dose-response curves are sharper, and secondary effects become easier to track—a detail confirmed in published studies, as well as private reports from our pharmaceutical partners.

    While longer ceramides (such as C18 or C24) dominate the skin and central nervous system in vivo, their stubborn insolubility often frustrates researchers. C6 Ceramide, by contrast, handles more like a modern synthetic reagent: it dissolves more readily in DMSO, ethanol, and aqueous mixtures, making it approachable in high-throughput assays and serial dilutions. In our own production labs, these solvent advantages simplify quality testing and stock solution preparation. Our team often advises clients on making concentrated stock solutions without fear of instability or unwanted aggregation.

    Responding to Regulatory and Application-Specific Demands

    Our experience serving regulated industries brings home how nuanced the demands for ceramides have become. Any mislabeling or ambiguity in the raw material’s crystalline form, residual solvents, or heavy metal content risks invalidating an entire batch of drug substance or research results. The only way to meet these standards—time after time—is to control every production step internally. No shortcuts, no relabeling, no diluted batches bought and resold. For C6 Ceramide, we document not just the core chemical parameters (mass spec, HPLC retention, melting point) but also track and report potential trace residues—so clients avoid costly retesting and regulatory setbacks.

    The globalization of supply chains brought plenty of headaches: sudden changes in source quality, unexplained delays, and vague documentation. By manufacturing C6 Ceramide in-house, we eliminate layers of uncertainty. Our partners know who made their product, where it came from, and which standards governed its handling. If a project evolves and demands custom scale-up, tighter impurity thresholds, or a fresh certificate suite, we deliver from our own facility—not by making excuses or waiting for a response from an unknown offshore factory.

    Industry Context: Why Experience as a True Manufacturer Matters

    Fake stories and unreliable supply plague specialty chemical markets. End-users often get burned by repackaged or recertified material. Over the years, we’ve reverse-engineered dozens of competitor samples at customer request—finding unreported contaminants, mixed chain-lengths, and old stock passed off as fresh. Most of these problems come from trading shortcuts rather than deliberate malfeasance. As manufacturers, we offer the antidote: documented origin, full-chain-of-custody records, lot-specific analytical data, and direct accountability. In regulated environments—clinical research, pharmaceutical development, and advanced materials—this chain of trust removes doubt and speeds project timelines.

    Every kilogram of C6 Ceramide we ship reflects direct investments in safety, automation, and staff training. Our safety audit routines now stretch well beyond what’s required by industry standards. Production staff rotate through hazard analysis workshops, and our product testing stays ahead of regulatory curves. This focus on standards was not forced on us by rules—our customers’ feedback, and their high-stakes projects, made it indispensable. For many partners, being able to phone a chemist on our team—and receive real, technical answers about C6 Ceramide’s properties or applications—beats any glossy brochure or generic “datasheet” sent by a trading house.

    Supporting Innovation in the Field

    Technological advances in synthetic biology and targeted therapies continue reshaping expectations for ceramide suppliers. C6 Ceramide plays a central role in research on cell stress, programmed death, membrane microdomains, and inflammatory signaling. Because our staff works with dozens of these groups directly, we see what problems keep cropping up. Cell culture batches dying off, in vitro assays giving non-standard curves, or weeping phase separation in cream formulations—again and again, the issue traces back to contaminated or mischaracterized ceramides. As the source manufacturer, we can reproduce issues in real time, run side-by-side comparisons, and offer hands-on fixes. Competitors working through third parties usually offer little insight or practical help in such cases.

    For formulation chemists and biologists pursuing new delivery systems or nanocarriers, C6 Ceramide’s solubility and rapid cellular uptake matter even more. Blending it into lipid nanoparticles, vesicles, or hydrogels often creates highly sensitive formulations. Our team keeps a close eye on physical stability, shelf life, and release properties with each new application. Collaborating directly with users means we can offer technical guidance that directly addresses reproducibility or performance blocks. By changing process steps or recommending alternate solvent systems, we help resolve bottlenecks faster than waiting for unclear distributor advice or slow manufacturer responses.

    Clearer Differences from Other Ceramides

    In practice, what’s most important for project success isn’t a marketing claim or a technical handout. It’s the ability to see, measure, and document why one molecule works differently than another. Our analytical team routinely compares C6 Ceramide’s behavior against C2, C8, C16, and C24 analogs in common assays. The shorter chain length of C6, compared to the more conventional C16 or C24 species, permits faster diffusion into aqueous systems and more manageable solubility in polar solvents. That translates into higher productivity in automated dosing, improved reproducibility in cell experiments, and easier integration into complex mixture matrices.

    In skin science, researchers find C6 Ceramide less occlusive but more bioactive for specific signaling studies. For pharmaceutical contexts centered on sphingolipid metabolism, C6 Ceramide presents unique opportunities for controlling enzymatic access and kinetic profiles. Because it doesn’t aggregate or crystallize as quickly as longer-chain analogs, sample handling and dosing present fewer headaches for end users. These nuanced physical and biological impacts push project results—especially when documentation, source clarity, and direct troubleshooting support stand behind every shipment.

    Quality Guarantee Backed by Direct Accountability

    One of the regular complaints we still encounter comes from scientists who invested months into tests, only to have controls fail or results skewed by off-spec material. Over years of partnership with research and commercial clients, we’ve built up supplier qualifications, independent reanalysis, and stability challenge logs that cover not just C6 Ceramide but a variety of custom analogs. Our lot-specific traceability logs, from raw input through final packaging and shipment, take the guesswork out of reordering or troubleshooting. This level of documentation stands as our answer to ambiguity in the specialty chemistry space.

    Direct access to our technical support team isn’t an afterthought—it’s part of the product. Whether a laboratory needs a data package for a grant application, a formulation specialist faces solubility anomalies, or a process engineer encounters unexpected yields, our staff stand ready to dive into the technical details. Because everything happens under our roof, we own the data, know the product history, and can respond quickly with targeted solutions instead of canned replies.

    Shaping the Future: Sustainability and Sourcing Concerns

    Sustainability counts as more than a slogan for our team. Ceramide production puts pressure on fatty acid and sphingosine supply chains—which carry economic and environmental impacts. By investing in both bio-based and synthetic starting materials, we’ve improved efficiency and reduced unforeseen supply shocks. Our environmental stewardship includes safe disposal of hazardous byproducts, solvent recycling, and reduction of carbon-intensive steps wherever possible. Because responsible practice only counts if it’s verifiable, we maintain open books for clients needing third-party certification or compliance data.

    Research partners focusing on green chemistry have driven us to adopt streamlined synthetic routes for C6 Ceramide, which save energy, minimize reagent waste, and use less harmful solvents. These changes didn’t happen overnight, and they required significant upfront investment and rigorous adjustment of in-house protocols. The payoff comes mainly from stronger client trust and clearer communication across the product life cycle. When a customer faces environmental audits or seeks compliance with international standards, our full records support smooth passage, rather than last-minute document chases or forced substitution with lower-grade material.

    Direct Communication Yields Results

    Manufacturing specialty chemicals at scale rarely delivers easy days. Every batch runs under careful eyes, with cross-checks from both experienced operators and quality auditors. With C6 Ceramide, every improvement in process control or documentation comes in response to hands-on input from laboratories and manufacturers. Instead of hiding behind empty assurances, we’ve always favored direct, honest feedback channels—and we’ve been quick to adapt production and logistics in light of what customers report on the ground. This approach has minimized waste, improved reliability, and saved countless research hours for our clients worldwide.

    C6 Ceramide represents more than a molecular formula or a commodity listing. It is the result of hard-earned lessons, scientific debate, regulatory demand, and ongoing investment in analytical rigor. For users who care about clarity, stability, and verified chain-of-custody from source to bench, our direct control yields measurable benefits at every step—from baseline purity to regulatory compliance and eventual process innovation. Working with a real manufacturer removes the shadow of uncertainty, giving project leaders the confidence to push the boundaries of what their research and products can achieve.