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Piceatannol

    • Product Name Piceatannol
    • Alias Astringenin
    • Einecs 607-535-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    473918

    IUPAC_name 3,3',4,5'-tetrahydroxy-trans-stilbene
    CAS_number 10083-24-6
    Molecular_formula C14H12O4
    Molar_mass 244.24 g/mol
    Appearance White to pale yellow solid
    Solubility_in_water Slightly soluble
    Melting_point 277-279°C
    Chemical_category Stilbenoid
    Source Found in passion fruit, grapes, rhubarb, and red wine
    Synonyms trans-3,3',4,5'-Tetrahydroxystilbene
    PubChem_CID 5281670
    Boiling_point Decomposes before boiling
    Stability Stable under normal conditions
    Taste Bitter
    Storage_conditions Store in a cool, dry place, protected from light

    As an accredited Piceatannol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Piceatannol is supplied in a sealed amber glass vial, labeled with chemical details, containing 100 mg of fine white powder.
    Shipping Piceatannol is shipped in tightly sealed, chemical-resistant containers, protected from light, moisture, and air. During transit, packaging complies with regulatory standards for safe handling of chemicals. The shipment is clearly labeled with hazard information, and temperature control may be applied to maintain product stability and quality during delivery.
    Storage Piceatannol should be stored in a tightly sealed container, protected from light and moisture. It is best kept at -20°C in a dry, cool, and well-ventilated area. Avoid exposure to air and strong oxidizing agents to prevent degradation. Following these conditions helps maintain its stability and chemical integrity for research or laboratory use.
    Application of Piceatannol

    Applications of Piceatannol in Industrial Manufacturing

    Piceatannol, a naturally occurring stilbene compound, supports several industrial sectors with its distinct chemical activity. As a direct manufacturer, we provide piceatannol tailored for high-value applications where purity, dosing, and compliance drive formulation procedures and downstream processing.

    1. Pharmaceutical API Intermediate for Oncology Drug Synthesis

    Pharmaceutical producers incorporate piceatannol as an advanced intermediate during targeted anticancer formulations, especially in the synthesis of kinase inhibitors for solid tumors and hematologic malignancies. Its hydroxylation pattern fits specific molecular modifications, ensuring reactant stability and precise functionalization under GMP-controlled environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Annex 2 for Biotechnological and Biological Products
    • USP-NF monograph reference for related stilbenes, qualification via compendial methods
    • FDA cGMP 21 CFR Parts 210 and 211 for drug manufacturing

    Typical usage ratio

    • Batch inclusion varies from 0.05% to 0.9% by weight as API intermediate; adjustment depends on the final target molecule and process yield optimization requirements

    Downstream process integration

    • Reaction vessel charging during Stage II/III of oncology API synthesis
    • Precursor feeding under controlled temperature and solvent conditions
    • Subject to multiple purification cycles including chromatography and crystallization before conversion into API or further modification

    Final product types

    • Small molecule kinase inhibitors for clinical oncology therapy
    • Reference standards and analytical controls
    • Advanced pharmaceutical intermediates for commercial and R&D pipelines

    2. Food Antioxidant Additive for Functional Nutrition Products

    Functional food manufacturers utilize piceatannol for its strong free radical scavenging ability in beverages, nutraceutical bars, and fortified emulsions. Its application extends to oxidation control in polyunsaturated fat-rich matrices, directly influencing product shelf life and nutrient retention in compliance with international food standards.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius General Standard for Food Additives (CODEX STAN 192-1995)
    • US FDA 21 CFR 172.105 for food additive safety and ingredient declaration
    • EU Regulation (EC) No 1333/2008 on food additives
    • GB 2760 National Food Safety Standard for Food Additive Use (China)

    Typical usage ratio

    • Commonly 10–80 ppm in finished beverage matrix
    • 10–50 mg/kg in solid food blends; adjustment considers legal limits, sensory impact, and antioxidant synergy in full formulations

    Downstream process integration

    • Direct addition during wet mixing or emulsification stages of bar and beverage production
    • Dissolution in solvent for liquid premix phase
    • Uniform dispersion checked during in-process quality control to ensure homogeneity

    Final product types

    • Functional beverages (ready-to-drink teas, juice blends)
    • Nutrition and energy bars
    • Omega-3 fortified foods
    • Plant-based milk alternatives and health-focused meal replacements

    3. Cosmetic Ingredient for Anti-Aging and Skin Brightening Formulations

    Cosmetic manufacturers apply piceatannol for its inhibitory action on melanin synthesis and oxidative skin stress. It serves as a bioactive ingredient in serums, creams, and specialty skin treatments requiring EU and US cosmetic regulatory conformity, introduced at critical compounding stages for active stability.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • US FDA Voluntary Cosmetic Registration Program (VCRP)
    • Japan Standards of Quasi-drug Ingredients (JSQI)
    • ISO 22716 Good Manufacturing Practices for cosmetics

    Typical usage ratio

    • 0.01%–0.1% by weight in facial serums
    • Up to 0.2% in overnight creams, with levels finalized after stability and dermatological compatibility testing

    Downstream process integration

    • Added during cool-down phase after emulsification to preserve bioactivity
    • Dispersed using high-shear mixing for even distribution in water-based and oil-based carriers
    • Combined with stabilizers and chelators as required by end-formula

    Final product types

    • Anti-aging creams and night repair serums
    • Brightening ampoules and spot-correction gels
    • Specialized pre- and post-sun care lotions
    • Premium skin masks and leave-on skin treatments

    4. Analytical Reference Standard for Food and Pharma QC Laboratories

    Specialized laboratories depend on high-purity piceatannol as a quantitative and qualitative reference in HPLC, GC-MS, and liquid chromatography platforms, especially for the analysis of polyphenol profiles and metabolite tracking in R&D and batch release testing.

    Industry compliance standards

    • ISO/IEC 17025 requirements for calibration and testing laboratories
    • USP–NF Secondary Standards Protocols
    • European Pharmacopeia (Ph. Eur.) monographs relating to analytical standards
    • ICH Q2 Analytical Validation Guidelines

    Typical usage ratio

    • Stock standard prepared in the concentration range of 1–100 μg/mL depending on assay sensitivity and instrument method
    • Dilutions made per SOP specific to target analyte quantitation protocol

    Downstream process integration

    • Preparation of calibration curves for method validation
    • Routine QC and batch quality control sample spiking
    • Reference for multi-component screening in pharma and food matrices

    Final product types

    • Standard reference solutions for HPLC viscosity calibration
    • Kit components for metabolite analysis services
    • Certified test kits for polyphenol routine analysis
    • R&D laboratory control samples

    5. Plant Biostimulant in Agricultural Crop Enhancement

    Agribusiness formulators use piceatannol as a phenolic compound to trigger plant defense mechanisms, enhancing abiotic stress responses and improving post-harvest quality in horticultural crops. Formulations comply with national plant health regulations, and use precision dosing during foliar application and seed treatment.

    Industry compliance standards

    • EU Regulation (EU) 2019/1009 on Fertilising Products (biostimulants category)
    • US EPA FIFRA compatibility for inert ingredient inclusion
    • China National Standard GB/T 38727-2020 for fertilizer quality
    • ISO 16128 for natural and organic ingredient definition in agro-inputs

    Typical usage ratio

    • Foliar sprays: 15–100 mg/L based on crop type and phenological stage
    • Seed treatments: 5–30 mg/kg seed mass; adjustment considers harvest interval and weather cycles

    Downstream process integration

    • Solubilized for direct application or inclusion into complex biostimulant blends
    • Co-applied with micronutrient carriers under controlled mixing and extraction settings
    • QC verification for residue and homogeneity in finished agricultural inputs

    Final product types

    • Foliar biostimulant formulations
    • Seed enhancement coatings
    • Post-harvest quality improvers for fruits and vegetables
    • Ready-to-use agrochemical blends

    6. Fine Chemical Precursor for Polyphenolic Polymer Research

    Material science laboratories exploit piceatannol’s reactive aromatic structure for synthesizing polyphenolic polymers and advanced resins. It serves as a controlled monomer, influencing polymer crosslinking, mechanical strength, and antioxidant properties in specialty coatings and biomedical device research.

    Industry compliance standards

    • ISO 9001:2015 certified manufacturing for specialty chemicals
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals – EU regulation
    • RSL (Restricted Substances List) adherence for end-use in medical polymer research
    • OECD Test Guidelines for chemical safety and polymer characterization

    Typical usage ratio

    • Typically 1–5% by weight in research-scale polymerization reactions
    • Ranges adjust for degree of polymerization, chain length objectives, and desired final material properties

    Downstream process integration

    • Reactant blending with other monomers or cross-linkers during solid or solution-phase reactions
    • Addition scheduled to synchronize with catalyst initiation points and temperature program protocols
    • Post-reaction purification and property analysis according to project targets

    Final product types

    • Novel polyphenolic coatings for packaging and biomedical surfaces
    • Prototype antioxidant resin blocks
    • Functional composites for advanced material characterization
    • Research-grade specialty films and sheets
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    Certification & Compliance
    More Introduction

    Piceatannol: Supporting Reliable Innovation in Science and Industry

    The Story Behind Piceatannol Production: From Bench to Bulk

    Long before Piceatannol powder settled in our warehouses, we tested its chemistry in small batch reactors. Our technical team worked hands-on with extraction techniques and synthetic routes, checking yields, purity, and reproducibility every step of the way. As the research community’s understanding of Piceatannol grew, we fielded more questions about consistency, practical usage, and compatibility with other raw materials. Our transition from lab to plant came after dozens of iterative adjustments, each time analyzing HPLC profiles, optimizing crystallization, and cleaning up side reactions until the lot-to-lot data met our satisfaction.

    Piceatannol Model and Specifications: Built for Clarity and Reliability

    The Piceatannol we ship today reflects those years at the bench. We decided on a pharmaceutical-grade crystalline model, regularly available in quantities suited for both research and commercial formulation. Each batch consistently exceeds 98% purity by HPLC, with moisture and ash levels kept to a minimum—decisions driven by real feedback from scientists and purchasing managers. Because particulate size and powder flow impact blending and dissolution, we monitor these physical attributes during every run. Our customers work in biological research, nutraceutical development, and sometimes specialty coatings. Each application influences how closely we guard these manufacturing details, but reliability stands at the core of our process.

    How End Users Apply Piceatannol: Real-World Benchmarks

    Scientific literature credits Piceatannol with a range of bioactivities, and we saw a demand spike among laboratories exploring its roles as an antioxidant and enzyme modulator. Academics often specify low-end quantities for cellular and molecular assays, where consistent molecular mass and low contaminant profiles matter. We ship these research packs with accompanying quality reports and reference spectra, making sure that the product matches published specifications for test reproducibility. Industrial groups want bulk Piceatannol for pilot studies in nutritional products or advanced materials. Here, packaging integrity, traceability, and clean analytical reports become the priority, especially when the final product must later stand up to regulatory attention.

    The Details That Set Our Product Apart

    Not all Piceatannol is handled with the same attention to technical detail. Through early contract projects, we discovered some customers compared our output directly against imported products with unclear origins or uneven appearance. Variability in color, odor, and solubility once caused issues in downstream formulation—sometimes Piceatannol arrived brownish, oily, or with unidentified residuals. We responded by tightening purification, picking storage conditions to prevent oxidation, and documenting every process change. Regular feedback between our analytical chemists and process engineers forged a product with sharper whiteness, longer shelf life, and lower batch impurity. These outcomes shaped our policies: we document batch spectra, retain reference samples, and keep an open door for customer audits.

    Why Purity and Traceability Matter

    A common issue we’ve encountered revolves around subtle impurities—either from incomplete synthesis or environmental exposure—creating unpredictable results in sensitive applications. For example, a handful of research partners observed cytotoxicity at lower concentrations than the published literature, only to find that crude extracts from other suppliers contained trace contaminants. We learned to validate every batch with both spectroscopic and chromatographic techniques, offering transparency around the minor constituents. For customers scaling their Piceatannol use, this directly addresses their compliance burden and fosters trust during project audits. Reliable sourcing affects not just compliance, but actual experimental outcomes and product safety.

    Supporting Customer Success in Translational Research

    Lab groups have highlighted the gap between benchtop trials and pilot manufacturing. Piceatannol at the hundred-gram scale can behave differently in a bioreactor, a capsule fill, or a transdermal patch compared to microgram laboratory tests. We regularly collect application data from both settings, flagging issues like clumping, dusting, or unexpected interactions with excipients. Consultation leads to adjusted particle size distributions or modified packaging to suit mechanized handling systems. Scientists appreciate the level of partnership this site-wide commitment creates, especially when translating academic discoveries to commercial launches.

    Minimizing Common Issues with Piceatannol Handling

    In the early years, we fielded calls about handling losses or solubility challenges. Piceatannol’s powder has a tendency to static, making accurate weighing tough on dry winter days. This led us to optimize powder flow and recommend best practices for laboratory handling—like using antistatic scoops and sealed containers. We maintain a stock of technical bulletins with troubleshooting tips driven by real user feedback. For instances where labs met solubility or stability hurdles, our team developed wetting protocols and supplied custom particle size lots to improve dispersion in aqueous bases. These practical details reduce material waste and smooth adoption at scale.

    Why We Pay Attention to Crystal Form and Storage

    Over years of manufacturing, we found that Piceatannol’s physical characteristics shift with humidity and exposure to light. Early batches stored in basic plastic containers occasionally developed clumping or off-odors, which we traced back to minor photodegradation. Today, we seal bulk containers in UV-resistant, low-moisture packaging and hold samples in environmental chambers to measure shelf stability over months at a time. This routine investment keeps product performance predictable for customers whose own regulatory filings rely on tight physical and chemical standards. Learning these details through repeated cycles keeps our shipments steady and guards partners against unpleasant surprises.

    Our Perspective on Competing Products: Quality in a Crowded Market

    Talking with our customers revealed a striking variability in the global Piceatannol market. Reports of inconsistent labeling, vague origins, or undependable purity linger, especially from generic bulk sources that batch-blend powders from multiple sites. Some products may meet only minimal compositional standards, making trace-level impurity checks impossible. We see frequent substitutions of similar polyphenols, leading to unpredictable DNA, protein, or membrane-binding in downstream research. Our team views this as more than a technical quirk—it risks research reproducibility, delays clinical or dietary filings, and shakes trust in commercial relationships. By anchoring on rigorous identity and traceability standards, we find fewer reports of failed validations and less downstream troubleshooting.

    Manufacturing and Analytical Infrastructure: Built for Traceability

    Our plant runs closed-system reactors under constant monitoring. Batch histories, from raw material to finished product, pass through electronic records that keep mistakes and guesswork out of the loop. Analytical scientists run identity checks on all incoming supplies, and advanced methods pick up on trace metals, solvents, and process impurities well below regulatory thresholds. Each lot ships with reference spectra and test result overviews. Customers auditing our facility regularly observe cross-checking between shifts, along with independent confirmation by outside reference labs. Internal records document subtle process trends over time, allowing us to see and correct drifts before they affect product consistency.

    Piceatannol and Compliance: A Continuous Commitment

    More firms now use Piceatannol as part of regulated products—dietary supplements, topical formulations, and bioactive coatings. Regulatory scrutiny of ingredient identity, impurity profiles, and supply chain security has only become stricter. We keep audit-ready documentation for each batch. If a recall or regulatory request arises, our team can quickly pull the relevant test data, shipment logs, and reference samples. By investing in compliance support, we help customers focus on innovation, not paperwork panic. This partnership mindset plays out every day as we field regulatory questions and respond to evolving guidelines.

    Research Collaborations Shape Tomorrow’s Quality Standards

    By working closely with university labs and industry partners, we spot emerging needs and challenges ahead of time. For instance, some collaborations flagged batch interface reactivity concerns during encapsulation or spray drying. In response, we tuned surface chemistry and particle size, sharing pilot data and application notes to smooth their product rollouts. By joining grant teams and expert panels, our scientists inform—and learn from—leading-edge formulation and regulatory practices, spreading this knowledge through formal and informal networks. This practice-driven feedback loop steers our upgrades, benefiting both first movers and long-term users.

    Optimizing Supply Chain for Reliability

    Supply chain interruptions test even the most robust manufacturing playbooks. During years when demand surged dramatically, we saw the effects of delayed solvent shipments, fluctuating raw botanical yields, and even port congestion. Learning from these bottlenecks, we now maintain buffer stocks of both raw extracts and processed intermediates. Strategic supplier agreements ensure priority access to critical inputs. Whenever possible, we source backup materials locally to guard against global shocks. This practical resilience matters more than ever as customers plan multi-year research and product launches with our Piceatannol as a foundational input.

    Continuous Improvement Driven by Data

    Every complaint, return, or technical challenge enters our improvement pipeline. Teams meet regularly to address each root cause—ranging from particle morphology to transporter selection. Implementation of in-line process analytics allows us to pinpoint deviations in real time, driving down rework and batch corrections. By sharing customer usage data, anonymized where required, we spot common issues—stability during high-speed tableting, flavor impacts in nutrition bars, or compatibility in water-phase emulsions. Collecting these lessons means that each year’s Piceatannol output improves incrementally, driven by evidence, not guesswork.

    Real-World Challenges and Practical Solutions

    Scaling Piceatannol from grams to kilograms, customers face a variety of technical and operational challenges. We’ve seen solubility bottlenecks in beverage formulations, foaming in high-throughput mixing, and interactions with nutrient blends that weren’t forecast by small-scale work. Our technical support team troubleshoots directly with these formulators, offering solubility enhancers or recommending encapsulation partners. In packaging, we developed double-layered containment for moisture protection in humid climates, reducing degradation over transit and storage. When customers reported unexpected color changes, joint root cause work led to storage and transit modifications that prevent such issues.

    Differences Between Our Piceatannol and Competing Sources

    Through direct experience, we observe that many competing Piceatannol sources neglect careful documentation and analytical rigor. While price pressure always exists, repeated stories of rejected lots or compliance failures remind us that true cost includes wasted time and lost trust. Our focus on documentation, third-party verifications, and controlled process steps gives our customers confidence. These investments explain the difference in batch performance and support—our approach builds lasting business partnerships, not transactional sales.

    Typical Applications: What Our Customers Achieve with Piceatannol

    Our customers use Piceatannol in novel polymers, metabolic studies, dermal patch development, and as research standards in bioanalytical labs. In metabolic research, the material’s consistent analyte profile enables detailed pharmacokinetic studies without batch-to-batch drift. Developers of nutritional products use our documentation for clean regulatory submissions. Each application brings forward a new set of technical questions, pushing us to adapt packaging, particle size, or analytical scope. As groups achieve product launches, publish research, or secure clinical trial approvals, we track these outcomes and use them to inform the next generation of our own manufacturing controls.

    Meeting Challenges Head-On: Case Reports from the Field

    One partner needed kilogram-scale Piceatannol for specialty nutritional bars, encountering clumping and mixing issues during early production. By evaluating their process, our team recommended a new feed technique and delivered Piceatannol with a different particle size distribution, which solved the handling issue and improved end-product appearance. In another instance, a research customer logged inconsistent cell culture responses. Joint investigation found minor batch impurities in a competitor’s material. After switching to our benchmarked supply, their results stabilized and publication timelines returned to plan.

    Looking Toward the Future: Ongoing Innovation and Support

    The market for Piceatannol will keep evolving as new research uncovers more uses and as regulatory requirements rise. As a manufacturer, we see ourselves as both a supplier and a collaborative problem-solver. Every insight from a customer lab, production line, or quality team shapes our daily work. Regular dialogue with end users helps us predict shifts in demand, anticipate technical challenges, and plan process refinements. Our goal: to stay a reliable partner as customers’ needs grow.

    Commitment to Transparency and Continuous Learning

    The chemical manufacturing field rewards openness and responsiveness. We publicly share analytical methods, safety considerations, and shipping practices without reservation. If a technical or regulatory challenge arises, we work visibly and honestly through it. This mindset removes obstacles to customer progress and keeps learning flowing in both directions. Managing Piceatannol production well means putting direct evidence and shared expertise ahead of shortcuts.

    Final Thoughts: Trust through Proven Experience

    Our experience manufacturing and supporting Piceatannol users highlights the value of meticulous production, technical accessibility, and transparent supply chains. By listening closely to what formulators, scientists, and developers truly need, we continually adapt our processes and set higher benchmarks for the wider market. For projects that depend on consistency, safety, and regulatory confidence, these hands-on lessons translate into dependable results where they matter most.