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Disodium Glycyrrhizinate

    • Product Name Disodium Glycyrrhizinate
    • Alias Dipotassium Glycyrrhizate
    • Einecs 259-018-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    747580

    Cas Number 73049-73-7
    Molecular Formula C42H61Na2O16
    Molecular Weight 899.91 g/mol
    Appearance White to off-white powder
    Solubility Freely soluble in water
    Taste Sweet
    Melting Point 218–225°C (decomposition)
    Ph 1 Solution 5.0–7.0
    Main Use Flavoring agent and anti-inflammatory ingredient
    Source Derived from licorice root (Glycyrrhiza glabra)
    Einecs Number 277-713-6
    Stability Stable under normal conditions

    As an accredited Disodium Glycyrrhizinate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Disodium Glycyrrhizinate is packaged in a 25 kg fiber drum with an inner plastic bag, labeled for safe chemical storage.
    Shipping Disodium Glycyrrhizinate is typically shipped in tightly sealed, food-grade containers or drums to prevent contamination and moisture absorption. It should be stored and transported in cool, dry conditions, away from direct sunlight and incompatible substances. Proper labeling and documentation are required, adhering to relevant safety and shipping regulations.
    Storage Disodium Glycyrrhizinate should be stored in a tightly sealed container, away from moisture, heat, and direct sunlight. Keep it at room temperature in a dry, well-ventilated area to prevent clumping and degradation. Avoid exposure to strong acids or bases. Proper labeling is essential, and it should be kept out of reach of incompatible substances and unauthorized personnel.
    Application of Disodium Glycyrrhizinate

    Purity 98%: Disodium Glycyrrhizinate with 98% purity is used in oral pharmaceutical formulations, where it enhances anti-inflammatory efficacy and safety profile.

    Molecular Weight 822.94 g/mol: Disodium Glycyrrhizinate of molecular weight 822.94 g/mol is used in topical creams, where it ensures consistent absorption and reliable therapeutic results.

    Particle Size D90 < 50 μm: Disodium Glycyrrhizinate with particle size D90 less than 50 μm is used in powder blends for supplement tablets, where it provides uniform dispersion and rapid dissolution.

    Stability Temperature up to 60°C: Disodium Glycyrrhizinate stable up to 60°C is used in beverage formulations, where it maintains flavor-modifying properties during pasteurization.

    Water Solubility 10g/L: Disodium Glycyrrhizinate with water solubility of 10 g/L is used in liquid OTC syrups, where it improves formulation clarity and patient compliance.

    pH Range 4.5-6.5: Disodium Glycyrrhizinate with an effective pH range of 4.5-6.5 is used in cosmetic lotions, where it preserves product stability and skin compatibility.

    Assay ≥98% (HPLC): Disodium Glycyrrhizinate assayed at ≥98% by HPLC is used in anti-allergy lozenges, where it delivers precise dosing and consistent clinical performance.

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    Certification & Compliance
    More Introduction

    Disodium Glycyrrhizinate: A Reliable Ingredient from Our Manufacturing Floor

    Built on Decades of Craft in Chemistry

    Our experience with Disodium Glycyrrhizinate goes back years, long before global demand took off and well before every other supplier lined up to offer it. Working deep in the manufacturing trenches means we don’t just know the molecule; we know exactly what it takes to make it perform safely and consistently at scale. Few other ingredients spark as much debate in food and personal care labs today. Real knowledge comes from batches we have run, tweaks we have made, and hiccups we have solved. When manufacturers look to tighten flavor profiles, soften aftertaste, or manage anti-inflammatory effects, Disodium Glycyrrhizinate often finds its way into the test runs because of its roots in licorice.

    Models and Specifications Forged Through Real-World Demand

    Our lines focus on the food and pharmaceutical grades of Disodium Glycyrrhizinate, with purity regularly shipped at 98% or higher, according to customer feedback in beverages, cosmetics, and health products. Powder remains the favored model, in either fine or granular consistency — not because it sounds impressive, but because our partners want smooth blending with minimal dust and no bitter edge. Typical appearance falls in the white to off-white spectrum. Moisture and sodium content land within narrow ranges each time, checked by in-house analytical techs who know what sloppiness looks like and reject it. Over the years, we learned the value of running routine HPLC purity checks, rather than just sending out a batch because it matches a certificate. Small details up front save a lot of headaches in downstream QA and regulatory review.

    Handling requests for specification details has kept us honest. End users ask for precise data: pH values that won’t turn beverage systems cloudy, low arsenic and heavy metal readings to pass pharmaceutical audits, instant solubility without fuss. Rather than hiding the process or talking over people’s heads, we’ve developed reporting methods anyone in the industry can interpret quickly. Several times, we worked side by side with technologists from multinational food brands, producing joint validation runs on composition and spectral signatures before orders ramped. That kind of dialogue is only possible if both sides share technical language and a commitment to traceable, batch-level data.

    Application Use Cases: Lessons from the Production Floor

    Disodium Glycyrrhizinate pulls double duty as both a flavor modifier and a functional compound. In beverage plants, the ingredient shines by masking off-notes from high-intensity sweeteners, especially stevia and aspartame, without introducing its own overpowering taste. Our team has seen it restore balance in sports drinks and clear sodas, rescuing formulations from the complaints that dogged earlier prototypes. Lab staff tell us that the right Disodium Glycyrrhizinate cuts bitterness without slipping into an unwelcome licorice aftertaste – a tricky balance our batch testing aims to guarantee.

    Personal care formulators pick it up for its demonstrated anti-inflammatory impact, particularly in skin creams targeting redness and irritation. They demand consistency on the sodium load to avoid textural shift and product destabilization. Our trials with cosmetics firms exposed just how sensitive some gels and creams are to trace ionic content. Sticking to controlled production, plus running real-time quality screening, supplied the reliability these brands required. We never stop at just the certificate; we validate new batches with partners, since we have learned from hard experience that “all clear” on paper sometimes hides surprises down the line.

    In pharma and nutraceuticals, Disodium Glycyrrhizinate raises the compliance bar. Regulatory filings need all the residual solvents and excipient traces right out in the open. Every time a batch goes to a medicine producer, our documentation has to track more than just origin and composition — stability, allergen risk, and bioburden each get flagged and reviewed. Over time, handling audits cemented our appreciation for thorough upstream testing and the value of full traceability, which simplifies downstream risk for both us and the customer.

    Why Disodium Glycyrrhizinate Stands Out from Other Glycyrrhizinate Salts

    Sourcing good Disodium Glycyrrhizinate isn’t as simple as picking a salt or random licorice extract. Ammonium glycyrrhizinate and monoammonium salts turn up as alternatives, yet these carry their own flavor footprints, solubility quirks, and less predictable sodium content. In beverage and supplement work, sodium glycyrrhizinate appeals because it dissolves cleanly and leaves minimal off-taste — something that revealed itself over countless pilot batches in the factory, not through theory alone.

    Production lines value predictability. Disodium Glycyrrhizinate’s sodium base offers steady response in both low and high pH, and that stability takes out much of the guesswork operators face with other salts. Application teams regularly highlight that when batch quality swings too far, flavor houses see drift, and extra unplanned testing eats away at formulation budgets. Our repeated investments in monitoring equipment came not from wanting to impress, but from seeing hidden deviations up close — and suffering warranty claims as a result, years back. Now our processes focus on those finer points so every kilo ships with the confidence drawn from both strict testing and tough lessons.

    Traceable Licorice Origins: Managing Supply Reality

    Every plant operator knows a supply chain can wobble if raw material quality strays. Glycyrrhizin sourcing needs more than just procurement call sheets. We have handpicked downstream suppliers who harvest, shred, and extract licorice root with documented field histories. Over time, we weeded out inconsistent suppliers after seeing color shifts, sticky residues, or unexplained residue levels in early raw lots. Each crop season, we send technical staff for spot audits, not to generate fancy reports but because after one bad season of off-spec glycyrrhizic acid, you never want to gamble with unproven sources again.

    Careful selection of raw licorice pays out in the trace metals, ash, and solvent profile you see in every batch. We track pesticide status back to the field, since some pharma applications cut off at the faintest sign of residues. Lab workers on our side push for extraction solvents aligned with food and pharma codes, meaning we steer clear of shortcuts that might work for informal sectors but carry lasting regulatory headaches. Our partners in beverage and personal care recognize this difference as the months pass and testing data stacks up, not just on the spec sheet but on their final product shelf stability.

    Manufacturing Practice: The Real Test of Quality

    Modern GMP standards didn’t come just to win certificates. Operators who face annual regulatory audits or sudden buyer inspection teams appreciate the value of records, transparent SOPs, and a workforce that knows its quality checkpoints. From tank to drum, and from the initial glycyrrhizic acid extract to the conversion and crystallization of Disodium Glycyrrhizinate, our floors hold to repeatable procedures and check steps. Years of facing importers’ surprise visits, and tracing every lot after a batch recall decades ago, taught us that you don’t skimp on even the smallest handling protocol. The stakes are too high when ingredients end up in products consumed or applied by millions.

    Some requests call for tailored fineness, others for a particular moisture window. Technical limits exist, and we don’t overpromise — our teams would rather say “no” than cut corners to meet an unrealistic ask. In verifying key properties like purity, appearance, sodium content, and microbial load, we run checks batch-after-batch, not just for export-sized drums, but also for early R&D kilo packs. That consistency reassures partners under real market pressure and allowed us to build direct paths with major downstream brands across Asia, North America, and the EU.

    Meeting Market Demand: Transparent, Not Flashy

    Shipping millions of tons is one thing; keeping up integrity in every batch is another. Market demand for Disodium Glycyrrhizinate remains durable, with spikes from sugar-reduced formulas and new, functional beverage concepts. Nutrition houses and global supplement players ask for not just the standard powder, but for grades that minimize sodium or meet detailed allergen profiles. We adapted by working on smaller batch fill-outs, introducing intermediate lot tracing, and opening batches for third-party lab checks, which build buyer trust in a field where one major recall can send a brand into free fall.

    Specialty users — from those fermenting kombucha to those crafting energy sticks or skincare patches — approach with narrow targets. Sometimes sodium load matters less than microbiological freedom, sometimes the presence of specific trace flavonoids matters more. Our discussions with these groups improved our line discipline, driving shorter production runs and enforcing mid-batch sampling points as standard operating procedure, not as a crisis fix.

    Continual Refinement Based on Industry Reality

    No production run meets every dream spec right out of the gate. Feedback from clients who use Disodium Glycyrrhizinate in liquid, powder, paste, or gel formats returns to our lab team, who apply practical fixes grounded in their hands-on knowledge. We have adjusted crystallization temperature ranges, changed filtration mesh size, swapped drum lining material, all based on hard-won feedback from partners working at the coal face of formulation and production, not under fluorescent lights in distant offices.

    Over the years, we fielded requests for non-GMO status, kosher, halal certifications, and new forms suitable for emerging markets. Meeting each of these demands isn’t a box-ticking exercise. It pushed us to design training modules for our operators, ensure supplier compliance, re-map documentation, and more than once, consign a batch to waste rather than risk shipping out a subpar product. That discipline ingrains over time, and it’s visible in how we control batch numbers, records, and response time to deviations in quality.

    Risk Management and Regulatory Navigation from a Manufacturer’s Perspective

    Manufacturers face pressure from two sides: buyers pushing for ever-lower costs and regulators calling for full compliance. Both can result in dangerous shortcuts if not managed by experience. Every notification from the FDA, EU Food Safety Authority, or local market authorities spurs a round of process checks and, occasionally, tough discussions inside the plant. We transitioned cleaning protocols, adjusted water activity measurements, and rebuilt traceability software not because market trends demanded it, but because we witnessed the real fallout from lapses in record-keeping in the early 2000s.

    Oversight from buyers in strict markets shapes our output more than any consultant’s report. Working through REACH and international food additive lists, translating local language requirements and batch-level traceability into day-to-day practice, means taking compliance beyond paperwork. We opened our doors to joint audits, signed off on regular residual solvent analysis, and proved that every step — from raw licorice extract to finished Disodium Glycyrrhizinate — follows documentable process routes.

    Whenever recalls happen in our sector, they usually trace back to supplier mismatch, missing data, or wishful testing. We built response teams, scenario drills, and a batch quarantine system into our workflow, not because it sells more product, but because those systems actually saved business relationships when issues cropped up. Regulatory stability and plant-level discipline speak for themselves, over hundreds of batches and through evolving rules governing food, pharma, and personal care ingredients.

    Partnership, Not Just Product

    Part of manufacturing runs beyond the machinery or the chemical. Every ton of Disodium Glycyrrhizinate reflects back-and-forth with the buyers who actually use what we make and rely on our teams to understand realities they face, from high-acid beverage tolerance to zero-allergen screening. The difference between a trading house and a manufacturer sits not only in the ability to deliver, but to troubleshoot, adjust, explain, and back up every specification with records. Our longest partnerships have grown from responding openly to formulation failures, delivering trial blends, and facing market pushback — not by hiding mistakes or sugarcoating process realities, but by offering evidence and timelines.

    For formulators balancing price against quality, every conversation about Disodium Glycyrrhizinate circles back to the same points: material traceability, response speed to issues, openness to technical support, and willingness to co-investigate production anomalies. After many cycles of market entry, changes in consumer trends, and tightening regulation, we recognized that a reputation for straight talking does more to ensure market longevity than any one price point or marketing campaign.

    Looking Ahead: Continual Innovation Backed by Direct Experience

    Change isn't something manufacturers fear; adjustment forms a daily reality. Consumer push for more natural, less processed components raises challenges for even widely used compounds like Disodium Glycyrrhizinate. We run lab pilots using new extraction approaches, greener solvents, and water-saving production methods not because it creates press releases, but since operating authorities and informed consumers raise the bar. Ongoing research with R&D centers led us to trial process modifications, deliver unique compliance documentation, and prep new forms targeting medicinal regulatory innovation.

    By keeping close tabs on global licorice root supply stability, updating technical staff on emerging allergen or contaminant risks, and exposing every batch to third-party validation, we keep our output ready for whatever the food, beverage, or pharma sector throws next. Longevity in this business doesn’t rely on old habits but on learning from every shipment, every claim and counter-claim, every round of feedback from operators on the factory floor to end-users fine-tuning flavor or efficacy.

    The sum of this experience sits not in brochures, but in the quiet confidence with which our teams produce every batch of Disodium Glycyrrhizinate, facing up to scrutiny and always ready for the next specification, the next technical curveball, and the ongoing challenge to keep a globally trusted ingredient safe, reliable, and ready for the world’s taste, health, and cosmetic markets.