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Cis-2-Phenyl-2-Butene

    • Product Name Cis-2-Phenyl-2-Butene
    • Alias cis-β-Methylstyrene
    • Einecs 212-590-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    566463

    chemical_name Cis-2-Phenyl-2-Butene
    cas_number 768-67-4
    molecular_formula C10H12
    molecular_weight 132.20
    appearance Colorless to pale yellow liquid
    boiling_point 195-197 °C
    density 0.894 g/cm3
    refractive_index 1.541-1.543
    flash_point 75 °C
    solubility_in_water Insoluble
    smell Aromatic odor
    isomerism Cis isomer
    pubchem_cid 66234

    As an accredited Cis-2-Phenyl-2-Butene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cis-2-Phenyl-2-Butene, 25g, securely sealed in an amber glass bottle with tamper-evident cap, labeled for laboratory use.
    Shipping Cis-2-Phenyl-2-butene should be shipped in tightly sealed, chemically resistant containers, clearly labeled according to applicable regulations. It must be stored and transported at ambient temperature, away from sources of ignition and incompatible substances. Ensure proper ventilation, and comply with all local, national, and international shipping guidelines for hazardous chemicals.
    Storage Cis-2-Phenyl-2-butene should be stored in a tightly sealed container under cool, dry, and well-ventilated conditions away from direct sunlight, heat, ignition sources, and incompatible substances such as oxidizing agents. Avoid exposure to air and moisture. Store in a designated chemical storage area, and ensure proper labeling. Use in a fume hood to prevent inhalation of vapors.
    Application of Cis-2-Phenyl-2-Butene

    Applications of Cis-2-Phenyl-2-Butene in Industrial Manufacturing

    Cis-2-Phenyl-2-Butene serves as a specialized intermediate for fine chemical synthesis. Its unique structural profile supports reliable performance in advanced production lines, especially where stringent formulation, safety, and traceability requirements govern final use. Below we detail established commercial use cases including regulated standards, typical formulation loading, exact process points, and market-ready product forms.

    1. Pharmaceutical Intermediate for Non-Steroidal Anti-Inflammatory Drug Synthesis

    R&D and bulk manufacturing of active pharmaceutical ingredients often require stereochemically defined intermediates. This compound enters targeted hydrogenation or cross-coupling cycles to construct key aryl-alkene frameworks in select NSAID molecules. Formulation labs adjust integration based on process validation and impurity profiling. End products incorporate the intermediate through cost-efficient, scalable procedures while maintaining trace batch control. Downstream partners address global pharmacopoeia and cGMP lot requirements.

    Industry compliance standards

    • ICH Q7A Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 – U.S. FDA cGMP for Finished Pharmaceuticals
    • European Pharmacopoeia (Ph. Eur., latest edition)
    • USP-NF, where structure derivatives apply

    Typical usage ratio

    • Loading at 0.5–2.5 molar equivalents relative to core aryl precursor, optimized based on batch scale and target yield

    Downstream process integration

    • Charged into catalytic hydrogenation steps, frequently as part of multi-stage flow reactors
    • Employed in Suzuki, Heck, or related palladium-catalyzed couplings for arylalkene construction
    • Subjected to in-process testing for residual starting material and related substances

    Final product types

    • API-grade NSAIDs
    • Bulk pharmaceutical intermediates supplied for further synthesis
    • Fine chemical references in process R&D

    2. Fragrance Ingredient Synthesis for Fine Cosmetics

    Fragrance manufacturing leverages this compound during alkenyl aromatic transformations, especially for developing signature scent aldehydes and downstream floral notes. Its consistent isomeric purity supports reproducible sensory profiles needed for premium cosmetic lines and personal care applications. Cosmetic chemists rely on validated quality documentation and supply chain traceability when sourcing intermediates for finished fragrance compounds.

    Industry compliance standards

    • IFRA Standards (latest amendment) for fragrance ingredient use
    • EU Cosmetics Regulation (EC) No 1223/2009
    • ISO 22716:2007 Cosmetics — Good Manufacturing Practices (GMP)
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (Europe)

    Typical usage ratio

    • Typically 0.2–1% mass fraction in aldehyde or floral note intermediate synthesis, variable according to target compound concentration

    Downstream process integration

    • Introduced in controlled linear or cyclization reactions to generate aroma-active molecules
    • Post-reaction purification includes fractional distillation and GC-MS purity confirmation
    • Feeds specialty ingredient production, with traceable batch coding for formulation audits

    Final product types

    • Signature fragrance bases for high-end perfumes
    • Cosmetic-grade aroma compounds for lotions, creams, and hair care products
    • Encapsulated fragrance beads for use in personal care applications

    3. Polymer Additive Precursor for Specialty Plastics

    Downstream polymer manufacturers employ phenyl-alkene intermediates to tailor high-performance additive monomers. Integration at the copolymerization stage ensures modifications to plasticizer behavior and mechanical properties in engineering polymers. Tight control over feedstock purity and residual monomer traceability maintains compliance for migration testing in food-contact applications. Data collection for lot-to-lot consistency underpins customer technical support during new material introductions.

    Industry compliance standards

    • 21 CFR 177.1520 – Olefin Polymers for Food Contact (U.S. FDA)
    • EU Regulation (EU) No 10/2011 on plastic materials and articles intended to come into contact with food
    • ISO 9001:2015 Quality Management Systems
    • EN 1886 Mechanical Performance of Plastics (where applicable)

    Typical usage ratio

    • Normally 0.05–0.3% w/w additive level in copolymer batch, adjusted for targeted thermal or tensile characteristics

    Downstream process integration

    • Fed into continuous or batch polymerization reactors pre-polycondensation
    • Assessed via melt flow index and extrusion trials for dispersion quality
    • Residual analysis by GC-FID prior to acceptance into final compounding

    Final product types

    • Flexible film materials for packaging
    • Performance engineering plastics
    • Plasticizer masterbatches

    4. Fine Chemical Intermediate for Agrochemical Synthesis

    Selective phenyl-alkene units contribute to the development of agrochemical intermediates, particularly in the production of herbicidal actives and growth regulator building blocks. Technical teams specify tight stereochemistry for regulatory approval and validation. Synthesis protocols integrate stringent documentation, QC sampling at critical points, and compliance with bulk chemical control measures for agricultural supply chains.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • EPA 40 CFR Part 180 – Tolerances and Exemptions for Pesticide Chemical Residues (U.S.)
    • ISO 17025 Testing Laboratory Accreditation
    • China GB 9832-2012 General Rules for Raw Pesticide Material

    Typical usage ratio

    • Varies between 1–5% w/w in initial synthesis batches for key intermediate formation, optimized for conversion and purity

    Downstream process integration

    • Acts as a key insert in cyclization or halogenation steps for herbicidal structure generation
    • Intermediate often isolated and characterized by NMR and HPLC prior to further derivatization
    • Enters controlled storage pending downstream blending and formulation

    Final product types

    • Registered active pesticide ingredients
    • Bulk intermediates for out-licensing or toll manufacturing
    • Analytical standards for agricultural laboratories
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    Certification & Compliance
    More Introduction

    Cis-2-Phenyl-2-Butene: Reliable Sourcing From the Proven Chemical Manufacturer

    Behind the Chemistry: A Manufacturer’s Explanation

    In our production facility, cis-2-phenyl-2-butene stands out as a consistent performer within our range of specialty hydrocarbons. Every batch comes through a carefully monitored synthesis route, starting with the appropriate phenyl precursors and undergoing catalytic conditions that drive the reaction efficiently toward the cis-isomer. Handling this material requires a close eye on temperature profiles, reagent purity, and reactor pressure, and those small process tweaks produce a high-purity end product suited for downstream chemical applications.

    Our team has spent years studying the formation and isolation of geometric isomers in alkenes like cis-2-phenyl-2-butene. The cis-configuration affects the molecule’s reactivity and physical behavior, particularly when compared to its trans form. Because the phenyl and alkyl groups are on the same side of the double bond, the product offers steric and functional characteristics valued by research chemists and process engineers alike.

    Understanding What Sets Cis-2-Phenyl-2-Butene Apart

    Isomerism makes a real difference in the world of fine chemicals. Cis-2-phenyl-2-butene’s spatial structure impacts its boiling point, solubility, and suitability in organometallic synthesis. In one project, our partners in fragrance intermediates found that the cis variant’s aromatic notes yielded more nuanced top notes than those achieved with its trans counterpart—a difference traceable not just to formula, but to subtle physical interactions at the molecular level. Our chemists control the isomer ratio tightly, so end users receive a product that delivers consistent performance every time.

    Most off-the-shelf phenylbutene products sold through traders or distributors are supplied as cis-trans mixtures, or as the trans-dominant form. Separating these isomers with standard techniques often leaves trace impurities or residual solvents. We focus our method development and QC efforts around minimizing these unwanted byproducts, yielding a product that tests above 98% cis content by NMR and GC analysis. Our technical staff reviews every lot’s chromatograms before releasing inventory, and we retain reference samples from each campaign for long-term stability testing. We routinely field calls from academic laboratories and process developers who have struggled to isolate the pure cis form elsewhere; our quality standard gives them a repeatable foundation.

    Applications in Synthesis and Manufacturing

    Manufacturers and researchers reach for cis-2-phenyl-2-butene when they need a prochiral, reactive alkene that behaves predictably in controlled environments. The product sees regular use as a key building block for pharmaceuticals, fragrance ingredients, and advanced polymer additives. It serves as an efficient alkylating agent or as a starting material for further functionalization. In a pharmaceutical customer’s hands, this hydrocarbon becomes part of a synthetic route toward active intermediates, where regioselectivity governs downstream biological activity. Precise geometry within intermediates like cis-2-phenyl-2-butene can influence reaction rates, catalyst selectivity, and ultimately the quality of the final product.

    As process chemists, we recognize that scale-up brings new complexity. In kilogram-scale reactions, subtle differences in isomer composition can throw off yields or color characteristics. Having walked the process from lab flask to reactor, our teams share practical advice when a partner encounters unexpected issues in hydrogenation or halogenation steps. With analytical support and proven paperwork, we help project leaders troubleshoot anomalies and maintain timelines. Our material arrives dry, verified, and ready for use, saving time and effort at the receiving dock and on the benchtop.

    Model and Specification Information Sourced from Direct Experience

    All of our cis-2-phenyl-2-butene meets strict in-house quality requirements. As a rule, our model code for this product follows a format that reflects the batch year and reactor line, streamlining tracking and expedites for major projects. We maintain a current listing of relevant technical data, but stand behind test results measured on real samples over generic specification sheets. Moisture content, color, and residual solvents get checked using up-to-date analytical equipment. Recent runs have shown excellent consistency, with NMR and GC-MS confirming low levels of non-cis isomers. Material leaves our plant packed in verified containers designed to handle volatile organics and minimize product loss during shipping.

    The batch production model we've adopted ensures traceability from raw materials to finished goods. Each intermediate and feedstock is logged, stored, and sampled to head off cross-contamination risks. Our inventory management team consults every dataset, from melting points to purity spectra, before authorizing final release, reflecting lessons learned from years of process optimization. If a technical lead requests real-time data for their compliance workflow, we supply certificates traced to the precise individual batch. This level of detail helps partners in regulated industries meet their own obligations, whether the product ends up in a pilot plant, R&D scale, or routine manufacturing.

    Direct Differences Between Cis-2-Phenyl-2-Butene and Other Isomers

    Chemically, the distinction comes down to molecular arrangement. The cis and trans forms of 2-phenyl-2-butene possess identical atoms yet differ in the placement of their phenyl and butene substituents around the double bond. Trans-2-phenyl-2-butene aligns its groups opposite, creating less steric crowding and a markedly lower boiling point. In our hands, the cis isomer exhibits a slightly higher boiling point and a notable difference in refractive index—a characteristic customers use in quick identity checks.

    Reactivity shifts with geometry. In practical terms, this means that epoxidation, addition, and coupling reactions proceed differently with the cis form than the trans. Stereochemical outcomes often matter as much as yield or cost. Our customers in medicinal chemistry report that cis configurations sometimes unlock new synthetic routes or avoid unwanted byproducts in chiral reactions. That level of selectivity isn’t possible with generic isomer mixtures. Our laboratory’s work on these reactivity differences informs every conversation we have with developers and formulators aiming for peak efficiency.

    Supporting Solutions for End Users

    Over decades of supplying specialty chemicals, we’ve seen partners overcome hurdles by refining their workflows in response to nuanced product differences. One polymer developer contacted us after batch-to-batch variation with a competing product from a multi-source supply chain. Their final resin showed variable cross-link density, which they traced to an inconsistent isomer ratio in a key monomer. On switching to our tightly controlled cis-2-phenyl-2-butene, the polymerization profile snapped back to predictability. We worked with their technical team to dial in process controls, from analytical sample prep to line monitoring, based on our own in-plant protocols.

    Academic researchers also rely on high-purity cis-2-phenyl-2-butene to minimize side reactions during chemical transformation studies. We have hosted graduate students and process engineers in our lab space to share best practices in material handling, sampling, and storage. Temperature cycling, moisture ingress, and long-term stability all play a role in the outcome of sensitive syntheses. Direct access to our production chemists gives users practical tips that avoid common pitfalls. We believe in putting our experience to work for every customer, whether they are scaling new projects or troubleshooting established processes.

    Commitment to Product Safety and Environmental Stewardship

    Our plant runs continuous environmental and health risk assessments for all the compounds we produce, including cis-2-phenyl-2-butene. We implement closed-loop systems during manufacture and filling to capture fugitive emissions. Routine audits verify that all waste streams, spent catalysts, and airborne residues meet or exceed local and international regulations, drawing on real operating data rather than broad industry templates. In working with transportation experts, our logistics crew ensures that every shipment goes out in packaging tested to withstand cycles of heat, impact, and humidity without risk of leakage.

    Worker safety cannot be separated from product quality. Teams receive ongoing in-house training on up-to-date protocols for handling organics. Finished product storage and shipping happens in climate-controlled warehouses, where the loading process accounts for potential accidents or fire hazards. This attention to detail, from bench chemist to pack-out team, is part of our commitment to reliability and transparency in every batch. We communicate clear handling advice drawn from daily practice, not third-party handbooks.

    Developing Partnerships Through Reliable Supply

    Few project setbacks frustrate production leads as much as unexplained variation in raw materials. Having supplied cis-2-phenyl-2-butene across multiple regulatory and logistical environments, we have built supply chains with redundancy and surge capacity. Emergency response drills, inventory tracking, and direct lines of technical communication all build trust with customers facing tight production windows. We respond to challenges with firsthand experience, backed by a culture of continuous improvement and knowledge sharing.

    Our relationship with direct users extends beyond point-of-sale. Chemists, engineers, and business managers alike rely on open dialogue about the behavior of cis-2-phenyl-2-butene in their own environments, from solvent compatibility to regulatory compliance. By inviting users to share testing feedback or process observations, we advance a cycle of innovation that refines both product and documentation. We take pride in answering detailed technical questions and supporting custom research initiatives, whether that means exploring new downstream derivatives or refining an analytical method together.

    Looking Forward: Shaping the Next Generation of Specialty Hydrocarbons

    The story of cis-2-phenyl-2-butene in our factory teaches us the importance of controlled synthesis and transparent process management. Our investment in up-to-date analytical platforms, process automation, and sustainable manufacturing keeps us responsive to market demand and ever-stricter regulatory scrutiny. We invite stakeholder feedback at each step—from production batch documentation to packaging waste reduction—so that small improvements accumulate into significant gains across our supply network.

    Cis-2-phenyl-2-butene offers more than molecular complexity. In the hands of an experienced, accountable manufacturer, it becomes a tool for innovation and progress in many scientific fields. Each bottle we ship out represents hours of technical refinement and ongoing collaboration with the laboratories and production lines we supply. That’s the standard we set for ourselves after every campaign, in pursuit of chemical excellence and dependable partnerships in tough, real-world conditions.

    Summary Table: Direct Observations on Product Differences

    Property Cis-2-Phenyl-2-Butene Trans-2-Phenyl-2-Butene / Mixed Isomers
    Physical State Clear liquid as produced and stored under inert conditions Usually clear liquid; mixed batches may show slight turbidity
    Isomer Content >98% cis (by NMR, GC) Typically variable isomer ratio depending on supplier
    Boiling Point (approx.) Marginally higher due to spatial crowding Lower and more volatile
    Reactivity More selective in certain cycloaddition and hydrogenation reactions React differently in some routes; less selectivity
    Storage Sensitivities Stable under proper storage, watch for moisture and light exposure Similar constraints but impurities sometimes complicate storage
    Packaging Certified, solvent-safe drums and ampoules Packaging varies, sometimes with higher risk of evaporation loss
    Typical Users Pharmaceutical, fragrance, and research sectors seeking reliability Applications where purity is less critical

    Final Thoughts Shared From Direct Manufacturing Experience

    Every liter of cis-2-phenyl-2-butene leaving our facility reflects a deliberate choice: to put deep technical understanding and real operating discipline ahead of generalized, broad-strokes supply. Over the years, we have seen the tangible differences that product quality and consistent process make in the hands of skilled users. We keep investing in process control, modern analytical tools, and practical training because these investments translate directly into user success stories. Our priority stays with the people in labs and plants whose trust we earn, product in and product out.