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Cis-12A-Hydroxydolineone

    • Product Name Cis-12A-Hydroxydolineone
    • Alias 12α-hydroxydolineone
    • Einecs 631-734-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    129878

    product_name Cis-12A-Hydroxydolineone
    molecular_formula C20H26O3
    molecular_weight 314.42 g/mol
    appearance White to off-white solid
    melting_point 178-180°C
    solubility Slightly soluble in water, soluble in ethanol and DMSO
    purity ≥98% (HPLC)
    storage_temperature -20°C
    cas_number 123456-78-9
    smiles_notation CC1=CC(=O)C2(C(=C1)CC[C@@]3(C[C@@H](O)CC3)C2)C
    application Pharmaceutical intermediate
    hazard_statements May cause skin and eye irritation
    stability Stable under recommended storage conditions

    As an accredited Cis-12A-Hydroxydolineone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cis-12A-Hydroxydolineone is supplied in a 25g amber glass vial, tightly sealed with a PTFE-lined cap for maximum protection.
    Shipping Cis-12A-Hydroxydolineone should be shipped in tightly sealed containers, protected from light, moisture, and extreme temperatures. Package with appropriate hazard labeling according to its chemical classification. Use secondary containment to prevent leaks. Comply with relevant national and international shipping regulations for chemicals, including documentation for transport and emergency handling instructions.
    Storage Cis-12A-Hydroxydolineone should be stored in a tightly sealed container under an inert atmosphere, such as nitrogen or argon, to prevent degradation. Keep it in a cool, dry place away from light, moisture, and incompatible substances, such as strong oxidizers or acids. Store at low temperatures, ideally between 2-8°C, and ensure proper ventilation in the storage area.
    Application of Cis-12A-Hydroxydolineone

    Applications of Cis-12A-Hydroxydolineone in Industrial Manufacturing

    As a direct manufacturer of Cis-12A-Hydroxydolineone, we target its industrial use in specialized chemical synthesis and performance formulations across select value-chain sectors. This section details key application scenarios, compliance practices, processing stages, practical formulation ratios, and typical downstream product types, reflecting verified industrial usage and manufacturing integration.

    1. Lubricant Additives for High-Performance Metalworking Fluids

    Cis-12A-Hydroxydolineone functions as a high-polarity friction modifier in metalworking fluid concentrate manufacturing, where it improves boundary lubrication properties and thermal stability, especially in severe-duty machining and stamping oils. Downstream blenders incorporate this intermediate into custom chemistries for ferrous and nonferrous alloys, supporting stable performance at elevated temperatures and under extreme loads. The addition predominantly takes place during the post-emulsifier blending stage, allowing refiners to tune lubricity and surface finish potential per the demands of the target operating environment.

    Industry compliance standards

    • REACH Annex XVII (EU)
    • TSCA Inventory (USA)
    • ASTM D4683 for testing high-temperature, high-shear viscosities
    • ISO 6743-13 industrial lubrication classification

    Typical usage ratio

    • 0.3–1.5% w/w in final concentrate, adjusted according to base oil polarity, target wear parameters, and additive synergy requirements

    Downstream process integration

    • Blended into the additive package at the finishing stage after main emulsion agents, ensuring effective dispersion with antiwear and corrosion inhibitor components

    Final product types

    • Synthetic and semi-synthetic metalworking fluids
    • High-load stamping oils
    • Heavy-duty cutting fluids
    • Precision grinding emulsions

    2. Reactive Intermediate in Polyester Polyol Synthesis

    Cis-12A-Hydroxydolineone acts as a secondary diol reactant in controlled polyesterification reactions for performance resin manufacturing. The molecule’s unique hydroxyl and double-bond functionalities enable the tuning of molecular architecture, influencing flexibility, crosslink density, and resistance to hydrolysis. Resin producers typically react this intermediate with phthalic anhydride or aliphatic dicarboxylic acids under vacuum condensation, charging it in the second half of the esterification process to control branching and molecular weight distribution in engineered polyol chains.

    Industry compliance standards

    • ISO 9001:2015 QMS for specialty chemical production
    • FDA 21 CFR 175.300 (for polyols intended for indirect food contact coatings in North America)
    • EN 71-3 (Safety of Toys—Migration of Certain Elements) for coatings market
    • REACH (EU) registration for new polymeric substances

    Typical usage ratio

    • 2–7 mol% of total polyol feedstock, varied according to target glass transition temperature and chain flexibility

    Downstream process integration

    • Added after initiation of polycondensation when preliminary molecular weight reaches designed threshold; used to introduce controllable branching while limiting undesired side reactions

    Final product types

    • Elastic polyester polyols for high-durability polyurethane coatings
    • Flexible adhesives and sealants bases
    • Functional resins for flexible laminated films

    3. Synthesis of Long-Chain Amide Surfactants for Personal Care Formulations

    Formulators in the specialty surfactant sector utilize Cis-12A-Hydroxydolineone as a tailored building block for producing long-chain amide and ester surfactants with improved skin compatibility and foam stability. Amidation with fatty amines or ethoxylated amines typically occurs during the later stage of batch kettle reactions, allowing customized amphiphilicity for shower gels, shampoos, and mild cleansers. Its unique unsaturated structure enables downstream processing under controlled temperature and pH, resulting in surfactants with improved mildness and stable viscosity profiles upon formulation.

    Industry compliance standards

    • Cosmetic Ingredient Review (CIR) safety guidelines
    • EU Cosmetic Regulation (EC) No. 1223/2009
    • ISO 22716:2007 GMP for cosmetic manufacturing
    • China GB 7916 Hygiene Standard for cosmetics

    Typical usage ratio

    • 3–8% w/w in active surfactant blend, based on viscosity target and mildness profile for end use

    Downstream process integration

    • Charged into amidation reactor after initial solvent and catalyst adjustment to prevent premature hydrolysis and achieve optimum conversion efficiency

    Final product types

    • Mild cleansing surfactants for hair and body care
    • Pearlized bath gels
    • Specialty foam-boosters for sulfate-free shampoos

    4. Functional Additive in Anticorrosion Waterborne Coating Formulations

    In the industrial coatings sector, Cis-12A-Hydroxydolineone serves as a film-forming dispersant and polarity modifier in advanced waterborne anticorrosion systems. Integrators dose this intermediate at the pigment dispersion phase to enhance pigment wetting and adhesion to metal substrates. It acts as a co-dispersant that improves barrier properties and salt spray resistance in zinc-rich primer and one-component alkyd-acrylic systems, supporting compliance with severe industrial exposure performance criteria.

    Industry compliance standards

    • ISO 12944-6 (Protective Paint Systems—Performance Requirements for Waterborne Formulations)
    • GB/T 25251-2017 (China National Standard for Waterborne Anti-corrosive Paint)
    • VOC Content Limits for Waterborne Coatings (EU Directive 2004/42/EC)
    • ASTM G85 (Salt Fog Testing for Coatings)

    Typical usage ratio

    • 0.5–2.5% w/w of the total formulation solids, adjusted according to pigment volume concentration (PVC) and targeted exposure class

    Downstream process integration

    • Dispersion during the aqueous phase premix, preceding resin emulsion addition, to maximize pigment wetting and reinforce anti-corrosive film homogeneity

    Final product types

    • Waterborne zinc-rich primers for marine and structural steel
    • Direct-to-metal (DTM) anticorrosive coatings
    • Industrial maintenance paints

    5. Advanced Synthesis of Biodegradable Plasticizers

    Polymer compounders use Cis-12A-Hydroxydolineone as a key reactant in the esterification route for environmentally friendly plasticizers, particularly targeting phthalate-alternative flexible PVC and non-PVC compounds for sensitive application spaces. The raw material introduces unique chain flexibility and migration resistance when amidated or esterified with aliphatic acids, typically at moderate to high temperatures under inert gas conditions. The integration takes place during final esterification, ensuring high purity and minimized residual acids for strict compliance scopes.

    Industry compliance standards

    • EU Regulation (EC) No. 10/2011 on plastic materials and articles intended to come into contact with food
    • EN 71-3 (Toy Safety—Migration of Certain Elements)
    • California Prop 65 requirements on phthalate alternatives
    • UL 94 Safety of Flammability for Plastics Materials

    Typical usage ratio

    • 10–25 phr (per hundred parts resin) in flexible PVC or TPE compounds, fine-tuned by desired softness and migration resistance

    Downstream process integration

    • Charged into final esterification batch after major diacid reactants reach over 90% conversion, followed by vacuum stripping and in-line filtration before compounding

    Final product types

    • Flexible PVC cables and hoses
    • Biodegradable children’s toys and packaging
    • Soft thermoplastic elastomer blends for food contact films
    Free Quote

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    Certification & Compliance
    More Introduction

    Introducing Cis-12A-Hydroxydolineone: A Reliable Solution from a Manufacturer’s Standpoint

    Why We Commit to Making Cis-12A-Hydroxydolineone

    Working in chemical manufacturing for decades brings a deep understanding of value—not just production value, but real-world impact. Cis-12A-Hydroxydolineone stands out in our lineup because it answers a direct need from manufacturers, researchers, and formulators searching for precision-driven performance. The path to delivering a compound like this never runs on guesswork. We rely on repeatable, clearly defined processes, minimizing deviation and tracing every bottle back to origin. Each synthesis batch receives careful controls on purity, structure, and yield. Industry feedback always drives adjustments to stay ahead of shifting demands. People out in the field inform us what works and what misses the mark, so we keep tuning specifications as science and production keep moving forward.

    Chemical Profile and Specifications Drawn from Experience

    Labs and pilot plants deliver much more than numbers. Our catalog covers a range of products, yet only Cis-12A-Hydroxydolineone hits the combination of stability, functionality, and application flexibility sought by modern formulators. Its model, identified by decades of in-house process refinement, yields a pale crystalline solid with consistently high assay values above 98%. Structural validation by NMR and GC-MS matches with what industry standards define for cis-isomer purity. Every shipment includes transparent documentation because every formulation and application team wants full confidence in what they’re using from the outset.

    Batch-to-batch control is not a slogan; it’s enforced in-process, during reaction, workup, and purification. We operate continuous and batch reactors, so the production scale ranges from kilogram to multi-ton lots. Technical teams run daily spot checks, scrutinizing every intermediate to make sure we never send out-of-range material down the line. Potential contaminants and isomeric residues never fade into the background. The goal is to let every customer skip past worries about inconsistent raw materials and focus energy on innovating downstream.

    Understanding the Role of Cis-12A-Hydroxydolineone in Modern Formulation

    People who know chemistry want details: how a molecule acts in specific processes, how readily it incorporates, and how modifications ripple through the final product. Our Cis-12A-Hydroxydolineone works in a range of synthetic pathways where structural integrity is crucial. It’s found its place in fine chemicals, active ingredient research, and specialty material development. Chemical engineers report its special role as a chiral intermediate, especially where precise stereoselectivity changes endpoints or productivity. Years ago, researchers gave feedback about unwanted side products derailing pilot studies—today’s product formulation addresses earlier issues, keeping side reactions and mis-isomerization at bay.

    Solubility habits and compatibility profiles deserve close attention. Working within real benches and reactors, our tech teams saw how standard solvents like toluene, DCM, or ethyl acetate treat this compound in practical conditions. No one wants unpredictable precipitation or runaway exotherms. Heat stability and storage resilience evolved by observing storage challenges during shipping across multiple climate zones. After each incident, modifications to packaging and controls followed. These are everyday issues that shaped the exact nature of the Cis-12A-Hydroxydolineone our users receive today.

    Differences That Matter: Putting Cis-12A-Hydroxydolineone in Context

    With new materials coming online every year, direct comparison makes decisions much simpler for procurement teams. A key lesson from past customer calls is that product numbers and chemical charts rarely show what actually matters in operation. Competing molecules sometimes offer similar chemical names but differ where it hits hardest: contamination sources, residual solvent content, or minor isomers that trip up end-use applications. Our synthesis methods were rewritten several times to weed out side products, especially diastereomers that mimic but do not perform identically. That improvement took countless hours and pilot batch failures, but it pays off when customers report clear GC traces and smooth regulatory submissions.

    Cis-12A-Hydroxydolineone resists oxidation and hydrolysis under ambient storage, something earlier analogs or off-patent versions failed to achieve. Some market alternates cut corners on purification, leading to ongoing waste in downstream synthesis—something formulators don’t appreciate until a rejected batch or morning spent troubleshooting reactor residue. By focusing on specific impurity removal, we reduce costly process downtime for our users and give their QA teams fewer headaches during audits.

    Real-World Usage: Our Customers Shape the Product

    The stories behind why chemists use Cis-12A-Hydroxydolineone go beyond clean analytics. Pharmaceutical chemists ask pointed questions about reactivity and compatibility with standard coupling protocols. Years of fielding these queries led us to dial in solvent recommendations and optimal reactivity profiles. Early adopters tried it in asymmetric catalysis, often running small-scale explorations that later expanded into pilot lots. As users ran into solubility issues in multistep syntheses, our process chemists modified purification steps, ultimately allowing smoother downstream transitions.

    In recent years, buyers from material science outfits approached us looking for building blocks that perform in high-stakes polymerization. They discovered that minute variations in stereopurity affected final performance properties far more than datasheets suggested. We worked together on batch trials and mapped out property changes across gradients of isomeric content. The insight shaped future production parameters and shifted our internal QC standards. Direct insights from users keep the cycle moving—today’s process lessons build tomorrow’s improved synthesis runs.

    Quality Control: Lessons from the Production Floor

    After multiple product cycles, a manufacturing team learns that investments in analytical infrastructure offer measurable returns. Our facility features both bench and automated analytics for NMR, LC-MS, HPLC, and FTIR. These aren’t incentives for marketing; they come directly from customer audits where they checked how we maintained strict batch segregation and handled sample retention. A few years ago, storage complaints led us to reengineer our container selection process, shifting to high-barrier polymers and vacuum sealing steps. That cut back on repeat customer calls about shelf-life and outdoor storage performance.

    It takes direct human oversight to catch subtleties that instruments miss. Routine spot checks and line tests give earlier glimpses into drift, letting us correct batches before shipment. Shipping partners view our documentation and shipment tracking as the gold standard, cutting down misdelivery or delay by working closely with logistics teams that know our handling policies in and out. Traceability covers each step, from bulk reactors to packaging lines, so every drum and bottle traces back to reaction day and equipment batch.

    Supporting Research—with an Eye Toward Laboratory Longevity

    Academic partners seek reliability above all. Over the years, feedback from grant-funded researchers let us understand how inconsistent materials slow the pace of discoveries. Many research programs hinge on their initial stock, and batches that deviate—no matter how slightly—force lengthy recalibrations and reruns. By making those concerns front-and-center within our own QC loop, we let project leaders and grad students spend their hours on results, not troubleshooting upstream issues.

    Requests for reference samples let partners test their protocols with authentic material. Once protocols succeed, larger lots are pulled from matching synthesis runs to preserve continuity. Handling requests for technical data often sparks iterative feedback: suggestions on crystal habits, response to certain solvents, or minor optimization tips feed directly into the next improvement cycle.

    Industry Perspectives: Investing in Solutions, Not Just Products

    Professional experience says that consistent value comes from manufacturing partnerships, not one-off sales. Many users stick with a supplier through thick and thin, but only when both sides work together. We keep getting calls about regulatory submissions, technical audits, or documentation for pre-clinical studies. The demands start early and require thorough data retention. By maintaining batch records and regulatory compliance archives, we streamline user paperwork when timelines press in.

    Occasionally, clients shift toward alternative sources in a bid to cut costs, only to loop back due to unforeseen production issues—usually around purity, lot variability, or missing certificates. We treat this not as a setback but as a signal to update our own offering and communicate what sets our product apart in practice. Instead of reacting defensively, we use the opportunity to demonstrate by practical example the underlying value of applied chemical experience.

    Addressing Challenges by Investing Upstream

    Overproduction woes, off-spec batches, or unplanned downtime eat up far too much industry overhead. Years managing continuous reactors highlighted where equipment upgrades and engineering changes could head off costly recurring problems. We focused capital expenditures on upstream process controls: tighter feed measurement, in-line analytical probes, and automated temperature regulation. These changes paid off quickly, reducing lot variability, slashing reject rates, and boosting plant uptime.

    On the people side, technician training never stops. Each new process transfer or chemistry scale-up triggers a round of in-house education. We run regular cross-training so staff can lead troubleshooting, manage maintenance cycles, and conduct analytical signoff. Between audit requirements, continuous improvement culture, and on-the-ground collaboration, the real difference in chemical manufacturing comes down to the knowledge of the production and QC teams. Every successful batch of Cis-12A-Hydroxydolineone reflects their hands-on experience.

    Environmental Responsibility Runs Throughout Production

    The chemical industry faces constant scrutiny over emissions, waste handling, and sourcing. Our facility integrates closed-loop systems and solvent recycling stations, standing as evidence of the ongoing push toward reducing environmental footprint. By investing in proprietary processes, we cut back on hazardous byproducts and minimize solvent bleed-off. These steps require investment and regular process updates. Regulators drop by periodically; we see their input as a way to refine, not just comply.

    Every batch documentation includes details on raw material origin, and we favor sources with trackable environmental stewardship certifications. By eliminating certain overused precursors and switching over to greener chemistries where feasible, operational impact drops. Not all changes are easy, but experience has proven that cautious innovations create a more sustainable industry standard—one that will benefit anyone downstream using Cis-12A-Hydroxydolineone or its derivatives.

    Innovation: Pushing for Reliability and Adaptability

    Research never stays the same. Traditional recipes might endure for years, only to evaporate in the light of new academic studies or regulatory pressures. Rather than waste time chasing trends, we focus on incremental shifts rooted in feedback, both internal and from long-standing users across sectors. Advances in analytical sensitivity or synthetic method updates don’t just change how we make a batch—they inform how we communicate the strengths and limitations of each product lot.

    Staying close to user communities led us to trial variant processes under NDA with specialty partners trying to eke out marginal gains for niche applications. Early results sometimes challenge what our own process library predicted. Documented trial outcomes, both positive and negative, get logged and examined for future learning. Manufacturing and R&D groups talk constantly, breaking the old wall between lab-scale curiosity and plant-scale reliability. The best ideas rarely come from formal review; they show up as observations passed along by users in the thick of multistep processes or as a new reaction pathway requiring better substrate compatibility.

    Transparency Above All: Building Trust

    Open manufacturing—in both data handling and customer relations—remains the single greatest factor sustaining user loyalty. Each point along the supply chain, from initial inquiry to final quality sign-off, receives its due diligence check, kept traceable for regulatory audits or process troubleshooting. Audit trails covering temperature logs, batch composition, and shipment records provide confidence to everyone building a process around Cis-12A-Hydroxydolineone.

    We do not view customer troubleshooting requests as problems to be avoided but as opportunities for shared improvement. This mindset has helped countless times, especially when a process operator finds a subtle drift that only reveals itself in scaled processes. Each flagged instance prompts root-cause work across technical and production teams. Batch records log these findings, with corrective steps folded in every subsequent cycle. By closing the loop in this way, we turn isolated incidents into long-term process upgrades that benefit anyone sourcing from our line.

    Navigating Global Supply: Learning from Supply Chain Disruptions

    Events of the past decade underlined that secure supply means more than ample storage and flexible logistics. Factory shutdowns, shipping lane issues, and raw material scarcity exposed vulnerabilities in global sourcing. Shifting production closer to source materials, setting up regional storage hubs, and nurturing relationships with trusted local partners now buffer sharp swings in demand or transportation hiccups. Every role in the manufacturing cycle contributes new lessons. Facing down logistical challenges, we found value in maintaining open communication channels with customers. If a delay looms, advance warning and options prevent users from finding themselves stuck in the middle of production runs. This approach builds mutual resilience into the system.

    Backup strategies mean more than extra stock. Dynamic forecasting tools, periodic supplier audits, and preemptive batch qualification form the backbone of a stable delivery window. Unexpected events still crop up. The difference lies in how quickly technical and logistics teams react, loop in customer contacts, and update production priorities to address shifting schedules or needs.

    Staying Ahead by Listening and Learning

    Decades immersed in chemical manufacture teach that learning never ends. Each cycle of production, each period of market flux, demands ongoing adaptation. By keeping lines open with clients, regularly reviewing analytical results, and encouraging hands-on plant involvement, we build Cis-12A-Hydroxydolineone not just as a compound but as a living commitment to progress. The result is not just another chemical for the catalog, but a tool developed through accumulated experience—reflecting the everyday realities and aspirations of users ranging from startups to global innovators. The work never truly finishes—the reward remains in each successful synthesis, each customer milestone, and the shared satisfaction of making chemistry a little more predictable and a lot more valuable, one well-made molecule at a time.