Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Cirsilineol

    • Product Name Cirsilineol
    • Alias 3',4',5-Trimethoxy-6,7-dihydroxyflavone
    • Einecs 228-139-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    898338

    ChemicalName Cirsilineol
    IUPACName 5,4'-Dihydroxy-6,7,3'-trimethoxyflavone
    MolecularFormula C18H16O7
    MolecularWeight 344.32 g/mol
    CASNumber 523-44-4
    Appearance Yellow crystalline powder
    Solubility Slightly soluble in water, soluble in organic solvents
    MeltingPoint 266-270°C
    Purity Typically ≥98%
    Source Isolated from several species of Artemisia and other plants
    StructureType Flavone
    StorageCondition Cool, dry, and dark place

    As an accredited Cirsilineol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cirsilineol, 25 mg, supplied in a sealed amber glass vial with screw cap, labeled with chemical name, purity, and handling precautions.
    Shipping Cirsilineol is shipped in tightly sealed, chemical-resistant containers under ambient or cool conditions to prevent degradation. Packaging ensures protection from light, moisture, and contamination. All shipments comply with local and international regulations for laboratory chemicals, including appropriate labeling and documentation, ensuring safe handling and transport to the destination.
    Storage Cirsilineol should be stored in a tightly sealed container, protected from light and moisture, and kept at a cool temperature—preferably between 2–8°C (refrigerator). Ensure the storage area is well-ventilated and away from incompatible substances, such as strong oxidizing agents. Proper labeling and adherence to laboratory safety protocols are essential to maintain the compound’s stability and integrity.
    Application of Cirsilineol

    Applications of Cirsilineol in Industrial Manufacturing

    Cirsilineol, a polymethoxyflavone extracted primarily from Artemisia and other plant sources, finds well-established use in specific industrial sectors due to its distinct functional properties. As a manufacturer, we deliver Cirsilineol to downstream partners operating in compliant, high-value markets that demand consistency and traceability, ranging from pharmaceutical intermediates to specialty food preservatives. Below, we detail the real-world manufacturing applications where our material directly supports regulated production, with process-specific information relevant for your operational teams.

    1. Pharmaceutical Intermediates for Anti-inflammatory Formulations

    Regulatory-approved API manufacturers utilize Cirsilineol as an intermediate or active component within non-steroidal anti-inflammatory drug formulations, leveraging its established bioactivity profile. GMP-compliant sites typically introduce this flavone during the intermediate synthesis or blending phase, favoring its purity and standardized supply chain documentation. Application technique, ratio, and quality controls derive from pharmacopoeia and regional dossier requirements, aligning with batch-record traceability demanding rigorous process validation and contaminant testing regimes.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF monographs (for reference extracts and related substances)
    • EMA Guideline on Herbal Medicinal Products (EMA/HMPC/2014/439/Rev.2)
    • Pharmacopoeia of the People's Republic of China (ChP) specific to flavonoid APIs

    Typical usage ratio

    • Ranges from 0.1% to 5% by weight in intermediate blending; ratio determined by bioactivity assay, process yield, and finished dosage requirement per NDA/ANDA submission.

    Downstream process integration

    • Added post-extraction or isolate purification; incorporated with other actives during granulation or direct blending ahead of tableting or encapsulation steps.

    Final product types

    • Oral solid dosage forms (tablets, capsules) for pain and inflammation management
    • Herbal anti-inflammatory tablets and coated film caplets
    • Intermediate bulk for contract manufacturing organizations (CMOs)
    • Custom compounding for research and clinical trials

    2. Natural Food Preservative Systems for Oils and Beverages

    Commercial food manufacturers adopt Cirsilineol as an antioxidant additive for edible oils, nutritional beverages, and select bakery products where plant-derived preservation aligns with "clean label" positioning and export market regulations. Industrial processors dose this flavone at the oil refining or beverage formulation phase to delay oxidative spoilage, with documented scaling to maintain stability during shelf-life testing. Precise addition rates follow permitted food additive limits, and verification involves accelerated aging and sensory evaluation by QA panels.

    Industry compliance standards

    • GB 2760-2024 National Food Safety Standard for Food Additives (China)
    • FDA regulations (21 CFR 182 – GRAS Substances; as related to flavonoid antioxidants)
    • CERT ID and Non-GMO Project for plant-derived inputs
    • FSSC 22000:2018 Food Safety System Certification

    Typical usage ratio

    • 0.01%–0.05% by weight for edible oils; 0.005%–0.02% in beverage blends; ratio refined through R&D stability trials based on matrix fat content and target shelf life.

    Downstream process integration

    • Dosed during final deodorization in oil production or at emulsification/solubilization in beverage mixing tanks prior to bottling or aseptic packaging.

    Final product types

    • Premium vegetable and salad oils for retail and food service
    • Plant-based ready-to-drink (RTD) beverages
    • Bakery goods and snack bars with natural antioxidant claims
    • Dairy-free emulsions for alternative dairy markets

    3. Cosmetic Actives for Skin Protection and Repair

    Formulators in the cosmetics and personal care sector employ Cirsilineol as a botanical active in serums, creams, and wound-repair topical products. The compound enters at the actives addition stage under controlled mixing conditions, avoiding degradation at elevated temperatures. Industrial protocols specify dosing according to skin-safety dossier and local regulatory notification; additional analytical controls verify consistent color and antioxidant potential within formulation lots. Our ingredient traceability supports finished goods marketed with “plant-based” and “antioxidant-enriched” claims under ISO and national cosmetic standards.

    Industry compliance standards

    • ISO 22716:2007 Cosmetics – Good Manufacturing Practices (GMP)
    • EU Cosmetics Regulation (EC No. 1223/2009)
    • Cosmetic Ingredient Review (CIR) safety dossiers
    • China NMPA Registration for new cosmetic ingredients

    Typical usage ratio

    • Typical addition of 0.05%–0.2% by weight; actual content finalized with skin irritation/toxicity testing, prototype panel feedback, and end-use category (leave-on vs. rinse-off).

    Downstream process integration

    • Incorporated in phase B (“cool phase”) post-emulsification or after aqueous actives addition; homogenized into final bulk before filling and packaging line QA.

    Final product types

    • Antioxidant serums and facial creams
    • Spot repair ointments for minor wounds
    • Soothing lotions for sun-exposed or stressed skin
    • Cosmetic sprays for antioxidant claims in functional beauty formulas

    4. Animal Feed Additives for Poultry and Aquaculture Health

    Cirsilineol has been adopted in the veterinary and feed industry as a plant-derived antioxidant supplement for poultry and aquaculture feeds. Nutritionists and feed formulators introduce it into premix or pelletizing stages, following national regulatory guidance and targeted animal health metrics. Process design ensures even distribution and maintains antioxidant activity post-extrusion. Batch documentation—a critical point under feed GMP—includes trace element and mycotoxin interaction monitoring to assure safe use in concentrated feeds.

    Industry compliance standards

    • EU Regulation (EC) No 1831/2003 on additives for use in animal nutrition
    • China GB/T 13078 Animal Feed Hygiene
    • FDA CVM Guidance for Industry #221: Veterinary Feed Directive
    • FAMI-QS Code (Feed Additive and Premixture Quality System)

    Typical usage ratio

    • 0.01%–0.05% by feed weight in poultry; 0.005%–0.02% in aquaculture diets; content modified for species, fat profile of diet, and antioxidant status of base formula.

    Downstream process integration

    • Blended into vitamin/mineral premix; introduced before extrusion/pelleting of compound feed; monitored for heat/pressure stability via post-processing analytics.

    Final product types

    • Layer and broiler feed concentrates
    • Aquafeed for shrimp and finfish grow-out
    • Specialized starter feeds for improved oxidative balance
    • Functional enrichment feed blocks and tablets
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    Certification & Compliance
    More Introduction

    Cirsilineol: A Direct Manufacturer’s Perspective

    Introducing a Flavone Unmatched in Quality and Reliability

    At our manufacturing site, Cirsilineol means more than a simple listing on a catalog. Years of steady development, hands-on synthesis, and batch-scale isolation have shaped the way we produce and supply this flavone compound. From the chemical’s earliest research days to current applications in the pharmaceutical and nutraceutical industries, there’s been one constant: the need for chemical integrity and traceable production. Our Cirsilineol keeps that promise, batch after batch, crafted and controlled in-house from start to finish.

    Model and Specifications: Quality from First Principles

    We manufacture Cirsilineol with a focus on high purity and fully traceable sourcing. In the lab, consistent purity above 98% is a non-negotiable benchmark. Most inquires request powder form, with crystal structure and color confirmed by professional eyes, not just machines. Each batch undergoes HPLC analysis and NMR confirmation by chemists with decades in the field. We supply Cirsilineol in volumes that fit laboratory research and pilot-scale production. We know cost, solubility, and material handling can make or break a project, so our technical team personally checks compatibility before shipping.

    Practical Usage: Where Cirsilineol Makes an Impact

    Research teams value Cirsilineol for its natural origin and wide array of reported bioactivities. Its most prominent usage falls into bioassay screening, especially in the anti-inflammatory and antioxidant testing sectors. Our clients in pharmaceutical R&D appreciate that our direct line of production means their incoming material never passes through unauthorized storage. The risk of contamination runs much lower than with intermediaries that store and repackage powders. When cancer research calls for reference-grade flavones, we often receive requests for analytical standards or substrate for semi-synthesis, which requires clean input and signed-off spectral documentation. Nutraceutical companies sometimes approach us after finding routine commercial extracts too low in Cirsilineol content for serious development. Providing them with high-purity material, they can skip the unreliable step of botanical extraction and focus on formulation or delivery technologies.

    Daily, we see smaller biotech startups drawn to our direct manufacturing system. They need gram-to-kilogram scale, and we can provide that without routing the order through trading networks. This ensures that the Cirsilineol sitting in their cold room is exactly as described, with matching spectral data and no surprise impurities. Feedback from researchers points to consistent performance between lots. Dryness and handling are important, so every shipment leaves us freshly processed and vacuum-sealed. If larger pharmaceutical concerns require bundles of Cirsilineol in various weights, we package to order and guarantee chain-of-custody documents so regulatory submissions face fewer unwanted questions during audits.

    Comparing Cirsilineol With Other Flavones and Extracts

    We’ve produced a range of flavonoids and have learned, through trial and long experience, where Cirsilineol stands apart. Unlike simple flavones such as apigenin or chrysin, Cirsilineol contains three methoxy groups and two hydroxyl groups, creating a unique substitution pattern that influences solubility, reactivity, and biological activity profiles. It’s popular in structure-activity relationship studies exploring oxygen radical scavenging or kinase-inhibition, areas demanding material free of isomeric or partially substituted impurities. Many commercial sources blend plant extracts, advertising total “flavonoid content” without specifying how much Cirsilineol appears. In direct contrast, we quantify pure Cirsilineol—not just a plant powder with ambiguous composition. High-pressure synthesis and careful crystallization keep by-products out of the finished material.

    A few customers have compared our Cirsilineol to semi-purified samples they sourced from extraction-based suppliers. The difference turns up most clearly in analytical reproducibility: HPLC traces from our production runs show a clean, sharp peak, without background noise from mobile phase contaminants or degradation products. This matters for any lab conducting LC-MS, NMR, or biological assays that require reliable calibration. Regulatory compliance teams report fewer headaches when sourcing directly from a chemical manufacturer that controls the chain, as documentation for GMP audits and pharmacopoeia submissions is complete from day one.

    Hands-On Production: Why Internal Manufacture Changes the Game

    Our chemists can track every raw material we use, from the first order through every transformation step. Chlorinated solvents, palladium catalysts, and specialized glassware never leave our secured, negative-pressure rooms. Full traceability means that if a customer ever asks about a minor impurity, or wants additional analytical data, we respond within hours—because the answer comes from records logged by our own team rather than generic paperwork prepared by an unknown distributor. The spectroscopic fingerprints accompany every batch, reflecting our internal controls for purity, moisture, and microbiological safety. Unlike trading companies, we have no reason to relabel old stock to match a new order; we know the age and quality of every gram.

    Physical handling makes a difference, too. Cirsilineol isn’t a commodity bulk chemical. We find it sensitive to moisture and light, prone to slow degradation if mistreated. Long supply chains compound risk, with temperature cycling and atmospheric exposure. Keeping everything in-house, from controlled storage through shipping, gives our logistics team complete oversight. If a shipment needs extra desiccant, or a customer in a humid region requests double-bagged containers, we adjust the packaging on short notice. Years in this business have taught us that the finer points—dryness, particle size, and container integrity—distinguish real chemical manufacturing from basic reselling.

    Supporting the Research Community

    Direct access to a dedicated synthesis team simplifies life for researchers. We don’t filter technical questions through sales departments or call centers scattered across the globe; our in-house chemists answer queries about melting point, reactivity, or long-term storage. Should a university group require Cirsilineol with deuterated labels for mechanistic studies, we can tailor the synthesis route and verify isotopic purity through in-house NMR. Real-time feedback works both ways: when a team at a pharmaceutical lab finds a new bioactivity or method for Cirsilineol, their data loops back to our R&D department, shaping future production runs or analytical standards.

    Collaborations flow more smoothly when there’s trust in the material itself. Graduate students and postdocs depend on reliable starting material—without surprise shifts between lots or unexplained peaks in spectra. Some of our industrial customers have shifted to direct sourcing after failed experiments with ambiguous extracts or poorly characterized imported material. With our approach, materials used in peer-reviewed publications and grant applications arrive with a data package that facilitates journal or regulatory review. If regulatory authorities request expansion of the analytical profile, we access our archived samples and provide fresh analysis.

    Safety, Compliance, and Responsible Manufacturing

    Chemical manufacturing, especially for specialty products like Cirsilineol, goes hand-in-hand with regulatory scrutiny. Our site implements strict SOPs for handling, waste management, and environmental controls. All solvent recovery and effluent treatments comply with the latest local and international guidelines. Rather than ship all over the supply chain, we keep production and dispatch within a traceable, tightly managed framework. Each batch is mapped from precursor chemical to finished, packaged product, minimizing both risk and environmental burden.

    We believe in full transparency with our manufacturing footprint. Our chemists and staff live near our facility and have a direct stake in ensuring that each process minimizes impact on the environment and community. The documentation that leaves with every unit of Cirsilineol includes not only purity and structural confirmation, but a complete tabulation of hazardous waste management and worker safety protocols. This means research labs can submit environmental and safety documentation to oversight boards without combing through pages of third-party records. Responsible chemical management is not only a requirement—it’s a commitment to our partners and to the scientific community.

    Solving the Pitfalls of Conventional Supply Chains

    Inconsistent materials slow scientific progress, and much of it starts in fragmented sourcing channels. Over time, we’ve assisted teams that reported unexpected loss of activity, odd reactivity patterns, or regulatory headaches after sourcing Cirsilineol from brokers. Tablets pressed from insufficiently pure starting materials can show degradation; research data from impure batches may not reproduce. Direct cooperation with manufacturers reduces these pitfalls. By preparing Cirsilineol to order, quickly shipping under controlled conditions, and freely sharing analytical data, our team helps streamline the workflow for customers around the globe.

    Regulatory pathways—whether for drug candidates, formulations, or analytical method validation—require transparency. Each container of Cirsilineol can be traced to its manufacturing date, internal batch file, and raw material lot. We guarantee all materials avoid cross-contamination with other chemicals manufactured on our lines, and all secondary packaging is certified food-safe when requested. When research teams need documentation for grant proposals or early-stage IND filings, they work directly with our chemists and compliance staff, not anonymous intermediaries. This partnership extends to confidentiality when customers ask for customized synthesis or wish to keep their projects under wraps; our company structure supports NDAs, direct technical reviews, and shipment of coded reference materials without exposing project data to outside parties.

    Continuous Improvement Based on Direct Feedback

    A clear advantage of controlling our Cirsilineol production is the steady flow of feedback from customers using the compound in demanding environments. If a certain research partner discovers minor side reactions during a scale-up, we’re in position to assist with modifications to synthetic routes or crystallization steps, not just supply more of the same. This adaptability keeps our product line relevant to changing requirements, such as ultra-pure Cirsilineol for toxicology, material for topical delivery development, or input for asymmetric synthesis of analogs.

    The continuous loop—materials science, production adjustment, and real-world testing—ensures our output reflects not only literature standards but meets tough, real-world criteria. Every successful screening result and successful regulatory filing returns valuable insight to our technical team. Over the years, we’ve refined pre-packing, modified purge controls, and added analytical layers all in direct response to user feedback. This cumulative approach distinguishes our manufacturing process and helps us stay ahead of evolving research challenges.

    Looking Forward: Serving Modern Science

    Applied science is pushing chemical boundaries. The days of basic extract powders and unaudited supply channels are giving way to targeted purchasing backed by reliable data and strict traceability. For clients on the leading edge—whether pharmaceutical, nutraceutical, or academic—there’s no substitute for material with a clear, traceable history. We see material managers and scientific buyers seeking to limit risk, respond quickly to regulatory inquiries, and remove obstacles to technology transfer. Our direct manufacturing model addresses those critical needs from the start.

    New applications for Cirsilineol continue to emerge, some beyond basic pharmacology. Crop protection, veterinary science, and diagnostic reagent fields increasingly request material with well-defined properties and zero ambiguity in chemical composition. Rather than rest on reports from the past, we actively work with these groups to define requirements, propose modifications, and share our perspective on how best to achieve workable outcomes with real chemical lots.

    The Manufacturer’s Promise: Knowledge, Commitment, and Accountability

    In every step of the Cirsilineol journey—from exploratory synthesis through commercial shipment—our work draws on decades of accumulated technical skill and a culture of personal responsibility. Feedback from researchers, production staff, regulators, and applications specialists doesn’t just improve the compound; it guides our approach to everything from raw material purchasing to waste processing. Where some see a commodity, we recognize a critical ingredient for sensitive, often high-profile studies.

    This ethos grounds our commitment to the scientific community: real facts, responsive service, and total accountability for every unit of Cirsilineol leaving our facility. Whether for next-generation therapeutics or cutting-edge analytical methods, our perspective as the manufacturer guarantees that clients receive material that supports their work without compromise.