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Cinnamtannin Iii

    • Product Name Cinnamtannin Iii
    • Alias Cinnamtannin B2
    • Einecs 94484-58-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    702183

    name Cinnamtannin III
    chemical_formula C45H34O18
    appearance Brownish crystalline solid
    solubility Slightly soluble in water
    melting_point Approx. 221-223°C
    source Cinnamon bark (Cinnamomum species)
    compound_type Proanthocyanidin (Tannin)
    CAS_number 125224-53-5
    structure_type Trimeric proanthocyanidin
    IUPAC_name (2R,3R,4S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol-(4'→8)-catechin-(4'→8)-catechin
    pubchem_cid 44622339

    As an accredited Cinnamtannin Iii factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cinnamtannin III is packaged in a 10 mg amber glass vial, sealed with a screw cap, and labeled for laboratory research use.
    Shipping Cinnamtannin III is shipped in tightly sealed containers, protected from light and moisture. Packaging complies with chemical safety regulations to prevent leaks or contamination. During transport, the substance is handled as a laboratory chemical, ensuring temperature control and secure handling to avoid degradation and ensure the product's integrity upon arrival.
    Storage Cinnamtannin III should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area, ideally at room temperature or lower, away from incompatible substances like strong oxidizers. Proper labelling and storage in accordance with relevant safety guidelines are essential to maintain its stability and prevent degradation.
    Application of Cinnamtannin Iii

    Applications of Cinnamtannin III in Industrial Manufacturing

    As a direct manufacturer, we deliver Cinnamtannin III for advanced technical formulations across tightly defined downstream segments. Our material supports controlled performance in processes where compliance, quality, and proven industrial methods are essential. Below, we outline core end-use scenarios, relevant standard frameworks, dosage recommendations, process details, and resulting finished goods.

    1. Pharmaceutical Intermediate for Cardiovascular Therapeutics

    Pharmaceutical manufacturers use Cinnamtannin III in the synthesis of cardiovascular drug intermediates, particularly flavonoid-based formulations targeting vascular support. Our supplied material enters as a chiral precursor or co-ingredient in semi-synthetic molecule production, where strict purity and process validation are mandatory. Processing strategies typically include solvent extraction and chromatographic purification to reach pharmacopeial grade, which ensures consistency for tableting and encapsulation stages.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monograph compliance for herbal-derived substances
    • Good Manufacturing Practice (GMP) certification according to WHO and FDA cGMP regulations
    • Good Laboratory Practice (GLP) for analytical and residual solvent monitoring

    Typical usage ratio

    • Formulation input: 0.5–2.0% weight basis in combination with core active moieties; final dose adjusted per pre-clinical bioavailability and pilot scale-up data

    Downstream process integration

    • Introduced post-API synthesis as a chiral modulator or immediately after plant extraction fractionation; solubilized in pharmaceutical-grade solvents; subjected to final crystallization prior to mixing with tablet or capsule base excipients

    Final product types

    • Prescription cardiovascular drugs (tablets, capsules)
    • Adjunctive formulations for blood pressure and microvascular circulation

    2. Natural Antioxidant for Functional Food and Beverage Enrichment

    Food industry manufacturers integrate Cinnamtannin III into functional food mixes and beverage fortification systems for its antioxidative polyphenol content. It enters as a concentrated plant extract (typically from cinnamon bark) and serves as a natural additive to extend shelf-life, act as a flavor mask, and provide health-positioned benefits in premium lines. Compliance with food-grade extraction protocols and residue controls is strictly observed, and material characterization is performed on every batch to ensure clean label acceptability.

    Industry compliance standards

    • US FDA 21 CFR part 170-199 (Food Additives)
    • GB 2760-2014 Food Safety National Standard for Use of Food Additives (China)
    • EFSA Guidance on Botanical Preparations for Food Supplements (EU)
    • HACCP and ISO 22000 Food Safety Management Systems

    Typical usage ratio

    • Fortification: 50–200 mg/kg in beverage bases; 0.02–0.1% in powdered food mixes, adjusted per organoleptic trials and antioxidant assay results

    Downstream process integration

    • Blended into water-based or dry mix formulations during secondary ingredient phase; undergoes homogeneity verification by HPLC or spectrophotometry after high-shear mixing; stability tested at target product pH and temperature

    Final product types

    • Ready-to-drink antioxidant beverages
    • Functional snack bars and meal replacement powders
    • Prebiotic or dietary fiber drink concentrates

    3. Cosmetic Active Ingredient in Anti-Aging and Whitening Formulations

    Cosmetics formulators source Cinnamtannin III for integration as an active polyphenol in anti-aging creams, serums, and whitening lotions. Its specific tannin structure enables use as a plant-based alternative to synthetic antioxidants and skin brightening agents. Regulatory compliance is closely monitored through adherence to rigorously documented ingredient status and purity declarations, supporting integration into both leave-on and rinse-off cosmetic matrices.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • ISO 22716:2007 (Cosmetic GMP)
    • FDA Voluntary Cosmetic Registration Program (VCRP)
    • INCI (International Nomenclature Cosmetic Ingredient) listing for product transparency

    Typical usage ratio

    • Main phase addition: 0.05–0.5% by weight in finished emulsions; ratio customized based on in-vitro ROS scavenging and human skin irritation assay data

    Downstream process integration

    • Added in the cool-down phase of emulsion manufacturing after primary emollients; solubilized under controlled pH; microfiltration used for particle size distribution prior to bulk filling

    Final product types

    • Anti-wrinkle creams and night serums
    • Whitening and brightening moisturizers
    • Polyphenol-rich face masks and mists

    4. Feed Additive for Livestock Antioxidant Supplementation

    Animal nutrition producers utilize Cinnamtannin III as an antioxidant enhancer in specialized livestock feed premixes, aiming to support animal health and minimize oxidative stress during intensive production cycles. The material is supplied as a standardized botanical extract, with its inclusion strictly regulated regarding maximum residue levels and consistent batch potency. Entry into feed formulation follows documented HACCP protocols, and residue testing ensures traceability throughout integrated value chains.

    Industry compliance standards

    • FAMI-QS Code of Practice for Feed Additives (Europe)
    • AAFCO Official Publication (USA)
    • Chinese Feed Additive Regulation GB/T 21917
    • ISO 22000:2018 (Feed Safety)

    Typical usage ratio

    • Supplementation: 30–120 mg/kg in compound feed; dosage adjusted to balance antioxidant activity with digestion profiles across monogastric and ruminant species

    Downstream process integration

    • Incorporated during premix blend step before addition to bulk feed; dry-mixed with vitamin and mineral ingredients; subject to batch QC for polyphenol uniformity

    Final product types

    • Complete compound feeds for poultry and swine
    • Specialty health supplements for young livestock

    5. Natural Preservative in Plant-Based Food Packaging Films

    Producers of edible films and plant-based packaging employ Cinnamtannin III for its role as a natural preservative and antimicrobial barrier. Introduced during the polymer or starch film formation stage, it offers inhibition of spoilage organisms without recourse to synthetic additives. The material’s migration and retention characteristics are mapped closely against food contact material standards to ensure safety and controlled release throughout product shelf life.

    Industry compliance standards

    • US FDA CFR 21 Part 177 (Indirect Food Additives: Polymers)
    • EU Regulation No 10/2011 on Food Contact Plastics
    • Chinese Standard GB 9685-2016 for Additives in Food Contact Materials
    • ISO 9001:2015 (Quality Management for Packaging Materials)

    Typical usage ratio

    • Incorporation: 0.1–0.5% (w/w) into biopolymer matrix; exact proportion determined by antimicrobial activity curve and targeted migration limits

    Downstream process integration

    • Added during water-based or extrusion blending with starch or cellulose base; film casting or extrusion performed at controlled temperatures to preserve polyphenol structure; antimicrobial validation performed post-drying

    Final product types

    • Edible food wraps and films
    • Antimicrobial coatings for fresh produce packaging
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    Certification & Compliance
    More Introduction

    Cinnamtannin III: Growing Demand, Consistent Quality

    Experience and Focus Behind Every Batch

    Cinnamtannin III stands as one of our workhorse polyphenols, known for its pure structure and rigorous, batch-to-batch repeatability. Over the last decade, we have built up in-house extraction, purification, and finished powder processes around this molecule because, in our field tests, it delivers both bioactivity and solid physical stability. As a chemical manufacturer, our focus on cinnamtannin series compounds came from real problems in natural extracts — if you have ever run analytical on a dozen so-called “natural tannin” preparations, you will often see a scattershot of different oligomers, unwanted byproducts, and contaminants that sabotage downstream chemistry. Early on, our labs targeted high-purity Cinnamtannin III as a core product to strip away these pain points for formulators who can’t gamble batches or chase down mystery peaks in HPLC traces.

    Innovation Rooted in Chemistry, Not Hype

    Cinnamtannin III is a B-type condensed tannin, comprising a trimeric proanthocyanidin backbone. We make it via tightly controlled extraction from select botanical sources. Whereas most condensed tannins — marketed by dealers as “procyanidin-rich extracts” or “catechin tannins” — offer uncharacterized blends, every lot we ship includes the original HPLC fingerprint and reference spectra from our facility. Analysts and technical teams overseeing R&D and scale-up expect this documentation. They want clear, well-quantified identity, which directly influences stability, reactivity, and biofunction in end-use applications. We fine-tuned our solvent system and fractionation steps to exclude mono- and dimeric impurities. That way, formulators working in the food, nutritional, or pharmaceutical sectors can build predictable, dosed products and avoid regulatory headaches linked to unidentified “trace” molecules.

    Putting Performance First: Model and Specifications

    Our current production process delivers Cinnamtannin III in model CNMT-3M as a free-flowing fine powder, light tan to brown, tailored for ease of blending and direct incorporation. Analytical testing confirms a minimum assay purity of 96% by HPLC using our in-house calibration method, which is validated up to multi-kilogram scale. Water and ethanol solubility data is matched lot-wise, so customers running pilot processes can make realistic technical decisions for new formulations. The typical moisture content is capped below 3%, and the powder is milled using stainless equipment dedicated to polyphenolics. That prevents introduction of metallic or cross-compounds so often missed by traders reselling generic plant extracts. Stability studies, performed over several years under both ambient and accelerated conditions, demonstrate minimal degradation of the core structure. This chemical uniformity pays off in consistent process outcomes — from enzymatic assays to microemulsion studies to granule coating trials.

    Direct Impact on R&D and Commercial Formulation

    We took feedback from our direct customers — universities looking for reliable standards, consumer goods firms needing repeatable bioactivity, supplement companies scaling functional blends — and rebuilt our quality assurance protocol to double down on traceability. Whereas commercial “bulk tannins” sometimes contain high levels of procyanidins or unknown phenolic artifacts, Cinnamtannin III model CNMT-3M shows a sharp trimer profile, with low residual monomer or dimer content. By controlling parameters from field selection to in-house fractionation, our technologists keep both identity and analytical purity tight. No two plant batches are perfectly identical in nature, but precise process controls and high-frequency QC checkpoints mean customers see repeatable results. Manufacturers and product developers aren’t forced to reformulate or troubleshoot due to unpredictable variances that often occur in material purchased from traders or re-packers.

    Distinction from Other Polyphenols and Competitor Materials

    The main difference between our Cinnamtannin III and generic “tannin blends” lies in chemical uniformity. Many suppliers market mixtures pulled from various plant sources and label them with vague terms like “proanthocyanidin tannin A” or “high-catechin fraction.” Our product holds a clear molecular signature, so downstream chemists, food scientists, and regulatory personnel can work off well-defined inputs. For pharmaceutical and nutraceutical applications, this distinctiveness translates into greater reproducibility in clinical tests and product trials. We regularly hear from technical teams who struggled for years with heterogeneous raw materials. Switching to CNMT-3M often removes multiple troubleshooting steps because analytical composition is tightly matched to specifications, and batch certificates match real, unique fingerprints — not reused template data.

    Transparency from Field to Finished Lot

    Many extract suppliers depend on the open market for source plant material, introducing uncontrolled variation. Our supply chain for Cinnamtannin III begins with contracted growers operating under best agronomic practices. While we invest more in upfront screening and materials governance, it generates strong traceability. Farmers supply raw botanical material that meets our own testing. The extraction process here is fully internalized — not sub-contracted — so we maintain a firm hand on solvent purity, extraction temperature, time, and fraction selection. We perform pre-shipment analytical on every batch, and maintain retention samples so customers can call for re-analysis years after delivery.

    Supporting Product Development and Application Engineering

    Our direct technical support team collaborates with R&D departments to integrate Cinnamtannin III into finished formulas. For developers needing tannin profiles with distinct properties — such as those looking for specific astringency, antioxidant behavior, or compatibility across emulsions — our product’s narrow specification range offers predictable performance. Customers developing functional foods, beverages, and botanical supplements often discover that typical broad-spectrum tannins can cause off-flavors, precipitation, or variable bioactivity during product life cycle. With CNMT-3M, our clients can dial in dosage and process parameters with less rework. Recently, a client in beverage formulation replaced an undefined tannin blend with our Cinnamtannin III. Their team documented improved flavor stability and repeatable functional claims through accelerated shelf-life trials. Other customers working in cosmeceuticals report that our material passes stricter impurity and heavy metal limits compared to the market average, simplifying compliance with rapidly evolving regulations.

    Process Insights: Lessons Learned Over Years of Manufacturing

    Consistent production begins at raw material selection. Over time, we refined our partnerships with dedicated growers and shifted toward cultivars delivering richer, more uniform precursor content. This steady input improved extract yields and kept processing steps tighter, reducing reliance on aggressive purification that sometimes degrades active compounds. We regularly run pilot-scale extractions in parallel to the main process as an early-warning system for seasonal variability or unexpected shifts in plant chemistry. All input and in-process material is logged and tracked in our in-house electronic batch record system, letting us catch anomalies and feed-forward answers to our QC lab before scaling further.

    Process conditions matter. Variables like extraction temperature, solvent polarity, and fractionation speed all contribute to isolating clean Cinnamtannin III. Many generic extractors push for high yields at the expense of purity, capturing unwanted monomers, aglycones, or brown polymeric contaminant. We set lower cut-offs on main processing parameters, accepting modest yield loss to ensure only trimeric condensed fractions reach finished lots. This discipline enables our technical and regulatory partners to qualify our product for uses with low threshold tolerances — for instance, functional beverages with clear label ingredient expectations or pharmaceutical preparations needing tight impurity controls.

    Refining Quality Assurance and Traceability

    Our QA starts with documentation. Each lot of Cinnamtannin III is accompanied by material-specific COA, referenced back to both current laboratory data and library standards built from prior production histories. Library matching makes it easy for customer QC labs to confirm product identity using their preferred chromatographic or spectrometric method. We encourage prospective customers to request sample lots and perform independent verification, which has led to deep trust with clients seeking supply reliability for clinical trials or commercial launches. We maintain a retention archive of starting plant material, intermediates, and finished powder for every lot released. This approach supports traceability in the event of any downstream issue.

    Quality also means stability. We invest in ongoing shelf-life and accelerated aging studies — tracking not only assay decay but changes in physical characteristics such as solubility, color drift, and powder flow. This testing gives end-users a tangible sense of how our product will behave in their own processes, under storage and stress scenarios. As a result, customers are able to future-proof final products or catch shelf-life risks before commercial scale-up.

    Real Applications: Solving Challenges for Our Community of Users

    Food manufacturers mixing botanical tinctures or seeking antioxidant function in finished beverages often tell us that standard plant tannins bring unpredictable mouthfeel or sedimentation in solution. They report repeated headaches with batches “turning cloudy” or creating off notes in flavor. Our Cinnamtannin III stands apart in these real-life applications because of its predictable dispersibility and defined astringency profile. Whether incorporated into a high-solids juice or a functional beverage with tight ingredient tolerances, formulations run more smoothly. Analytical teams in the nutraceutical field benefit from the product’s singular HPLC trace, removing complexity from stability and process validation.

    Pharmaceutical formulation presents its own challenges. Variability in input tannin chemistry has torpedoed clinical trials and batch scale-up in the past. Recent engagement with clients developing polyphenol-based supplements or topical preparations highlighted how uncontrolled tannin mixtures set projects back through unpredictable stability or consumer complaints. Switching to a chemically defined source like Cinnamtannin III offered analytical clarity and supported regulatory submissions with well-documented specifications.

    Listening and Responding: What End-Users Need and Ask For

    Practical feedback from our user base continues to shape how we develop and ship Cinnamtannin III. For customers seeking high-purity product, requests center around not just the main trimeric content but also low levels of related tannins, heavy metals, and pesticide residues. We’ve invested in robust screening and third-party verification to meet these expectations — even as legal and regional standards keep shifting. End-users in food and beverage appreciate our stability work, using real shelf-life data and process simulations to troubleshoot and optimize their recipes long before sending a product to market. Supplement producers push for both analytical clarity as well as transparency over origin, which we meet by documenting farm-to-finish provenance.

    Continuous Improvement: Where We Focus Next

    Quality in Cinnamtannin III is no longer only about purification; it’s about continuity in both product and process. We are doubling down on tighter starting material screens, more granular lot testing, and advanced powder handling to minimize batch-to-batch drift. As more regulatory bodies raise the bar for documentation, we are scaling digital traceability systems for seamless integration into supplier qualification pipelines. Our next-generation monitoring uses real-time analytical throughout production runs, so QC corrections can be made as soon as deviations arise.

    Packaging and logistics have evolved as well. Controlled-atmosphere storage now extends product shelf-life by limiting oxidation and moisture ingress. We select anti-static, sealed composite containers for global freight, reducing clumping and dust formation. We train our supply chain staff to recognize physical signs of powder degradation, helping prevent inadvertent acceptance of off-spec material. All shipments come with detailed documentation, and support staff are available throughout the shipping process — from batch release through customs inspection and end-user acceptance.

    Regulatory and Sustainability Commitments

    Compliance forms a pillar of our process. Cinnamtannin III meets established industry requirements for food and supplement ingredients with tested, verifiable limits for heavy metals, pesticide residues, and microbial contaminants. We maintain an open-door auditing policy, welcoming visitors from regulatory, commercial, or partner organizations to inspect production. Increasingly, our customers value not only analytical integrity but also environmental stewardship. Our raw material procurement team works alongside farms using sustainable agronomic techniques, reducing overharvest and supporting local biodiversity. We recycle solvents wherever possible, and energy use for extraction and drying is regularly benchmarked for improvement. By investing in clean, reproducible chemistry, we contribute to a more transparent, lower-impact tannin supply chain.

    Collaborative Development: Obstacles and Opportunities

    As new application domains emerge, we continue fielding questions and accommodating requests for Cinnamtannin III. For beverage and supplement formulators, the question is often how to optimize inclusion rates without over-delivering astringency or impacting solubility. We work alongside these customers, supporting pilot trials, and providing technical documentation that demystifies performance at various inclusion levels. Our development laboratory is involved throughout scale-up, delivering formulation prototypes, shelf-life data, and compatibility results with typical flavor and excipient systems.

    In research, customers sometimes face limited literature or contradictory experimental results due to lack of uniform standards. Our product’s verified structure and certificate data build confidence for scientists requiring repeatable outcomes, whether investigating antioxidant properties, molecular interactions, or next-generation delivery systems.

    What Sets Us Apart in the Market

    The big differentiator comes down to long-term consistency and accountability. Traders and generic suppliers rarely know, or can guarantee, the minute structural profile or source of their material. Their supply chains are fragmented, with risk of contamination and analytical drift. Our manufacturing process is vertically integrated, beginning with source material and ending with in-house packaged finished product. We deliver a level of chemical certainty and traceability that few others can match. Better traceability means users can scale projects and bring products to market faster, with less risk of disruption or recall.

    Unique Customer Outcomes

    Over the years, some of our clients switched to Cinnamtannin III after losing valuable time troubleshooting off-balance formulas or failing regulatory reviews due to unclear input material. In several cases, researchers running clinical studies found that lot-to-lot consistency of CNMT-3M allowed them to publish clear, reproducible data — something not possible using locally sourced or re-packaged “natural tannin” powder. Commercial partners in the food and supplement sector have traced label compliance and consumer acceptance improvements directly back to adoption of our standardized extract.

    Feedback from global partners reveals that the field is shifting away from broad, undefined extracts to clearly structured, traceable compounds. This change helps increase trust with both end-users and regulators. The risk of project failure drops when active chemical input is well defined, batch-traceable, and reproducible. Building future products requires strong technical partners — and that means going beyond the lowest bidder in sourcing, instead selecting deeply experienced producers willing to show their work.

    Final Thoughts on Product and Process

    Manufacturing Cinnamtannin III requires attention to every link in the process: grower partnerships, continuous plant chemistry surveillance, careful extraction, targeted fractionation, and robust in-lab and in-process validation. Each step reflects lessons learned from direct customer problems and our own relentless drive to improve. The future of botanical polyphenols, and of condensed tannins in particular, hinges on making reliable, transparent material available for advanced application — whether in food, nutrition, health, or other technical areas. By investing in the core chemistry, securing impeccable supply chains, and building in scientific validation at every stage, we help our clients achieve faster launches, stronger research findings, and consistent commercial success. Only through this level of diligence can the true potential of Cinnamtannin III shine in modern formulas and groundbreaking product development.