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Cinnamtannin D1

    • Product Name Cinnamtannin D1
    • Alias d1-cinnamtannin
    • Einecs NA
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    631280

    compound_name Cinnamtannin D1
    CAS_number 115759-74-9
    molecular_formula C69H56O32
    molecular_weight 1401.18 g/mol
    appearance Yellowish powder
    source Cinnamon bark (Cinnamomum verum)
    solubility Soluble in DMSO, poorly soluble in water
    classification Proanthocyanidin (tannin)
    IUPAC_name (2R,3R)-[(2R,3R,4S)-Flavan-3,3',4',5,7-pentol]3-(4-hydroxyphenyl)-2,3-dihydro-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
    PubChem_ID 15237454
    optical_rotation [α]D20 +36 (c 1, MeOH)

    As an accredited Cinnamtannin D1 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cinnamtannin D1 is packaged in a 10 mg amber glass vial with a secure screw cap, labeled for research use.
    Shipping Cinnamtannin D1 is shipped in tightly sealed containers under cool, dry conditions to protect from moisture, light, and air. Packaging complies with chemical safety standards, using inert materials to prevent contamination. All shipments are accompanied by appropriate labeling and documentation to ensure safe handling and regulatory compliance during transit.
    Storage Cinnamtannin D1 should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of heat or ignition. It should be kept in a tightly sealed container to prevent moisture absorption and contamination. Proper labeling and storage at room temperature, preferably in a desiccator or under inert atmosphere, are recommended for maintaining its stability and quality.
    Application of Cinnamtannin D1

    Applications of Cinnamtannin D1 in Industrial Manufacturing

    Cinnamtannin D1, a naturally derived polyphenolic compound, serves as an active functional ingredient across key industrial sectors, driven by its well-characterized antioxidant, antimicrobial, and stabilizing properties. Explore how major downstream industries integrate this raw material within their regulated manufacturing environments, highlighting definitive use-cases, regulated dosage ranges, precise process steps, and the types of finished goods where it enables high value.

    1. Functional Food and Nutraceutical Production

    Manufacturers in the health food sector incorporate Cinnamtannin D1 as a clean-label antioxidant and bioactive to formulate high-value dietary supplements and functional foods that require proven antioxidative performance without synthetic additives. Its established phenolic content supports shelf-life extension and targeted health claims within recognized legal and quality frameworks. Integration often occurs at the premix or granulation stages, relying on strict control of dosage levels to comply with applicable standards on botanical extracts in food-grade applications.

    Industry compliance standards

    • GB 2760-2024 National Food Safety Standard for Use of Food Additives (China)
    • EU Novel Food Regulation (EU) 2015/2283
    • US FDA Dietary Supplement Health and Education Act (DSHEA)
    • ISO 22000 Food safety management systems

    Typical usage ratio

    • 0.03%–0.15% by weight in fortified beverages and functional snack bars; 40–200 mg daily per serving in capsule/tablet supplements, adjusted per local novel food acceptance and total phenol intake guidelines.

    Downstream process integration

    • Powder blending with carrier matrices for tableting or encapsulation
    • Direct dosing into liquid premixes for beverage processing
    • Wet or dry granulation steps in solid dietary supplement lines
    • Controlled temperature mixing to prevent phenolic degradation

    Final product types

    • Polyphenol-enriched health beverages
    • Dietary supplement tablets and capsules
    • Functional protein bars and snacks
    • Antioxidant drink powders and premixes

    2. Pharmaceutical Oral Formulations

    Pharmaceutical manufacturers employ Cinnamtannin D1 as a bioactive excipient for oral dosage forms, supporting product claims connected to anti-inflammatory, metabolic, or cardiovascular health formulas. Its consistent quality and traceability meet strict pharmacopoeial and GMP requirements. Pharmacies and contract manufacturers incorporate the ingredient during blending, granulation, or direct tableting, ensuring batch-to-batch homogeneity and documentation aligned to registered drug master files and site audits.

    Industry compliance standards

    • Chinese Pharmacopoeia (ChP)
    • US Pharmacopeia (USP) – dietary and herbal supplements chapter
    • Good Manufacturing Practice (GMP) for pharmaceutical products (ICH Q7, PIC/S)
    • ISO 9001:2015 Quality Management Systems for pharmaceutical manufacturing

    Typical usage ratio

    • 25–125 mg per tablet or capsule; 0.05–0.2% by blend mass, adapted based on desired polyphenol content and target product claims. Clinical formulation protocols and regulatory filings dictate exact amounts.

    Downstream process integration

    • Inclusion at powder mixing for uniform distribution
    • Pre-mill blending for granule production
    • Direct compaction for uncoated or film-coated tablet manufacturing
    • Cohesive mixing with excipients prior to encapsulation

    Final product types

    • OTC and prescription oral solid pharmaceuticals
    • Medicinal herbal tablets
    • Phytomedicine capsules for metabolic health
    • Adjunct formulas in combination therapies

    3. Cosmetic and Personal Care Formulations

    Personal care and cosmetic producers integrate Cinnamtannin D1 into antioxidant-rich dermal creams, lotions, and anti-aging serums. Its polyphenolic character addresses oxidative stability and extends product shelf-life without the need for synthetic stabilizers, aligning with growing consumer and regulatory focus on natural ingredients. Integration is handled at the emulsion formation or aqueous phase, carefully balancing levels for efficacy and texture while ensuring compliance with regional cosmetic safety regulations.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • Personal Care Products Council INCI listing (USA)
    • China Safety and Technical Standards for Cosmetics 2024
    • ISO 22716:2007 Cosmetics – GMP guidelines

    Typical usage ratio

    • 0.02%–0.1% by weight in facial serums, masks, and moisturizing creams. Formula optimization may reduce or elevate levels based on desired antioxidant capacity and texture stability in specific product lines.

    Downstream process integration

    • Dissolution in water phase at controlled temperatures prior to emulsion blending
    • Hydration steps for hydrogel or sheet mask bases
    • Uniform mixing during final base preparation for creams and lotions
    • Co-formulation with botanical extracts in specialty products

    Final product types

    • Facial and body creams with anti-oxidant claims
    • Hydrogel facial treatment masks
    • Serums for anti-aging and skin barrier care
    • Daily moisturizers for sensitive skin markets

    4. Animal Feed and Veterinary Additives

    Animal nutrition and veterinary additive manufacturers utilize Cinnamtannin D1 to support performance feeds targeting oxidative stability and health management in companion and livestock animals. Its addition inhibits lipid peroxidation in premix and finished feeds, reducing spoilage and aligning with non-antibiotic feed additive trends. The ingredient is incorporated during feed premix blending or directly in pelleting, matching strict feed hygiene, residue, and safety guidelines.

    Industry compliance standards

    • EU Regulation No 1831/2003 on additives for use in animal nutrition
    • US Association of American Feed Control Officials (AAFCO) Ingredient Definition
    • China Feed Additive Catalogue GB/T 5919
    • ISO 22000:2018 for animal feed safety

    Typical usage ratio

    • 60–250 mg/kg (ppm) in complete feed formulations for ruminants and pets; adjusted according to species and intended shelf-life extension outcomes. Dosing must fall within regulatory daily intake thresholds.

    Downstream process integration

    • Homogeneous premix blending for mash feeds
    • Direct inclusion in pelleting or extrusion feed lines
    • Coating application for specialty feeds and supplements
    • Dry blending with vitamin/mineral premix carriers

    Final product types

    • Complete ruminant and monogastric animal feeds
    • Companion animal nutritional supplements
    • Veterinary functional feed additives
    • Performance pet treats and snacks

    5. Beverage Preservation and Shelf Life Extension

    Beverage producers employ Cinnamtannin D1 in the formulation of natural antioxidant systems for ready-to-drink teas, fruit juices, and plant-based drinks. Its role centers on delaying lipid and flavor oxidation, especially in heat-treated or shelf-stable beverages, without altering taste or requiring artificial additives. Manufacturers add the ingredient during post-extraction blending or before final pasteurization steps, carefully validating dosage to balance preservation and regulatory acceptance.

    Industry compliance standards

    • GB 2760-2024 National Food Safety Standard for Use of Food Additives (China)
    • US FDA 21 CFR Parts 170–199 for food ingredient safety
    • EU Regulation No 1333/2008 on food additives
    • HACCP systems for beverage manufacturing

    Typical usage ratio

    • 0.01%–0.06% by beverage volume in teas and functional drinks; 10–50 ppm total phenol concentrations, subject to regional regulatory maximums and intended shelf-life duration.

    Downstream process integration

    • Incorporation into bulk liquid matrices post-extraction
    • Blend addition prior to filtration and thermal processing
    • Homogenization step to ensure even dispersion in final beverage batches
    • Quality control testing for residual polyphenol content after pasteurization

    Final product types

    • Shelf-stable herbal tea beverages
    • Fruit and vegetable juice blends
    • Plant-based protein drinks
    • Functional RTD (ready-to-drink) beverages
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    Certification & Compliance
    More Introduction

    Cinnamtannin D1—An Insight into Quality, Consistency, and Applications

    Understanding What Sets Cinnamtannin D1 Apart

    Years of hands-on experience in manufacturing botanical extracts have taught us the value of knowing exactly what goes into every batch, and Cinnamtannin D1 stands out as one of those compounds that brings more to the table than just its presence in production schedules or inventory lists. As manufacturers, we focus on purity, traceability, and replicable yields—factors that come from working close to the raw materials, controlling temperature curves during the extraction process, and knowing which parameters make genuine difference to researchers, developers, and end-users.

    Cinnamtannin D1, classified as a proanthocyanidin, occurs naturally within Cinnamomum species, particularly in the bark. Decades of pharmacognosy and phytochemical research highlight its potential in health applications, although any claim relies on evidence-based findings and honest evaluation. The unique feature of Cinnamtannin D1 comes from its complex tannin structure, which alters how the compound interacts in formulation work, giving those in product development a degree of flexibility and reliability that's only achievable by keeping batch-to-batch deviations as tight as possible during production.

    Manufacturing Confidence: From Raw Material to Refined Extract

    Pulling high-quality Cinnamtannin D1 out of plant sources takes more than established SOPs and certification sheets. The compound’s intricate structure means any slip in solvent ratios or time spent during extraction and purification impacts not just the yield but how the final product performs on analytical tests. Through repeated validation of our process controls, including high-performance liquid chromatography (HPLC) for every lot, manufacturers avoid common pitfalls—like protein contamination or off-color fractions—that plague less attentive producers. Because we draw directly from harvested raw bark, traceability is testable at every stage, allowing customers and collaborators to verify origin and purity rather than relying on a promise.

    Beyond chromatography, physical parameters like appearance, solubility, and particle morphology get monitored too. Not every batch turns out the same shade or shows identical granular properties, so routine adjustments keep things within the specified range. Years on the production floor reveal the stubborn spots—where humidity causes clumping or where slight changes in pH affect the stability of dissolved tannins. Addressing these tangible issues head-on means fewer surprises later, whether the Cinnamtannin D1 moves into analytical labs, clinical teams, or ingredient procurement for new product launches.

    Specifications That Matter—And Why Manufacturers Prioritize Them

    Most customers approach us with an end-use in mind, whether as part of a supplement blend, a research study, or a specialty formulation. A key specification requested for Cinnamtannin D1 remains purity—usually quantified by percentage content through HPLC or similar methods. Typical output provides a purity of over 95%. Achieving this threshold consistently stems from tight process control rather than luck. With raw bark as starting material, environmental variability often throws challenges: seasonal shifts in alkaloid content, fluctuations in moisture content when barks arrive at the gate, or unexpected microbial growth after heavy rainfall. Our experience managing these live factors translates into readiness to tighten up raw material specs, carry out additional filtration rounds, or discard substandard lots—without letting pressure from “faster” deliveries compromise integrity.

    Moisture and ash content, often overlooked, deserve attention as well. While neither impacts the proanthocyanidin content directly, both provide insight into extraction thoroughness and the potential for unwanted baggage—minerals or unextracted organics that mar analytical results. Our process keeps moisture below 5%, based on the most reliable drying techniques learned by trial and error over years. Ash content, a telltale sign of extraneous plant residue, regularly stays within recognized safe margins, as each new lot undergoes gravimetric determination in our lab.

    Particle size holds a practical dimension, though some overlook its importance outside pharmaceutical tableting. Uniform, micron-scaled particles allow more predictable dissolution and dispersion, thereby supporting consistent blending and limiting segregation in larger-scale processing. Specialists in R&D departments appreciate avoiding headaches caused by uneven flow or sticking during pilot production.

    Cinnamtannin D1 in Practical Application—What Experience Reveals

    Discussions often focus on the health potential of Cinnamtannin D1, but as a manufacturer, real-world application starts with how the compound handles during downstream processing. In fields investigating antioxidants and polyphenols, Cinnamtannin D1 shows up in both in vitro models and pilot-scale supplement blends. Given the polyphenolic backbone, solubility can become a sticking point. Repeated agitation and temperature-controlled reconstitution help address solubility hurdles, especially during formulation into liquids and gels.

    Over the years, inquiries from pharmaceutical companies, food scientists, and functional ingredient formulators keep coming up: Will this batch handle high-shear mixing? How does it fare under exposure to acidic or basic conditions? Does it hold color or precipitate during warehouse storage at high humidity? Precise records of stability and behavior under test conditions inform our answers, enabling us to provide insights grounded in lived production realities rather than theory.

    Not all applications require identical grade or concentration, so flexibility in batch sizes—from pilot to industrial scale—matters. Experience tells us that scaling up introduces new challenges: temperature gradients across reactors, transfer losses, filtration speed downsides. We continue to optimize form factor, flexibility, and packaging to match requests from both researchers and commercial producers who need active content matched tightly to their application without carrying excess inactive ballast.

    Differences That Make a Difference: Cinnamtannin D1 Compared to Other Plant Tannins

    Long days working with a range of tannin-rich extracts highlight real differences between Cinnamtannin D1 and similar polyphenols. Structurally, Cinnamtannin D1 belongs to a class known as A-type proanthocyanidins, marked by a specific interflavan linkage not found in B-type varieties common in grape seeds or certain berries. This seemingly minor molecular variation produces practical variations in antioxidant action, solubility, and interaction with proteins. For example, A-type bonds confer stronger stability against acidic hydrolysis, reducing breakdown during product formulation.

    Other products often get sourced from plants like grapes or cranberry, which yield B-type proanthocyanidins. Although both classes exhibit potent antioxidant activity, our repeated analytical comparisons show that Cinnamtannin D1 usually exhibits higher resilience to heat, and a lower tendency to brown or degrade under moderate pH stress. Customers aiming for innovative products—like functional beverages or long-shelf-life cosmeceuticals—recognize these subtle but crucial differences after hands-on trials with different suppliers’ samples.

    Sensory properties offer another differentiation point. Cinnamtannin D1 delivers a characteristic astringency, unmistakable compared to the softer undertones of tannins from other sources. While astringency isn’t always desirable for all product types, manufacturers and formulators working in food additives or traditional medicine value this property for applications where mouthfeel and the traditional taste footprint signal natural authenticity. The pronounced flavor is less suited to hidden applications but stands out where authenticity or clarity of botanical origin matters.

    Stabilizing Cinnamtannin D1—Upstream and Downstream Considerations

    Controlling the stability of Cinnamtannin D1 starts even before the first solvent touches the bark. Variability in raw material would lead to unpredictable outcomes unless source selection gets handled by staff who know exactly what high-grade bark looks and smells like. Long-term experience picking out lots that store well over weeks or months teaches that color, texture, and even the bark’s moisture level impact final extract stability. Our internal records and memory banks both agree: starting fresh yields better chemistry downstream.

    Downstream, keeping the extract stable requires not just packaging under inert gas or UV-protected containers but monitoring how the tannin interacts with storage materials themselves. Certain plastics or metals contribute leachables or accelerate breakdown, so the choice for packing gets narrowed to those materials proven through shelf-life testing in our own cold rooms and environmental chambers.

    Heat stability also deserves mention as a distinct benefit. In pilot-scale food applications, Cinnamtannin D1 resists breakdown at pasteurization temperatures, holding up better than competitors’ alternatives derived from less robust sources. The lesson? Not all “tannins” behave identically. Only by making, storing, and using the extracts firsthand does this subtlety become clear.

    Supporting Science—Generating and Sharing Reliable Data

    An important responsibility falls on the manufacturer to support the work of formulators, researchers, and product developers with real, timely, and transparent science. Our facility maintains routine internal studies—measuring not only purity and potency but also tracking parameters such as oxidative stability, solubility in various solvents, and bioavailability in cell models. Every data point adds to a growing internal library, accessible to long-term partners and new clients alike.

    Real data replaces guesswork. Over time, we’ve shared sample lots with labs working on analytical chemistry, clinical nutrition, and innovative delivery systems like slow-release matrices. Their feedback makes its way back into process refinement, especially as new evidence suggests whether Cinnamtannin D1 offers unique functional advantages or demands further adjustment. Openness to sharing these findings proves essential in building trust, keeping us focused on continuous improvement rather than static “perfect” protocols.

    Potential Concerns and Proactive Solutions

    A common worry from customers: batch variability and the genuine risk that this year’s extract might differ slightly from last year’s. This uncertainty disrupts research reproducibility and regulatory submissions. Since we answer directly for production—not through third-party brokers—we hold ourselves accountable. Our strategy combines hedging raw materials for consistency, reinvesting in training for QC analysts, and adjusting extraction parameters as soon as shifts appear on routine checks.

    Microbial contamination poses another real worry, especially given the trend toward lower residual solvents and minimal processing in “green” production lines. After some early setbacks years ago, we integrated additional microbial kills steps—thermal and UV—in tandem with robust post-extraction filtration. Collaborators appreciate knowing that each batch gets tested for common pathogens and mycotoxins, validating the focus on safety and compliance before product even ships out.

    Adulteration and substitution present growing issues in global trade for botanical extracts. We lean on extensive in-house reference libraries of spectral and chromatographic data, kept up-to-date with the latest published markers and proprietary benchmarks from our experience. We consistently reject questionable raw material lots outright; years spent chasing after “bargain” inputs taught us expensive lessons. Adulteration becomes detectable through side-by-side analysis, something we offer willingly to partners facing doubts.

    Connecting with Partners Through Experience

    Direct relationships matter in specialty ingredient manufacturing, particularly for novel options like Cinnamtannin D1. Over the years, we’ve seen customers return because they trust not just our paperwork but our open-door approach to technical questions and sampling. Transparency about lot status, flexibility in order size, and willingness to facilitate site visits all stem from the knowledge that a product's reputation builds over years, not with glossy brochures.

    Our approach also includes long conversations with R&D teams on-site, troubleshooting sticking points in pilot runs, and adjusting particle size cuts or packaging methods mid-cycle to suit unique product launches. Manufacturers learn early that rigid, one-way service stifles innovation—the best results follow when both sides draw insights from hands-on trial and error.

    Looking Forward: Sustainable Manufacturing and Product Longevity

    Environmental responsibility can’t be a buzzword. Harvesting Cinnamomum sources for Cinnamtannin D1 needs to minimize waste and avoid damage to ecosystems. We’ve shifted procurement to verified sustainable sources, using only barks cut from trees that continue growing. Detailed field audits and processing statistics confirm compliance with sustainability targets set internally and by external partners.

    Processing plants also recycle water, utilize waste biomass for clean energy, and implement ongoing assessments to reduce solvent usage year on year. Few see the direct savings in a bottle of Cinnamtannin D1 extract, but the cumulative result ensures the product’s longevity without gutting future supply.

    Reflections from the Production Line

    Years spent manufacturing botanical compounds engrave basic truths about quality, resilience, and the real motivations of end-users. Cinnamtannin D1 remains a prime example of an ingredient where close, iterative process control, transparent relationships, and plain persistence create reliable, practical difference. The nuances—from choosing the right barks to validating every lot for physiological and functional consistency—find no shortcut.

    Those on the production side of the industry carry the weight of responsibility every time a new request comes in. More than supplier paperwork or sample vials, it is open communication with developers, careful stewardship of natural resources, and months of trial followed by improvement that truly define a Cinnamtannin D1 extract worth trusting. Each batch reflects the hands and minds that created it, speaking volumes beyond a line of analytical data.