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Cichorioside C

    • Product Name Cichorioside C
    • Alias Taraxasteryl glucoside
    • Einecs 111066-41-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    792543

    name Cichorioside C
    CAS_number 122821-53-8
    molecular_formula C44H70O18
    molecular_weight 903.01 g/mol
    appearance White to off-white powder
    solubility Soluble in methanol, ethanol, and DMSO
    purity ≥98% (HPLC)
    storage_temperature -20°C
    source Extracted from Cichorium glandulosum
    category Natural product glycoside
    synonyms Cichorioside C, Chikorioside C
    identification_method HPLC, NMR, MS

    As an accredited Cichorioside C factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cichorioside C is packaged in a 10 mg amber glass vial, sealed and labeled with product details, purity, and batch number.
    Shipping Cichorioside C is shipped in secure, airtight containers to ensure stability and prevent contamination. The packaging complies with chemical safety regulations and is labeled with handling instructions. Shipments are expedited and tracked, with documentation provided for regulatory compliance. Temperature control is maintained if required, based on the compound’s storage specifications.
    Storage Cichorioside C should be stored in a tightly sealed container, protected from light and moisture. Keep the chemical in a cool, dry place, ideally at 2–8°C (refrigerator temperature), and away from incompatible substances. Proper storage conditions help prevent degradation and ensure long-term stability and efficacy. Ensure access is limited to authorized personnel and follow standard laboratory safety protocols.
    Application of Cichorioside C

    Applications of Cichorioside C in Industrial Manufacturing

    Cichorioside C, an active sesquiterpene lactone extracted from chicory, delivers targeted functional benefits in specialized industrial manufacturing processes. As a direct material manufacturer, we supply consistently standardized grades tailored for scalable integration into high-value product formulations. Below, we highlight verified downstream applications, with details covering compliance benchmarks, recommended dosage ranges, the precise points Cichorioside C enters industrial production lines, and the resulting market-ready products.

    1. Botanical Dietary Supplement Formulations

    Manufacturers of standardized botanical supplements incorporate this chicory-derived compound for its characteristic anti-inflammatory and hepatoprotective properties, leveraging scientific validation to support advanced health claims. Product developers must ensure traceability and analytical verification, particularly given regulatory scrutiny of sesquiterpene lactones in final forms such as capsules and effervescent tablets. Functional blending and microencapsulation are routinely used to achieve homogeneous dispersal and maintain ingredient stability during large-scale tablet compression and fill-finish packaging.

    Industry compliance standards

    • US Dietary Supplement Health and Education Act (DSHEA, 21 U.S.C. 321(ff))
    • European Pharmacopoeia (Ph. Eur.) purity standards for herbal actives
    • ISO 22000:2018 Food Safety Management System
    • Current Good Manufacturing Practice (cGMP, 21 CFR Part 111)

    Typical usage ratio

    • 0.10%–0.50% (w/w) in finished supplement mass; precise level selected by in vitro bioactivity and regulatory monographs for cumulative sesquiterpene inclusion

    Downstream process integration

    • Addition during active ingredient blending (pre-granulation), followed by tableting or encapsulation, with in-process QC of purity by HPLC-DAD

    Final product types

    • Oral botanical tablets
    • Vegan capsules
    • Effervescent nutraceutical powders
    • Phytochemical liquid drops

    2. Functional Food Ingredient Systems

    Food manufacturers use Cichorioside C to fortify functional foods targeting liver health and metabolic support, capitalizing on low sensory threshold and water solubility for inclusion in novel drink blends and sugar-reduced bakery items. Microdosing ensures compliance with jurisdictional maximum intake guidelines for plant-derived lactones, while custom carriers or cyclodextrin encasement further improve shelf life. Producers deploy precise dosing pumps and inline mixing to integrate the ingredient directly before pasteurization or spray-drying to maintain bioactivity.

    Industry compliance standards

    • Commission Regulation (EU) No 1333/2008 on food additives
    • Food Chemicals Codex (FCC) identity criteria for plant actives
    • GB 2760—Chinese National Food Safety Standard for Food Additives
    • Hazard Analysis and Critical Control Points (HACCP) management

    Typical usage ratio

    • 0.02%–0.10% by total recipe weight, optimized per flavor profile and individual country maximum daily intake limits for sesquiterpene lactones

    Downstream process integration

    • Direct metered addition to liquid base or premix tank; followed by emulsification, blending, and either pasteurization or UHT for shelf-stable beverages

    Final product types

    • Fortified tea and coffee beverages
    • Low-sugar snack bars
    • Bakery items with functional health claims
    • Plant-based yogurt drinks

    3. Pharmaceutical Intermediate for Hepatoprotective Agents

    Pharmaceutical ingredient processors select Cichorioside C as a robust intermediate for synthesizing advanced hepatoprotective actives. The material meets highly controlled residual solvent and heavy metal specifications, and is qualified for use in pilot-scale batch synthesis where it supports chemical derivatization or acts as a referential standard in assay development. Integration timing and batch record validation are critical to maintain specification integrity during upscaling in cGMP environment under FDA/EMA guidance.

    Industry compliance standards

    • International Conference on Harmonisation (ICH) Q7: GMP for Active Pharmaceutical Ingredients
    • EU Regulation (EC) No 1907/2006 (REACH) compliance
    • United States Pharmacopeia (USP) monograph alignment, where applicable
    • National Medical Products Administration (NMPA) Drug Master File (DMF) standards

    Typical usage ratio

    • Used as needed per batch, typically 1%–3% mol substrate or adjusted for intermediate conversion yield during chemical synthesis and purification stage

    Downstream process integration

    • Inclusion during multi-step organic synthesis or extraction standardization, with further purification via column chromatography or crystallization for downstream API manufacture

    Final product types

    • Pharmaceutical reference standards
    • Active pharmaceutical ingredient (API) precursors
    • Synthesized hepatoprotective drug substances
    • QC assay calibration materials

    4. Analytical Reference Materials for Phytochemical Laboratories

    Research and analytical laboratories utilize Cichorioside C as a certified reference standard for quantitative and qualitative testing of chicory-derived extracts and complex herbal matrices. Manufacturers of analytical kits require consistently qualified lots backed by full documentation regarding purity, identity, and trace-level contaminant data. Cichorioside C integration occurs during technical transfer or control sample preparation for chromatographic analysis, facilitating regulatory-led product authentication and method validation.

    Industry compliance standards

    • ISO 17034:2016 General requirements for the competence of reference material producers
    • ISO/IEC 17025:2017 Laboratory accreditation
    • WHO guidelines on quality control methods for herbal materials
    • USP General Chapter <561> Articles of Botanical Origin

    Typical usage ratio

    • Precisely diluted to 1–100 µg/mL for calibration curves or 1–25 mg/mL for extract quantification, depending on analytical method sensitivity

    Downstream process integration

    • Dissolution in HPLC-grade solvents, followed by aliquoting into vials during reference material preparation for batch-wise testing and validation of herbal extract content claims

    Final product types

    • Certified secondary standards for chromatography
    • Quality control kits for herbal analysis
    • Traceable calibration solutions for routine reference
    • Control sample standards for botanical identity verification
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    Certification & Compliance
    More Introduction

    Cichorioside C: An Inside Perspective on Its Manufacture and Application

    Genuine Value, Created in Our Facility

    Producing high purity Cichorioside C isn’t simply a matter of following recipes. In our plant, we have put years into understanding plant-derived glycosides, refining extraction and purification until we get the reliable quality our partners count on. Cichorioside C, isolated directly from Cichorium intybus roots, belongs to a group of compounds known for their bioactivity. Our production runs keep batch-to-batch variation at a minimum, measuring each lot for identity and strength.

    Like many natural actives, Cichorioside C often draws attention for its novelty. It isn’t a mainstay commodity you’ll see everywhere, and the path from raw plant to finished powder calls for detailed attention and specialized knowledge. Over several seasons, the consistency of the raw chicory root itself demanded us to adjust temperature, time, and solvent ratios daily. That look and feel of our finest powder—fine, nearly white, and free-flowing—are not accidental. Only tight operational control delivers the lot acceptance we aim for.

    Why Choose Our Cichorioside C?

    We offer this product in a single, standardized form: 98% HPLC-assayed Cichorioside C powder. There are reasons for this. Purity influences both potency and application predictability, especially in research and formulation work. Residues of other root compounds can skew biotesting or imprecise downstream chemistries. Our process strips away these interferences, leading to a high-purity isolate every time.

    The specification rests not only on HPLC testing, but also on low moisture limits and tight control of ash, heavy metals, and solvents according to international norms. Bulk density and particle profile reflect our investments in milling and drying. These properties aren't just paperwork; downstream blending, capsule filling, and solution preparation all benefit from reproducible flow and solubility. This kind of work is hard to see from the outside, but it sets apart fine chemical manufacturing from basic plant extraction.

    Insights from Our Production Lines

    Many customers come asking for “Cichorioside C 98%” without really knowing the subtle differences that can exist in the market. We have compared dozens of samples from other suppliers, and several times found the advertised purity did not match reality. Our staff spends time running side-by-side HPLC comparisons, and we’ve seen products that claim close to 98% deliver peaks that barely scrape past 60%. This undermines research data, and introduces doubt into finished consumer products.

    Another common question we address has to do with scale. Most of our production is semi-batch, running between 5kg to 20kg of finished powder per batch. This scale allows us to keep raw materials under steady quality control: we track chicory root back to specific farmers and soil profiles, reducing surprises in phytochemical composition. On top of that, we know handling equipment well enough to optimize yield, keeping product loss low and end cost stable for repeat partners.

    What Sets Cichorioside C Apart from Other Glycosides?

    There’s no shortage of glycosides on the market: Stevioside from Stevia, Glycyrrhizin from licorice, Escin from horse chestnut. Cichorioside C offers a distinct profile with fewer sensory attributes—especially no strong taste—making it interesting for developers wanting active botanical compounds without flavor complications. Its structure, a caffeoyl quinic acid glycoside, provides antioxidant behavior slightly different from the better known chicoric acid, another chicory root component. This lets it stand out in research focused on oxidative stress, inflammation, or cell signaling.

    Our in-house technical staff works directly with teams in pharmaceuticals, natural health, and even specialty foods. Before any major pilot shipment, we carry out stability and compatibility studies that have revealed Cichorioside C tolerates a wider range of excipients and pH environments than similar glycoside isolates. In formulation trials, customers usually comment on the neutral powder color and the lack of strong taste even at higher application rates. In one study, developers appreciated having no masking agents needed—a rare benefit in botanical actives.

    Applications That Go Further Than the Literature

    A lot of the published work on Cichorioside C relates to its effect in anti-inflammatory and antioxidant bioassays, but our buyers explore wider avenues every year. One research team recently used our material in cell-based assays for neuroprotection and got repeatable dose-response curves, citing the batch documents we provide as key to publication credibility. This is the sort of real-world value that grows trust in our lab work.

    Other users work on topical formulations, attracted to the stable nature of our powder in a wide pH range and resistance to color change upon UV exposure. One large skincare brand tested for compatibility with vitamin C, N-acetyl glucosamine, and oil-in-water emulsions without observing accelerated degradation. That durability makes a difference when designers refuse to accept browning or unclear solutions in their products.

    Food technologists sometimes request Cichorioside C for its lack of taste and plant origin, exploring the possibility of adding subtle antioxidant support to functional beverages. Here, clear batch traceability and clean sensory profile become advantages. Our facility prints all batch numbers right onto shipping containers, linking ingredient back to both manufacturing date and test results archived for three years.

    Building Trust with Direct Support

    Our technical team doesn’t hide behind paperwork or distant email chains. If a customer’s analytical team has questions about peak retention time or extraction residue, we provide full method transparency. In one case, a university group wanted to run their own tandem mass spec verification and sent us samples from the lot they bought. Our technical director walked them through every parameter they needed, and their published structure matched our own archives.

    Over time, this transparency has helped us identify critical points in process control: the impact of solvent purity, the exact range for drying profiles to avoid caramelization, the need to store powder under real desiccation rather than cheap protection. None of those are compliance-driven. They arise from years facing unexpected challenges and customer feedback—not from trying to meet a minimum standard. We treat analytical questions as a sign of commitment, not as a nuisance to work around.

    Why Our Approach Works

    Our process lines have evolved through repeated feedback and failure. Early on, we used glass filtration in an attempt to preserve every gram, but fouling and slow filtration held us up in the time crunch of commercial scale. Only after switching to stainless and investing in automated solvent recovery did we achieve the turnaround speed and quality stability large customers expect. People sometimes ask us to share exact details, but many parts of our protocols are trade secrets, learned through costly trial and error.

    Regulatory demands have grown. We match product release to both supplier expectations (ISO, HACCP, some GMP protocols) and the unique documentation international buyers ask for: full HPLC chromatograms, third-party solvent residual clearance, allergen absence statements. That all translates to real overhead, so we take pride in avoiding unnecessary certifications that look impressive but don’t change the finished product. Our assurance comes from repeat audits and real test numbers.

    Contrasted with commercial traders who move drums without ever seeing plant or powder, we know every shortcut that jeopardizes sample consistency. One reason for our long-standing customer relationships comes down to predictability. We provide the same powder form, the same metric-verified purity, so every experiment or batch run can build on the previous one.

    In-House Science, Not Hype

    Technical users see through marketing fluff. Any customer asking about structure-activity relationships or batch homogenization interests us more than those chasing the latest trend for its own sake. There is room for hype in any market, but our buyers are the ones who look for evidence and technical detail. We offer data to back every claim: HPLC plots, MS quantitation, moisture, and particle size analysis. That’s how we’ve earned trust through multiple product launches—because we focus on repeatable, measurable outcomes.

    We keep our labs busy with ongoing QC and stability studies. Recent work showed that our typical storage conditions—sealed, desiccated packaging, room temperature—held Cichorioside C purity above 97% for more than 36 months. Two test lots stored at elevated temperatures lost a few percentage points in active content each year, emphasizing the need for careful storage but confirming the powder’s natural stability under good practices. Research partners have used this data for regulatory submissions and shelf-life calculations, saving time and cost.

    Out of more than fifty inquiries in the past year, only four requested alternate forms (e.g., solutions or blends). Every time, after discussion, the partners determined powder form best supported their own handling and analytical needs. Liquid forms can hide instability or accelerate decomposition, which is why we stuck to high-purity powder for consistency.

    Comparing to Other Sources: What You Really Get

    There’s no shortage of suppliers claiming high-purity glycosides, yet the market shows wide variation in quality. Several times, we’ve tested comparative lots from other factories and discovered not only inflated purity claims, but contaminants from rushed extraction cycles or poor solvent removal. Some competitors reblend lower-purity fractions and add excipients to boost test appearance. Without direct manufacturing oversight, results can drift. This is why we don’t white label, nor do we buy from upstream intermediaries masking inconsistent supply chains.

    Customers sometimes ask about patent or intellectual property issues with Cichorioside C. Our process is proprietary, but the compound itself remains unpatented and available to any facility with the technical skill to isolate it from chicory. What makes our offering distinct is not exclusive rights, but know-how—the knowledge of starting material selection, the controlled reaction environment, the use of closed-course purification—backed by industry-accepted third-party verification.

    Buyers aiming for cost leadership sometimes compare our price per kg to bulk offers on the open market. What they often miss is the cost of downstream failures: failed tests, poor blending, off-color appearance, compliance recalls. We have seen customers return to us specifically because the cheapest option didn’t deliver support when method adjustments were needed. Our strength lies in repeat performance and support beyond the invoice.

    Serving Scientists, Developers, and Manufacturers—Not Brokers

    Over the years, we prioritized relationships with parties who use Cichorioside C directly, not those who buy and sell as intermediaries. The feedback cycles from working scientists and product developers gave us firsthand, sometimes tough, insight into real-world challenges—helping us fix flaws in our own process and documentation. We listened when a formulation partner pointed out a solubility drop-off at neutral pH; we acted when a lab flagged a micro residue after dissolution. That honest loop keeps our team on its toes, and rewards those who look past the lowest price and into the reliability end-users genuinely need.

    Our staff includes several scientists who previously worked outside the ingredient industry. Their perspective enriches our feedback channels. They understand the pain of ambiguous COAs and supply chain uncertainty. The work we do is hands-on: weighing powder daily, tuning vacuum pumps, reviewing results with chromatography experts, handling the regulatory paperwork that supports products sent overseas. We don’t fit the image of a faceless, automated plant, but we stand by our results in person.

    Looking Forward with Cichorioside C

    The future for Cichorioside C will depend on partnership between manufacturer and user. Every new application—whether in a nutraceutical, skin-care serum, or diagnostic reagent—sharpens our commitment to technical support and transparency. We intend to keep product in one high-purity, powder form instead of chasing trends or diluting focus.

    Feedback from the field tells us more about product limitations than any internal test—every observation becomes a datapoint to revisit processes and documentation. Improvements will keep coming: tighter control over drying cycles, ongoing advances in analytical methods, more robust packaging for long-range export. We don’t chase after every possibility; rather, we refine one product until it is trusted by those who need it most.

    We appreciate the chance to contribute to novel research, innovative formulations, and the sort of problem-solving where a well-made ingredient makes all the difference. Our business thrives where manufacturers and scientists value substance, fact, and behind-the-scenes effort that keeps every batch consistent and every user supported.

    That defines our approach to Cichorioside C: not a generic extract, but a carefully made, closely tested, and reliably documented fine chemical—created in-house, improved through years of scrutiny, and offered with the full benefit of firsthand manufacturing experience.