Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Cichoriin

    • Product Name Cichoriin
    • Alias Esculin
    • Einecs 207-615-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    803159

    name Cichoriin
    IUPAC_name esculetin 7-O-beta-D-glucopyranoside
    molecular_formula C15H16O9
    molecular_weight 340.28 g/mol
    CAS_number 531-55-5
    appearance yellow crystalline powder
    solubility soluble in water and ethanol
    melting_point 229-230°C
    source from Cichorium intybus (chicory) and other plants
    classification coumarin glycoside
    uses pharmaceutical and biochemical research
    storage_conditions store at 2-8°C, protected from light

    As an accredited Cichoriin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Cichoriin is packaged in a 1g amber glass vial, sealed and labeled with product details, storage conditions, and safety information.
    Shipping Cichoriin is shipped in a tightly sealed, chemical-resistant container to prevent contamination and moisture exposure. It is handled as a non-hazardous substance under normal conditions but must be transported according to regulatory guidelines. The package includes proper labeling and documentation, ensuring safe delivery and compliance with chemical shipping standards.
    Storage Cichoriin should be stored in a tightly sealed container, protected from light and moisture. Keep the storage area cool and dry, ideally at 2-8°C (refrigerated) or as recommended by the supplier. Avoid exposure to excessive heat, humidity, or direct sunlight to maintain the chemical’s stability and prevent degradation. Ensure proper labeling and safety precautions are followed.
    Application of Cichoriin

    Applications of Cichoriin in Industrial Manufacturing

    As a direct manufacturer specializing in the production of Cichoriin, we support various industrial sectors that demand consistent quality and regulatory adherence. Below, we outline key downstream use cases where this compound delivers necessary functionality and compliance for high-value manufacturing processes. Each application reflects actual industry adoption rather than generalized or hypothetical scenarios, addressing specific technical needs for process engineers, formulators, and production managers.

    1. Natural Food Preservatives for Dairy Products

    Dairy processors employ Cichoriin in cultured and fresh dairy formulations to extend shelf life through its proven antioxidative and antimicrobial properties. By integrating the ingredient at the mixing and standardization step, food technologists reduce spoilage incidents and limit synthetic preservative reliance for fresh cheese, yogurt, and sour cream lines. Its compatibility with heat processing and fermentation further ensures consistent action throughout the product lifecycle, directly supporting clean label objectives in regulated food markets.

    Industry compliance standards

    • Codex Alimentarius General Standard for Food Additives (GSFA)
    • EU Regulation (EC) No 1333/2008 on food additives
    • FDA 21 CFR Part 172—Food Additives Permitted for Direct Addition to Food for Human Consumption
    • ISO 22000:2018 Food Safety Management Systems

    Typical usage ratio

    • 0.05%–0.15% w/w depending on product water activity and desired preservation length; technicians adjust based on finished product pH and dairy fat content

    Downstream process integration

    • Added to milk base during early mixing and standardization prior to heat treatment or fermentation; disperses fully in aqueous phase at process temperature

    Final product types

    • Set and stirred yogurts
    • Soft and semi-hard cheeses
    • Sour cream
    • Fermented dairy drinks

    2. Botanical Extract Formulation for Dietary Supplements

    Nutraceutical manufacturers incorporate Cichoriin as a standardized botanical antioxidant in solid and liquid dosage forms targeting free radical reduction. Extraction and blending lines value its high assay stability and low impurity profile, which remain unaffected during granulation, tableting, or encapsulation. This ensures proper active content for labeling and batch consistency, supporting compliance with international health supplement regulations.

    Industry compliance standards

    • USP Dietary Supplements Compendium
    • China Food Safety Law on Health Food Ingredients
    • EU Food Supplements Directive 2002/46/EC
    • GMP (Good Manufacturing Practice) for Dietary Supplements, 21 CFR Part 111

    Typical usage ratio

    • 1 mg–10 mg per daily serving; typically formulated at 0.02%–0.1% in blends, with adjustments based on finished dosage weight

    Downstream process integration

    • Dry powder incorporated during blending prior to granulation for tablets; liquid extracts dissolved into syrup or solution matrix post-filtration

    Final product types

    • Effervescent tablets
    • Capsules and softgels
    • Liquid nutraceutical syrups
    • Antioxidant powder blends

    3. Functional Beverage Additive in Herbal Drinks

    Producers of plant-derived soft drinks use precise Cichoriin supplementation for antioxidant enrichment in functional beverage portfolios. Blenders integrate the compound during the syrup preparation stage, where its solubility supports even dispersion and label transparency. The ingredient’s stability during pasteurization and aseptic filling is crucial for mass bottling operations aiming to maintain declared activity and clean taste in the final brew.

    Industry compliance standards

    • Food Chemicals Codex (FCC)
    • EU 2015/2283 Novel Foods Regulation
    • China GB 2760—National Food Safety Standard for Use of Food Additives
    • HACCP (Hazard Analysis and Critical Control Points) beverage safety plans

    Typical usage ratio

    • 5–30 ppm (mg/L) adjustable to bottle fill volume and beverage acidity; levels determined by shelf life and antioxidant declaration requirements

    Downstream process integration

    • Introduced during syrup blending prior to dilution and final in-line homogenization; monitored in solution before pasteurization or UHT treatment

    Final product types

    • Herbal and plant-based soft drinks
    • Ready-to-drink antioxidant teas
    • Cold brew botanical infusions
    • Functional water-based beverages

    4. Natural Cosmetics Ingredient for Skin Care Creams

    Cosmetic laboratories select Cichoriin for its botanical origin and performance as an anti-oxidant agent in high-value cream and emulsion products. Incorporated during the cool-down phase after emulsion formation, it preserves active congener stability without affecting viscosity or sensory texture. Its traceability and purity support claims for naturally derived and protective skin care lines, ensuring finished goods meet both technical and consumer transparency standards.

    Industry compliance standards

    • EU Cosmetics Regulation EC 1223/2009
    • ISO 22716:2007 GMP for Cosmetics
    • REACH Regulation (EC) No 1907/2006 for raw material sourcing
    • US FDA Voluntary Cosmetic Registration Program (VCRP)

    Typical usage ratio

    • 0.01%–0.05% w/w; optimized through pilot batches for skin compatibility and product shelf life requirements

    Downstream process integration

    • Added in post-emulsification cooling, below 40°C, to preserve molecular integrity; integrates with plant butter or hydrosol phases

    Final product types

    • Facial creams and lotions
    • Plant-based serums
    • Natural barrier creams
    • Moisturizing balms

    5. Pharmaceutical Reference Standard for Analytical Laboratories

    Contract labs and finished-dose manufacturers utilize Cichoriin as a phytochemical reference standard in HPLC and TLC assay validation for active ingredient verification. Provided with traceable purity documentation and full certificate of analysis, labs integrate this standard during QC workflows where quantification accuracy underpins regulatory batch release for herbal drug products and botanical ingredient imports.

    Industry compliance standards

    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • Chinese Pharmacopoeia (ChP)
    • ICH Q2(R1) Validation of Analytical Procedures

    Typical usage ratio

    • Reference standard concentrations set by each pharmacopoeia method (typically 0.1–1.0 mg/mL for standard curves in assay validation)

    Downstream process integration

    • Prepared as calibration solution for method validation and comparative testing; used in every batch QC verification for active content and adulterant exclusion

    Final product types

    • Botanical pharmaceutical ingredient lots
    • Plant drug finished dosage forms
    • Herbal medicine export shipments
    • Chemical reference material kits
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    Certification & Compliance
    More Introduction

    Cichoriin: Focusing on Quality and Real-World Performance

    Understanding the Value of Genuine Cichoriin

    For years in this industry, the difference between an average batch and a trusted one always stands out the moment it enters the production line. Cichoriin, with its specific crystalline structure and tight purity specifications, does more than just check a box on an ingredient checklist. Our facilities have invested in optimizing the extraction and refinement of Cichoriin to ensure traceability, batch consistency, and process transparency. The material we produce follows known reference models—certain grades tailored for analytical, research, and industrial applications, never compromising key characteristics.

    Handling raw plant-based compounds like Cichoriin, especially from Cichorium intybus and related species, challenges manufacturers to filter out unwanted bioside products while maintaining a clean fingerprint for industry use. We built our protocols around high-performance liquid chromatography testing, always cross-checking against international chromatograms. The reason for this steadfast approach comes from years of field experience: inconsistent purity leads to unpredictable results in both research and formulated products. Control over these details makes a direct impact in the materials science and life science sectors.

    A Straightforward Look at Model and Specifications

    Unlike generic powder forms, our Cichoriin lines carry defined model numbers corresponding to application and process discipline. Whether demanded by pharmaceutical researchers needing mg-scale for in vitro work, or by pilot plants producing kg-scale quantities, each model offers a clear documentation trail. The crystalline fraction, melting point, solubility in key solvents—these are results we log batch by batch. End users receive Cichoriin they can analyze using standard protocols and get expected performance.

    Moisture content, particle size, and absence of co-extractives often fall by the wayside in mass-market batches, yet they are non-negotiable in our facility. During milling and drying, our technical team monitors and controls air, humidity, and exposure, avoiding residual loads that can muddle spectroscopic data or compromise formulation stability. Over the decades, we've dealt firsthand with complaints driven by off-the-shelf product containing trace contaminants or pigment residues, a clear signal that shortcuts were taken upstream.

    In practical terms, our product specification sheets include identification by verified NMR and UV-vis, residual solvent tests, and compliance with key regulatory indices. An audit trail sits ready for every lot, reflecting a real ongoing dialogue with partners and clients who need assurance beyond a surface level certificate.

    How Cichoriin Gets Used: Insights from Real Applications

    Over time, feedback about Cichoriin use cases helps shape our own processes. The molecule’s relevance spans several areas: researchers test it for biological activity, food ingredient developers incorporate its properties, and industrial groups explore its potential in specialty chemical blends. In every case, purity and traceability remain the dividing line between productive work and lost time chasing inconsistencies.

    Research teams, who run cell-based assays or seek to replicate published experimental designs, need compounds that show repeatable behavior. If an extracted Cichoriin sample varies subtly in structure or includes micro-impurities, downstream data scatter and confidence erodes. In food and nutraceutical development, trace pesticides or unlisted plant-derived residues not only break regulatory compliance but also risk real-world product recalls—something no reputable business wants to face. From our seat as manufacturers, real transparency and honest reporting have often made the difference during client audits and crisis moments.

    A recent uptick in demand for Cichoriin in phytochemical research has brought in a wider array of testing inquiries. On more than one occasion, universities and start-ups have reported problems after sourcing questionable product online, ranging from mismarked identity to inconsistent solubility. The science teams facing unreliable raw material see both precious grant money and time lost. Our engagement with these clients often includes walking through analytical results, discussing extraction choices, and flagging unrecognized signals on their spectra—steps that bring everyone back to a troubleshooting mindset, rather than dealing with irreproducible work.

    Cichoriin Versus Similar Plant Compounds

    A common question from new users: what really sets Cichoriin apart from, say, Esculetin or related coumarin derivatives? Over the years, we've studied and produced various coumarins, and see first-hand the subtle but important differences. Cichoriin’s glycoside structure, its solvation behavior, and specific absorbance spectrum make it more than a commodity bioactive. In the lab, a contaminant masquerading as Cichoriin produces off-target effects, throws off stability curves, and distorts the cost-benefit calculations that drive formulator decisions. Our quality control requires not just thin-layer chromatography, but multi-dimensional NMR and confirmed digital spectra, to ensure end users aren’t left guessing.

    Other products on the market claim similarity in performance, but analytical comparison often reveals shortcomings: elevated background extractives, poor resolution on chromatograms, or simply a lack of real batch-to-batch data. Years ago, one high-profile supply-chain audit flagged non-standard Cichoriin with high levels of esculin—a sign of incomplete purification from root material. Situations like these push the whole team to remain vigilant on process and both chemical and supply chain documentation. The feedback from long-term pharmaceutical clients reinforces that even minor inconsistency shows up under real world stress-testing, whether during analytical validation or in the stability studies required for regulatory filings.

    We take these differences seriously. It’s not just about hitting a chemical name—it’s about accountable manufacturing. Over-processed or improperly dried Cichoriin can end up losing key activity, so we continuously refine our methods and trace all modifications. This constant adaptation takes coordination across technical staff and management—not just a one-off checkmark at a finish line. In our experience, those who cut corners find themselves out of the market pretty quickly.

    Transparency in Manufacturing: Root to Ready Formula

    Trust in specialty ingredient supply depends less on sales talk and more on evidence. We bring buyers and research groups into our workflow, offering site visits and regular, transparent reports. Each crop cycle introduces new variables; rain patterns, field rotation, even regional transport can influence the root stock, so we track each variable throughout the process.

    Our facility works directly with established agricultural partners, reviewing soil reports and agrochemical logs to avoid questionable plant material. Every incoming shipment includes both physical and chemical assessment. If a field shows abnormal pest management practices, we reject the material outright and require upstream partners to remediate before any further steps. It’s not just risk management—it’s sustainable business.

    The challenge of countering fraudulent or diluted raw material has only increased with the rise of non-transparent online players. More than once, we’ve helped clients recover from supply disruptions after unproven third-party suppliers sent substandard product labeled as “pure Cichoriin.” In one notable case, a multinational food brand traced a stability failure to unexpectedly high levels of non-target plant glycosides. Our testing, including tandem LC-MS, pinpointed the cause and allowed them to save both their line and their reputation. It's these learning moments that shape ongoing investment in traceability.

    Continuous Improvement Driven by Real-World Feedback

    Manufacturing complex natural compounds rarely stands still. Feedback from long-term clients, partner labs, and even independent third-party auditors continually informs our adjustments. As regulatory standards shift, so do our protocols. We build these learnings into every production lot, keeping communication active across departments and with outside partners.

    For example, input from academic clients running high-specificity studies on Cichoriin activity led to a tighter control of drying processes and updated final sieving screens. Industrial-scale formulators struggling with solubility issues influenced our mid-line filtration upgrades, enhancing final product behavior in larger blends. Internal testing, customer batch returns, and review of unrelated case studies in journals collectively help us avoid complacency. Each data point—reported or discovered—enters a knowledge base to inform future manufacturing cycles.

    Often, a company stops paying attention once a process looks reliable. We've seen competitors fall behind or lose major contracts because they missed subtle quality drifts over time—minuscule changes in process solvent purity or a slight shift in drying temperature. Experience says if you don’t measure, you don’t find. We measure frequently and adjust quickly, using both manual and automated tools, keeping the cycle of data collection and response front and center.

    Proactive Solutions for Industry Gaps

    Many plants incorporate specialty compounds in growing product segments, tightly regulated by regional and global standards. Preparing for changing compliance rules, our facility has built in regular workflow reviews: full spectrum heavy metal scans, expanded pesticide monitoring, and verification of new solvent residues. We don’t wait for regulators to catch flaws—actively engaging in industry roundtables and standards groups shapes our protocols long before enforcement arrives.

    We also contribute anonymized data to academic partners and independent research forums, offering context on trends we observe—such as regional shifts in Cichoriin root composition or solubility changes with climate variation. Sharing results makes our industry stronger and supports sound science from the ground up.

    Digital records from farm to finished material also separate us from resellers and undisclosed traders. This helps customers respond faster during formulation troubleshooting and provides real evidence for both legal and research accountability. Our approach has allowed early problem detection in both standard and custom product runs, saving both us and the client from expensive loss.

    People Behind the Product

    Cichoriin manufacturing succeeds when skilled staff attend to every detail. Our process and quality teams work alongside logistics, agricultural partners, and downstream customers, refining each step based on both planned and unforeseen feedback. We source, produce, and ship with employees who understand the level of trust riding on every batch—routine product returns from competitors often end up back with us for analysis and remediation.

    Long-term retention of technical staff means knowledge deepens instead of turning over. Several line supervisors have logged over two decades on the floor, fine-tuning extraction and filtration to improve both purity and yield. Our R&D chemists maintain both historical and contemporary databases of performance—learning from both past missteps and new emerging challenges. In this market, people invested in their work ensure the difference between a commodity and a reliable building block for advancement.

    Looking Forward: Adapting for Tomorrow’s Applications

    As research pivots to emerging uses of Cichoriin—such as advanced material science, food preservation testbeds, or complex pharmaceutical development—the expectation for robust supply rises. We never assume the current process fits tomorrow’s needs. Collaboration with downstream partners gives us insight into new application areas, like micro-encapsulation, which calls for specialized particle size distribution, or dual-solvent blending that raises technical challenges on residuals management.

    Our investments in new instrumentation, staff training, and digital workflow tracking all exist to support current and emerging customer needs. We watch both academic literature and customer R&D results to spot early warning trends, such as shifts in legal maximums for certain residuals, or changes in analytical reference standards accepted in major markets. With every shift, experienced manufacturing knowledge and a documented process foundation help avoid surprises.

    Practitioners and buyers often see behind-the-scenes choices in their own operations reflected in the quality, reliability, and safety of raw materials. Open communication, ongoing technical education, and persistent supply chain diligence remain the heart of what we do. Where other players overpromise and underdeliver, we ground our reputation in repeatable results and technical transparency.

    The evolving landscape of specialty compounds in industrial chemistry means every day starts with fresh challenges but also new opportunities for excellence. We welcome the dialogue and the ongoing scrutiny because, in the end, the product only matters if it performs in the real world, in real hands, and under real tests.