Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Bergenin

    • Product Name Bergenin
    • Alias Cuscutin
    • Einecs 211-370-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    Specifications

    HS Code

    715657

    Cas Number 477-90-7
    Molecular Formula C14H16O9
    Molecular Weight 328.27 g/mol
    Appearance White to off-white powder
    Solubility Soluble in water and methanol
    Purity Typically ≥98%
    Melting Point 236-238°C
    Source Extracted from Bergenia species (e.g., Bergenia ciliata)
    Storage Condition Store in a cool, dry place, protected from light
    Boiling Point Decomposes before boiling
    Synonyms Vakerin, Norbergenin 4-O-methyl Ether
    Structure Type C-glycoside of 4-O-methyl gallic acid
    Uv Maximum Absorbance 278 nm (in methanol)
    Chemical Class Phenolic compound
    Usage Phytochemical, research chemical, potential antioxidant

    As an accredited Bergenin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Bergenin, 25g, packaged in a sealed amber glass bottle with tamper-evident cap and clear hazard labeling for laboratory use.
    Shipping Bergenin is shipped in tightly sealed containers to protect it from moisture, light, and air. It is packaged according to chemical safety regulations, labeled clearly, and may include cold packs if temperature-sensitive. Shipping complies with local and international transport guidelines for non-hazardous chemical substances.
    Storage Bergenin should be stored in a tightly sealed container, protected from light and moisture. Keep it at room temperature, ideally between 2-8°C (refrigerated if specified by the supplier), and away from excessive heat or direct sunlight. Ensure storage in a dry, well-ventilated area and avoid exposure to incompatible substances to preserve its stability and effectiveness.
    Application of Bergenin

    Purity 98%: Bergenin with purity 98% is used in pharmaceutical antioxidant formulations, where it provides high free radical scavenging activity.

    Melting point 233°C: Bergenin with melting point 233°C is used in solid dosage nutraceuticals, where it ensures thermal stability during tablet processing.

    Particle size <50 microns: Bergenin of particle size <50 microns is used in topical cream preparations, where it offers enhanced dermal penetration and absorption.

    Stability temperature 60°C: Bergenin with stability temperature 60°C is used in beverage fortification, where it maintains bioactivity after pasteurization.

    Molecular weight 328.28 g/mol: Bergenin at molecular weight 328.28 g/mol is used in analytical reference standards, where it provides accurate quantification in HPLC assays.

    Water solubility 12 mg/mL: Bergenin with water solubility 12 mg/mL is used in aqueous antioxidant solutions, where it achieves homogeneous distribution and improved efficacy.

    Purity 95%: Bergenin of purity 95% is used in anti-inflammatory botanical extracts, where it ensures consistent therapeutic performance.

    Residual solvent <0.1%: Bergenin with residual solvent below 0.1% is used in intravenous drug formulations, where it reduces toxicity and improves patient safety.

    Loss on drying <5%: Bergenin with loss on drying below 5% is used in encapsulated dietary supplements, where it maintains long-term product stability.

    Assay 99%: Bergenin with assay 99% is used in quality control testing, where it provides reliable standardization in analytical laboratories.

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    Competitive Bergenin prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing Bergenin: A Reliable Botanical Extract Direct from Our Facilities

    The Origin and Fundamental Qualities of Bergenin

    As a manufacturer that has spent decades focused on the extraction and refinement of bioactive molecules, we observe many plant-derived substances cycle through waves of interest and demand. Bergenin stands out from this crowd not only for its stable presence in pharmaceutical research and health applications but for its sheer reliability during processing. Our team sources Bergenin directly from dried bark and roots of Bergenia species, choosing high-altitude harvest sites with controlled growing conditions that minimize impurities and agricultural residues.

    In our facilities, the route from raw material to finished product passes through our own controlled extraction rooms. Bergenin emerges as a white to off-white crystalline powder, with a distinct melting point and solubility. Regular testing within our laboratory keeps batch consistency tight, measured by HPLC with purity levels exceeding 98%, and moisture content kept below 2%. Foreign matter checks, heavy metal screenings, and rigorous microbial controls ensure Bergenin leaves our plant in a state that allows direct use in further formulations, research activities, or direct tableting, depending on customer needs.

    Bergenin’s Broad Utility

    From practical encounter, our Bergenin streamlines workflow along the value chain, largely thanks to its predictable performance in both large-scale and pilot applications. Customers in the pharmaceutical sector rely on Bergenin for its anti-inflammatory and hepatoprotective properties. Academics and clinical researchers frequently request it to study activities connected to its antioxidant, antidiabetic, and antiulcerative effects, and they require absolute clarity on identity and purity. Natural health supplement makers value Bergenin's compatibility with a wide range of excipients without stability issues under standard storage.

    Our process eliminates seasonal swings in supply quality and ensures that year-round, clients receive consistent, well-documented material. Because we manage total traceability—from field to drum—questions about botanical authenticity or adulteration do not complicate downstream development. We have found this level of transparent supply suits both stringent regulator environments and faster-moving supplement markets.

    Comparing Bergenin to Other Extracts

    Chemical manufacturers often encounter customers weighing Bergenin against a list of other plant-derived bioactives. In this space, Gallic acid, Quercetin, Curcumin, or even Arbutin serve as reference points. Our Bergenin draws customers who pursue specific anti-ulcer or liver-protective features that similar polyphenols do not fully deliver.

    While other extracts can show wide variation in purity and batch-to-batch composition, our Bergenin maintains narrow parameter ranges. Curcumin, for instance, tends to pose issues with light sensitivity and solubility challenges in non-polar solvents. Quercetin, heavily dependent on source crop and harvest timing, often demands additional purification steps. In contrast, Bergenin keeps a stable crystalline structure and dissolves reliably in polar solvents—particularly beneficial for formulation scientists.

    Arbutin, sometimes substituted for Bergenin in traditional applications, reveals a different chemical profile under stress testing. Our Bergenin demonstrates a stronger resistance to hydrolysis during long-term storage. As more manufacturers and R&D labs hunt for plant-based substances with simplified logistics and clear activity, Bergenin stands apart by resisting the seasonal and supply-chain volatility that plagues peers.

    Manufacturing Bergenin: Practices and Principles

    The science behind Bergenin extraction is well-established, but execution decides outcome. We adhere to batch production, using stainless steel reactors and food-grade solvents under controlled temperature and pressure. Operations occur in positive-pressure clean areas to discourage outside contamination. Every stage, from the chopping of botanical feedstock to the final vacuum drying of the product, sits under our direct supervision—not contracted out to sporadic third parties.

    We run validated cleaning cycles between every production campaign, documented by swab tests analyzed for residual solvents and microbial contaminants. Solvents are recovered and recycled multiple times, slashing both environmental impact and cost. Where plant supply is especially contaminated by environmental factors, we apply additional pre-extraction treatments—charcoal filtration, pH adjustment, or short-duration thermal denaturation—to protect the core Bergenin molecule from unwanted modification.

    Thanks to our own long-term relationships with primary growers, we have visibility into farm practices. Soil, water, and pesticide usage are recorded years in advance, and regular audits maintain continuity. Customers familiar with incomplete or questionable documentation from intermediaries find this vertical integration answers most compliance and traceability questions without delays or surprises.

    Our Approach to Quality and Regulatory Compliance

    Years of close work with both major pharmaceutical houses and niche herbal product developers taught us that quality is a moving target as much as an absolute measure. Bergenin arrives with full documentation: ingredient traceability, in-house certificate of analysis, chromatogram data, and contaminant screenings. Our labs employ both routine and non-routine methods, resetting calibration regularly and rotating analysts to build redundancy.

    Product managers appreciate knowing every consignment remains on hold until independent verification of all specifications. Microbial, heavy metal, residual solvent, mycotoxin, and pesticide screenings complete within 72 hours of manufacturing, not weeks later. Whenever global regulations shift—whether new REACH rulings or pharmacopoeial changes—our compliance personnel update our SOPs and testing routines, reporting changes back to customers in clear terms.

    We maintain digital batch records for ten years. That history enables us to answer complex inquiries instantly, support regulatory filings, and provide complete recall capability. After years supplying Bergenin to strict markets, our documentation evolved to match EU and North American demands, as well as the standards found in advanced Asia-Pacific health product sectors.

    Practical Insights for Users of Bergenin

    Technologists, product developers, and formulation chemists deploy Bergenin in settings that demand both robustness and flexibility. Granulation processes tolerate its melting point, so tablet pressing produces a usable compaction without binder overload. In encapsulation lines, particle size consistency handles automated filling at industrial speeds. Analytical scientists appreciate straightforward HPLC fingerprinting, with injection and separation running reproducibly years apart thanks to our process controls.

    During conversations with regular clients, we learn about production floor challenges: dusting losses, dissolution issues, clumping, cross-reaction with common excipients. Our Bergenin responds favorably thanks to the particle size and moisture content controls we maintain. End product shelf tests report color and odor stability, and we run accelerated aging tests to ensure product integrity across typical logistics scenarios—long shipments, varied humidity, exposure to light or high temperature.

    Bergenin’s handling properties stand out during handover between production and R&D. Batches arrive with all supporting QC documentation, so pilot-scale researchers avoid delays from paperwork gaps. In high-volume food or beverage applications, we work directly with partners to tweak mesh size, moisture, or packaging format to fit specific formulation lines.

    Bergenin Versus Synthetic Alternatives and Botanical Uncertainties

    The market sometimes offers synthetic lookalikes or ambiguous blends for price advantages. Our Bergenin remains botanical in origin, and ongoing supply chain audits go deep—into DNA authentication, mass balance calculations, and high-resolution spectroscopic fingerprinting. Inspection teams regularly detect attempts at substitution or adulteration elsewhere. By retaining year-round ownership of the raw material, extraction, refining, and supply chain, we present data-backed reassurance for brand owners and final customers.

    At times, natural extracts expose buyers to inconsistent supply and background contamination. Our Bergenin sidesteps these pitfalls, with customs documentation, chain-of-custody tracking, and transparent process records. This system wins over clients tired of recalls, product withdrawals, and marketplace reputation loss due to ambiguous or contaminated batches. In the long run, real-world quality control—combined with real technical service—builds far deeper value than short-term savings.

    Supporting Research with Bergenin

    Academic groups and commercial research teams reach out for Bergenin when examining promising new therapeutic pathways. With its antioxidant and anti-inflammatory activities, Bergenin gives research chemists and pharmacologists a reliable tool for cell-based assays, animal studies, and even early-stage clinic preparations. In collaborative projects, we often adapt batch sizes and supply chain management to allow phased deliveries matched to grant milestones or R&D timelines. Regulatory-grade documentation supports publication in peer-reviewed journals and submission to ethics boards.

    We regularly interact with grant administrators and protocol reviewers who require evidence not only of biological activity but also of chemical consistency across experiments. Bergenin batches from our facility ship with all necessary analytical and process documentation, making it easier for researchers to establish repeatable, credible results. Over the years, our Bergenin featured in both small pilot studies and multi-center trials, with feedback cycles driving process improvements back into our own manufacturing lines.

    Stability, Storage, and Logistics of Bergenin

    We package Bergenin for varied logistical realities. Standard product consignment ships in light-resistant HDPE drums, sealed with nitrogen or argon, depending on customer preference, to repress oxidative darkening and hydrolytic decomposition. For R&D or pilot programs, we supply smaller flask quantities with tamper-proof closures and barcoding. All shipping partners operate under our own quality and security guidelines, and we test retention samples from each shipment at regular intervals to monitor for unexpected degradation or outside contamination.

    Clients sharing feedback from global warehouse sites reported consistent shelf stability, even during transit through tropical or arid climates. After thousands of shipments over two decades, we have not seen wide shelf-life variation, so users can plan production and product launches with confidence in inventory reliability. Our shipping support teams provide storage and handling guidance for each new facility or product introduction, and we supply supporting documentation to confirm insurance needs or regional regulatory requirements.

    Bergenin and Environmental Stewardship

    Economic and environmental sustainability remain intertwined. With Bergenin, we view stewardship beyond isolated certification. Our relationships with upstream growers emphasize careful harvesting practices and forest management. We work to reduce excess waste and promote biodiversity, replanting and rotating harvesting to avoid monoculture depletion.

    Inside our production facility, solvent recovery and energy efficiency programs have helped to cut both costs and environmental footprint. Emissions from extraction and drying processes are scrubbed and monitored by internal auditing. As climate policies and biodiversity guidelines evolve, our team stays ahead—verifying both plant origins and manufacturing impact for clients concerned with their own sustainability commitments.

    We keep testing new process improvements as part of yearly operational reviews. Pulse vacuum drying, reduced-temperature solvent exchange, and in-process energy recovery constitute part of the overall plant modernization strategy. These investments maintain our position as a long-term partner to clients who need quality materials free from contamination, as well as strong assurances about social and environmental responsibility through all tiers of the supply chain.

    Future Directions for Bergenin Use and Development

    Pharmaceutical pipelines constantly search for safer, plant-based compounds, and Bergenin’s activity profile continues to attract both formulators and clinical researchers. As new findings emerge about its anti-obesity, immunomodulatory, or anti-proliferative capabilities, we scale our own extraction and purification lines to prepare for changing demand. Regulatory affairs teams scan for upcoming monograph changes or patent trends, and we respond by investing in process upgrades and documentation for rapid response.

    With the shift toward natural health products and functional foods, Bergenin fills an active ingredient gap between heavy-duty pharmaceuticals and lighter nutraceuticals. Our technical team works directly with product developers to co-design delivery formats, dosing innovations, and stability trials matching these evolving demands. Stability in regulatory compliance, manufacturing reproducibility, and technical support set the foundations for innovation, letting finished product brands pursue ambitious new launches or research grants without bottlenecks at the raw supply end.

    Looking forward, as demand grows from both established and emerging markets, we have set aside capacity to increase scale, refine processes, and maintain sharp control of raw material sources. Production flexibility, rooted in decades of technical expertise and real partnerships with growers and researchers, allows us to confidently support clients—no matter what shape the next phase of Bergenin innovation takes.

    Real-World Reliability through Experience

    Experience from the ground up forms the backbone of our Bergenin business. Process engineers, chemists, logistics planners, and customer service teams not only know Bergenin as a chemical structure but as a concrete product that can make or break a product pipeline. Problems on a hot day in extraction, lessons from a challenging regulatory audit, insights from a dissatisfied client—these events shaped the Bergenin we deliver today.

    Our continuing investment in process rigor, regulatory alignment, supply-chain transparency, and environmental care positions Bergenin as a substance that does more than meet paperwork targets. It powers real-world solutions for clients who need extract quality, delivery certainty, and research support they can count on. This approach—build on technical facts, real dialogue, and tested experience—lets our Bergenin continue to do steady work at the heart of new therapies, supplements, and research projects across the globe.