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Ammoniated Glycyrrhizic Acid

    • Product Name Ammoniated Glycyrrhizic Acid
    • Alias Ammonium Glycyrrhizinate
    • Einecs 259-820-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    340713

    Chemical_Name Ammoniated Glycyrrhizic Acid
    CAS_Number 53956-04-0
    Molecular_Formula C42H65NO16
    Molecular_Weight 840.97 g/mol
    Appearance White to off-white powder
    Solubility Soluble in water
    Taste Intensely sweet
    Source Licorice root (Glycyrrhiza glabra)
    Sweetness_Intensity 30-50 times sweeter than sucrose
    Usage Flavoring agent and sweetener
    pH_Range 5.0 - 7.5 (in aqueous solution)
    Odor Slight characteristic odor
    Stability Stable under normal storage conditions
    Melting_Point Approx. 215°C (decomposes)
    Synonyms Glycyrrhizin ammonium salt

    As an accredited Ammoniated Glycyrrhizic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ammoniated Glycyrrhizic Acid, 500g, packaged in a sealed amber plastic bottle with a tamper-evident cap and clear labeling.
    Shipping Ammoniated Glycyrrhizic Acid is shipped in tightly sealed, chemical-resistant containers, protected from moisture and direct sunlight. Packages are clearly labeled, handled by trained personnel, and comply with regulatory guidelines for safe transport. During transit, it is kept in a cool, dry place to maintain stability and prevent contamination.
    Storage Ammoniated Glycyrrhizic Acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Protect from moisture, heat, and incompatible substances such as strong acids and oxidizing agents. Follow all relevant safety and local regulatory guidelines for the storage of chemicals to ensure safety and product stability.
    Application of Ammoniated Glycyrrhizic Acid
    Purity 98%: Ammoniated Glycyrrhizic Acid with 98% purity is used in pharmaceutical formulations, where it enhances anti-inflammatory efficacy and safety.Solubility > 500 mg/L: Ammoniated Glycyrrhizic Acid with solubility greater than 500 mg/L is used in beverage production, where it improves sweetness and homogeneous dispersion.Stability up to 120°C: Ammoniated Glycyrrhizic Acid stable up to 120°C is used in heat-processed food manufacturing, where it maintains flavor-modulating properties under thermal conditions.Particle Size < 50 µm: Ammoniated Glycyrrhizic Acid with particle size under 50 microns is used in cosmetic formulations, where it ensures smooth texture and improved skin absorption.pH Stability Range 4-8: Ammoniated Glycyrrhizic Acid stable in pH range 4-8 is used in oral care products, where it preserves efficacy in varied pH environments.Moisture Content < 3%: Ammoniated Glycyrrhizic Acid with moisture content under 3% is used in powder nutraceuticals, where it prolongs shelf life and prevents caking.Molecular Weight 822.94 Da: Ammoniated Glycyrrhizic Acid with molecular weight 822.94 Da is used in drug delivery systems, where it facilitates efficient bioavailability.Residue on Ignition < 0.2%: Ammoniated Glycyrrhizic Acid with residue on ignition less than 0.2% is used in injectable solutions, where it ensures high purity and safety for parenteral administration.
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    Certification & Compliance
    More Introduction

    Ammoniated Glycyrrhizic Acid: Our Perspective as Direct Manufacturers

    Understanding Our Product’s Role in Modern Industry

    Ammoniated glycyrrhizic acid has found a true place in both flavor and pharmaceutical industries. We have been producing this compound for years and continue to see steady demand across various segments. This product comes from glycyrrhizic acid extracted from licorice root—when reacted with ammonia, it forms a white to off-white powder. Over the course of our operation, we have seen manufacturers of food, beverages, tobacco, and medicines favor this ingredient for more than taste—it stretches into sweetness modulation, masking off-flavors, or lending physical benefits in formulations that few other sweeteners can match.

    Specifications and Consistency: Variations Born of Experience

    We deliver ammoniated glycyrrhizic acid under the model AGAC-100 primarily, due to its balanced purity and process-friendly profile. Specifications on our batches regularly reach at least 98% content by HPLC, with moisture typically controlled below 7%. Through years of process optimization, we manage particle sizes suitable for both solids and liquids, especially in food and oral care formulations. Our team has learned that even subtle modifications in drying temperature or filtration steps influence the flow and solubility behaviors. Not every market requires maximum purity. Some sectors, especially where the end-use is flavor masking, allow a tolerance on purity if the overall flavor profile is right and non-active residues meet requirement. Experience matters—for customers focused on color stability in syrups or beverage bases, adjusting filtration or crystallization conditions during manufacturing makes a tangible difference in appearance and usability.

    Applications: Real-World Feedback Shapes Our Product

    We’ve seen ammoniated glycyrrhizic acid bridge important gaps in product formulas. As a direct manufacturer, our technical staff receive feedback on flavor performance in caramel and cola-flavored soft drinks, on consistency in chewing gums, or on foam stabilization in beer. We have worked closely with teams on the confectionery side to tweak granulation for better blending with sugar, so the finished product doesn’t show telltale white streaks. Pharmaceutical customers inform us regularly about bitterness-masking trials—our compound often performs more durably than other licorice derivatives. In veterinary products, especially oral formulations for animals, the palatability provided by ammoniated glycyrrhizic acid drives higher compliance rates. We still receive samples from pilot runs testing the ingredient’s capacity to disguise harsh medicinal notes. End-use environment matters, not just regulatory compliance.

    Differences From Other Sweetening Agents and Licorice Derivatives

    Having produced both refined glycyrrhizic acid and various ammonium salts, we can speak directly to the differences. Ammoniated glycyrrhizic acid stands apart from non-ammoniated forms like monopotassium or dipotassium glycyrrhizate. The ammoniated version shows markedly better solubility in water, which matters in syrup and beverage production—less time dissolving in process tanks, fewer clumping issues, faster throughput. Some flavor chemists note the ammoniated type gives a softer, more lingering sweetness as opposed to the sharper aftertaste from potassium-based products. Formulators often report fewer issues with color interactions or precipitation.

    Other natural sweeteners such as stevia or thaumatin also sit in this space, but none have the same ability to mask sodium in low-salt foods, or to impart characteristic ‘licorice’ flavor so cleanly. Many artificial sweeteners can’t withstand thermal cycles seen in high-heat confectionery processes, while ammoniated glycyrrhizic acid’s stability at pH values from 4 to 9 and at elevated temperatures extends its range of use. Sugars like sucrose or glucose simply add sweetness, while this molecule coordinates flavor, mouthfeel, and even foam in ways we have validated through our own trials and customer feedback.

    The difference in molecular structure—fully ammoniated, as opposed to partially—means less bitterness and higher sweetness index, and in real use, this plays out as higher customer satisfaction with products requiring taste masking.

    Regulatory and Processing Considerations: Insights from Manufacturing Lines

    As the producer, we field regulatory questions from global clients. Keeping up with food safety standards in every region takes real effort. Our ammoniated glycyrrhizic acid meets relevant food-grade specifications and regularly clears heavy metals, pesticide residues, and microbial standards set by national agencies and international consortiums. Some regions—like the United States—limit the average daily intake for glycyrrhizic acid derivatives based on chronic exposure studies. Our responsibility as a manufacturer pushes us to help customers pre-calibrate recipes and reassure regulatory auditors on compliance.

    We also see elevated scrutiny around residual ammonia content. Through well-controlled reaction and purification steps, finished product leaves our facility with ammonia values at or below the limits imposed by end-user safety standards. Clients formulating for infant or nutraceutical applications check this data on every lot. Every batch runs through rigorous in-process analytics—including TLC fingerprinting, HPLC quantification, IR, and hygienic checks for pathogenic bacteria. Picking the right testing regime took experience; not every test suits every product grade. For some beverage applications, clarity holds higher priority than trace heavy metals, and our teams learned to adjust in-line controls accordingly.

    What We’ve Learned from Production Challenges

    There are hands-on realities to manufacturing ammoniated glycyrrhizic acid, and these can influence every aspect of the finished product. Raw licorice varies by harvest year and growing region, and even the best pre-screening can’t remove all variability. Sometimes, a product run requires minor process modifications to hit consistency on color and solubility. Purity comes down to patience in the crystallization step—rushing means higher impurity carry-over and worse flavor. The ammonia saturation stage has its own sensitivities; under-dosing leaves too much glycyrrhizic acid, while over-dosing can yield unpalatable side flavors.

    Fine-tuning drying times affects not only physical appearance but also bulk density. Years ago, we discovered rushed drying led to increased dusting during transfer and loss of handleability. Addressing this didn’t require new equipment, but better scheduling and more careful monitoring by line operators. Equipment fouling happens, especially if raw material runs lean in active content. Cleanouts and careful filtration extend the life of process tanks and keep trace contaminants below limits. It’s impossible to substitute hands-on know-how here—parameters that look good on paper offer little help once an abnormality shows up in a production batch.

    Supply chain hiccups with base licorice mean the technical team sometimes switches to secondary sources. In these cases, pre-blending or pre-extraction steps change to protect taste and color characteristics downstream, based on years of troubleshooting.

    Handling Customer Diversity—From Beverages to Pharmaceuticals

    Direct engagement with customers reveals how flexible our ammoniated glycyrrhizic acid needs to be. Beverage manufacturers want predictable flow behavior and easy dissolution for syrup pre-mixes. They often prioritize product clarity and reduction of particulates over fine margins of purity. In energy drinks, mouthfeel and aftertaste play a large role, so granulation passes through additional sieving to help finished drinks pour and mix smoothly.

    Pharmaceutical and cosmetic formulators require certified allergen-free and non-GMO status. They analyze trace component data batch-to-batch and expect in-depth documentation of extraction and ammoniation parameters. Their teams sometimes commission personalized comparative studies against their own reference standard. We match that expectation—sending out COAs, SDS, stability data, and sample vials for review—because these decisions matter more than simple price competition.

    In the tobacco sector, flavor profile, dust content, and compatibility with casing agents determine everything. Too much dust means more rejects in automated cigarette making, and our bulk packaging lines include final-stage dust recovery. Our R&D work with tobacco blenders helps fine-tune product characteristics, sometimes pushing us to reconfigure certain upstream filtering steps.

    Supporting Brand Claims and Consumer Safety—What We Stand Behind

    Consumers increasingly want supply chain transparency. As the manufacturer, it falls on us to document everything from source licorice to finished powder. Product traceability forms the backbone of our audits, including documentation of each lot, which goes back several years by requirement. This system isn’t only for compliance—it means our downstream partners can validate label claims, allergens, and country-of-origin standards.

    For end products like medicines and nutritional supplements, parent companies demand direct input from ingredient manufacturers about potential allergens, cross-contamination, and adherence to GMP. Our own site routinely fields inspections by both customer teams and regulatory agencies. We keep trace files including full process flow, instrument calibrations, and even packaging checks, since a pallet’s humidity protection affects final shelf life. We don’t treat quality claims as marketing slogans—every test, adjustment, and audit step arises from years of learning what can go sideways, handling those risks before product leaves our gate.

    Environmental and Sustainability Factors—What We Contribute and Where We Still Need Progress

    Sustainable sourcing of licorice roots remains a real challenge for the industry. Wild harvesting impacts soil quality and can strain native ecosystems if left unmonitored. In the past, uncontrolled harvesting led to over-exploitation in Central Asian markets. We now draw only from documented, certified-sustainable farms for the licorice supply in our ammoniated glycyrrhizic acid, and we refuse shipments without traceable paperwork. As a factory, waste streams—mainly spent root pulp and ammonium-containing mother liquors—need careful handling. Our wastewater lines pass through multi-stage treatment to ensure ammonia doesn’t burden the local water table.

    Ongoing work aims to reduce energy use by improving efficiency in the leaching and drying stages. Initial tests with lower-temperature drying have not hurt product quality but cut down overall plant energy requirements. Supply chain partners asked us to investigate possible use of renewable power; current feasibility studies go beyond rhetoric and look directly at electrical and steam balances for our batch lines.

    Packaging solutions also need attention. Years ago, our bulk packs used single-use polyethylene liners, which linger in warehouses. We now trial recyclable and bio-based liners, with field results looking promising. Every sustainability improvement must meet storage, shipping, and contaminant-control standards—sometimes, new solutions create unexpected risks, like higher internal moisture, which affect shelf life and handling. Our approach will always prioritize product safety, documenting every packaging test to support both regulatory audit and client sustainability goals.

    Protecting Product Integrity and Ensuring Result Consistency

    A recurring lesson in decades of manufacturing ammoniated glycyrrhizic acid comes down to two things: process control and staff experience. Unstable reaction pressures or variable filtration mean measurable differences in sweetness profile batch to batch—sometimes not obvious until a customer calls with a question about last month’s order. We’ve invested heavily in operator training programs and process instrumentation that flag small parameter drifts before product enters a packing drum.

    We sample and retain portions of each batch in a locked climate-controlled archive. Our staff pull from these samples to check for shelf-life consistency, especially before we recommend extended storage to clients. Overly humid shipping environments once led to caking and slower solubility in tropical distribution chains. Identifying and compensating for the root causes of product performance in real-world conditions builds genuine trust with food and pharma manufacturers, and helps us improve over time. It’s not about chasing laboratory specifications alone—end-user results inform every adjustment we make on the production floor.

    Industrial Scale and Adaptability

    Producing ammoniated glycyrrhizic acid at scale brings unique practical challenges. High-volume clients, especially those tied to seasonal beverage production windows, require responsive ramp-up and reliable order fulfillment. Our facility capacity must flex with demand spikes, and raw material stockpiling sometimes stretches months in advance of campaign runs. Balancing throughput with uninterrupted quality takes tight scheduling, equipment redundancy, and relationships with logistics teams to navigate transportation constraints.

    Our willingness to adapt—to shift a process train, to tweak a particle size, to rush an order through the lab for unusual end-uses—comes from working directly with serious players across the value chain. Smaller-scale buyers sometimes want more hands-on consultation, requesting detailed use-cases or sample blends before placing full orders. We remain open to collaborative troubleshooting across food, beverage, nutraceutical, and tobacco players, so product isn’t simply “supplied” but integrated into each client’s reality.

    Investing in R&D and Continual Improvement

    Every year brings updates in processing technology, analytical chemistry, and ingredient application trends. Direct feedback from end-users—their successes and their pain points—drives focus in our R&D labs. By developing more concentrated grades and experimenting with new granulation profiles, our teams respond to real market needs. In the past, a beverage partner’s request led to a variant grade that dispersed instantly in cold water, something we hadn’t considered problematic until their QA team showed us the bottlenecks in their formulation line. Small- and medium-sized pharma formulators often supply direct analysis of how glycyrrhizic acid and its derivatives affect bioavailability and compliance. Success depends on conversation, not isolation.

    We see digitalization reshaping quality control and traceability—cloud-linked monitoring, blockchain for ingredient transparency, and advanced sensor networks built into extraction units. As a direct producer, we invest in these upgrades out of clear benefit both to ourselves and to our customers. There’s satisfaction when a client reviewing a digital batch record finds every data point documented, paving the way for both immediate confidence and long-term audit-readiness.

    Our commitment involves boosting manufacturing efficiency, enhancing safety, lowering environmental impact, and ensuring that every shipment brings repeatable, reliable results. This approach to continual improvement sets direct manufacturers apart and pushes the boundaries for ammoniated glycyrrhizic acid’s use across modern product portfolios.

    Conclusion: A Direct Manufacturer’s Voice for Ammoniated Glycyrrhizic Acid

    Thousands of tons of ammoniated glycyrrhizic acid circulate through beverage, pharma, food, cosmetic, and tobacco producers every year. Beneath that volume sits years of hands-on knowledge, process insight, and direct engagement with real-world users’ needs. As direct manufacturers, our perspective draws from every challenge overcome and every opportunity found to push product performance, safety, sustainability, and transparency up a notch. Our daily commitment: to ensure every customer—no matter their scope or segment—benefits from that experience, and continues to find value in a product rooted in both tradition and ongoing technical innovation.