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HS Code |
353795 |
| Product_Name | (S)-Naringenin |
| CAS_Number | 480-41-1 |
| Molecular_Formula | C15H12O5 |
| Molecular_Weight | 272.25 |
| IUPAC_Name | (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one |
| Appearance | Off-white to pale yellow powder |
| Melting_Point | 247-250°C |
| Solubility | Soluble in ethanol, DMSO, and methanol |
| Purity | ≥98% (HPLC) |
| Canonical_SMILES | C1CC(=O)C2=C(O1)C=C(C=C2O)C3=CC=C(C=C3)O |
| Optical_Rotation | [α]D +53° (c=1, EtOH) |
| Synonyms | S(-)-Naringenin, (S)-4',5,7-Trihydroxyflavanone |
| Storage_Condition | Store at 2-8°C, protect from light |
| Chirality | S-enantiomer |
| InChI_Key | MULRZOXFXXLJMC-QPLCGJKRSA-N |
As an accredited (S)-Naringenin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | (S)-Naringenin is supplied in a 1-gram amber glass vial, securely sealed, labeled with product details and safety information. |
| Shipping | (S)-Naringenin is securely packaged in compliance with international regulations for chemical transport. It is shipped in sealed, clearly labeled containers to ensure product integrity and safety. Accompanied by a material safety data sheet (MSDS), shipping options include express and temperature-controlled services, depending on the destination and customer requirements. |
| Storage | (S)-Naringenin should be stored in a tightly sealed container, away from light and moisture, ideally at 2–8°C (refrigerated) to maintain its stability. The storage area should be well-ventilated and free from sources of ignition, oxidizing agents, and strong acids or bases. Ensure proper labeling and comply with safety guidelines for handling chemicals. |
Applications of (S)-Naringenin in Industrial ManufacturingAs a direct manufacturer of (S)-Naringenin, we supply this bioflavonoid to multiple industrial sectors where its molecular properties drive consistent downstream performance. Below, we detail specific applications, process roles, compliance expectations, integration methods, and typical product endpoints characterized by real industrial needs and regulatory frameworks. 1. Pharmaceutical API Intermediate for Cardiovascular TherapiesPharmaceutical production facilities incorporate (S)-Naringenin as a chiral building block in the multi-step synthesis of active pharmaceutical ingredients, including investigational and approved compounds for cardiovascular indications. Strict compliance with pharmacopeial monographs and cGMP protocols governs all phases, from incoming raw material testing to batch release. Manufacturers standardize ratio inputs based on stoichiometric demands of the target molecule, with purity verification at multiple synthesis stages. This integration enables precise chiral conversion, minimizing downstream byproducts and optimizing yield for high-value drug products. Industry compliance standards
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2. Food Additive Precursor in Functional Flavonoid-EnrichmentFood ingredient manufacturers utilize (S)-Naringenin as a precursor in producing high-purity flavonoid concentrates for fortifying nutraceutical beverages, dairy alternatives, and plant-based bakery items. Facilities adhere to global food safety regulations and maintain rigorous traceability for all additive inputs. Formulation specialists control the proportion based on both allowable limits and desired nutritional labeling, ensuring consistent flavor release and antioxidative profiles. Downstream, the ingredient is solubilized and blended during aqueous extraction or emulsion phases, ensuring homogeneity before product finalization. Industry compliance standards
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3. Cosmetic Antioxidant Agent for Skin Care FormulationsCosmetic manufacturers deploy (S)-Naringenin for its targeted antioxidative and skin-calming attributes in premium skin care lines. Cosmetic GMP validation and region-specific ingredient inventories govern implementation, requiring full documentation of material purity and absence of prohibited substances. Specialist formulators set the input level based on the desired antioxidative index and stability over shelf life, with typical ratios defined by in vitro efficacy and regulatory clearance. Processing integrates the raw material at the emulsification or solubilization stage, followed by high-shear mixing to ensure micron-level dispersion suitable for creams, lotions, and anti-aging serums. Industry compliance standards
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4. Plant Protection Biostimulant in Agricultural FormulationsAgrochemical formulators use (S)-Naringenin as a core biostimulant additive supporting plant defense mechanisms and improving abiotic stress tolerance in high-value crops. Formulation chemistry, field residue restrictions, and regional biostimulant regulations dictate both sourcing and in-tank working levels. Agronomists and product managers calibrate input concentration based on crop type, growth phase, and application frequency, while precision processing ensures compatibility with other micronutrients or pesticide blends. The additive is incorporated into liquid formulations, ready-to-mix powders, or seed treatment solutions, backed by stability and phytotoxicity validation. Industry compliance standards
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5. Industrial Reference Standard for Analytical LaboratoriesAnalytical standards producers and QC laboratories acquire (S)-Naringenin as a certified reference compound for system suitability, calibration, and method development in food quality assurance, pharmacological screening, and botanical authentication workflows. Comprehensive documentation, including characterization certificates and batch traceability, is essential for international acceptance. Reference grade material forms the basis of working standard preparations, with precise dissolution and dilution protocols reflecting downstream analyst requirements. Integration involves preparing standard solutions for HPLC, LC-MS/MS, or capillary electrophoresis, ensuring inter-laboratory reproducibility for both regulated and research applications. Industry compliance standards
Typical usage ratio
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Daily work in the plant often comes down to trusting your upstream suppliers. At the core of every health-focused product, flavoring innovation, or biochemical study stands a compound that must be consistent, traceable, and reliable. (S)-Naringenin earns its place in many research and production settings precisely because it delivers these qualities. As a flavanone that carries natural antioxidant properties and a defined stereochemistry, (S)-Naringenin is not just another ingredient—it is a keystone for those with their eyes on bioactivity and purity.
Work with phenolic compounds often stirs up talk about quality and authenticity. There is always temptation to cut corners, especially when market prices swing. As a direct manufacturer, our relationship with (S)-Naringenin has taught us that chemical authenticity changes the outcome of a project. Customers bring us stories of poor resolutions, off-notes, solubility headaches, and inconsistent performance when using racemic or non-purified sources. What sets (S)-Naringenin apart? Our process starts with chiral resolution or asymmetric synthesis steps that keep the product rich in the S-enantiomer, not a mix. This difference means your outcome—whether in a cell culture experiment or flavor formulation—remains both ho nest and reproducible.
On lab benches and production lines, every single batch starts from well-documented raw materials. Sourcing plant-derived precursors or using established catalytic synthetic methods, we follow a traceable route from precursor to finished product. Every chemist at our site knows that minute differences in processing or handling can create huge headaches for clients downstream. As a veteran manufacturer, we give (S)-Naringenin the same scrutiny as a pharmaceutical intermediate. We use chiral HPLC testing in every production run. The routine of recording, checking, and verifying purity here feels almost ritualistic. Even after years, nobody gets to skip the testing protocol.
We learned quickly that users do not want vague promises; they need defined numbers. Our (S)-Naringenin typically comes as a white to off-white crystalline powder, offering solubility in ethanol, methanol, and DMSO. Water solubility is limited, an honest caveat for formulators in beverage or aqueous preparations. Experienced users ask for the specifics: chiral purity above 98%, overall purity exceeding 99%. Moisture sits consistently below 1%. On particle size, we discuss requirements with each customer, since research and production lines sometimes clash—finer powder for rapid dissolution in lab work, larger crystal fractions for industrial processing. Practicality shapes these specs, not marketing.
One of the surest ways to gain respect from pharmaceutical R&D, food technologists, and academia is to deliver repeatable outcomes. Our batch-to-batch records reach back for years. Analytical data points for each run are always available. Staff turnover in our QA team stays low for a reason: only long experience produces the watchful eye that catches small variances in appearance, melting point, or impurity levels. A few years ago, a large customer flagged a trace impurity in a single drum using advanced LC-MS. We re-checked, identified the cause—a minor processing shift two steps back—and fixed it across the board. These root-cause corrections reinforce why we never take shortcuts.
Industry trends shift swiftly. Pharmaceutical research asks for traceability, absolute purity, and particularly the absence of racemates, since the biological effects of S- and R- forms often diverge. Food and beverage innovation prizes natural antioxidant capacity, along with mild bitterness and unique citrus notes that enhance complex profiles without overwhelming other flavors. Cosmetic formulating teams find value in both antioxidant and UV-protective properties of (S)-Naringenin, seeking clarity and uniform appearance in emulsions. Each discipline poses a different challenge. The same product may find its way into a sunscreen R&D trial, a functional beverage test kitchen, or a pharmacokinetics lab, each with its own demand for documentation and analytical support.
The (S)-enantiomer’s biological relevance plays a central role in many applications. Scientific literature supports that only the S-form achieves desired interaction with particular human enzymes—whether it be antioxidant defense, modulation of signaling pathways, or metabolism in plant biology. The wrong stereochemistry reduces the value of the end product or the validity of an experiment. Tradespeople and researchers avoid unnecessary regulatory or validation headaches by choosing single-enantiomer sources. Experience teaches that projects lose time, not to mention budget, when resolution has to happen in-house after the ingredient arrives.
We source raw precursors with known provenance, never relying on unknown brokers. Years of fine-tuning synthetic steps offer better yield and lower solvent residue. Analytical confirmation does not stop at final QC release; in-process monitoring catches drift before it balloons into a customer-facing issue. Our teams devote time to documenting lot histories—this means a user encountering a problem two years after purchase can trace the specific batch through manufacturing, analytics, and shipping logs. Accountability like this bears fruit: repeat customers, reputable collaborations, and less management drama.
A steady stream of inquiries highlights confusion about naringenin versus (S)-naringenin. Bulk naringenin often means a racemic mixture, containing both S- and R- forms, often with unresolved fractions and inconsistent particle distribution. These variants appear similar but act differently in biological and flavor contexts. Only hands-on users—those seeing unreliable cell results, unpredictable bitterness, or even safety data mismatches—learn to discern the difference. We designed our process for those seeking a true S-enantiomer, excluding cross-contamination or partial resolution that clouds scientific and commercial results. “Good enough” mixtures have no place where precision counts.
Years of dialogue with research partners and industry peers highlight the central role of open communication in product improvement. Pharmaceutical developers have flagged micron-sized deviations that affected blending uniformity. Food scientists taught us about off-notes introduced by trace byproducts. Plant biologists pressed for documentation of botanical versus synthetic sourcing. These interactions shape our continuous improvement: modifications in purification steps, stricter documentation, and the ability to meet custom particle requirements. Building in these upgrades results in higher confidence for the next user—the downstream benefit is real, not theoretical.
Over time, we observed requests shift from bulk drum supply to smaller, user-friendly packages, reflecting the adoption of (S)-Naringenin in niche research labs and early-stage product launches. Stability studies across nearly a decade show that the product, when stored cool and dry, maintains purity and activity for over two years. Outgassing, color shift, or caking stay well-controlled through careful drying and inert-atmosphere packaging. Our packaging team adjusts batch sizes and vessel types—amber glass, nitrogen-purged pouches, or FDA-listed drums—based on customer demand and feedback from field testing. Not a week goes by without someone seeking a novel package size or format; we learned to accommodate without sacrificing integrity.
Responsible manufacturing for products such as (S)-Naringenin includes understanding regulatory boundaries in global markets. The product finds use as a research chemical, flavoring substance, and ingredient for development. We monitor guideline changes from organizations such as FDA, EFSA, and local authorities. Certificate of analysis (COA), safety data, and all shipment records follow strict internal protocols. This reduces disputes and delays at the border, an outcome for which customers regularly show appreciation. Staying aligned with relevant regulations gives users, whether R&D-oriented or commercial, an extra layer of confidence.
In our role as a manufacturer, we often field questions about capacity and lead time. Over-promising leads to trouble; we set up production lines that match real customer forecasts. Labs tend to order one hundred-gram to kilogram lots for initial studies, while established producers place larger, multi-kilogram or drum-scale orders. Instead of chasing oversize speculation, our team matches production lots to qualified pipeline demand. The payoff is fresher inventory, higher turnover, and less likelihood of outdated stock reaching users. Our experience proves that matching supply to real demand lines up with safety and performance goals for everyone involved.
Stories from years of dealing with formulation teams, university research groups, and development labs show that open technical conversations beat transactional sales approaches. Our technical specialists have spent time at the benchtop and in the pilot plant, not just reading about them. This shared experience means we anticipate the “What if?” questions—about handling, compatibility, or scalability—that matter most in process development. We work alongside users conducting real-world pilot runs, rather than sending out brochures. In practice, this reduces project delays and the number of unwanted surprises.
Using (S)-Naringenin in a beverage line does not look the same as deploying it in a clinical research setting. Beverage developers encounter solubility challenges and seek natural claims. Researchers leverage its defined bioactivity or pursue metabolic tracing. More recently, cosmetic manufacturers tune their expectations toward stability in topical formulas. Our input helps each group optimize application and prevent wasted effort—pointing out, for example, compatibility with certain emulsifiers or the right order of addition in a blending process. Our team’s willingness to advise and adapt supports smoother product launches and fewer reformulation cycles.
Our own technicians handle (S)-Naringenin daily. Standard PPE, local exhaust, and well-marked storage zones remain non-negotiable basics; we have seen first-hand how dust mitigation helps avoid respiratory irritation. As a powder prone to static buildup, careful grounding and closed transfer protocols make all the difference, especially at scale. Downstream users appreciate clear, jargon-free guidance that grows out of direct handling experience. Problems flagged in the field—off odors upon opening, patchy dissolution, or accidental spills—feed back into our training and documentation. Years in the business taught us that “safety” means anticipating avoidable mistakes and sharing the knowledge openly.
Every once in a while, a collaboration project uncovers a new method or application for (S)-Naringenin that we had not anticipated. Recent years saw multiple partners advance promising research in metabolic health, anti-inflammatory mechanisms, UV protection, and sustainable antioxidant systems. They relied on our transparent manufacturing records and willingness to complete non-standard documentation. We offered samples, analytical comparisons, and open technical conversations. In several cases, feedback from these partnerships drove changes to our purification, drying, or packaging steps. The result: a product more closely attuned to frontline research and commercial breakthroughs.
Market excitement around natural products waxes and wanes, yet (S)-Naringenin maintains steady demand from process-driven applications. Regulatory shifts and consumer preference for clean-label antioxidants continue to shape orders and inquiries. Every uptick in demand sparks fresh scrutiny of our processes, analytics, and supply chain. By listening to direct user feedback, both positive and critical, we keep the production floor focused on continuous improvement. Awareness of adulteration and greenwashing in the broader market shifts attention back to those manufacturers willing to document every step.
After years in chemical manufacturing, we understand that details build reputation. Competitors may chase price or volume at the cost of documentation or traceability. We take the opposite approach: clarity about process, specification, and origin. Our confidence in (S)-Naringenin comes not from marketing claims but from thousands of samples, dozens of audits, and feedback cycles that never end. Work in this industry keeps us humble; every batch brings the potential for unseen challenge and improvement. We measure our success by repeat customers who build their own innovations on the foundation of trustworthy ingredients.
No manufacturer remains relevant without honest feedback from the field. Customers reach out because they care about more than specs on paper: they want process knowledge, troubleshooting support, and the assurance that corrections are possible down the line. We keep our lines open to questions about sourcing, process modifications, batch analytics, and custom applications. Regular dialogue with users motivates our team to revisit established methods and trial new improvements. Manufacturing (S)-Naringenin, in essence, means joining an ongoing partnership, not making a static product. The conversation keeps us sharp, responsive, and forward-looking.
Each batch tells a story of scientific discipline, operator skill, and real-world customer requirements. By focusing on authenticity and consistent delivery, we aim to produce more than a chemical: we offer a path to higher quality in food, health, and research products. Those seeking predictable performance, documentation, and open technical support find value in (S)-Naringenin that extends far beyond price or immediate supply. Experience, innovation, and active listening give us confidence to keep delivering a product designed for real-world challenges—not just for today’s market, but for all the leaps forward that customers will make tomorrow.