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Tyramine Hydrochloride

    • Product Name Tyramine Hydrochloride
    • Alias P-Hydroxyphenylethylamine hydrochloride
    • Einecs 214-928-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    189504

    Chemical Name Tyramine Hydrochloride
    Molecular Formula C8H11NO·HCl
    Molecular Weight 173.64 g/mol
    Cas Number 60-19-5
    Appearance White to off-white crystalline powder
    Solubility Soluble in water
    Storage Conditions Store at 2-8°C, protect from light and moisture
    Melting Point 248-250°C (dec.)
    Synonyms p-Hydroxyphenylethylamine hydrochloride
    Purity Typically ≥98%
    Usage Research and biochemical applications
    Pka 9.8 (amine group)
    Pubchem Cid 5791
    Stability Stable under recommended storage conditions
    Ec Number 200-464-6

    As an accredited Tyramine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Tyramine Hydrochloride, 25g: Supplied in a sealed amber glass bottle with a secure screw cap, labeled with product details and safety information.
    Shipping Tyramine Hydrochloride should be shipped in securely sealed containers to prevent moisture absorption and contamination. It must be clearly labeled, packaged according to chemical safety regulations, and typically shipped at ambient temperature. Ensure compliance with local and international transport regulations for laboratory chemicals, using appropriate cushioning and hazard labeling as required.
    Storage Tyramine Hydrochloride should be stored in a tightly closed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area, ideally at room temperature (15–25°C). It should be kept away from incompatible substances such as strong oxidizing agents. Ensure proper labeling and access is limited to authorized personnel. Follow all regulatory and safety guidelines when handling and storing.
    Application of Tyramine Hydrochloride

    Applications of Tyramine Hydrochloride in Industrial Manufacturing

    Tyramine hydrochloride serves as a specialized intermediate in multiple chemical value chains, supporting pharmaceutical synthesis, dye and pigment manufacturing, food and beverage additives, diagnostics reagents, and biochemical research. Our direct production expertise, stringent quality controls, and industry engagement ensure consistent supply for downstream sectors with precise compliance and formulation needs.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical companies use tyramine hydrochloride as a key precursor in the synthesis of antihypertensive and neurological medications, including monoamine oxidase inhibitor derivatives. The material reliably participates in condensation and coupling reactions that build intermediate molecular frameworks for APIs. Formulators adjust concentration based on yield optimization and impurity profiles, ensuring the resulting intermediates meet strict purity specifications for human health applications.

    Industry compliance standards

    • Complies with current Good Manufacturing Practices (cGMP, 21 CFR Part 210/211, US FDA)
    • Adheres to ICH Q7 guidelines for active pharmaceutical ingredients
    • Follows European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) monograph requirements for intermediates
    • Batch traceability and impurity profiling per WHO GMP

    Typical usage ratio

    • Used at 0.05 to 0.5 molar equivalents against core alkyl or aryl donors in API multi-step syntheses
    • Exact ratio tailored to the desired intermediate and process efficiency
    • Chemical engineers determine dose based on targeted conversion and residual control
    • QC sampling ensures levels remain below specification thresholds for regulated pharmaceuticals

    Downstream process integration

    • Introduced during reaction staging after catalyst setup
    • Added in controlled batches to maintain reaction temperature and pressure
    • Monitored via HPLC and NMR throughout the coupling step
    • Isolated intermediates purified before further transformation to APIs

    Final product types

    • Monoamine oxidase inhibitor drugs (e.g., selegiline intermediates)
    • Hypertensive disorder treatments (API intermediates)
    • Dopaminergic agent precursors
    • Other CNS-related synthetic building blocks

    2. Dye and Pigment Intermediates Production

    Dye manufacturers integrate tyramine hydrochloride in diazotization and coupling reactions to produce azo dye intermediates and specialized pigments for textile and printing industries. The aromatic structure reacts with nitrous acid and other colorant bases to develop high-purity chromophores, enhancing color intensity and shade stability in finished dye formulations. Precise monitoring supports consistent tonality and batch repeatability.

    Industry compliance standards

    • REACH Registration (EC No 1907/2006) for pigment intermediates
    • Compliance with OEKO-TEX Standard 100 for colorant safety
    • GMP Guidelines for colorants in food-contact textiles (EU 2023/2006)
    • ISO 9001:2015 certified batch records and quality control

    Typical usage ratio

    • 0.1 to 1.0 % by reaction mass depending on chromophore saturation
    • Adjusted according to required dye shade and application (vat, direct, acid dyes)
    • Process engineers vary ratio to optimize coupling efficiency
    • Variances logged for each production run for color reproducibility

    Downstream process integration

    • Charged into the diazotization vessel after pH stabilization
    • Contacted with sodium nitrite for in situ generation of reactive intermediates
    • Cycled through filtration and purification sequences before final blending
    • Samples tested against color index references in lab and pilot scale

    Final product types

    • Azo and anthraquinone dye intermediates
    • Reactive textile dyes
    • Industrial ink pigments
    • Specialty colorants for food packaging substrates

    3. Food and Beverage Flavor Modulation

    Food ingredient manufacturers employ tyramine hydrochloride as a modulator to enhance fermentation-derived flavor profiles and as a precursor in the controlled synthesis of certain aroma compounds. Regulatory restrictions require rigorous control of dosage and residuals in finished food products. Ingredient technologists monitor interactions with amino acids and fermentation agents to balance taste and compliance, with standard testing confirming low residuals before bulk shipment.

    Industry compliance standards

    • Conforms to FDA 21 CFR 172 (Food Additives Permitted for Direct Addition)
    • FAO/WHO JECFA evaluation of biogenic amines in food ingredients
    • Adheres to FSSC 22000 Food Safety System Certification
    • Complies with GB 2760-2022 (Chinese Food Additive Standards)

    Typical usage ratio

    • Levels strictly kept below 10 ppm in finished food applications per sector safety guidelines
    • Higher concentrations applied during fermentation or flavor synthesis but always reduced in final product through downstream processing
    • QC departments adjust usage for compliance with regional maximum residue limits
    • Ratios determined based on matrix, batch size, and fermentation kinetics

    Downstream process integration

    • Added to starter mixes or pre-blends in controlled lab-scale lots
    • Participates directly during flavor precursor generation steps
    • Subjected to strict in-process monitoring to prevent excessive buildup
    • Finished ingredient lots verified by GC-MS for compliance

    Final product types

    • Fermented soybean condiments (e.g., miso, soy sauce flavor precursors)
    • Cultured cheese aroma modulators
    • Specialty flavor concentrates for beverages
    • Processed food seasoning premixes

    4. Clinical Diagnostic Reagents Manufacturing

    Producers of clinical diagnostic kits utilize tyramine hydrochloride as a component in enzyme-amplified detection systems, leveraging its role as a substrate in peroxidase and tyrosine-related assays. The compound enables signal amplification in immunohistochemistry (IHC) and in situ hybridization workflows. High lot-to-lot consistency and low non-specific reactivity remain critical, as regulatory and laboratory quality systems supervise incoming material qualification.

    Industry compliance standards

    • Manufacture under ISO 13485:2016 for medical devices and diagnostic reagents
    • FDA 21 CFR Part 820, Quality System Regulation (QSR)
    • CE IVD Directive (98/79/EC) for European markets
    • Traceability and shelf-life validation according to CLSI guidelines

    Typical usage ratio

    • Formulated at 0.01 to 0.1 mg/mL in detection buffer cocktails
    • Dosing tailored to individual kit sensitivity and substrate turnover requirements
    • Ratio fine-tuned for assay amplification with minimal background signal
    • QC teams verify functional performance for each preparation

    Downstream process integration

    • Solubilized during reagent pack assembly under controlled cleanroom conditions
    • Maintains stability throughout kit shelf-life for consistent quantitative response
    • Integrated in multi-component substrate systems for enhanced assay output
    • End-of-line QC includes performance checks using standard curve references

    Final product types

    • Immunohistochemistry (IHC) detection kits
    • Enzyme-linked immunosorbent assay (ELISA) substrates
    • Tyramide signal amplification reagents
    • Histopathology tissue staining products

    5. Biochemical Research and Laboratory Synthesis

    Institutes and research labs use tyramine hydrochloride to study neurotransmitter metabolism, receptor binding kinetics, and enzyme-substrate interactions involving aromatic amines. Its high purity and reproducibility make it suitable for controlled studies in neurochemistry, enzyme assays, and synthetic standard preparation. Researchers document all handling stages to ensure result traceability and experiment reproducibility under institutional review protocols.

    Industry compliance standards

    • ISO 17025:2017 accredited laboratory practices
    • Internal analytical specification sheets
    • Material safety data sheet (MSDS) management and laboratory handling SOPs
    • Good Laboratory Practice (GLP) for experimental documentation

    Typical usage ratio

    • Applied at 0.001 mmol/L to 1 mmol/L in biochemical assay buffers
    • Concentration chosen based on assay detection limits and signal window
    • Technicians titrate amounts for time-course and dose-response studies
    • Reagent grade and lot documentation accompany each experimental setup

    Downstream process integration

    • Direct dissolution into experimental buffer or cell culture media
    • Staged additions during enzyme activity or inhibition assessments
    • Subjected to purification, extraction, or derivatization workflows as needed
    • Archived or retained for reference in repeat experiments

    Final product types

    • Research-grade assay controls and standards
    • Reference compounds for receptor binding analyses
    • Cell culture additives for mechanistic studies
    • Calibrants for neurochemical quantification kits
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    Certification & Compliance
    More Introduction

    Tyramine Hydrochloride: Manufacturing Insight From the Source

    Understanding Tyramine Hydrochloride From Our Perspective

    Tyramine Hydrochloride stands as an established compound in both research and pharmaceutical laboratories. As a company directly engaged in its synthesis from raw material stage to finished batch, we encounter every facet of its actual characteristics—not just the cleaned-up version you’ll find in third-party catalogues. Work with this compound means becoming intimately familiar with its behaviors as a crystalline powder, its stability profile in different conditions, and the degree of purity that various applications demand.

    For those who care about specifics, what leaves our facility under the name Tyramine Hydrochloride carries a purity threshold above 99%. We produce it primarily for laboratories focusing on neurotransmitter research, but we also serve those investigating its role in the development of antihypertensive agents, and its function in broader biochemical and clinical settings. High-purity standards rely on batch testing—actual in-house validation, not just compliance with paperwork or chasing minimum regulatory bars set by generic specifications.

    Our Process: Building Quality Into Every Step

    From experience, the biggest differences arise early in production. Careful sourcing of the precursor amine sets the foundation. Through a controlled hydrochloride salt formation, the crystallization step directly governs stability, solubility, and color. You cannot cut corners here. Even a slight variation in temperature or pH can induce color shifts and fine, hard-to-see contaminants. Our technicians spend long hours in real-time monitoring, with batch logs checked by people who know what to look for far beyond an HPLC printout. Look for a bright, white powder with a granular, free-flowing texture: these are signs the chemical is fresh, without trapped moisture or traces of side products.

    Our staff focuses on several diagnostic checks that go beyond ordinary specifications. Water content, loss on drying, melting point range, and identity verification are all checked every time. By sticking to our own in-house performance and traceability standards, our Tyramine Hydrochloride consistently avoids “batch drift”—that slow, almost unnoticed variation you find with some commodity products on the market over time.

    Distinctive Features: What Sets Direct Manufacturing Apart

    People used to buying from distributors sometimes ask why direct-supplied Tyramine Hydrochloride feels different to handle. The answer is in the details. Control over crystallization, drying, and packaging prevents agglomeration and off-odors. Each batch gets packaged into vapor-proof, pharmaceutical-grade containers—with the seal intact until it reaches the user’s bench. Freshness and physical integrity remain protected by this method.

    Our direct production lines keep the hydrochloride ratio exact; the free base to acid ratio gets checked at every scale-up and every production run. Too much acid, and the pH in solution drifts. Too little, and stability falters. That’s not just a concern for someone measuring out milligrams; even a small shift could alter reaction kinetics or biological outcomes in sensitive cell or animal studies. We test under actual working conditions—dissolving a portion in water or buffer, checking pH response, and confirming solubility clarity under both ambient and refrigerated conditions.

    Comparison with alternatives in the market shows clear contrasts. Many traders relabel Tyramine Hydrochloride sourced from multiple unnamed plants. That type moves through hands and can spend months in various warehouses. Each transfer increases the risk of exposure to heat or humidity. We ship direct from the plant within days of packing, and our containers use desiccant packets not as a last line of defense but as a routine barrier. Our clients know exactly how long a batch has sat since preparation—every outgoing pack is date-marked and batch-certified right in our facility.

    Technical Specifics Rooted in Real Lab Experience

    A compound’s utility depends on what people actually do with it. Researchers in neurochemistry trust our Tyramine Hydrochloride for its role as a substrate when studying monoamine oxidase (MAO) enzymes. Here, purity matters: even a low-level contaminant can skew enzyme reaction rates or introduce spurious assay peaks. We design our purification steps to remove not only organic impurities, but also traces of heavy metals, so labs aren’t surprised by unexpected results in downstream testing.

    Analytical and preparative labs benefit from known melting points (usually centered around 165°C with a tight spread), and a water content below 0.2%. These things are not “nice extras”—variability in these properties can upend a synthetic sequence or bioassay. Reproducibility is a direct result of how closely we police these points. Solubility checks in both water and common ethanol blends allow users to go straight to application without the trial-and-error many endure with lower-grade sources.

    Stability studies form the backbone of our storage advice. Keep the sealed containers dry and out of direct sunlight; under these conditions, our Tyramine Hydrochloride lasts several years without measurable degradation. We review this in internal stress test programs—not only pointing to written recommendations, but backing them up with actual retained samples re-tested every six months. By comparing against initial batch data, we confirm that our guidance is based on evidence, not simply generalized shelf-life assumptions.

    How This Product Differs From Common Market Alternatives

    Many people ask if Tyramine Hydrochloride from one manufacturer is truly different from another. As direct producers, we know that batch-to-batch consistency doesn’t happen automatically. It requires in-lab expertise and willingness to reject any lot falling short of internal benchmarks—even if it passes the looser “industry standard.” Reseller stock occasionally shows telltale signs of mishandling: caking, discoloration, slight acid smell. Our technicians train to spot these risks before anything leaves the facility.

    Physical differences tie back into purity but extend to handling characteristics. We use controlled drying cycles to maintain a powder that pours easily, rather than one that clumps after exposure to air. Original, unopened packs keep ambient moisture out almost entirely. That means from the first scoop to the last, you get the same reactivity profile and material performance, whether you’re running microgram assays or preparing large scale preps.

    In the marketplace, some “tyramine hydrochloride” actually contains blended-in excipients or stabilizers, sometimes undisclosed. Our batches are pure, straight product—no hidden diluents, no agents mixed in for flow or shelf-life modification. Our transparency matters to the scientists who rely on known quantities and known properties. If the customer gets a bottle from us today, and another batch a year later, they don’t have to alter their protocols or instrument settings.

    End-User Outcomes: Lessons From Customer Feedback

    It’s one thing to quote numbers about purity; seeing what happens in the lab offers a different sort of verification. We’ve watched spikes in high-performance liquid chromatography for competitor materials, only for our material to show a single clean peak. Academic labs and pharma R&D teams both report fewer failed batches, more reliable calibration curves, and faster prep times due to easy dissolution and absence of physical clumping.

    In one well-documented case, a neurobiology group traced recurring assay interference to an off-white sample of tyramine hydrochloride purchased from a broker—the batch carried a lingering smell and unusual solubility profile. They transitioned to our supply after exchanging technical data. Within weeks, their inconsistent assay results stabilized. No further troubleshooting needed on their end.

    Small pilot runs and teaching labs find value in standardized portion packets – each weighed and filled under nitrogen to further protect the content. Our user base includes both high-throughput screening labs and lower-volume research projects, but our quality control approach meets the stricter needs among the former without adding needless costs for the latter.

    Sustainability, Safety, and Future Directions

    Running synthesis at an industrial scale creates waste risks you don’t see in mix-and-dispense labs or repackaging operations. By handling both raw inputs and finished outputs in closed systems, we minimize environmental impact. We have reduced solvent consumption year by year, and have transitioned to energy-efficient crystallizers for key stages. Waste streams are monitored for byproducts, and we recover and recycle hydrochloric acid in outputs wherever practical.

    Worker safety has evolved alongside product quality. Early extraction steps once exposed technicians to strong fumes; now, vacuum lines and fume scrubbing units keep exposure to a minimum. Each handling crew gets up-to-date on safe dosing, proper labeling, and secure chemical management. No batch leaves our site without passing both quality and safety oversight.

    As regulatory expectations rise, we keep documentation in full detail—lot numbers tie back to specific syntheses, quality audits, and test results. Clients request traceability more often as global supply chains face disruption. Being the source enables us to answer technical questions with real history, not vague reassurances. In recent years, more clients ask for documentation supporting both animal-product-free processes and allergen-free status. Engineers and auditors can review our protocols and see that cross-contamination risk remains continuously controlled.

    Industry Challenges—And Our Ongoing Response

    Manufacturing chemicals like Tyramine Hydrochloride in today’s climate means facing both regulatory scrutiny and supply chain shocks. Real shortages in precursor chemicals sometimes appear as brief price spikes or temporary delays; at our site, years of forward-contracting raw material sources and maintaining buffer stock help smooth out the impact. Where world events cut off supplier nations or cause customs slowdowns, our control of in-house synthesis allows us to keep clients informed with precise lead time estimates.

    Documentation, too, has changed. Beyond basic Certificates of Analysis, we now deliver detailed impurity profiles and provide proof of compliance with more markets. Customers running GMP processes or regulated pharma projects receive audit support, up-to-date process details, and transparency about any process changes. Our chemists and QA team stay involved directly—not as off-stage compliance managers, but as part of the conversation.

    Another challenge: increasing expectations for “green chemistry.” We’ve adapted formulations to minimize hazardous waste and reprocess spent solvent within the plant. Every new generation of equipment promises better efficiency, but hands-on review remains essential. Automated batch controls trigger alerts, but trained chemists interpret them in context; manual observation stops problems before a mechanical fault can propagate.

    Investing In Relationships: Why Customers Stay With Us

    Lab projects change direction, and commercial plans often shift. The ability to meet changing needs without batting away questions is what distinguishes direct manufacturers from anonymous warehouse resellers. Being ready to scale production up or down quickly takes careful planning, but it also means direct technical support is available whenever protocols shift or researchers need advice.

    From our plant to the bench, Tyramine Hydrochloride makes its path without detours. Each stage, from receipt of precursor to final port-of-exit inspection, follows a documented and carefully supervised chain. No corners get cut, and no batch launches before every item meets our own benchmarks—not just the lines regulators require. Our experience tells us that chemical manufacturing, at its best, goes deeper than the minimal. As the industry evolves, holding to this approach means our customers rely on more than a document or label: they rely on a relationship with people who understand what’s inside every bottle, and how it got there.

    Looking Forward: Building On Standards, Not Resting On Them

    We see more research groups working with neurotransmitter analogs and derivatives each season. Demand still focuses on core compounds like Tyramine Hydrochloride, but the questions we answer become ever more detailed. Whether it’s solubility at extreme pH, response to elevated temperatures, or compatibility with advanced analytical setups, our experience as direct producers enables us to provide real answers.

    Our teams maintain continuous training and cross-functional learning to keep every production stage aligned with both academic and industrial client needs. The chemical sector never stands still; every day brings questions about novel applications, stricter documentation, and more exacting safety and environmental standards. By investing in people, process, and openness, we ensure that our Tyramine Hydrochloride remains not only fit for purpose, but an asset to anyone who chooses science over speculation, and committed manufacture over commodity distribution.