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Trans-2-Hexenoic Acid

    • Product Name Trans-2-Hexenoic Acid
    • Alias (t)-2-Hexenoic acid
    • Einecs 233-575-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    866906

    Cas Number 2316-21-4
    Molecular Formula C6H10O2
    Molecular Weight 114.14 g/mol
    Iupac Name (E)-hex-2-enoic acid
    Appearance Colorless to pale yellow liquid
    Boiling Point 217-218 °C
    Melting Point -3 °C
    Density 0.967 g/cm3 at 25°C
    Solubility In Water Slightly soluble
    Flash Point 99 °C
    Pubchem Cid 5363368
    Odor Fatty, sour, cheesy

    As an accredited Trans-2-Hexenoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Trans-2-Hexenoic Acid, 100g: Supplied in a sealed amber glass bottle with tamper-evident cap, labeled with hazard and handling instructions.
    Shipping Trans-2-Hexenoic Acid should be shipped in tightly sealed containers, away from moisture, heat, and incompatible substances. It requires labeling as a corrosive substance and adherence to relevant hazardous materials regulations. Appropriate protective packaging ensures safe transport, minimizing risk of leaks or exposure during transit. Compliance with local and international shipping guidelines is essential.
    Storage Trans-2-Hexenoic acid should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and direct sunlight. Keep the container tightly closed and clearly labeled. Store separately from incompatible materials such as strong oxidizers, bases, and reducing agents. Use appropriate chemical-resistant containers to prevent leaks or contamination and ensure compliance with safety regulations.
    Application of Trans-2-Hexenoic Acid

    Applications of Trans-2-Hexenoic Acid in Industrial Manufacturing

    Trans-2-Hexenoic Acid serves as a valuable C6 unsaturated carboxylic acid for specific industrial segments. This raw material supports precise downstream transformations in fine chemicals, agrochemicals, specialty polymers, flavors and fragrances, and pharmaceutical intermediates manufacturing. As an original producer, our application guidelines help customers meet strict industry and regulatory requirements for consistent, compliant end products.

    1. Synthesis of Pharmaceutical Intermediates

    Manufacturers of active pharmaceutical ingredients use Trans-2-Hexenoic Acid as a starting material in the synthesis of select β-lactam and cyclic intermediates. The conjugated alkene structure enables key addition and cyclization reactions under controlled conditions. Downstream quality checks rely on full traceability and GMP-compliant production records, ensuring batch-to-batch reproducibility and safety for regulated pharmaceutical preparations.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • U.S. FDA 21 CFR Part 211 (cGMP)
    • European Pharmacopoeia 11th Edition (where applicable)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 10–22% w/w as a precursor in multi-step pharmaceutical synthesis routes; adjusted based on target molecule and yield requirements.

    Downstream process integration

    • Charged during initial condensation phase or alkylation stage.
    • Reacts with amines, hydrazines, or aldehydes under controlled inert conditions.
    • Integrated into closed-system batch reactors with in-process HPLC monitoring.

    Final product types

    • β-lactam intermediates for antibiotic synthesis
    • Saturated and unsaturated cyclic acids
    • Key building blocks for cardiovascular and anti-infective APIs

    2. Agrochemical Formulation (Herbicide Intermediates)

    Trans-2-Hexenoic Acid enters as an essential building block in the synthesis of specific selective herbicide actives. The acid’s unsaturation allows downstream formulating plants to construct complex molecular scaffolds with tailored side chains. Process controls focus on reaction time, temperature, and solvent management to limit byproduct formation and assure chemical purity for agrochemical registration.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 for agrochemical manufacturers
    • REACH Regulation (EC) No 1907/2006
    • U.S. EPA Registration (when formulated in crop use products)

    Typical usage ratio

    • 5–15% w/w feedstock in synthesis of target herbicide intermediates; precise percentage set by route and design yield.

    Downstream process integration

    • Reacted via Diels-Alder or Michael addition in closed reactors.
    • Added during pre-polymerization or halogenation step.
    • Monitored by GC-MS for residual acidity and purity profile.

    Final product types

    • Herbicide intermediates (alkenyl acids and esters)
    • Selective weed control actives for cereals and vegetables
    • Agricultural premix components (pre-emergent and post-emergent herbicides)

    3. Flavor and Fragrance Ingredient Production

    Trans-2-Hexenoic Acid contributes as a precursor in the manufacture of specialty flavoring esters and aroma molecules, especially in “green” and “fruity” profiles. Food and fragrance manufacturers use it in highly controlled esterification and reduction reactions to generate high-purity flavor bases compliant with international food safety guidelines. All processes carry full traceability of origin and production history, meeting flavor houses’ strict internal specifications.

    Industry compliance standards

    • IFRA Code of Practice (International Fragrance Association)
    • Food Chemicals Codex (FCC)
    • 21 CFR 172.515 (U.S. FDA – Food Additives Permitted for Direct Addition to Food for Human Consumption)
    • EC Flavor Regulation (EU No. 1334/2008)

    Typical usage ratio

    • 0.1–8% w/w in esterification mixtures; percentage determined by product concentration, sensory threshold, and regulatory maximums.

    Downstream process integration

    • Combined with food-grade alcohols in catalyzed reactors.
    • Used in batch or continuous-flow synthesis prior to micro-distillation.
    • Monitored for residual acid and final purity via GC/FID and sensory evaluation panels.

    Final product types

    • Hexenyl acetate and hexenyl butyrate (fruity/green flavorings)
    • Green leaf aroma chemicals for beverages and personal care
    • Food-grade compound flavors

    4. Specialty Polymer and Resin Synthesis

    Producers of high-performance specialty polymers utilize Trans-2-Hexenoic Acid as a chain modifier or as a functional monomer in the creation of targeted unsaturated polyester resins. Its double-bond configuration imparts flexibility and chemical resistance to finished resins. The material requires clear lot-level quality documentation and continuous analytical tracking for each batch submitted to composite and coating formulators.

    Industry compliance standards

    • ISO 9001:2015 Quality Management (polymerization and compounding plants)
    • EN 13900-4 (Pigments and extenders – Application in polymer compounds)
    • RoHS Directive 2011/65/EU (when used in electronics resins)
    • REACH compliance within the European Union

    Typical usage ratio

    • 1–6% w/w as co-monomer or chain modifier; ratio set by mechanical properties required in the finished polymer.

    Downstream process integration

    • Added during prepolymer or masterbatch compounding phase.
    • Mixed with base monomers prior to initiator introduction in continuous or batch reactors.
    • Logged in ERP systems for end-to-end traceability.

    Final product types

    • Unsaturated polyester resins for composites
    • High-flexibility coating resins
    • Specialty adhesives with enhanced chemical resistance
    • Industrial molding compounds

    5. Fine Chemicals and Specialty Ester Manufacturing

    Trans-2-Hexenoic Acid forms the base of various specialty esters for industrial and cosmetic applications. Downstream ester manufacturers employ selective catalytic esterification to yield products suitable for use in lubricants, emollients, and surfactants, with the process controlled for low free acid content and batch purity. Our production supports full end-user documentation for quality audits and product registrations in regulated markets.

    Industry compliance standards

    • ISO 22716:2007 (Cosmetic GMP, for personal care esters)
    • REACH Registration for industrial chemicals
    • EU Regulation 1223/2009 (for cosmetic raw materials)
    • Technical Data Sheets and Material Safety Data Sheets in line with global SDS standards

    Typical usage ratio

    • 2–12% w/w as acid reactant in esterification; value set by application area and customer final viscosity targets.

    Downstream process integration

    • Combined in fixed-batch or continuous esterification reactors with defined catalysts.
    • Integrated with downstream fatty alcohols or glycols under vacuum and controlled temperature to minimize color formation.
    • Full-lot sampling and QC measurement of acid value and ester content before dispatch.

    Final product types

    • Fine chemical alkyl and aryl hexenoates
    • Emollient esters for cosmetic bases
    • Industrial lubricants and hydraulic fluids
    • Non-ionic surfactants for textile and cleaning products
    Free Quote

    Competitive Trans-2-Hexenoic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Trans-2-Hexenoic Acid: Manufacturer's Perspective on Quality, Application, and Differentiation

    Understanding Trans-2-Hexenoic Acid in Industrial Practice

    Each step taken in our factory for the production of Trans-2-Hexenoic Acid reflects the focus and discipline gathered through years dealing with specialty carboxylic acids. In daily operations, the most critical part remains the purity of the trans isomer. We prioritize a strict regime of reagent control, temperature maintenance, and storage to hold the profile and consistency of the final product. Through this approach, Trans-2-Hexenoic Acid emerges as an honest reflection of diligent chemical manufacturing — not just another molecular entity pushed through for a spec sheet.

    Our main product variant typically comes in colorless to light yellow liquid form, boasting a purity well above 98%, with trans configuration confirmed by our internal GC-MS and NMR analyses. Moisture content and residual solvents are managed, as trace water and impurities can affect the downstream reactions for which many of our customers rely on this acid.

    Use Cases Built on Experience

    Over repeated cycles and batches, we have learned practical nuances regarding how Trans-2-Hexenoic Acid interacts with diverse applications. Customers from fragrance and flavor synthesis benefit from its distinctive sharp, fatty, and slightly green note — which sets it apart from more common carboxylic acids like hexanoic and 3-hexenoic acid.

    Technical-grade material often goes into intermediate synthesis routes in pharmaceuticals, especially during the construction of more complex unsaturated acids and esters. Functionality in these cases matters much more than just a molecular formula. Even minor variations in the cis-trans ratio will impact final product yield for a customer. As manufacturers, we keep the focus on a process that avoids isomerization and tail-end impurities — since stray components can generate side products or force unnecessary purification downstream. This is a lesson we have reinforced by listening to process complaints and, more importantly, seeing real chromatograms come out of pilot plants using our acid as a feedstock.

    Trans-2-Hexenoic Acid stands apart from similar molecules like its saturated cousin, hexanoic acid, due to the presence of the double bond. This difference means reactivity changes dramatically, with Trans-2-Hexenoic offering more options for addition reactions, and coupling steps with aromatic rings. In practice, this means new flavor compounds or pharmaceutical intermediates, with cleaner profiles and sharper control of structure. Synthetic chemists and production engineers have remarked on the way it allows for more controlled chain extensions and selective transformations, especially when compared with acids lacking the trans geometry.

    Process Controls and Product Cleanliness

    One challenge we overcame over years of production relates to odor. Customers in flavor and fragrance industries judge raw materials by nose at every delivery. Minor amounts of non-trans isomers or heavier-end alcohols introduce off-notes — so we’ve put screening procedures in place well beyond legal requirements, including GC headspace checks and regular sensory panel scoring. Each lot is run through deodorization and low-temperature storage before dispatch. This control reduces returns and instills confidence. Repurposing labor to this task has paid off in reduced product recalls and greater repeat customer business, a solution clear in operational data.

    We have adopted bulk storage standards which reduce exposure to air and moisture. Stainless steel tanks, nitrogen-blanketed storage, and quick-drain isolation are now all part of our setup. This lowers the risk of oxidation that can produce hexenal or related byproducts. The business learned early on the value of shipping in airtight drums after seeing a sharp drop in customer complaints about color shift and rancid notes a few weeks after delivery. Reduced losses at this stage means higher reliability, and fewer headaches for blending rooms at our client facilities.

    Distinctiveness: What Sets Our Product Apart

    On the practical side, customers often ask what truly differentiates Trans-2-Hexenoic Acid from other unsaturated or straight-chain acids. The answer begins with the presence of the double bond in the trans position, which becomes crucial for stereoselective reactions in both R&D and production. Our acid provides a sharper, more predictable addition point compared to mixtures of cis-trans or fully saturated variants. For instance, certain perfume intermediates synthesize in higher yield and lower side-product formation when started from a pure trans-2 configuration; our technical team routinely exchanges detail with partners in these projects.

    There’s a subtlety in downstream processes — for example, flavor aldehydes made from this acid differ markedly from those made from cis- or mixed isomers. Our discussions with food and beverage formulators point out that the perception of “fresh-cut grass” or “green apple peel” tones is crisper, longer-lasting, and less prone to fading under storage when produced from our trans-2 material. These claims hold up under blind sensory panels and shelf-stability studies compared to reference samples made from commercially available mixed-isomer acids.

    We also talk with pharmaceutical synthesis teams who value product traceability. Regulatory audits demand more than just batch paperwork — customers benefit from in-depth analytics such as optical rotation (which confirms absence of isomerization), plus impurity profiling for any unwanted aldehydes, dicarboxylic acids, or higher-molecular-weight oligomers. Such hands-on data helps our clients pass downstream inspections with fewer surprises.

    Specifications Rooted in Reality

    Factories do not live by purity alone. For each lot of Trans-2-Hexenoic Acid, we offer tight controls not just on the headline GC numbers but on practical residue, color, and aroma. There’s little point in supplying theoretically 99% pure material if the last 1% presents as oxidized tails or gives offaged, sour notes. Through daily QC, tracked samples, and in-line processing adjustments, we have lowered out-of-spec incidents by a measurable percent yearly.

    Standard packaging, unless otherwise specified, comprises UN-certified HDPE drums sealed with tamper-evident closures. These steps evolved after years of container trials — paper kegs and basic barrels once led to greater loss from permeation or accidental contamination, so this investment aligned manufacturing outcomes with actual user feedback. Volumes for commercial customers range typically from 20 liters to full ISOTainers. Each shipment ships with traceable CoA, MSDS, and analytical history for the actual production date, not just a model lot, owing to our commitment to transparency.

    Our plant also regularly audits its waste streams, as sustainability pressure grows on chemical manufacturing. By working with local EH&S authorities, we have introduced byproduct capture that channels offcut acids into recovery or conversion rather than simple incineration. These closed-loop adjustments not only check a box but save operational resources, cut long-term disposal costs, and meet emerging customer purchasing policies centered on greener processes.

    Challenges and Solutions in Sourcing and Logistics

    Over the past decade, volatility in the prices and supply chains for carboxylic acid precursors has increased. To buffer against this, we have diversified trusted relationships with several upstream suppliers of butadiene and hexanal; regular on-site audits of these vendors ensure quality in each reagent. Cutting reliance on a single region for starting materials helped us avoid inventory shocks over the last few years marked by pandemic and logistics logjams.

    On the container logistics side, we engaged in direct partnerships with logistics companies familiar with bulk chemical handling, especially those running specialty tanker lines with inert lining and vapor-recovery options. This avoids cross-contamination risks and trace odor carryover from unrelated cargo. We learned through unfortunate cargo rejection cases — caused by lingering monomers or unwashed residues in third-party tanks — to insist on tighter controls and to bear some added cost if it guarantees customer satisfaction downstream. Like in much of chemical manufacturing, the up-front investment in reliable logistics beats the headaches of field rejects, demurrage, and brand reputation risk.

    We maintain real-time batch tracking for all outgoing loads, using barcoded drum logs and shipment-level trace through our ERP system. This approach reduces mix-ups and affords both our own team and our customers a reference point for any quality adjustment or complaint investigation. Over time, these records become a source for process improvement, as patterns in temperature retention, batch homogeneity, or even subtle shifts in impurity levels can be traced back to specific tanks, mixer operators, or even shift changes.

    Comparative Advantages Over Other Acids

    Purchasers and formulators sometimes weigh Trans-2-Hexenoic against other straight-chain carboxylic acids such as hexanoic, pentanoic, or their cis-isomer variants. Years spent bench-testing alongside these other acids reveal that Trans-2-Hexenoic grants a unique combination of volatility and reactivity, essential in aroma chemistry. Hexanoic acid, for instance, offers a chewy, fatty scent but lacks the green, crisp edge derived from the unsaturation in the trans-2-hexenoic chain. Using the trans configuration, flavorists or perfumers achieve more vibrant, lasting top notes, which allow for reduced dosages in finished compound — a gain that directly impacts cost efficiency on the client side.

    On the chemical synthesis side, we have seen sharper reactivity patterns involving the double bond, suitable for Michael additions and selective oxidation or reduction steps. Past projects saw our Trans-2-Hexenoic Acid serve as a scaffold for synthesizing insect pheromones, flavor precursors, and medicinal intermediates, with the reaction efficiency depending on precise control of double-bond placement. This differentiation isn’t just theoretical; customer yield improvements and reduced waste have been reported when shifting to our single-isomer grade from mixed or generic product purchased elsewhere.

    For specific applications like flavors, oxidation or self-condensation of off-grade acids leads to distinctly “old” or cardboard-like notes in finished goods. The higher the purity and isomeric control, the cleaner the end note in a beverage or aroma compound. Production managers in related food plants have reported back with stability data showing more consistent results and fewer taint complaints once switching to our audited lots.

    Process Evolution and Listening to Industry

    Each year, adjustments in our plant stem from the feedback loop with real users — the chemists, flavorists, and production engineers trusting their products to our material. Practical observation has led to tweaks such as in-line fractionation for stubborn ether residues, reformulation of supply chain redundancies, and expansion from simple acid-form batches to value-added derivatives for more strategic customers. Efficiency gains have often arrived not from boardroom meetings, but from our plant technicians spotting patterns in customer complaints, or noticing odd notes during in-house blending trials.

    In recent years, there’s been growing demand for tighter quality documentation — particularly in regulated markets such as food and pharma — so we increased our investment in analytical equipment and kept training our lab team upfront. These changes did more than tick compliance boxes; they trimmed our response time on customer queries and cut time to resolve any outlier events. Regular round-robin testing against reference standards allows our team to calibrate not just our process, but our trust in third-party labs so that customer claims find quick, fact-based resolution.

    We have not only responded to audits from major multinationals, but have collaborated during process development phases. For specialty flavors, for instance, our R&D teams have worked alongside client scientists to trial slight shifts in feedstock ratios or catalysts — leading to a more robust acid with less batch-to-batch variation on color or taste.

    Looking Ahead: Industry and Sustainability Trends

    Growing expectations for transparency and minimal environmental impact have reshaped how we present and deliver Trans-2-Hexenoic Acid. Beyond satisfying business partners, improved documentation for our acid supports market entry into increasingly regulated or quality-conscious regions. Clients want proof on every drum, batch, and certificate. This comes from real upgrades in plant system traceability and waste reduction practices, not just from “greener” marketing language.

    Closed-loop solvent reclaim and energy-efficient distillation now form part of our production toolkit. While such systems require capital outlay, their effect on both emissions and long-term operating costs proves the value with each passing production season. For downstream partners, this cascade of improvements gives assurance on origin, process integrity, and supply resilience.

    Specifically, packaging reuse, drum returns, and on-site reclamation mean more of each raw material makes it into finished batch, less headed for disposal. Process technicians have noticed less fouling in shipping lines and easier compliance reporting — both traceable to these environmental and procedural tweaks.

    By constantly tuning our internal processes in direct response to end-user needs, and by maintaining open channels with industry partners, we deliver not just a molecule, but a dependable, traceable ingredient for the world’s labs and production lines. Trans-2-Hexenoic Acid represents years of plant-level learning and adaptation, rather than just ticking off another CAS number from a chemical catalog.

    In a sector driven by real-world results, this carboxylic acid gives more than a simple yield improvement or cost saving; it builds trust through consistency and adaptability, shaping a better supply footprint for all stakeholders involved.