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Tetrachloropyridine-2-Carboxylic Acid

    • Product Name Tetrachloropyridine-2-Carboxylic Acid
    • Alias 6-Chloropicolinic acid
    • Einecs 259-208-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    134205

    Chemicalname Tetrachloropyridine-2-Carboxylic Acid
    Molecularformula C6Cl4NO2
    Molecularweight 243.89 g/mol
    Casnumber 25134-21-8
    Appearance White to off-white solid
    Meltingpoint 221-224 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Boilingpoint Decomposes before boiling
    Smiles C1=CC(=NC(=C1Cl)Cl)C(=O)O
    Inchi InChI=1S/C6Cl4NO2/c7-2-1-3(6(12)13)11-5(10)4(2)8
    Odor Odorless
    Storagetemperature Store at 2-8 °C
    Hazardclass Irritant

    As an accredited Tetrachloropyridine-2-Carboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Tetrachloropyridine-2-Carboxylic Acid, 25g: Supplied in a sealed amber glass bottle with tamper-evident cap, labeled with chemical details and safety warnings.
    Shipping Tetrachloropyridine-2-Carboxylic Acid is shipped in tightly sealed, chemically resistant containers to prevent leakage and contamination. Packages are clearly labeled with hazard warnings, compliant with local and international regulations. Temperature and handling instructions are provided to ensure safe transport. Only qualified carriers and handlers should manage this shipment.
    Storage Tetrachloropyridine-2-carboxylic acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances such as strong acids, bases, and oxidizers. Ensure that storage conditions protect the chemical from moisture and physical damage. Label containers clearly and follow local regulations regarding hazardous chemical storage and handling.
    Application of Tetrachloropyridine-2-Carboxylic Acid

    Applications of Tetrachloropyridine-2-Carboxylic Acid in Industrial Manufacturing

    Tetrachloropyridine-2-Carboxylic Acid serves as a targeted intermediate for fine chemical synthesis across several high-value industries. Our direct plant production supports customer processes with traceable batches and consistent technical grades, aligned with stringent downstream requirements.

    1. Agrochemical Intermediate Synthesis

    The compound is widely used as a core building block for synthesizing crop protection agents, particularly triazolopyridine herbicides and certain novel fungicides. Direct integration ensures high purity and controlled impurity profile, essential for safe and effective crop treatment formulations. Regulatory expectations require full documentation through synthesis and finishing operations.

    Industry compliance standards

    • REACH (EC 1907/2006) registration for intermediates
    • ISO 9001 quality management system
    • China Agricultural Chemical Product Quality Standard (GB/T 20784)
    • US EPA active ingredient assessment for agrochemical precursors

    Typical usage ratio

    • 15%–25% as a key intermediate input, ratio adjusted for target active ingredient yield and reaction selectivity in the downstream synthetic step

    Downstream process integration

    • Alkylation or halogenation in high-pressure reactors, followed by condensation or cyclization
    • Loaded as the first reactant during synthesis chain assembly

    Final product types

    • 3,6-Dichloropyridine-based herbicides
    • Triazolopyridine fungicides
    • Selective weed control agents for cereal crops

    2. Pharmaceutical Active Ingredient Synthesis

    In pharmaceutical fine chemistry, manufacturers use this material as a controlled intermediate for developing pyridine-derived APIs, such as antibacterial and antiviral drugs. High purity, documented batch traceability, and impurity screening are strictly validated to ensure safety at every critical synthesis stage. Documentation follows cGMP principles through all intermediates to final APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 US FDA cGMP regulations
    • EU GMP Part II requirements
    • ChP, USP, or EP relevant monographs (where required for traceability of starting materials)

    Typical usage ratio

    • 10%–18% in multi-step synthesis; the ratio varies for specific drug synthesis routes and yield optimization

    Downstream process integration

    • Introduced early in the reaction pathway for pyridine ring modifications
    • Used in condensation step or selective substitution reactions under controlled conditions

    Final product types

    • Anti-infective pharmaceutical intermediates
    • Pyridine-based anti-viral compounds
    • Advanced intermediates for anti-cancer research

    3. Specialty Dye and Pigment Manufacturing

    Colorant manufacturers select Tetrachloropyridine-2-Carboxylic Acid as a functional intermediate for producing high-thermal-stability dyes and specialty pigments. The molecular structure supports specific chromophore modifications, enabling strong fastness profiles in industrial coatings and printing inks. Tight specification control over chlorination level reduces color defects in final dispersions.

    Industry compliance standards

    • EN 71-3 Safety of Toys—Migration of certain elements (for pigment use in children’s products)
    • ISO 1248 Pigments—General test methods
    • Oeko-Tex Standard 100 for textile dyestuffs
    • REACH substance restrictions for colorants

    Typical usage ratio

    • 12%–22% in pigment intermediate blending, ratio tailored by required fastness and color intensity parameters

    Downstream process integration

    • Utilized during the heterocyclic ring introduction in chromophore synthesis
    • Charged in the first or second step of multi-stage dye production depending on color depth targets

    Final product types

    • Organic pigment dispersions for plastics and coatings
    • Industrial printing inks
    • Textile-resistant specialty dyes

    4. Electronic and LCD Material Manufacturing

    Producers of functional electronic chemicals use this acid as a precursor for synthesizing semiconductor-grade pyridine derivatives and advanced LCD liquid crystal monomers. Precision purification and crystal structure validation are crucial for downstream performance. Continuous supply chain traceability supports mass production of high-end display and microelectronic parts.

    Industry compliance standards

    • RoHS Directive 2011/65/EU for restricted substances
    • ISO 14644-1 Cleanroom production (for electronics process chain)
    • IEC 61249 for laminate and interconnect applications
    • JIS C 5015/5016 for electronic chemical raw materials

    Typical usage ratio

    • 6%–15% for monomer or precursor synthesis; proportion refined depending on electronic grade and device application

    Downstream process integration

    • Reacted under closed and dry conditions for monomer assembly
    • Sourced in first or intermediate synthetic step for LCD and microelectronic chemical production

    Final product types

    • Liquid crystal display (LCD) monomers
    • Pyridine-based components for integrated circuits
    • Specialty electronic coatings

    5. Polymer Additives and Crosslinking Agent Production

    Formulators for advanced polymers utilize Tetrachloropyridine-2-Carboxylic Acid as a precursor to crosslinking agents that impart chemical resistance in specialty plastics and thermoset resins. Our technical grade supports high-stability requirements, boosting downstream material performance in laminates and specialty moldings. Ongoing quality audits ensure every shipment matches downstream technical data sheets.

    Industry compliance standards

    • ISO 9001 controlled production environment
    • UL 94 flammability standards (for finished plastics)
    • REACH polymer regulatory frameworks
    • ASTM D5630 polymer additive content testing

    Typical usage ratio

    • 3%–10% in crosslinker or additive masterbatch production, ratio fine-tuned by the required polymer backbone structure and crosslink density

    Downstream process integration

    • Employed in early compound formation for crosslinker synthesis
    • Added in blending stage for modifier or additive masterbatch

    Final product types

    • Epoxy resin crosslinkers
    • Specialty thermoset molded parts
    • Polymer additive masterbatches for high-resistance plastics
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    Certification & Compliance
    More Introduction

    Understanding Tetrachloropyridine-2-Carboxylic Acid as Made by the Manufacturer

    A Chemist’s Perspective: Why We Value Tetrachloropyridine-2-Carboxylic Acid

    Making chemicals is more than filling tanks and drums. When preparing Tetrachloropyridine-2-Carboxylic Acid, every run reflects the raw science responsible for its creation. In the shop, there’s satisfaction seeing this product go from planning sheets, through each reaction step, to something other industries depend on. The formula might seem straightforward—C6Cl4NO2—but the process is anything but.

    In our facility, we have learned that quality actually matters more than whether a product matches a catalogue line. For Tetrachloropyridine-2-Carboxylic Acid, purity can vary widely from batch to batch, depending on source chemicals, reactor controls, washing steps, drying cycles, and the vigilance of operators at each step. We have experimented and learned from missteps. Minor residual moisture or trace contaminants change downstream behavior, and these faults tend to snowball into larger issues for customers. We look at every stage—from chlorination, through pyridine handling, to final acidification—with a focus that comes from knowing what even a small miscalculation will do.

    Our Production Experience: What Sets Our Process Apart

    The product has appeared in the market under other names, but most are acquainted with its use as a building block in agrochemical or pharmaceutical research. We keep it tightly controlled in our line-up because many customers complain about color bodies and particulate content in generic supplies. Through experience, we've found consistent color—usually faint off-white to pale yellow—and grain control are proof of better origins. Granule breakdown, dust, agglomerate issues, and pourability matter for people who handle it every day. In our own process, we run filtration steps that last hours, depending on batch size, with repeated inline checking.

    Our staff treat maintenance of instrumentation as non-negotiable. Chromatography checks show that leftovers from incomplete reactions, like unreacted pyridine or multi-chlorinated byproducts, haunt weak processes. They show up as odd peaks, confusing end-users. We assign extra hands just to run analytical samples per shift. In our plant, skilled hands and eyes are as important as automation. Automation alone never removes the need for human judgment here.

    Technical Nuances: Understanding the Model and Specifications

    Tetrachloropyridine-2-Carboxylic Acid manufactured here follows our house route, which starts with highly pure pyridine derivatization. We operate jacketed glass-lined reactors for chlorination and follow with cooling regimes tailored for each scale-up. Our current batch output ranges from five to one hundred kilograms depending on contracts. For standardization, the most common form we handle is a free-flowing crystalline powder, confirmed through microscopy and particle distribution analysis.

    Moisture content is checked batchwise with Karl Fischer titration, targeting levels below 0.2%. Residual solvents sit under 0.3%. Melting point is monitored for historical consistency—usually falling in the 195-198°C range over several years. We map impurities to common byproducts and refuse lots failing in excess of 0.5% total unknowns on HPLC. Multiple washings—typically five to seven per lot—remove soluble byproducts.

    Over years of feedback, end-users told us why these details matter: variable melting points disrupt downstream reactions, speckled color frustrates QA checks, and poor handling rivals many common health and safety complaints in plants. We built extra holding facilities to remove delays and bottlenecks so product transitions remain smooth, and customer feedback shows that uncluttered logistics beat last-minute scrambles every time.

    Sensible Use and Reasoned Applications

    Most chemists search for Tetrachloropyridine-2-Carboxylic Acid as an intermediate due to its reactive positions on the aromatic ring. The presence of four chlorines and a carboxylic acid unlocks cross-coupling and derivatization reactions, frequently headed toward more complex herbicides, fungicides, or pharmaceutical actives. In large chemical companies, these properties mean fewer synthetic steps, cleaner transformations, and fewer purification headaches in scale-up.

    Academic labs sometimes request smaller quantities for mechanistic work, exploring the unique halogen dance available only in high-chlorinated pyridines. We have noticed the jump in demand whenever new research papers cite bioactive analogues starting with this molecule. Companies often contact us for custom runs to test unlisted derivatives, requiring flexibility in both quantity and speed.

    People working on scale-up projects expect straightforward dissolution characteristics and compatibility with various polar and non-polar solvents. Our quality focus guarantees predictable solubility, critical for those who mix it into organic syntheses. Testimonials from industrial chemists often mention clean filtration and unimpeded reaction kinetics. This comes only when the initial material is right.

    Comparisons With Other Pyridine Carboxylic Acids

    A crowd of pyridine-based acids compete in the market: some prepared with fewer halogens, or substituents in alternate positions. Tetrachloropyridine-2-Carboxylic Acid distinguishes itself by a unique blend of electron-poor ring and carboxyl group, closing the door to simple substitutions, but opening new selectivity opportunities in coupling or halogen-exchange chemistry. Most other variants lack this powerful halogenation, meaning they do not hold up in frontline applications demanding aggressive reactivity or unusual biological properties.

    For example, trichloro- or dichloro-pyridine acids work well for research teams interested in stepwise modifications, but their failure rates soar when confronted with environmental resistance or shelf-life issues. We handle regular calls from formulators who have found that replacement with lesser-chlorinated versions often ends with poor performance, especially in bioactivity screens or materials with harsher use conditions.

    Our experience tells us that those seeking maximized selectivity, reactivity, or downstream yield tend to prefer tetrachloro variants even though they come at a higher initial cost, and the supply chain for raw chlorinating agents is not always stable. Plant operators and synthetic chemists alike comment on batch reproducibility and storage stability. This reflects the robust nature of four-fold chlorination, especially in environments where variable humidity, heat, or transport stress put similar products at risk of caking or degradation.

    We compete with overseas vendors offering similar materials. Some bring their products to market at lower costs, often skipping burdensome steps or using lower-grade reactants, which we have traced by their unusual impurity fingerprints. Many customers return to us after trying less reliable alternatives, especially once their technical teams grow tired of inconsistent purity results or trace-metal contamination. Reliability matters, especially for those who run multi-tonne campaigns relying on days or weeks of trouble-free operation.

    Challenges in Tetrachloropyridine-2-Carboxylic Acid Manufacturing

    Making this molecule consistently challenges even well-established plants. One major lesson we learned involves the hazards of aggressive chlorination: poor ventilation or flawed reactors can spell disaster, risking both product loss and worker safety. We invested years strengthening fume handling and protecting employees, knowing that human error in a pressure-filled environment is unforgiving.

    Another persistent obstacle is raw material quality. Sourcing high-grade pyridine is now harder, as demand in other chemical niches has outpaced traditional supply. Over time, we have had to forge close partnerships with primary pyridine producers, creating shared testing protocols and mutual contingency stocks. Direct feedback on impurity panels leads to faster corrective actions, avoiding costly shutdowns or off-spec shipments.

    Process waste reduction remains top-of-mind for us and our industry partners. Regulatory pressure pushes manufacturers everywhere to cut halogenated byproducts, and public scrutiny around chlorinated organic waste influences both operational choices and reputational outcomes. Our on-site treatment plants focus on solvent recovery and neutralization. Plant operators redesign filtration and separation processes each year, seeking the elusive balance between ecological responsibility and viable production economics.

    Batch failures teach humility. Even the tightest process slips when overlooked—temperature overshoots, incomplete extractions, or uneven agitation create problems downstream. Realistic planning and honest internal review bring process drift to light, saving trouble for our customers. Sometimes, names on delivery manifests do not match application details, creating confusion at the customer end; we have learned to keep our technical support teams accessible, usually solving most of these pain points in real time.

    Commitment to Customers and Broader Impact

    Long-term relationships build from reliability and openness. We keep regular two-way dialogue with technical partners, checking what works—or what needs change. This keeps us grounded. We can only improve by knowing exactly how customers are affected, whether it’s a shift in extraction parameters, particle size, or labeling clarity. Often, large pharma or agro companies come with niche needs, pushing us to adjust crystallization or packaging at short notice. We can only do this because our staff take responsibility at every stage.

    A major reason our clients stick with us concerns traceability. Every batch gets archived reference samples, with detailed logs kept from raw material lot to final drum. Audit teams from clients sometimes arrive unannounced, looking to dig into records—our team is used to opening the books, sharing methods, and talking through every anomaly. We invite critique, knowing it often exposes blind spots and spurs process improvements otherwise overlooked in the daily rush.

    Technical transparency translates outward, too. We regularly attend chemicals symposia and regulatory briefings, keeping up with shifts in compliance and industry standards. As environmental and safety regulations grow more stringent, we anticipate changes and tune our practices before compulsion. This minimizes scramble and secures reliability for everyone relying on our product.

    Perspectives on Solutions and Future Developments

    Looking ahead, supply security and technical advancement go hand in hand. As the market for high-chlorinated aromatics grows, large-scale plants attract attention from regulators, advocacy groups, and customers concerned with sustainability and ethical sourcing. We respond by advancing recycling schemes for waste streams, capturing more solvents for reuse each year, and investing in smarter process controls.

    Industry-wide, pressure mounts for greener alternatives or safer intermediates. Some experiments aim to swap out harsh chlorination reagents for milder systems; others attempt to use continuous flow reactors to cut batch-to-batch inconsistency. These methods show promise, though not every advance scales without trade-offs. As a manufacturer, we track these trends, trialing them on pilot lines before roll-out.

    Customer innovation often drives our change. Requests for new derivatives or specialty grades push labs and plant engineers to adjust. Rather than resist these demands, we involve key partners early in our R&D, swapping samples and getting field data before final product launches. This keeps us nimble without sacrificing the robust processes proven over the years.

    Supporting academic research remains a priority for us. We set aside lots each quarter for collaborations with universities or non-profits, eager to see inventive methods or new applications. More than once, student feedback has led to minor edits in our procedures, resulting in fewer customer complaints or better technical utility.

    Informed by the Workshop: Day-by-Day Realities

    From our perspective in the facility, maintaining the quality of Tetrachloropyridine-2-Carboxylic Acid is an act of daily vigilance. QC specialists track every index, warehouse teams keep conditions monitored, and process engineers fill logs by hand to spot trends missed by automated sensors. There is pride on the floor when bulk samples return with glowing client reports. Recognition spreads through our team; operators know their work ends up in products found on farms, hospitals, and research labs around the globe.

    We take seriously the feedback channel that runs straight from the shop floor to the technical liaison desks handling customer complaints or improvement requests. Each member here understands that even incremental gains—slight changes in granule sizing, purity, labeling, or drum selection—might translate into hours of downstream labor saved at a client’s site. Over years, small gains add up to big wins in trust and repeat business.

    Making Tetrachloropyridine-2-Carboxylic Acid at this scale means more than just economic output. The impact ripples out: reduced off-gassing and cleaner effluent streams matter for communities near the plant; robust testing and traceable documents reassure our buyers; and process innovation shapes what tools the next generation of researchers will use.

    Conclusion: The Manufacturer’s View on Why This Product Matters

    From the first flask to the final drum, Tetrachloropyridine-2-Carboxylic Acid holds a special place in our operation. As applications spread in complexity, our role grows with it—balancing new demands, unexpected obstacles, and opportunities for continued refinement. Plant stories rarely make headlines, but the reality is that steady hands, hard-earned knowledge, and open channels with end-users drive every improvement. Each lot rolling out the door reflects thousands of decision points and a real-world knowledge base tested by changing market and regulatory tides.

    The value in Tetrachloropyridine-2-Carboxylic Acid comes not only from its chemistry but from the unseen processes, people, and shared industry standards behind each package. For us, this ongoing journey matters just as much as the chemical itself.