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Tetraamylammonium Iodide

    • Product Name Tetraamylammonium Iodide
    • Alias TAAI
    • Einecs 243-243-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    550183

    Chemical Name Tetraamylammonium Iodide
    Chemical Formula C20H46IN
    Molar Mass 429.49 g/mol
    Appearance White to off-white solid
    Cas Number 6224-98-6
    Density 1.17 g/cm3
    Melting Point 245-250 °C (decomposes)
    Solubility In Water Soluble
    Pubchem Cid 24525
    Storage Conditions Store at room temperature, keep tightly closed

    As an accredited Tetraamylammonium Iodide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100-gram amber glass bottle with a tight-sealed cap, labeled "Tetraamylammonium Iodide," and detailed handling instructions.
    Shipping Tetraamylammonium Iodide should be shipped in tightly sealed containers, protected from moisture and light. It should be packed according to regulations for chemical substances, often in UN-approved packaging. The package must be appropriately labeled, including hazard information, and transported following relevant national and international regulations for chemical safety.
    Storage Tetraamylammonium iodide should be stored in a tightly closed container, protected from moisture and light, in a cool, dry, and well-ventilated area. It should be kept away from strong oxidizing agents and incompatible substances. The storage area should be clearly labeled, and access should be restricted to trained personnel. Use appropriate personal protective equipment when handling.
    Application of Tetraamylammonium Iodide

    Applications of Tetraamylammonium Iodide in Industrial Manufacturing

    As a specialized manufacturer of chemical raw materials, we ensure that each batch of Tetraamylammonium Iodide (TAAI) aligns precisely with the production demands of sophisticated downstream sectors. The applications outlined below highlight established industrial practices, regulatory standards, and process details relevant for processors, plant managers, and formulation specialists working at scale.

    1. Pharmaceutical Intermediate Synthesis

    Tetraamylammonium Iodide is widely incorporated in selective phase-transfer catalysis processes for the manufacture of pharmaceutical intermediates, including quaternization, halide exchange, and N-alkylation steps. In these applications, strict control over residual ions and impurity profiles is monitored to meet regulations for APIs and advanced pharmaceutical intermediates. The material is charged during aqueous-organic interfacial reactions, enabling precise transfer of iodide ions under controlled alkaline or neutral pH environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 Current Good Manufacturing Practice for Finished Pharmaceuticals
    • EU EudraLex Volume 4 (Pharmaceutical GMP)
    • Ph. Eur., USP, JP monograph specifications for intermediates, where applicable

    Typical usage ratio

    • 0.5–2.5 mol% relative to the substrate, adjusted according to catalyst turnover number and reaction kinetics

    Downstream process integration

    • Introduced in situ to interfacial phase-transfer or halide exchange steps within multipurpose reactors prior to quenching and downstream purification

    Final product types

    • Quaternary ammonium compound pharmaceutical intermediates
    • API precursors
    • Iodinated specialty intermediates for contrast agents and radiopharmaceuticals

    2. Ionic Liquid Preparation

    Selected research and commercial plants use Tetraamylammonium Iodide as a precursor for the synthesis of room-temperature ionic liquids, where the quaternary ammonium cation structure offers tunable physicochemical properties for energy storage, extraction, or catalysis applications. Manufacturing lines dissolve the iodide salt in controlled solvent environments, then conduct further anion exchange or functionalization reactions under nitrogen blanketing to prevent oxidation.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EC 1907/2006), for manufacturing or importing ionic liquids in Europe
    • GLP requirements for process traceability in pilot and scale-up batches

    Typical usage ratio

    • 1.0 equivalent relative to target anion in ion-exchange or metathesis reaction systems, typically 10–40 wt% solutions

    Downstream process integration

    • Charged to jacketed glass-lined or stainless reactors with controlled agitation and temperature; followed by downstream filtration, recrystallization, or vacuum drying for ionic liquid isolation

    Final product types

    • Room-temperature ionic liquids for electrochemical devices
    • Extraction solvents for rare earth separation
    • Green reaction media

    3. Organic Synthesis Catalysis

    In the field of specialty and fine chemicals, TAAI serves as an organic phase catalyst in nucleophilic substitution and alkylation reactions where it improves yield and selectivity, especially for iodide-driven conversion steps. Laboratories and kilo-scale plants measure its impact in reactions by HPLC or GC, ensuring minimized by-products that complicate downstream separations. Direct addition at precise stoichiometric levels supports consistent batch reproducibility and regulatory documentation.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • Responsible Care Global Charter, when used at large-scale chemical manufacturing sites
    • Internal analytical validation protocols for batchwise process verification

    Typical usage ratio

    • 0.2–1.0 mol% relative to halide substrate, modulated according to desired reaction rate and substrate reactivity

    Downstream process integration

    • Dosed at the organic or biphasic reaction set-up stage, prior to commencement of heating, with real-time monitoring of reaction endpoint and post addition neutralization

    Final product types

    • Specialty aromatic compounds
    • Fine chemical intermediates
    • Iodo-organic building blocks for agrochemical synthesis

    4. Electrodeposition Additives for Surface Finishing

    Tetraamylammonium Iodide finds established application as an additive in precious metal electrodeposition baths, particularly for optimizing grain structure and ductility in gold and platinum plating used for electronics, connectors, and medical devices. Electroplating operations introduce the iodide salt in calibrated concentrations to adjust cathode efficiency and deposit uniformity, while analyzing bath composition to remain within written quality protocols for final component integrity.

    Industry compliance standards

    • IPC-4552A Performance Specification for Electrodeposited Gold for Printed Boards
    • ISO 4527:2003 Metallic coatings—Electrodeposited coatings of gold for engineering purposes
    • RoHS Directive (2011/65/EU) for electronic hardware
    • QC testing under ASTM B488 for gold coatings

    Typical usage ratio

    • 5–100 ppm in plating bath, adjusted based on test panel performance and cross-section analysis of deposit

    Downstream process integration

    • Added as a secondary iodide source post-make-up and after each bath rejuvenation, with regular titration to maintain precise ion balance

    Final product types

    • Gold-plated electronic connectors and semiconductor components
    • Ultra-thin platinum-plated medical electrodes
    • Corrosion-resistant terminal finishes

    5. Laboratory Reagent for Halide Exchange Studies

    Many high-throughput chemical research and analytical laboratories procure TAAI as a controlled halide ion source in studies of halide exchange, nucleophile reactivity, or mechanistic organic chemistry. Laboratories utilize solid or solution-phase additions in microgram to gram scales, stressing analytical purity and minimized trace contamination for accurate kinetic and mechanistic profiling. Strict protocols cover use, disposal, and documentation for traceability in regulated environments.

    Industry compliance standards

    • ISO/IEC 17025:2017 General requirements for the competence of testing and calibration laboratories
    • GLP Principles (OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring)
    • Internal SOPs for laboratory reagent handling and chemical inventory management

    Typical usage ratio

    • Typically 0.01–1.0 mmol per experiment, calculated to deliver stoichiometric or substoichiometric iodide depending on the designed reaction mechanism

    Downstream process integration

    • Direct addition during reagent set-up; frequently weighed as crystalline solid or measured as standardized solution just prior to experimental start

    Final product types

    • Reaction intermediates for kinetic analysis
    • Calibrant solutions for chromatographic method development
    • High-purity reference materials for mechanistic research
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    Certification & Compliance
    More Introduction

    Tetraamylammonium Iodide: Direct from the Manufacturer

    Putting Our Expertise to Work

    Tetraamylammonium iodide isn’t a run-of-the-mill ingredient. We’ve made it for years in our own plant, so we know the ins and outs that only someone elbow-deep in production truly understands. Each time we synthesize this compound, our team tracks the consistency and controls every variable, from reaction temperature to final particle size, aiming for the highest purity we can achieve every batch—not just for the sales pitch, but because our customers actually run reactions that count on that reliability.

    What Sets Our Product Apart

    Chemistry doesn’t leave room for guessing games. We hear from labs that other quaternary ammonium iodides from general suppliers sometimes leave behind impurities or vary in performance from batch to batch. As a direct manufacturer, we safeguard our process controls at every step, keeping moisture, contamination, and byproducts in check. This means that the Tetraamylammonium iodide we ship features a narrow melting range, tight control of residual solvent, and a defined crystalline form. These features might sound trivial to a generalist, but if you’ve ever lost yield or struggled with side reactions, you know why they matter.

    The amyl groups in our product sit just right—neither too branched nor too linear—giving a blend of solubility and compatibility across different systems. Customers performing phase-transfer catalysis or working on organic syntheses frequently note that Tetraamylammonium iodide’s particular molecular architecture gives it an edge over related products like tetrabutylammonium iodide or tetrahexylammonium iodide. The C5 chain length strikes a balance: it steers away from the volatility and solvent handling headaches of shorter alkyl analogues while avoiding the waxy, poorly soluble pitfalls seen with longer chains.

    Chemical Model and Specifications—From Experience, Not Just Datasheets

    Our Tetraamylammonium iodide carries the formula C20H44NI. With a molar mass around 409.47 g/mol, every batch undergoes titration and chromatographic analysis to ensure the iodide content stays above 99%. For those running scale-up syntheses or sensitive catalytic work, this kind of consistency matters. We pay attention to every step, from reactant purification to recrystallization, followed by vacuum drying to cut down on traces of water. This consideration isn’t just about good manufacturing practice standards—it’s about hearing from actual chemists which problems crop up with lesser-grade offerings.

    No one likes surprises, especially in critical R&D or pharmaceutical labs. Our batches display a melting point in the expected range, a sign that major impurities or misreactions never sneak in. As a manufacturer, we don’t just send out a product—we track batch-to-batch variation, log problem reports, and test for shelf stability so researchers and formulators don’t end up troubleshooting preventable issues weeks or months later.

    How Customers Use Tetraamylammonium Iodide—Insights From the Plant Floor

    We’ve watched this salt head out to pharma firms, electronic material producers, and academic labs, each group using it in slightly different ways. In phase-transfer catalysis (PTC), the ion pair formation and transfer characteristics stand out. Chemists handling nucleophilic substitution reactions depend on the precise pairing and solubility profile to migrate reactants across immiscible phases. Others leverage its properties as a precursor in the synthesis of ionic liquids, deep eutectic solvents, or for specific halide exchange reactions that don’t cooperate with more standard quaternary salts.

    Tetraamylammonium iodide outperforms some shorter-chain analogues when tolerance to organic solvents or higher temperatures matter. In certain benzylic alkylation or halogen exchange routes, the compound sidesteps stubborn emulsion problems or solubility limitations that plague alternatives. We’ve seen specialty resin developers lean on amyl groups for broader compatibility, letting them tweak solvation power or substrate range without retooling half their process. Even battery or sensor research teams turn to this salt for unique electrolyte formulations, relying on its defined structure and performance over generic substitutes.

    Differences That Actually Impact Performance

    Users sometimes ask, “Why not just use any quaternary ammonium iodide?” The answer lives in hands-on results. Tetraamylammonium iodide offers a remarkable balance between lipophilicity and manageable solid-state behavior. Overly short alkyl chains, as in trimethyl or tetraethyl analogues, leave you with products that attract water, dissolve unpredictably, and introduce conductivity problems in electrochemical contexts.

    Take tetrabutylammonium iodide for comparison—the butyl groups do well for basic PTC work but may lack the right combination of hydrophobicity for more stubborn organic reactions. On the other side, tetrahexyl and longer chains turn troublesome with low melting points, sticky residues, or handling challenges. We’ve been through enough batches to see residues gumming up reactor drains or clogging filters when the chain length goes too high. Tetraamylammonium iodide lands in the sweet spot—a manageable melting point, solid crystalline texture, and easy handling, even at slightly elevated process temperatures.

    Controlling the manufacturing archives for years, our experience flags any batch that drifts in color, texture, or solubility. We know by close observation which tweaks to make, whether it’s purifying an input amine a bit further or adjusting solvent polarity to sharpen crystallization. There’s no substitute for getting consistent feedback from returning customers who compare our iodide directly to off-the-shelf blends. This hands-on cycle helps us correct issues before product leaves our facility.

    Lowering Barriers for Research and Scale-Up

    Most scientific labs and industrial R&D groups eventually hit scale-up hurdles. We’ve kept our production lines nimble, supplying not just gram-sized bottles for the benchtop, but bulk orders that need strict controls for each delivery. After supplying Tetraamylammonium iodide across continents, we know just-in-time shipping, handling, and proper moisture barrier packaging are not optional. The real difference between using manufacturer-direct supply versus resellers comes out in consistent timelines and reliable documentation—certificate of analysis, controlled traceability, and technical backing direct from the plant supervisor.

    Customers running tight experimental cycles on high-value reactions have high standards. They ask about trace metals, residual solvents, and total halide analysis—questions we can answer confidently, since we handle every stage of synthesis rather than shipping in lots from third parties. Providing this detail saves expensive troubleshooting mid-campaign and makes us partners in the outcome, not just suppliers counting orders.

    Challenges in Handling, and What Works

    Tetraamylammonium iodide stays stable over months if stored properly, but anyone who has worked with quaternary ammonium salts knows that they can pick up water or degrade under poor storage. We recommend sealed vessels with desiccant and limit exposure to air in humid environments. Fresh batches load up into thick-walled, airtight containers to prevent caking or powder flowing, especially for high-precision work.

    We’ve tackled questions about process sensitivity to temperature swings and humidity spikes. To address these real-world challenges, we test retention and stability under both ambient and simulated shipping conditions—hot warehouses, long-haul trucking, and ocean containers. We learned that cutting corners on packaging leads to recrystallization and clumping, so we use dedicated, lined drums for bulk requests. This approach cuts down on customer complaints and keeps core performance factors locked in place.

    Operators who scale up from Lab to Pilot Plant appreciate honest disclosure about handling: avoid steel scoops, don’t let open powder sit out, wash down lines regularly. Using this approach reduces contamination risk and keeps low-metal grades—critical for catalytic or battery work—within spec.

    Learning From User Feedback—A Two-Way Street

    We collect technical feedback after every major shipment, not just as a formality but as an early warning system for improvement. Customers have flagged issues like batch-to-batch color drift, minor free amine odor, or stubborn residue, and we treat these flags seriously. By tracing root causes—often as simple as trace impurities in base materials or aging filters—we update processes and retrain staff.

    Real-world experience beats theory when optimizing quaternary ammonium compound production. We shifted to higher-purity alkyliodides, tightened temperature ramps, and switched drying techniques over the years based on customer trial runs. This loop of field data and process response lets us stay relevant and trusted by our core user base in specialty science and industry.

    Meeting the Needs of a Demanding Industry

    Markets evolve fast. Where basic quaternary salts used to dominate, today’s users demand blends that perform across green chemistry, electronics, and advanced organic synthesis. New applications appear every season: ionic liquids for novel separations, phase-transfer catalysts for cleaner reactions, supports for film-forming, and even electrolytes for next-generation batteries. Tetraamylammonium iodide from our line meets the real-world requirements of these innovations by offering controlled reactivity and physical form that fit existing process equipment.

    As chemists and end-users shift toward more sustainable chemical pathways, the reduced volatility and ease of handling for this product matter more. Reducing workplace exposure and environmental load comes with no loss in yield or reliability. We benchmark every tweak to make sure that updates mean practical gains in application, never just a marketing line.

    Standing on Consistency, Not Hype

    The market’s flooded with generic re-bottled compounds that too often leave buyers solving midstream problems. As the actual manufacturer, we stand behind every lot of Tetraamylammonium iodide, because the difference in the field starts long before it ever ships out. Routine QA-QC, real process oversight, and direct feedback from actual users shape our approach.

    Looking back on years in production, the value isn’t just in shipping kilograms of salt. It’s in knowing that what leaves our plant will actually work for the next chemist down the line—whether they’re synthesizing a new compound or assembling the next round of polymer films. This mindset runs deeper than transactional business—it’s the foundation of how we see our role as supplier and partner.

    The Broader View: Industry Trust, Science, and Progress

    Precision matters more now than ever. As regulatory bodies and clients both look for documentation, transparency, and reproducibility, we keep our eye on the future as much as the present. Each advance in quality or traceability we bring to Tetraamylammonium iodide production paves the way for wider confidence in the markets that depend on it. Reproducibility crises and lost batches strain budgets, timelines, and sometimes careers.

    We believe the manufacturing-side clarity we bring helps reduce these risks, not by magic, but by respect for process and listening to those who use the product every day. No hype, no overpromising—just a direct channel from plant floor to laboratory bench.

    By keeping methods straightforward, material clean, and communication open, we not only deliver chemicals—we build a foundation for scientific progress and reliable industry growth year after year. We look at every order as both a responsibility and an opportunity to contribute—to our partners’ success and the field’s continued advancement.