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Tert-Butylurea

    • Product Name Tert-Butylurea
    • Alias 1,1-Dimethylethylurea
    • Einecs 211-536-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    665432

    Chemicalname Tert-Butylurea
    Casnumber 6309-97-7
    Molecularformula C5H12N2O
    Molarmass 116.16 g/mol
    Appearance White crystalline solid
    Meltingpoint 68-71 °C
    Density 1.09 g/cm3
    Solubilityinwater Moderate

    As an accredited Tert-Butylurea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Tert-Butylurea is packaged in a sealed, amber glass bottle containing 100 grams, with clear hazard and identification labeling.
    Shipping Tert-Butylurea should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It must be clearly labeled and accompanied by a Material Safety Data Sheet (MSDS). Transport in compliance with local, national, and international regulations, typically under non-hazardous goods unless specified otherwise by destination or carrier requirements.
    Storage Tert-Butylurea should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible materials such as strong oxidizers. Protect it from moisture and direct sunlight. Ensure proper labeling and use secondary containment to prevent spills. Follow all applicable safety guidelines for storage of chemicals.
    Application of Tert-Butylurea

    Applications of Tert-Butylurea in Industrial Manufacturing

    As an experienced manufacturer of Tert-Butylurea, we supply downstream producers in sectors where technical purity, consistent performance, and regulatory compliance are critical for industrial formulations. The following sections detail major application corridors and illustrate typical implementation data, standard adherence, process design, and resulting product categories for this specialty raw material.

    1. Agrochemical Synthesis: Herbicide and Pesticide Intermediate

    Industrial-scale crop protection manufacturers introduce Tert-Butylurea at specific intermediatory stages when synthesizing urea-based herbicides and certain selective pesticides. The molecule participates in urea condensation reactions, particularly for tertiary substituents, leading to compounds with defined bioactivity. Fluctuations in raw material purity and input ratios directly affect the downstream formulation yield and phytotoxicity profile, so integrating precise quantities of this intermediate under strict compliance frameworks remains essential for agrochemical registrants.

    Industry compliance standards

    • FAO/WHO Specification for Agricultural Pesticides
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • China GB 3796-2019 Pesticide Technical Material Standards
    • US EPA Registration Data Requirement 40 CFR Part 158

    Typical usage ratio

    • Applied at 0.5%–5% by weight in the active ingredient stage, depending on reaction pathway and target yield; adjusted for substrate reactivity and downstream formulation platform (emulsifiable concentrates, suspension concentrates, etc.)

    Downstream process integration

    • Added directly to the urea condensate reaction vessel—either in partial dissolution or via metered feed, depending on the solvent system. The product acts as a nucleophilic agent, forming substituted urea moieties in multi-step synthesis cycles, followed by workup and isolation prior to further derivatization or granulation.

    Final product types

    • Urea-derived pre-emergence herbicides
    • Selective broadleaf pesticides
    • Combination crop protection active ingredients
    • Technical grade agrochemical intermediates

    2. Pharmaceutical Fine Chemicals: Synthesis of API Intermediates

    GMP-compliant pharmaceutical manufacturers use Tert-Butylurea as a key intermediate for certain active pharmaceutical ingredients (APIs), particularly as a building block in heterocyclic structure assembly. When scaling laboratory syntheses to pilot and industrial volumes, operators must monitor for batch consistency and impurity profiles to satisfy regulatory and pharmacopoeial requirements. The differentiated tertiary structure confers selectivity in downstream amide bond formation steps crucial for some barbiturate and anticonvulsant APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF Monographs where urea derivatives are specified as starting materials
    • EU GMP Directive 2003/94/EC
    • ChP/JP/Ph.Eur standards for multi-compendial APIs

    Typical usage ratio

    • Usually 1.0–3.0 molar equivalents relative to the target synthone in the condensation reaction; excess may be minimized by process optimization and recovery. Ratio varies according to route efficiency and target molecule complexity.

    Downstream process integration

    • Dosed under nitrogen into a controlled temperature jacketed reactor after initial ring closure steps; participates in carbamoylation or cyclization—followed by neutralization and phase separation. QC checkpoints focus on residual tert-butylurea analysis and downstream salt removal.

    Final product types

    • Central nervous system (CNS) bulk drug intermediates
    • Barbiturate precursor chemicals
    • Anticonvulsant and hypnotic API intermediates
    • Finished pharmaceutical intermediates under DMF/CEP registration

    3. Specialty Resin and Polymer Additives: Blocking Agent for Isocyanates

    Polyurethane and specialty coatings manufacturers utilize Tert-Butylurea as a blocking agent for aromatic and aliphatic isocyanates during prepolymer and adduct synthesis. This prevents premature curing, allowing resin producers to gauge precise unblocking temperatures in downstream application. The molecule’s tertiary configuration provides a defined deblocking profile, which is critical in heat-activated adhesives and storable PU systems—meeting industry durability and storage requirements.

    Industry compliance standards

    • ISO 9001 Quality Management Systems for Resin Manufacturing
    • REACH Registration Requirements for Isocyanates
    • ASTM D7487 (Standard Practice for Polyurethane Raw Materials)
    • DIN EN ISO 2813 for Paints and Varnishes

    Typical usage ratio

    • Added at 2%–6% by weight to the isocyanate components; dosage selected based on desired latency period and resin viscosity. Polyol-to-blocker ratios tailored per final resin specification and free NCO determination.

    Downstream process integration

    • Introduced after initial polyol mixing and prior to catalyst charging. Blocked isocyanate intermediates are processed via batch reactors with continuous agitation, followed by storage in moisture-controlled silos. Deblocking occurs during final product curing at specified temperatures.

    Final product types

    • One-component polyurethane adhesives
    • Heat-cured industrial coatings
    • Moisture-insensitive polymer dispersions
    • Flexible PU foam precursors

    4. Oil and Gas Drilling: Additive for Corrosion Inhibition in Drilling Muds

    Major service companies in oilfield operations specify Tert-Butylurea as a specialty additive for water-based and synthetic drilling muds, where it functions as a corrosion inhibitor for downhole steel components. The tertiary urea structure demonstrates compatibility with polymeric fluids and multi-ion brines found in deep drilling environments, delivering stability under high temperature and pressure while meeting environmental disposal requirements for mud systems.

    Industry compliance standards

    • API Specification 13A for Drilling Fluid Materials
    • ISO 10414-1 Oil and Gas Field Testing Procedures
    • OECD Guidelines for Testing of Chemicals (Environmental Safety)
    • REACH Annex XVII—Restrictions on Corrosive Substances

    Typical usage ratio

    • Dosed at 0.2%–1.2% by total mud weight depending on brine concentration, temperature, and pipe material grade; field engineers adjust based on real-time corrosion monitoring data and compatibility with other fluid treatments.

    Downstream process integration

    • Continuous inflow through chemical dosing pumps into mud mixing units, typically after primary base fluid preparation and before fluid recirculation to the drill string. Periodic in-situ adjustment performed according to corrosion coupon analysis.

    Final product types

    • High-performance water-based drilling fluids
    • Oil-based and synthetic drilling muds with corrosion control
    • Completion fluid additives for extended well life
    • Deep well stimulation chemicals

    5. Foaming Agent Precursor for Rigid Foam Manufacturing

    Industrial foam producers require Tert-Butylurea as a precursor in tailored blowing agent formulations, facilitating fine cell structure control and reduced thermal conductivity in rigid foam panels and insulation components. The compound ensures consistent evolution of non-corrosive gases during exothermic foaming reactions, with measurable impact on closed-cell index and dimensional stability in end-use insulation products. Its use supports manufacturing lines that must comply with evolving construction and appliance standards for energy efficiency and emissions.

    Industry compliance standards

    • EN 13165 (Thermal Insulation Products for Buildings)
    • UL 94 Flammability Requirements for Foamed Plastics
    • ASTM C518 for Thermal Transmission Properties
    • ISO 9001 Production Traceability in Insulation Manufacturing

    Typical usage ratio

    • Typically 0.3%–1.5% by weight of foaming formulation; precise loading depends on the foaming process (continuous vs. discontinuous), target cell size, and compatibility with polyol or isocyanate system.

    Downstream process integration

    • Integrated as part of the blowing agent blend during premixing; undergoes catalytic decomposition in high-shear foaming reactors. Critical dosing control occurs during panel or block molding to ensure repeatable expansion and gas containment.

    Final product types

    • Rigid polyurethane foam panels
    • Appliance insulation boards
    • Structural foam blocks for building envelopes
    • Refrigeration lining insulation
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    Certification & Compliance
    More Introduction

    Tert-Butylurea: A Practical Solution from the Factory Floor

    Introduction to Tert-Butylurea

    Tert-Butylurea brings reliability to chemical processing. Within our own factory, we rely on this compound in daily runs, producing it with consistent attention to purity and quality. This product shows its strength through performance, not glossy claims. We have worked closely with formulators and engineers over the years, recognizing the real differences our control over production can provide to customers. Every kilogram leaving our facility represents a balance: tight control of starting materials, steady monitoring of temperature and pressure, and a process designed to avoid contamination or batch-to-batch drift.

    As a manufacturer, not a reseller, we know the starting material profiles inside out. The raw isobutylamine and phosgene alternatives chosen affect more than just output yield—they influence color, melting range, and solution clarity. Our team pays close attention at each batch stage. For tert-butylurea, we maintain a white, free-flowing crystalline powder with minimal by-product content, keeping the melting point within 118–122°C, and routinely verifying absence of common impurities like residual urea or tertiary amines.

    Understanding Specifications in the Field

    For many clients, especially coating formulators and fine chemical synthesizers, differences between tert-butylurea producers are obvious. Some supply yellowish, off-odor product that tends to lump during transport. In our experience, those issues come down to lapses in process management or rushed filtration. We take time to ensure neutralization is complete and crystals are properly dried, so what arrives at our customers' facilities is true to spec. That means less downtime fussing with sieves, fewer rejects, and greater safety.

    Analysis in our quality control lab gives more than a certificate. Moisture content stays below 0.2 percent by Karl Fischer. Total nitrogen matches theoretical, confirming purity. Every shipment passes through this loop, not as a box-checking exercise, but because we rely on the same product internally for synthesis of intermediates—if one step is off, it affects the entire chain. So, we make tert-butylurea right the first time, simply because shortcutting now leads to real trouble down the line.

    Uses and Benefits Seen in Application

    Some products come and go with marketing trends. Tert-butylurea, in contrast, has found a home in roles demanding reliability. As a blocking agent for isocyanates, its reactivity profile fits well in protective coating systems. Its blocking group adds stability during storage, yet cleaves cleanly upon curing, with predictable release behavior at moderate heat. This greatly extends pot life and working windows for formulators. In adhesive and sealant work, its crystalline form makes blending straightforward—no caking in hoppers or uneven dosing.

    From our process engineers’ experience, urea derivatives often show variability when alternative alkyl groups are used. But tert-butylurea stands apart. It offers a unique balance: the tert-butyl group introduces bulk that suppresses side reaction rates, yet retains enough backbone similarity to urea for straightforward downstream processing. That allows chemists to tweak properties—such as hardness or chemical resistance—without resetting the whole formulation blueprint.

    Some buyers ask if sec-butylurea or n-butylurea could do the same work. We’ve tried making side-by-side test batches. What we found, consistently, is that tert-butylurea blocks isocyanates more effectively—thermal dissociation starts in a precise, narrow range with less variability, while linear and branched analogues release the blocking group too early or too late, which reduces flexibility in end-use settings.

    Perspective on the Current Market

    Raw material volatility shapes our choices in a way abstract spec sheets never show. We’ve watched prices for amines and carbonyl donors flux in wake of global disruptions. In response, we developed robust sourcing networks and use process intensification to keep costs steady while holding specs. Many large buyers depend on us for uninterrupted supply. Because of our chemical background, we don’t just resell commodity lots; we know which suppliers have cut corners and which batches need extra pre-treatment. This mechanical detail matters because a single contaminated lot can spoil a whole month’s output, and we carry that cost internally, never asking the customer to take the risk.

    We see increased interest in tert-butylurea from innovative coatings manufacturers, as environmental pressures drive reformulation and greener chemistry goals. Regulations in many regions now limit free isocyanate content and demand safer, longer-lived shelf-stable products. In response to increased scrutiny, we provide full traceability for our own product, tracking every input from batch start to final shipping document. This transparency builds trust—and we back it up by inviting visiting technical auditors directly into the plant, allowing them to see our hands-on controls and real-time analytical checks.

    Production Realities and Differences from Other Routes

    Some companies use continuous flow or stop-flow batch reactors to produce urea derivatives. We’ve deliberately chosen a classic stirred tank because it allows more precise control of reaction kinetics and crop size, minimizing fines and dust. Our operators have years of experience handling nitrogenous intermediates; they recognize subtle changes—like a shift in filtration rate or small color changes—that could signal deeper trouble. Rather than relying solely on automation, we insist on real human oversight in every shift.

    There’s a temptation to increase throughput by pushing higher reactant concentrations, but we have found this compromises product quality over time, leading to more downstream purification steps and inconsistent physical form. Careful dosing and attention to reaction endpoints lead to higher yields and less waste. The difference shows up when customers run their own purity checks: our product meets the theoretical values with little variance, saving them time at their own incoming inspection.

    We also recognize significant safety distinctions. Tert-butylurea, as produced in our facility, releases only minimal vapors under storage conditions. This contrasts with lower-alkyl analogues, which can off-gas or form unstable by-products if stored too warm. We package every lot in high-integrity, moisture-proof bags under nitrogen or argon, then double-seal drums to prevent any ingress. This effort might seem over-cautious, but it directly reduces seal failures and regulatory concerns at customer sites, particularly those running 24-hour operations with tight process tolerances.

    Supporting Sustainable Practices

    Manufacturing now means more than just hitting technical targets. We see pressure from downstream users and regulators to reduce waste, energy use, and hazardous by-products. With tert-butylurea, our chemists designed a low-emissions route that minimizes generation of ammonium salts, reducing liquid effluent volumes. Careful solvent recovery and internal recycling systems limit hazardous waste. We publish annual figures for solvent and freshwater use per ton of output, demonstrating commitment beyond compliance.

    Customers from the electronics and pharmaceutical sectors often demand detailed environmental audits before long-term contracts are signed. Our facility stands open to these reviews. We document not only environmental controls, but also worker safety training, emergency containment infrastructure, and record-keeping. Many competitors won’t provide this level of transparency, sometimes because they are resellers with little oversight of source plants. Owning the process lets us guarantee—from the field to the drum—what goes into and comes out of every batch of tert-butylurea.

    Customer Collaboration and Technical Support

    From time to time, a client brings a new application or asks about process adaptation—maybe a waterborne coating, an adhesive with unusual flexibility demands, or a custom curing profile. As the original manufacturer, we run small-scale pilot batches upon request, adjusting reaction ratios or particle size distribution. Direct feedback means we hear right away if a subtle modification could help—whether it's a slightly longer milling time for finer powder, or a tweak in final drying temperature to prevent trace moisture pickup.

    We share not just data, but practical advice. For instance, some users had issues with caking during humid summer months. We worked to recalibrate our drying protocol and adjusted packaging to enhance shelf-life—one of those on-the-ground realities that matter much more than what’s printed on a typical bulk chemical spec sheet. Over time, troubleshooting and discussion like this fosters long-term mutual trust and more efficient supply partnerships.

    Observations on Process Improvements

    Making tert-butylurea to high standards isn’t static. We continually review each step for safety, efficiency, and quality. Heat integration in our plant recovers process vapor energy, diverting it to preheat incoming batches, which shaves both costs and carbon output. On the cleaning side, switching from traditional solvents to more biodegradable mixtures has both simplified compliance audits and kept local discharge numbers well within limits.

    Every year, new instrumentation emerges, tempting manufacturers to automate further. We believe in blending human skill with appropriate technology. Automated batch-cutting software operates alongside visual checks. This hybrid approach allows us to catch those rare process upsets—something only a technician with years of hands-on work might spot in time. This philosophy infects our whole production ethos: owner-operator thinking, not arms-length management.

    Comparisons with Other Urea Derivatives

    Tert-butylurea differs from other aliphatic urea derivatives in behavioral nuances that only come out under real industrial use. For example, compared to n-butylurea, tert-butylurea displays improved resistance to hydrolysis during long transport or storage in humid climates. Over the years, we found n-butylurea can yellow and clump after exposure to warm moisture, driving up cleaning and downtime for clients. The bulkier tert-butyl structure blocks water ingress and elevates both shelf and working life.

    Other urea variants, such as methyl or ethyl derivatives, offer faster reactivity, but this comes at a cost: unpredictable block dissociation, lower melting points, and more pronounced odor profiles. Our field tests—and those shared from customer case studies—support the value proposition of tert-butylurea, especially for large-batch processes running continuously. Reliability with tert-butylurea means reduced test sampling, less batch rejection, and simpler process validation.

    Looking Ahead: Challenges and Opportunities

    Demand for downstream applications, especially in specialty polyurethane foams or advanced coatings, continues to evolve. With each passing year, regulatory pressures and performance metrics tighten, driven by end-users, governments, and NGOs. As manufacturers, we watch these changes firsthand and adjust process parameters proactively, so end-users aren’t left scrambling for substitutes.

    Potential obstacles remain. Supply chain disruptions can upend carefully balanced raw material flows; sudden surges in demand require operational flexibility. Here, experience building local partnerships and staying transparent with buyers pays off. By investing in on-site raw material storage, redundant delivery options, and local maintenance crews, we insulate our supply commitments, helping customers bridge unexpected gaps rather than leaving them searching for alternatives.

    Conclusion: Value Rooted in Experience

    Tert-butylurea, as we produce it, reflects not only technical precision but the lessons learned from years of operational diligence. We prioritize clear communication, rigorous lab work, and on-the-ground flexibility. Real-world production means dealing with surprises: weather events, customs holdups, occasional supply hiccups. What sets us apart is the willingness to face these challenges directly—adjusting runs, rerouting shipments, or running overtime so commitments are met.

    For buyers looking to move beyond the commodity mindset—who value a partner invested in detail, quality, and long-term improvement—our way of making tert-butylurea stands as more than a specification sheet. It represents a living commitment, from sourcing and synthesis to logistics and ongoing support. On the factory floor and in the boardroom, we believe the difference shows in every drum shipped, every formula checked, and every long-term partnership maintained.