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Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate

    • Product Name Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate
    • Alias Metol Brown S
    • Einecs 240-245-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    678569

    Product Name Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate
    Cas Number 68439-57-6
    Molecular Formula C12H18NNaO4S
    Molecular Weight 295.33 g/mol
    Appearance Light yellow to brown powder
    Solubility Soluble in water
    Ph 7.0 - 8.0 (1% aqueous solution)
    Storage Temperature Store at 2-8°C
    Usage Intermediate, dye or reagent
    Synonyms Sodium N-Ethyl-N-(3-methylphenyl)amino-2-hydroxypropanesulfonate
    Purity Typically ≥98%

    As an accredited Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is packaged in a sealed 100g amber glass bottle with a tamper-evident cap and clear hazard labeling.
    Shipping Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate is shipped in tightly sealed containers to prevent contamination and moisture exposure. It should be transported according to applicable chemical safety regulations, with proper labeling and documentation. Store in a cool, dry location. Handle with protective gear during handling and transit to ensure safe delivery.
    Storage Store Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate in a tightly sealed container, protected from light and moisture. Keep in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Label containers clearly and handle with suitable protective equipment. Follow local regulations for chemical storage and ensure easy access to safety data sheets (SDS).
    Application of Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate

    Applications of Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate in Industrial Manufacturing

    As an established manufacturer, we supply Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate to a range of precision-driven industrial sectors. This specialty additive finds proven applications across colorimetric reagent systems, diagnostic test manufacturing, industrial photometric analysis, biological dye formulation, and advanced analytical lab workflows. The sections below outline differentiated application environments, technical standards, dose optimization, production integration steps, and breakdowns of finished product types.

    1. Clinical Diagnostic Reagents – Colorimetric Assays

    Our material plays a critical role as a chromogenic substrate in clinical test kit manufacturing for high-sensitivity enzyme-based colorimetric assays. R&D and QC laboratories employ it in proprietary formulations to ensure selective reactivity and consistent batch-to-batch color development, essential for instruments interpreting glucose, cholesterol, and certain liver function parameters in clinical diagnostics. Formulation control and analytical performance drive the specified use regimes at this end-use stage.

    Industry compliance standards

    • ISO 13485 Quality Management Systems for Medical Devices
    • Clinical and Laboratory Standards Institute (CLSI) guidelines
    • EU In Vitro Diagnostic Regulation (IVDR) 2017/746
    • China GBT 21415-2014 In Vitro Diagnostic Reagents–Manufacturing Practice

    Typical usage ratio

    • 0.1%–1.2% (w/v), adjusted during optimization for substrate/enzyme pairing; instrument color yield targets and sample matrix influence concentration within this range.

    Downstream process integration

    • Dissolution during pre-formulation granulation or liquid blending for chromogenic solution preparation
    • Pre-dispensing into assay wells or lyophilization before kit assembly
    • Staging for QC color reference validation and packaging

    Final product types

    • Automated biochemical analyzer reagents
    • Point-of-care rapid diagnostic strips
    • Clinical multi-parameter test kits
    • OEM wet-chemistry reference standards

    2. Water Quality Analysis – Calibration and Indicator Reagents

    In the water treatment and environmental monitoring industries, this compound serves as a core active agent for colorimetric calibration reagents used in photometric analyzers. Municipal and industrial water testing labs depend on its reliable color signal for accurate quantification of contaminants, particularly in total chlorine, iron, and nitrite determination protocols. Traceability, regulatory alignment, and solution stability are prioritized at the application level.

    Industry compliance standards

    • U.S. EPA Methods 330.5, 315.1, 354.1 for water analysis
    • Standard Methods for the Examination of Water and Wastewater (APHA/AWWA/WEF)
    • EN ISO 7887:2011 Water quality—Examination and determination of color
    • OECD Good Laboratory Practice (GLP) Principles

    Typical usage ratio

    • 0.15%–0.9% (w/v), with final concentration set according to target analyte range and buffer presence; optimized for maximum color resolution and minimum interference in field kits.

    Downstream process integration

    • Solution compounding in batch reactors for large volume standards
    • Automated reagent bottle filling or pouch packaging for field kits
    • QA colorimetric verification prior to batch release

    Final product types

    • Portable photometer calibration standards
    • On-site test tablets and liquid test packs
    • Laboratory-grade water analysis kits
    • Factory-sealed indicator ampoules

    3. In Vitro Research Staining – Biochemical Laboratory Use

    Biochemical and life sciences research organizations use this material as a specialty stain in protein and enzyme activity detection assays, providing well-defined colorimetric endpoints for quantification. Researchers select it for its sensitivity, minimal cross-reactivity, and stable color intensity in cell-free system analysis and biotechnological R&D projects. Integrated controls and documentation facilitate compliance and reproducibility concerns.

    Industry compliance standards

    • ISO 17025 Laboratory Accreditation for Testing and Calibration
    • GLP compliance as per OECD series No. 1
    • NIH Recombinant DNA Advisory Committee guidelines (as applicable in biotechnology)

    Typical usage ratio

    • 0.05%–0.6% (w/v), precisely tuned according to sample absorbance range and protein concentration in microplate or cuvette assays.

    Downstream process integration

    • Direct dissolution into biological buffers during initial reagent assembly
    • Pre-mixing with stabilizers for ready-to-use laboratory kits
    • Inclusion in multi-component formulation for endpoint detection sequences

    Final product types

    • Protein quantification microplate kits
    • Enzyme activity analysis substances
    • Research-grade cell-free system stains
    • Biochemical teaching laboratory reagents

    4. Industrial Photometry – Photometric Standard Solutions

    Producers of photometric reference materials integrate the compound as a primary color reference for calibrating spectrophotometers and automatic analyzers used in industrial quality labs. Calibration service providers and end-use manufacturers employ it to develop traceable standard solutions, ensuring linearity checks in absorbance or transmittance measurements for metals, organics, and key process parameters in manufacturing workflows.

    Industry compliance standards

    • ISO/IEC 17025 for Calibration Laboratories
    • NIST Traceable Standards for Colorimetry
    • ASTM D1209 (Platinum-Cobalt Color), as referenced for industrial liquids

    Typical usage ratio

    • 0.2%–1.0% (w/v), tailored per calibration range and optical pathlength; adjusted by lab QC requirements for target absorbance and reference slope fidelity.

    Downstream process integration

    • Batch dilution with ultrapure water or matrix solutions in class A glassware
    • Sterile filtration and ampoule filling under cleanroom conditions
    • Sealing and labeling for traceability before shipment to calibration facilities

    Final product types

    • Spectrophotometer calibration ampoules
    • Factory-set reference solutions for process QC
    • Color standard test kits for technical inspection labs
    • On-site analyzer calibration sets

    5. Food Industry Quality Control – Analytical Reference Systems

    Food and beverage laboratory operations incorporate this colorimetric agent as a reference in validating color and clarity standards within analytical QC protocols. Its consistent chromogenic response underpins reliable calibration of hydration studies and additive residue screening. Use remains anchored to established food testing quality schemes, supporting rigor required by multi-national integrators and regulatory agencies.

    Industry compliance standards

    • ISO 22000:2018 Food Safety Management Systems
    • AOAC Official Methods of Analysis
    • Food Chemicals Codex (FCC)
    • EU Regulation (EC) 852/2004 on the Hygiene of Foodstuffs

    Typical usage ratio

    • 0.1%–0.5% (w/v), adjusted according to food matrix and detector sensitivity; concentration finalized during in-process assay method development.

    Downstream process integration

    • Standard solution preparation in laboratory analytical workflows
    • Automated dispenser filling for batch color reference kits
    • Documentation for conformity assessment and routine QC audits

    Final product types

    • Reference standards for beverage color assessment
    • Colorimetric food additive residue test kits
    • Commercial food QA laboratory calibration kits
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    Certification & Compliance
    More Introduction

    Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate: Downto-Earth Insight from the Production Floor

    Understanding the Science Behind This Sulfonate

    In our own chemical reactors, the process for making Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate brings science and skilled hands together. Here, on the frontline, we keep tight control over every step. This sulfonate stands out due to its specific balance of hydroxy and sulfonate groups anchored to the aromatic aniline, a structure that lends both stability and water compatibility. The combination of an ethyl and a methyl group on the aniline core isn’t there for show — these specific moieties tune its solubility characteristics and buffer its behavior in formulations. We see this first-hand as raw materials pass through our lines: consistent particle flow, stable mixing, clear solutions, and minimal foaming, which are crucial for our partners downstream.

    Years in manufacture teach the difference between theoretical performance and real-world function. Sulfonates like this one don’t hide their quirks; careful integration of the N-ethyl and 3-methyl groups takes those quirks and turns them into performance advantages. During synthesis, these substituents speed up dissolution and limit unwanted side reactions, especially where trace metallic ions or pH changes cause trouble. The resulting sodium salt form flows like a powder, resists caking in reasonable humidity, and dissolves rapidly in cold water during actual operations — these seem small on paper, but we know they translate into tangible gains once the product hits a filling line or a blend tank.

    Specifications That Matter to the End User

    From our side, hitting specification means more than a test certificate or a purity figure on a report. In the plant, purity is a living reality — we watch batches for color drift, off-odors, and missed conversions. Users often ask about lot consistency, and rightly so. Inconsistent composition can impact batch yield or generate haze or particulates where clarity is needed. To meet the markets that rely on tight quality — dyes, analytical reagents, and specialized detergents — our batches keep iron, heavy metals, and insoluble residues under tight controls. Production routes avoid halogenated intermediates or unstable soluble by-products, which cuts out headaches for formulators who chase wide specification bands.

    Real use cases drive the target specs for mesh size, moisture content, and active content. If a downstream partner runs closed-system dosing, caking resistance saves them money and time. If their equipment uses fast-dissolving solid feeds, our internal grind and sieve processes ensure dust levels stay manageable, improving both hygiene and product utilization. Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate doesn’t throw surprises in filtration, either — low residual ash and particle control mean filters don’t clog up the way they sometimes do with less-refined sulfonates. End-users who use spectrophotometry or precision detection see little interference from background absorbance, a quiet benefit that comes from tight control over organic byproduct removal.

    Applications Shaped by Production Wisdom

    Stepping away from generic description and into practical wisdom, we watch where our sulfonate shows its value. In the labs of global textile, water treatment, biochemical research, or color chemistry, our product finds its place beyond only being an additive. Customers who need predictable behavior in aqueous solutions and non-interference in downstream chemistries lean on this compound. For textile coloration or dye formulation, the molecular structure delivers enhanced wetting and improved dye solubilization — traits that can mean the difference between batch success and scrap. In detergent and specialty cleaning applications, low foaming and a mild, adaptable profile help blends stay compatible with sensitive fabric and high-speed industrial machinery.

    In analytical work, where colored indicators make or break titrations or biological staining accuracy, trace impurities or unexpected shifts become a scientist’s nightmare. Here, years of addressing actual user feedback led us to refine our purification process, avoiding the sulfur or halogen loading that brings noise into otherwise clean spectroscopic windows. This is not just a bullet point, but the result of chemistry teams pushing for cleaner, sharper baselines in real-world experimental setups. Our facility’s analytical chemists run every lot against a broader spectrum range than minimum requirements, because we know academic and industrial users expect fewer re-tests and less troubleshooting when batches are consistent.

    Why Specificity in Structure Counts

    Those curious about the need for the N-ethyl-3-methylanilino logic often ask us about similar sulfonates. Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate beats many in the same family on solubility and pH stability. Substituting the methyl position, or removing the ethyl from the nitrogen, always shifts the dissolution curve or brings risk of precipitation and side coloring. During upstream tests, altering these groups in pilot batches created products that clumped, released unwanted odor, or settled out too quickly for buffered analytical use. Standard sodium hydroxypropanesulfonate or monosubstituted analogs, while cheaper, don’t provide the same quick wetting, color, or chemical comfort for high-purity uses.

    Operational wisdom also affects our choice of finishing methods. Standard drying and grinding steps don’t always guarantee uniform flow — years of working with glass-lined dryers and tightening airflow through our milling stages drove us to develop in-line checks and batch-to-batch traceability. Those changes mean technicians on the user’s end aren’t fighting blocked feeders or inconsistent free-flow, especially in precise automated systems. Most packaged lots run with built-in anti-caking methodology developed from direct feedback, not just theory. Compared to bulk commingled sulfonates brought in by resellers, our approach is more about removing day-to-day hurdles: no mess, less mishandling, smooth product movement.

    From Factory Routine to User Challenges

    On a regular morning in production, the team monitors color consistency, adjusts dryer parameters, and logs any deviation in flow rate or particle size. Feedback loops with R&D and repeated coordination with bulk users have shown us time and again that the devil is in the details. Small changes in raw material quality or reaction time might not be visible under basic testing, but downstream, those changes matter. Textile manufacturers see variations in wash fastness or color bleed, analytical labs hit variable baselines, and cleaning-product manufacturers get complaints about residues. Close collaboration between synthesis and QC teams helps us nip these issues at the source, adjust process controls, and deliver product that users can count on in real-world batches, not just under ideal test conditions.

    Customers running pilot batches appreciate batch samples directly from main production, with no offgrade or uncharacterized material. Our sales and technical support never hide behind jargon or paperwork walls — we invite deeper technical questions and welcome plant visits where possible. During audits and external assessments, our open-book approach allows third-party reviewers or client chemists to check our documentation, raw materials, and change logs in detail. Since we run our own reactors, granulation, and logistics, feedback can translate into an immediate tweak or process upgrade, without negotiating with layers of third parties.

    The Hands-On Value of Consistent Quality

    Working directly from chemical manufacturing rather than through a distribution network changes the equation. Every lot ships with a labeled time, batch origin, and full analytical run, not just a generic tracking number. Sulfonates with loose specs or unknown handling histories may introduce surprises and force users into extra purification or averaging steps. Uncoated metal parts, inconsistent packaging, and moisture intrusion cause real-world problems like bridging or spoilage — we choose lined containers, double-bagging for humidity-sensitive applications, and use silica packs as needed based on actual seasonal trends observed in warehousing. Plant personnel monitor outbound shipments and track feedback on clumping or discoloration, adapting storage or shipping as needed from lessons learned the hard way.

    Production-scale reality means we can observe the impact of scale-up issues before they hurt the end-user. For example, we learned early that reactor load and temperature swing matter much for the color and solubility profile of Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate. Small batch and pilot parameters do not scale perfectly — optimizing jacket cooling rates, improving filtration holds, and extending mixing times brought tangible improvement, and reviews with end-users guided every step. Our support for custom packaging, mesh size, or on-demand blending doesn’t draw extra fees or delays; it comes from a grounded awareness of how even minor differences get magnified in automated processing and large-scale blending.

    Comparing to Other Sulfonates: Function over Hype

    Talk about substitution always circles back to cost and performance. Price-sensitive buyers sometimes ask if an alternative can work in their system. Standard sodium sulfonates (lacking the anilino group, or with mono-alkyl substitution) deliver basic solubility and surfactant function, but skip past issues like absorption characteristics, specific reactivity, or color stability in finished mixtures. Our product’s dual aromatic substitutions drive higher dye affinity and improved solution clarity in challenging chemical environments — the very tests where generic grades fall short in archival or long-lived applications.

    Direct discussions with QC teams at major user plants have drawn out these contrasts. Blends with higher trace iron or unwanted isomer content lead to streaking in dyes, unpredictable staining in biomedical settings, or clumping in dry blends. The specific molecular shape and regular purification behind our product aim to sidestep these failures. Our routine includes cross-checks between batches, routine recalibration of spectroscopy for minor byproduct detection, and rapid response to flagged issues. Over the years, the actual failure rates reported by clients using our sodium 3-(N-ethyl-3-methylanilino)-2-hydroxypropanesulfonate shrank compared to those using mixed-lot, lower grade, or import-only alternatives, especially in time-sensitive or deeply specialized research protocols.

    Partnerships Built on Transparency and Mutual Learning

    Manufacturing this compound on-site puts us side by side with evolving user needs. When a customer in Japan required rapid-dissolving grades for a novel textile inkjet platform, the factory team ran weeks of trials, adjusting recrystallization and neutralization to shave minutes off solution preparation time. For a European water testing company who ran into cross-contamination in standard grades, our technical crew adapted the RP-HPLC and UV scanning methods, pushing analytical limits to resolve a unique background impurity that a standard screen might miss. Knowledge moves both ways: user feedback cycles directly into engineering logs and ongoing process improvements.

    Beyond the technical, ethical manufacturing isn’t just a slogan in our plant. We run closed-waste loops for byproducts, switch to lower-toxicity cleaning solvents after years of observing internal health trends, and react quickly when partners request greenhouse-gas traceability or additional environmental metrics. Making changes from the ground up is faster and more honest from inside the production chain, as there’s no need to wrestle with third-parties reluctant to invest in greener solutions or traceability upgrades.

    Solutions Drawn from Factory-Floor Experience

    Process headaches and downstream failures push us to keep evolving. Users who handle dusty, poorly granulated sulfonates with inconsistent wetting point often face equipment fouling or extra filtration steps. With years of hands-on experience, our grinders, dryers, and handlers worked out an approach that minimizes powder drift and clumping, letting clients run with fewer filter changes and faster dissolutions. These process tweaks result from both daily scrutiny and the rare headaches that only emerge during a major client’s plant shutdown due to off-spec powders or melted bridges. Over time, the approach pivots around continual plant-level experimentation and direct communication.

    Unexpected spikes in humidity or a shipment delayed in customs during the rainy season have shown us the importance of reliable, redundant packaging, and the real-world value of online moisture and color checkers. When a large user called about a production halt caused by unexpected color specks, we traced it back to batch-level changes in one precursor source, which then led us to switch to a new vendor after a round of side-by-side trials. Continuous improvement is not a platitude, but a direct reaction to problems that real users and real operators encounter with every shipment and every handling cycle.

    Looking Forward with Knowledge Passed Down the Line

    This compound’s role in industry may evolve. As specialty dyes and analytical reagents change with advances in machinery and laboratory technique, production teams adapt raw material selection and reaction parameters. Inhibiting trace metal loading at the point of synthesis, and moving toward renewable source materials for incoming hydroxypropanesulfonates, both illustrate how manufacturing stays one step ahead of regulations and user requirements. Government rules shift, user applications change, and plant engineers remain alert to the changing demands, balancing cost, purity, and real-life handling.

    No one in the plant expects static processes or unchanging specifications. Regular cross-departmental audits, real incident report analysis, and standing offer of technical support put us in position to help fix or fine-tune uses outside of our direct experience. As direct factory manufacturers, our commitment lies in realizing practical, safe, and consistently reliable Sodium 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonate, not just for today’s needs but as the market and its challenges keep changing. Longevity in the industry comes from more than a good molecule — it relies on a skilled workforce, adaptability, trust built on real-world problem solving, and the refinement that follows both user feedback and our own years of experience in the business.