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Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate

    • Product Name Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate
    • Alias CHBSNA
    • Einecs 223-888-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    708746

    Chemical Name Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate
    Molecular Formula C6H3Cl2NaO4S
    Molecular Weight 265.05 g/mol
    Cas Number 66992-19-2
    Appearance White to off-white powder
    Solubility Soluble in water
    Storage Temperature Store at room temperature
    Synonyms Sodium 3,5-dichloro-2-hydroxybenzenesulfonate
    Purity Typically >98%
    Odor Odorless

    As an accredited Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate is supplied in a sealed, labeled amber glass bottle with tamper-evident cap.
    Shipping Sodium 3,5-chloro-6-hydroxybenzenesulfonate should be shipped in tightly sealed containers, protected from moisture and incompatible substances. Store and transport in a cool, dry, and well-ventilated area. Ensure compliance with applicable local, national, and international regulations regarding chemical handling and labeling. Handle with appropriate personal protective equipment during shipments.
    Storage Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong acids and oxidizers. Protect from moisture and direct sunlight. Ensure the storage area is secure and clearly labeled, with access limited to trained personnel. Follow all relevant safety guidelines for chemical storage.
    Application of Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate

    Applications of Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate in Industrial Manufacturing

    As a direct manufacturer with full vertical integration from raw materials to quality-controlled intermediates, we supply Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate primarily for advanced specialty chemical sectors. The following application scenarios highlight how commercial processors incorporate this compound into finished product manufacturing, informed by compliance requirements, typical usage levels, integration points in downstream processes, and concrete end-product types.

    1. Organic Pigment Intermediate for Dye Synthesis

    Specialty dye and pigment manufacturers rely on this sulfonate as a coupling component in azo, anthraquinone, and heterocyclic colorant synthesis. Its chloro-hydroxy aromatic structure provides unique chromophore formation and stability that is essential in high-performance textile and ink formulations. The material enters the process in multi-stage batch reactors where controlled pH and temperature are critical for colorant yield and purity.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (Annex XVII restrictions on aromatic amines)
    • CETP discharge norms for colorant effluents (local jurisdiction)
    • ISO 9001:2015 Quality Management Systems (for batch traceability)
    • ZDHC Manufacturing Restricted Substances List (MRSL) for textile dyes

    Typical usage ratio

    • 0.8%–2.5% by total reaction mass, adjusted by coupling component reactivity and targeted pigment yield. Higher concentrations used for deeper hues and greater fastness properties.

    Downstream process integration

    • Added after diazotization as the primary coupling agent in azo pigment synthesis.
    • Charged as a core reactant in the preparation of chlorinated azo and heterocyclic dye intermediates.
    • Introduced to the neutralization stage in pigment paste manufacturing for enhanced dispersion stability.

    Final product types

    • Water-based and solvent-based textile dyes
    • High-strength pigment dispersions for inks
    • Polymer-bound organic pigments for plastics masterbatch
    • Paper colorants for wood-free and specialty papers

    2. Pharmaceutically Active Intermediate Production

    This material functions as a precursor or building block for synthesis of certain active pharmaceutical ingredient (API) intermediates where hydroxy, chloro, and sulfonate groups are retained or serve as leaving groups in further modifications. Our customers integrate it during multi-step syntheses under cGMP, where traceability, low residual solvent content, and batch consistency are critical.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • Ph. Eur. (European Pharmacopoeia) monographs (for structural analogues; self-declaration required for non-monograph intermediates)
    • USP General Chapter <797> and <1078> for process water and cleanliness controls
    • ISO 14644 Cleanroom and Associated Controlled Environments

    Typical usage ratio

    • Between 0.3–1.2 equivalents relative to coupling or alkylating agents in stepwise synthesis; final ratio set following stoichiometric requirements for each target intermediate.

    Downstream process integration

    • Serves as an electrophilic aromatic component introduced early in the API route following nitration, reduction, or diazotization steps.
    • Used as a sulfonating agent or reactant for ring substitution reactions under strict pH and temperature control.
    • Added to jacketed glass-lined reactors prior to solvent addition for high-purity intermediate synthesis.

    Final product types

    • API intermediates for anti-inflammatory and anti-infective compounds
    • Sulfonated aromatic bulk intermediates for contract pharma synthesis
    • Building blocks for veterinary pharmaceutical actives

    3. Electroplating Bath Additive for Surface Finishing

    Electroplating chemistry suppliers incorporate this sulfonate as a brightener modifier and leveling agent in specialized plating baths for metals like nickel and copper. Its unique substitution pattern helps suppress undesirable grain growth and improves deposit uniformity, essential in electronics and decorative plating lines. Customers set concentrations through small-scale bath validation and ongoing QC.

    Industry compliance standards

    • RoHS (Restriction of Hazardous Substances Directive) for electronic hardware
    • IEC 62321 methods for heavy metal content and leachates
    • ASTM B571-97 (Standard Practice for Qualitative Adhesion Testing of Metallic Coatings)
    • ISO 4527 (Electroplated coatings of nickel plus chromium)

    Typical usage ratio

    • 30–200 ppm in working bath solution, based on pilot trials optimizing for leveling and deposit brightness; higher levels risk decreased bath stability.

    Downstream process integration

    • Dosed into recirculating plating baths after pH adjustment and initial metal ion complexing.
    • Fed continuously during production runs to maintain stable functional additive concentration.
    • Introduced in maintenance top-off protocols to restore brightener/leveler balance after drag-out losses.

    Final product types

    • Bright nickel-plated electronic contacts and connectors
    • Decorative chrome-plated sanitary fixtures
    • High-uniformity copper-plated PCB base layers
    • Precision-plated watch and instrument casings

    4. Photographic Chemical and Imaging Auxiliary

    In industrial photochemistry, this compound acts as a reducing agent stabilizer and anti-fogging component within developer and fixer formulations for commercial black-and-white and X-ray film processors. Its functional groups aid in controlling reduction potentials and prevent unwanted silver halide fogging during large-scale batch processing. Our customers work under strict environmental and quality protocols to support imaging reproducibility and waste minimization.

    Industry compliance standards

    • ISO 18901 (Imaging materials – Processed photographic films)
    • ANSI IT9.11 (Photographic processing effluent management)
    • CE marking for medical X-ray film chemicals
    • REACH Annex XIV listing for restricted chemicals and byproducts

    Typical usage ratio

    • 150–350 mg/L in developer and fixer working solutions, adjustable by film throughput and environmental load. The precise ratio is governed by process temperature and silver ion concentration.

    Downstream process integration

    • Dissolved directly in make-up tanks before solution filtration for high-volume film processors.
    • Metered via dosing pumps to batch fixer baths following initial solution makeup.
    • Included in microfiltration steps to minimize particulate contamination in sensitive processes.

    Final product types

    • Industrial and medical X-ray film sheets
    • Black-and-white motion picture films
    • Archival-grade photographic prints
    • Specialty imaging media for scientific purposes

    5. Specialty Paper Chemical—Color Developer Component

    Manufacturers of heat-sensitive (thermal) paper apply this sulfonate as a key coupler in color developer layers. Its halogenated and hydroxy-sulfonated aromatic ring provides sharp color stability and resistance to background discoloration, vital for receipts, tickets, and label stock. The compound disperses in highly controlled waterborne or solvent-borne coating slurries under precise QC monitoring, as uniformity directly affects print contrast and durability.

    Industry compliance standards

    • EN 12281:2002 (Printing and business paper requirements)
    • ISO 187 (Paper—Physical property QA)
    • FDA 21 CFR 176.170 (Paper contact substances compliance for food packaging paper)
    • BfR XXXVI (German approval for paper & board)

    Typical usage ratio

    • 0.4–1.1% by dry coating weight; applied as a proportion of the total developer formulation mass, with higher loading for direct thermal label stock demanding extended image stability.

    Downstream process integration

    • Dispersed into aqueous or solvent-based color developer slurries pre-coating via high-shear mixing.
    • Applied to base paper via Meyer rod or blade coating, then thermally cured inline to ensure layer integrity.
    • Integrated into QC sampling for residual sulfonate and uniform layer evaluation.

    Final product types

    • Thermal receipt and POS papers
    • Logistics label stock
    • Lottery and ticket stub stock
    • Medical diagnostic slip base papers
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    Certification & Compliance
    More Introduction

    Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate: Practical Value from the Manufacturer’s Bench

    Introduction: Understanding the Chemical Beyond the Label

    Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate, often abbreviated in our lab notes as SCHBS, reflects years of incremental improvements and steady work to meet the expectations of downstream partners. Our team’s relationship with this compound goes back over a decade, and much of our know-how is baked into the consistent batches rolling off our production line. This compound has its own way of behaving—sometimes predictable, sometimes presenting small surprises—and we have come to recognize the telltale signs of a healthy lot just by looking at its crystallinity and smelling the faint, almost metallic note it gives off at the end of a long synthesis day.

    What We Actually Make: Identity and Specifications

    Each batch of SCHBS hails from a controlled synthesis using chlorinated precursors and sulfonation steps that demand full attention to reaction time, temperature, and pH. This is not a commodity chemical. It typically demands tighter analysis compared to standard sulfonates, especially due to the double chlorine substitution and the role that hydroxy groups play in final reactivity. Our product leaves the plant as a white to off-white crystalline powder, with a precise sodium content that we monitor closely. With a typical assay above 98 percent and moisture levels below 1 percent, our chemical meets the needs of customers who reference strict process windows. Most of our peers know that trace organic or inorganic impurities can quickly derail a high-yield synthesis downstream, so our QC protocols center on UV-Vis absorption, HPLC retention time, and titration checks. This focus on analytical controls means each drum carries the confidence of a technician who signed off on the batch personally.

    Daily Manufacturing Realities: Scale and Challenges

    Operating a chlorination reactor on a medium scale brings its own learning curve. Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate’s raw materials supply swings with the market’s appetite for chlorinated aromatics, and periodic shifts in demand flow through to our orderbook instantly. When batch crystallization gets interrupted by a change in cooling rates or ambient humidity, the difference emerges in filterability and bulk density. Workers here learn not to trust a process until they have seen every run behave the same way, and if a shift in raw material grade shows up, our in-line analyzers catch it before the mistake ends up in a finished tote. Much of our edge comes from knowing the signals that suggest something is off—even subtle color or particle changes. So, every lot that leaves our plant is a handshake with the customer as much as it is a transaction.

    Usage in Downstream Industries: Where Our Product Works Hard

    SCHBS has a home in laboratories and production floors focused on specialty colorants, select intermediates within agrochemicals, and a small but reliable crowd of pharmaceutical research labs. Its double chlorine and hydroxy substitution make it a unique player in targeted synthesis, often as a coupling component or as a sulfophenol in the construction of reactive dyes. We have seen technical teams leverage its high purity to build azo-dyes with sharper hue profiles, especially for applications that reject off-tone colors or permanent stains. One mid-sized customer once told us that, out of three sources they tried for a run of experimental herbicide intermediates, only ours cleared the analytical tests without changing their process yields. There are not many shortcuts available with this compound; its reactivity means it either works or it doesn't, and that becomes clear in the first half kilogram of an R&D run.

    How SCHBS Stands Out: Differences You Can Measure

    Other sulfonates come packed as fine-grained powders, flakes, or even solutions. What marks Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate apart is a blend of high purity and a particular robustness toward oxygenation, even when stored in less-than-ideal conditions. This means longer shelf life and fewer headaches for warehouse managers. Many users have told us that SCHBS stores cleanly, avoiding the caking issues that plague more hygroscopic sodium salts. Also, the chromophoric substitution puts our product in a different reactivity bracket compared to simpler benzene sulfonates or hydroxybenzenesulfonates without chlorine substitution. Some new customers recall a false step with a lower purity version, where trace impurities introduced in the course of the chlorination or sulfonation left their projects with low reactivity, strange byproducts, or blockages at the filtration step. From our end, the difference starts from a tightly-controlled upstream supply chain and an in-house policy of running only single-batch intermediates, not blended “average” lots.

    Talking About Safety: Not Just a Checklist

    Handling SCHBS is pretty routine for us at the plant, but we do not ignore the fact that those working with chlorinated sulfonates need gloves, appropriate eyewear, and—when moving bigger drums—dedicated air handling. That chlorine content, despite being built into a stable aromatic ring, always calls for diligence during hot operations or spills. Our experience lines up with most chemical safety sheets: mild skin and eye irritation can follow contact, but in real-world use, we rarely see issues beyond housekeeping reminders. Warehouses storing this compound do better when they keep it dry and well-sealed, a lesson learned after one rainy spell set off a series of caking complaints a few years ago. Every time we cut a corner on packaging—or see a customer do the same—the effect shows up as sticky powder and wasted product. Longevity is as much a storage question as it is a chemistry one.

    Quality Control at the Source

    Manufacturers who take pride in what they send out usually keep their analytical rooms busy. Here, we never release a drum without UV-Vis confirmation and side-by-side HPLC against a reference standard of SCHBS that we’ve archived for years. This isn’t just routine; it has protected customer plants more than once. One notable story: a shipment slated for a dye synthesis plant in southeast Asia sat in customs for extra weeks due to paperwork delays. The customer reported no loss in reactivity or purity, thanks to the stabilizing protocols we follow before packing. If quality slips, the result is not a minor annoyance; it becomes a batch recall or weeks wasted in the field.

    Listening to End-User Feedback: Why it Matters

    Not all manufacturers pick up the phone after the product ships—or open shipments that come back with complaints. We do, and a chunk of what we improve each year comes from that feedback loop. Several years ago, one long-standing client in specialty dye manufacturing pointed to unexpected haze appearing in finished colors. We reran their process steps in our applications lab and discovered a trace sulfate leftover in some test runs, invisible to standard QC. Now, we run additional ion chromatography for every batch, spotting outliers before they leave the plant. Stories like this keep us honest and make us more careful on every subsequent run.

    What Technical Buyers Ask: Sizing Up a Reliable Source

    Chemical buyers working on tight process deadlines or proprietary R&D rarely gamble on an unknown supplier without proof. Questions roll in about lot-to-lot variation, shelf stability, and documentation. Our answer: show them data, let them compare samples head-to-head, and stand ready for an on-site audit. Sites that process sodium 3,5-chloro-6-hydroxybenzenesulfonate in automated reactors know just how much a hidden impurity can plug lines or trigger awkward off-gas events. That risk shrinks with a direct-from-the-source relationship. We build trust batch by batch, not by ticking boxes or hiding behind distributors.

    Environmental Responsibility: A Frontline View

    The manufacturing of organochlorine sulfonates brings with it a set of tough environmental questions. Our factory follows a closed water loop, neutralizing waste streams before discharge, but staying ahead of evolving laws is a reality that keeps us on our toes. The sodium salt form offers safer handling than some ancestors—free acids can rapidly eat through tools and tanks if overlooked. Chlorinated aromatic feedstocks must be contained, tracked, and treated on-site, with no shortcuts. The difference between a responsible operator and a shortcut-taker shows up over time—a local authority pays more visits, or customers start asking harder questions. It takes real investment to keep emissions down, keep solvents recovered, and remain open about the bottlenecks we encounter.

    Where the Product Evolves Next: Process Improvements on the Horizon

    Sodium 3,5-Chloro-6-Hydroxybenzenesulfonate doesn’t feel like a stagnant product to those who work with it every day. Chemistry is not static, especially where regulatory and end-user requirements keep rising. We’re pushing for continuous flow synthesis to improve yields and reduce solvent use, but also keeping an eye on green chemistry directives filtering into client requests. Some upgrades arrive as new impurity removal steps, some as more robust filter presses or drying techniques to keep the powder free-flowing even on humid days. If customers need larger lots or a special particle size, our team meets to find a way instead of shuffling the order to a reseller.

    Problems We’ve Encountered and Solved

    A few years back, we fought with supply instability when a key chlorinated raw material shifted vendor. Yields dropped, and color drifted out of spec. Within a month, two regular buyers noticed and called. Our chemists ran a diagnostics panel, traced the difference to a minor impurity in upstream lots, and changed vendors again. We also heard about unusual cloudiness in a new lot of waterborne formulations. On investigation, it surfaced that one drum had been stored under a leaky roof. Tracking these pain points led to adding more robust desiccant packs and a stricter outbound testing routine. Our takeaway: shortcuts get expensive, and listening cures more headaches than ignoring problems ever has.

    Conversation with Procurement and R&D

    Procurement teams often arrive with cost targets, but the best results stem from a straightforward discussion of their technical targets. Those who share application details—pH range, temperature, and tolerable impurity levels—save time. We believe open dialogue stops problems before they start. A research chemist who described the need for tighter control on bromate byproducts set us on a path to refining purification. Now, his lab can count on lot certificates that actually match reality.

    Building for the Future: What Customers Value

    Many of our regular clients now prioritize not just cost and specification but supply transparency, product traceability, and adaptive support during regulatory changes. We take part in regular audits and site visits by those rare customers who want a closer look at where their intermediates are born. This results in a more stable relationship, with fewer price shocks and emergency substitutes. Those who see the production line in person tend to stay longer, and they witness firsthand the precautions and procedures we implement on their behalf.

    Technical Differences: Not Just a Name on a Drum

    SCHBS carries more than a single function in production plants. Downstream, its role as a coupling agent or chromophoric anchor depends on purity, granulation, reactivity window, and long-term stability under storage. Compared with non-chlorinated analogues, the extra chlorine atoms confer distinct reactivity in electrophilic substitution steps. Many dye and pigment makers find that color strength improves with tight control of these substituents, while side reactions diminish when hydroxy and sulfonate groups are in the right places. Lower purity alternatives or off-grade blends can’t offer the same repeatability, especially in critical medical intermediates or regulatory-sensitive agrochemicals. From our end, each added check and realignment of synthesis protocol pays off in fewer plant shutdowns for clients later on.

    Behind Every Shipment: Real Accountability

    Trust stays fragile in the chemical business. This is true for sodium 3,5-chloro-6-hydroxybenzenesulfonate as it is for any high-purity intermediate. Over time, customers can sense the difference between a supplier who just ships boxes and one who lives and breathes their own quality. We understand that each container sent out becomes a test of our processes, an exam marked not by ourselves, but by someone else’s specification sheet. It is this pressure that keeps our plant striving for improvements and letting experience guide our decisions—from staff training to raw material audits. Technical language and product codes matter less than the ability to deliver what has been promised, batch after batch, through storms and market noise alike.

    Towards Shared Solutions: Manufacturer’s Perspective

    Across the industry, differences in sodium 3,5-chloro-6-hydroxybenzenesulfonate quality often trace back to source traceability, reaction control, and a commitment to strong feedback systems. Our team’s improvements haven’t come from chasing cost alone, but from dialog with users and solving practical problems on a live production line. When the industry moves, we adapt—whether that means qualifying new roll-off packaging to beat humidity, or stepping up impurity tracking as customer specs tighten. Each run in the plant echoes with the feedback of customers and the experience of those who have built the lines by hand. In the end, our compound reaches its full potential not just on the basis of its formula, but on the reliability, transparency, and problem-solving culture we stand behind from order to application.