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Sodium 2-Chloro-5-Nitrobenzenesulfonate

    • Product Name Sodium 2-Chloro-5-Nitrobenzenesulfonate
    • Alias N-1700
    • Einecs 221-088-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    577678

    Chemical Name Sodium 2-Chloro-5-Nitrobenzenesulfonate
    Cas Number 16410-40-1
    Molecular Formula C6H3ClNNaO5S
    Molecular Weight 259.60 g/mol
    Appearance Yellow to brownish powder
    Solubility Soluble in water
    Melting Point Decomposes before melting
    Purity Typically >98%
    Storage Conditions Store in a cool, dry place
    Synonyms 2-Chloro-5-nitrobenzenesulfonic acid sodium salt
    Ph 1 Solution Approximately 6-8
    Hazard Statements May cause skin and eye irritation
    Ec Number 240-462-3

    As an accredited Sodium 2-Chloro-5-Nitrobenzenesulfonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a sealed, amber glass bottle containing 100g of Sodium 2-Chloro-5-Nitrobenzenesulfonate, labeled with hazard warnings.
    Shipping Sodium 2-Chloro-5-Nitrobenzenesulfonate is shipped in tightly sealed containers, protected from moisture and direct sunlight. It should be handled by trained personnel using appropriate personal protective equipment. The chemical is classified as non-hazardous for transport but should be stored and shipped in compliance with local regulations. Avoid contact with incompatible substances.
    Storage Store Sodium 2-Chloro-5-Nitrobenzenesulfonate in a tightly sealed container in a cool, dry, and well-ventilated area, away from moisture, heat, and incompatible substances such as strong acids and bases. Keep the chemical out of direct sunlight and avoid exposure to oxidizing agents. Properly label the storage container and ensure access is limited to trained personnel.
    Application of Sodium 2-Chloro-5-Nitrobenzenesulfonate

    Applications of Sodium 2-Chloro-5-Nitrobenzenesulfonate in Industrial Manufacturing

    Sodium 2-Chloro-5-Nitrobenzenesulfonate serves as a critical intermediate in the synthesis of specialty chemicals, pharmaceuticals, and organic colorants. As a direct manufacturer, we support a range of production processes where our material features as a key active or reactive component. Below we outline primary industrial scenarios where downstream partners integrate our product into their proprietary technologies, compliant with the strictest international norms and technical protocols.

    1. API Intermediate for Sulfonamide Antibiotics

    Pharmaceutical manufacturers utilize this compound in multi-step syntheses for targeted sulfonamide antimicrobial active ingredients. It enters the process at the aromatic sulfonation stage, facilitating construction of the sulfonyl group required for antibacterial performance while meeting regulatory impurity limits set by authorities for parenteral and oral formulations.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP/NF (United States Pharmacopeia/National Formulary) impurity guidelines
    • European Pharmacopoeia (Ph. Eur.) for residual solvents and heavy metals
    • 21 CFR Part 211 (US FDA Current Good Manufacturing Practice for Finished Pharmaceuticals)

    Typical usage ratio

    • Used at 0.5–1.2 molar equivalent per target API intermediate, adjusted based on target molecule and proprietary catalytic efficiencies

    Downstream process integration

    • Added during aromatic sulfonation and subsequent nucleophilic substitution reactions, followed by work-up, crystallization, and step-wise purifications in GMP suites

    Final product types

    • Sulfachloropyridazine (veterinary and clinical grade APIs)
    • Sulfadimidine sodium (pharmaceutical syrups, tablets)
    • Sulfasalazine (anti-inflammatory tablets and suspensions)

    2. Dye Manufacturing: Disperse and Reactive Dyes

    Colorant producers introduce this sulfonated aromatic intermediate during the coupling and diazotization of monoazo and triazo dye molecules, enhancing chromophore solubility and durability. Its halonitro functional groups contribute to colorfastness and washing resistance, especially in textiles requiring stringent wash and light stability.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (certification for human-ecological safety of textile products)
    • REACH Regulation (EC) No 1907/2006 – Annex XVII (regulation on dyes and azo compounds)
    • ZDHC MRSL (Manufacturing Restricted Substances List for textile and leather chemicals)
    • ISO 105 (Textiles – Tests for colour fastness)

    Typical usage ratio

    • Introduced at 2–8% by mass of total dye intermediate charge; final ratio tailored according to required performance properties and shade depth

    Downstream process integration

    • Reacted in high-temperature batch reactors with aromatic amines, forming sulfonated monoazo or triazo dye frameworks prior to spray drying and granulation

    Final product types

    • Disperse yellow and brown dyes for polyester printing
    • Reactive blue and red dyes for cotton and viscose fiber coloration
    • High-wash-fast direct dyes for paper and leather industry

    3. Synthesis of Electronic-Grade Sulfonic Acid Compounds

    Advanced electronics and specialty materials manufacturers demand precise intermediates for the production of high-purity sulfonic acid derivatives. This compound enters the process development for photoresist auxiliaries and specialty electrolyte additives, where control of trace metal impurities and organic byproducts is critical for semiconductor reliability and yield.

    Industry compliance standards

    • SEMI C41 (Specifications for Electronic Grade Chemicals, SEMI International Standards)
    • IEC 62474 (Material Declaration for Electrical and Electronic Products)
    • RoHS Directive (Restriction of Hazardous Substances, 2011/65/EU)
    • ISO 9001:2015 (Quality management systems – requirements for high-purity material handling)

    Typical usage ratio

    • Applied at 0.8–1.5 molar equivalent in controlled reactions; precise dosing governed by target molecular weights and product purity criteria

    Downstream process integration

    • Dosed directly into condensation or sulfonation stages in cleanroom-validated reactors, followed by multiple stage filtration and distillation to achieve ppb-level impurity thresholds

    Final product types

    • Photoresist additive intermediates for semiconductor photolithography
    • P-toluenesulfonic acid derivatives for microelectronics encapsulation
    • Specialty sulfonic acid catalysts in printed circuit board production

    4. Intermediate for Agrochemical Synthesis: Herbicide Formulation

    Agricultural chemical producers use this intermediate to manufacture selected sulfonylurea and triazine herbicides. The compound enables introduction of specific nitro and chloro groups necessary for subsequent ring construction and enhances downstream formulation stability and biological specificity, conforming to global agrochemical safety requirements.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides
    • China GB 4420.1-2018 (National Standards for Pesticide Technical Material)
    • EPA 40 CFR Part 180 (Tolerances and Exemptions for Pesticide Chemical Residues in Food, USA)
    • ISO 9001:2015 (adopted for batch traceability and process control)

    Typical usage ratio

    • Ranges from 5–10% of the total input for the target herbicidal active’s synthesis, modulated by chain length and desired conversion rates

    Downstream process integration

    • Incorporated at early-stage condensation, followed by cyclization, extraction, and wet milling prior to technical active packaging and microencapsulation

    Final product types

    • Sulfonylurea herbicides (metosulam, halosulfuron-methyl)
    • Selective triazine pre-emergence herbicides (atrazine derivatives)
    • Granular and suspension concentrate pesticide formulations

    5. Polymerization Additive for Water-Soluble Polymers

    Producers of water-soluble polymers incorporate this compound as a sulfonation agent to impart hydrophilicity and ionic strength to specialty polyacrylamide and polyvinyl polymers used in municipal water treatment and oilfield EOR (enhanced oil recovery) systems. Its molecular configuration enables targeted functional group integration, resulting in improved polymer handling and end-use efficiency.

    Industry compliance standards

    • NSF/ANSI 60 (Drinking Water Treatment Chemicals – Health Effects, US)
    • EN 1407 (Chemicals used for treatment of water intended for human consumption – Polyacrylamides)
    • FDA CFR 21 173.310 (Boiler Water Additives)
    • ISO 9001:2015 (Quality management for industrial polymer production)

    Typical usage ratio

    • Ranges between 0.2–3.5% by weight, determined by the desired degree of sulfonation and final polymer charge density; dosing adjusted for viscosity and solubility targets

    Downstream process integration

    • Introduced during copolymerization or post-polymerization sulfonation in jacketed reactors; downstream blending, dilution, and stabilization steps ensure uniform product quality

    Final product types

    • Anionic polyacrylamide flocculants for municipal and industrial water treatment
    • Oilfield drag reducers and dispersants
    • Superplasticizer intermediates for concrete admixtures
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    Certification & Compliance
    More Introduction

    Sodium 2-Chloro-5-Nitrobenzenesulfonate: Our Experience Drives Reliable Results

    A Chemical Built Around Consistency and Detail

    Producing Sodium 2-Chloro-5-Nitrobenzenesulfonate day in and day out shapes how we understand both the chemistry and the expectations of those who rely on it. Each batch, from the time raw materials enter our warehouse to the point it ships out the door, reveals subtle, real-world lessons about what matters most to end users. Within sulfonated benzene derivatives, variations in substituent group placement and purity frequently determine if a process line runs smoothly or stalls. We have found that genuine, full-process control across all steps pays off, not only in analysis but on actual factory floors and formulation lines.

    Understanding the Product at the Core Level

    Sodium 2-Chloro-5-Nitrobenzenesulfonate has the molecular formula C6H3ClNNaO5S. This compound stands apart based on both its dual substitution pattern and the reactivity those groups offer. In our facility, we use a well-vetted synthesis route, preserving reaction control from sulfonation through chlorination and nitration. The finished salt arrives as a yellow crystalline powder that remains stable and easy to handle under routine industry conditions. Tests for moisture, pH, and residual solvents guide every lot, ensuring downstream users in dyes, pigments, or electronics avoid unexpected fluctuations.

    Consistency Is a Direct Result of Plant Decisions

    Control over source materials shapes everything that follows. Each raw chemical, whether sodium nitrite or chlorobenzene, comes with its own challenges. Early on, we learned that every impurity or slight variation in chlorination temperature will magnify through to the final sulfonate salt. Rather than shifting blame to suppliers, we apply extra purification and use real-time instrumentation. Chromatographic analysis is matched with hands-on sampling. We know from feedback that small deviations, even below a percent, show up in highly sensitive dye synthesis and photoresist applications. Relying on our own measurements, not outside promises, drives consistency.

    Why Substitution Pattern Matters More Than It Seems

    Working with aromatic sulfonates for decades, we see consistent trends in how positional isomers behave. The ortho, meta, and para positions for chloro and nitro groups yield very different compatibility profiles. In the 2-chloro-5-nitro arrangement, both electron-withdrawing groups sit apart far enough to limit internal deactivation during chromophore construction, but not so far as to lose reactivity entirely. Many clients tell us, especially in pigment synthesis, that attempts to swap in other regioisomers lead to poor color fastness, solubility issues, or even toxic byproduct formation. Replication matters more than theory. What our reactors produce is known, batch to batch, and independently retested before it leaves our site.

    Direct Applications and End-User Experiences

    We produce this compound mostly for the manufacturing of dyes, intermediates in the pharmaceutical sector, and additives for specialty polymers. Dyes using this salt deliver vibrant color intensity, having a chemical backbone that fuses well, whether for direct textile applications or as an intermediate. Feedback from users shows a clear benefit in shade stability and washing durability compared to less selectively substituted alternatives. In pharmaceuticals, customers pressing for higher-purity intermediates often approach us after dealing with inconsistent imports. Technical managers from formulation labs describe direct improvement in yields and a drop in reaction troubleshooting after switching to our make.

    In electronics, clients in Asia and Europe require metal-free organic salts with predictably low trace heavy metals. Our in-house equipment, from reactors to dryers and filters, never processes halogenated oils or metallic catalysts commonly blamed for trace contamination in competitor's lots. Factories running high-throughput PCB resins report fewer rejects once they switch to our sodium 2-chloro-5-nitrobenzenesulfonate, citing reduced discoloration and toning instability. These aren't claims on paper—they come from discussions with plant engineers, who see the real downstream effects of every component. Several large coatings and ink manufacturers say that fine-tuned batch control eliminates their need for secondary purification, saving money and downtime.

    Pushing for Better Product Every Year

    Our process upgrades don't come from market demands alone. Every year, plant staff and R&D chemists gather to review where even incremental gains can be made. In one example, a plant-level operator flagged a slight color shift on drying trays. Investigation traced it to a subtle difference in incoming sodium carbonate batch quality, changing the course of neutralization. The change might look trivial in a spreadsheet, but under high-sensitivity colorimetry, it affected UV-resistance and shelf appeal of certain blue and violet dyes produced with our product. This led us to adjust supplier vetting and in-line blending controls, achieving a tighter color window as proven in external ISO audits. Those results filtered out into fewer customer complaints about lot-to-lot variation and eliminated logistical mixing headaches for ink blend managers.

    Routine isn’t static. Minor solvent recovery improvements have delivered a dual benefit: lower environmental footprint and higher product purity. For many buyers, especially those operating under European and North American chemical regulations, this means less back-and-forth for compliance paperwork. In recent years, we’ve reduced residual toluene and other volatile organics in the finished salt by over 80 percent. Environmental managers at multinational dye plants no longer need to spend weeks on additional post-receipt testing—certified, measured data arrives with each shipment, matching their own lab findings. This practical, on-the-ground engineering matters just as much as meeting a number on a COA. We focus on what users see and struggle with, not just formulas and numbers.

    Real Differences from Similar Chemical Offerings

    Inside the universe of benzenesulfonates, shoppers encounter both generic sodium benzenesulfonates and competing chloro- or nitro-substituted products. Several differences shake out in plant trials. Generic benzenesulfonate lacks the electron density modification given by the 2-chloro and 5-nitro groups, leading to poor action as a coupling partner in azo dye manufacturing. Some users have trialed the mono-nitro or mono-chlorinated sulfonates, yet found themselves doubling stabilizer loads, disappointing end customers who demand resistance to oxidation or bleaching agents. The cost appears similar up front, but over dozens or hundreds of process runs, the need for corrective additives and higher reject rates outweighs the savings.

    Another comparison comes up against potassium salts and mono-sulfonated derivatives. Sodium salts often dissolve more predictably in aqueous-organic systems, reducing foaming and cake formation during mixing. In reactive dye intermediates, the interaction of the 2-chloro group opens up targeted coupling routes. A technical lead at a major pigment factory mentioned their transition from potassium-based variants cut their mixing times, improved dispersion, and reduced problems during spray drying. Experience teaches us that a small change in anion or side-chain can tip operational costs, even if the initial chemical looks correct on paper.

    Balancing Purity with Scale and Cost

    Pursuing higher purity levels creates real-life tradeoffs between throughput and rework costs. At scale, industrial buyers often face tough choices between price and downstream efficiency. Consistently shipping material at >99.5% HPLC purity didn’t just happen due to paperwork; it comes from day-to-day tracking of mother liquor recycling, filter cake disposal, and controlled thermal input during nitration. Early runs produced by others–with only broad-range analytical spot checks–caused major trouble for colorant manufacturers, who struggled with both process sludging and inconsistent endpoint color. By building separate process lines, limiting cross-contamination, and regularly investing in staff training, we’ve found it possible to meet tighter purity specs without driving up costs unnecessarily for our core buyers.

    We often field requests for semi-custom grades or narrow particle size ranges, especially from pharma contractors. Instead of offering a one-size-fits-all “premium” product, our philosophy has been to build flexibility into the plant itself: modular filtration, on-demand drying, and multiple-packaging formats. It takes more technical manpower, but the payoff shows clearly as repeat business and lower customer troubleshooting costs. As a direct result, one American inkformulator shifted all annual orders to our sodium 2-chloro-5-nitrobenzenesulfonate grades after repeated clumping and sedimentation problems with an off-the-shelf competitor.

    Safety, Transport, and Real-World Handling

    Many specs overlook real conditions in the warehouse and on the shop floor. Bulk handling brings dust control and moisture pickup concerns. Bags and drums we ship always use lined, tamper evident packaging, because a minor breach will draw water, leading to slow caking or flowability loss. Some customers in tropical and coastal climates told us that cheaper, unlined packaging led to inventory losses of up to 12 percent annually, with no recourse against exporters. Over time, we standardized all shipments on moisture-barrier solutions measured against both Asian monsoon and long-haul container transit scenarios, using employee monitoring at loadout points.

    On the safety front, teams working with this sulfonate daily have embedded best practices: dust capture on every transfer line, grounded containers to disperse static buildup, spill kits at every dispensing bay, and regular worker training. We have not experienced lost-time dust inhalation injuries since 2015, proven by our safety logs. This underlines plant-level engineering over simple paper protocols. Even seemingly minor changes, such as lowering transfer belt height and installing redundant air scrubbers, dramatically reduce real risk. Downstream, this hands-on focus shows up for clients running large dye reactors, with better operator feedback and decreased insurance claims.

    Regulation, Traceability, and Compliance Learnings

    Chemical industry clients face an ever-changing patchwork of local and international controls. From REACH and TSCA to local worker-safety enforcement, compliance is not just a checkbox. Each batch of sodium 2-chloro-5-nitrobenzenesulfonate runs on dedicated tracking, from incoming source drum to final shipment pallet. This isn’t about marketing “supply chain transparency”—it’s about solving headaches our buyers report, like delayed customs clearance or documentation mismatches. In 2022, a European coatings customer flagged non-aligned import lists; fast cross-check on our batch data meant we delivered harmonized paperwork within 48 hours, keeping their own line open.

    For our contracts in food coloring intermediates, we run dual lab validation on all azo dye precursor batches, not simply the sodium 2-chloro-5-nitrobenzenesulfonate itself, but the full supply chain, providing verified trace elements and impurity breakdowns. This routine makes audit requests from multinationals less disruptive, since on-demand data beats scrambling to “find” paperwork after the fact. Some smaller manufacturers try to run light on compliance, chasing faster cuts in cost, but feedback from world-scale dye producers reinforces that up-front transparency saves more lost production hours than nearly any other investment.

    Walking the Floor: On-Site Experience Informs Judgment

    Our position as manufacturer, not just formulator or reseller, means plant walking beats office plans. Every shift change, our managers walk the floor, inspecting batch labeling, drum sealing, and intermediate quality logs. Decisions made at bench level—swapping stirrer blade types, adjusting dryer temperature bands, or suspending a suspicious raw material—directly change outcomes down the line.

    On one occasion, an operator noticed odd stickiness in a new lot. Real-time plant inspection led to tracing a slight pH drift in the final wash water, tied to a newly installed tank cleaning protocol. We didn’t wait for a monthly review to flag the discrepancy: in-line process control led to immediate adjustment, preventing off-spec shipments. This on-the-ground intervention builds confidence in what leaves our plant—no external consultant, digital dashboard, or third-party lab will ever notice details that experienced hands catch after years working with the same chemical.

    Partnerships and Listening: Lessons from Client Collaboration

    Sales and procurement teams talk, but it’s the direct discussions with technical managers and line chemists that shape what we do. For several years, we have collaborated with pigment and specialty polymer companies, sharing test runs and on-site plant visits to co-design better batches. A client in South America flagged excess foaming in large-kettle operations. By adjusting particle size control and monitoring anti-foam carryover in slurry filtration, both teams saw measurable improvements, reflected in easier downstream filtration and higher reactor yields.

    This ongoing dialogue means we occasionally adapt packaging, tweak grade specs, or adjust shipping schedules—not due to outside pressure, but based on shared trial outcomes. Sometimes, we issue technical notices to help customers streamline their own in-house QC, drawing on process tweaks we’ve proven ourselves. These adjustments ripple back to benefit all users, not simply the initial requester. It’s a feedback system, not just a transactional handoff.

    Commitment to Improvement Over Hype

    Boasting or overreaching claims happens often in chemical trading circles, especially when reselling third-party stock. As direct manufacturers, we’ve learned that transparency—open specification sheets, documented complaints, and sharing near-miss experiences—delivers more long-term business than polished marketing ever could. Product reliability comes not from blank checks or slogans, but from daily plant routines, equipped laboratories, team experience, and relentless pursuit of better process. Customers visiting our site consistently point out the difference between a slick corporate presentation and a real plant running with disciplined safety, clean floors, proper labeling, and empowered workers.

    We emphasize steady delivery, rigorous test control, and granular responsiveness. Our sodium 2-chloro-5-nitrobenzenesulfonate batches consistently meet demanding customer needs because of this discipline, and the proof rests in continued repeat orders, not just single-contract wins. This approach keeps lines running, minimizes error-driven costs, and reduces the need for end-user reprocessing. Genuine focus on chemical experience and direct operator insight, not abstract generalities, truly defines the difference for every customer relying on us for their critical supply.