Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Salicylaldehyde Azine

    • Product Name Salicylaldehyde Azine
    • Alias 2-Hydroxybenzaldehyde azine
    • Einecs 209-972-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    542961

    Product Name Salicylaldehyde Azine
    Cas Number 94-67-7
    Molecular Formula C14H12N4O2
    Molecular Weight 268.28 g/mol
    Appearance Yellow solid
    Melting Point 196-198 °C
    Solubility Slightly soluble in water, soluble in organic solvents
    Boiling Point Decomposes
    Synonyms Salicylaldazine
    Storage Temperature Room temperature
    Purity Typically ≥98%
    Chemical Class Azine compound
    Hazard Statements May cause eye and skin irritation
    Applications Analytical reagent, ligand in coordination chemistry

    As an accredited Salicylaldehyde Azine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Salicylaldehyde Azine is supplied in a 25g amber glass bottle with a secure screw cap and detailed hazard labeling.
    Shipping Salicylaldehyde Azine is shipped in tightly sealed containers to prevent moisture and air exposure. It should be stored in a cool, dry, well-ventilated area, away from incompatible substances. Proper labeling and handling are required, following standard chemical shipping regulations for hazardous materials. Personal protective equipment is recommended during handling and transport.
    Storage Salicylaldehyde Azine should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect it from light, moisture, and excessive heat. Always label the container clearly and store it in accordance with local regulations and safety guidelines.
    Application of Salicylaldehyde Azine

    Applications of Salicylaldehyde Azine in Industrial Manufacturing

    Salicylaldehyde Azine finds distinct roles across multiple industrial sectors due to its reactive chemical structure, high purity, and compatibility with advanced synthesis protocols. Here, we detail its real-world applications, integration paths, and compliance guidelines customized to specific manufacturing environments.

    1. Pharmaceutical Intermediate Synthesis

    Leading pharmaceutical producers use Salicylaldehyde Azine as an advanced intermediate, primarily in the synthesis of heterocyclic drug molecules and API side chains. Our industrial clients integrate this material into the condensation stage for forming azine-containing scaffolds, where reaction control and traceability must align with strict QC workflows. Plants operate under cGMP, maintaining batch records and analytic traceability. Our QC lab supports scale-up batches from kilogram to tonnage, adapting the material’s reactivity for targeted medicinal chemistry outcomes. We validate every lot for residual solvents and defined impurity profile by HPLC and NMR.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • EMA Guideline on Manufacture of the Finished Dosage Form
    • Chinese Pharmacopoeia (CP) raw material intermediate requirements

    Typical usage ratio

    • 5–15% by molar equivalence relative to the target substrate, adjusted for desired yield and scale; optimization necessary for impurity control and throughput.

    Downstream process integration

    • Employed immediately before final API crystallization; enters condensation or cyclization step in a nitrogen-purged reactor; solvents and temperature profiles are adjusted per route-specific SOPs.

    Final product types

    • Benzothiazole-based APIs
    • Salicylaldehyde-azine-derivative pharmaceuticals
    • Intermediate bulk drugs
    • Research-grade reference standards

    2. Agrochemical Compound Production

    Formulators in the agrochemical sector utilize Salicylaldehyde Azine for constructing precursor fragments found in modern pesticidal agents and herbicide stabilizers. The chemical is introduced during synthetic build-up of target molecules with azine cores, allowing precise control over reaction selectivity. Facilities follow ISO 9001 QMS and align output with regional agrochemical regulations. Strict raw material inspection ensures batch uniformity for regulatory dossiers. Technical teams collaborate to define impurity limits, avoiding cross-contamination with other actives in shared reactor trains.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System
    • REACH Registration (EU Regulation EC No. 1907/2006)
    • GB 20664-2015 (China Pesticides Safety Management)
    • OECD Principles of Good Laboratory Practice (GLP) for agrochemical studies

    Typical usage ratio

    • 3–10% of formulation weight, recalculated between different target actives and batch sizes; adjustment depends on the synthetic route and post-reaction purification requirements.

    Downstream process integration

    • Incorporated into the initial condensation or cyclization step within closed reaction systems; typically followed by liquid–liquid extraction and solvent recovery before downstream formulation.

    Final product types

    • Herbicide intermediates
    • Aromatic azine-based fungicides
    • Technical grade pesticide actives
    • Chemical reference substances for residue analysis

    3. Dye and Pigment Manufacture

    Industrial dye firms employ Salicylaldehyde Azine as a key building block in synthesizing specialty azine-structured dyes and organic pigments. Leveraging its nucleophilic and electronic properties, colorant producers drive selective reactions yielding stable colorant scaffolds with enhanced lightfastness. Quality assurance mandates follow EN 71-3 for heavy metal residues and cross-check compliance under REACH for chemical risk. Pigment houses utilize automated batching and in-process spectroscopic QC to validate color and purity profiles batch by batch.

    Industry compliance standards

    • REACH (EC) No 1907/2006
    • EN 71-3 Safety of Toys – Migration of Certain Elements
    • ISO 9001:2015 Quality Systems
    • DIN 55945:2016-10 for pigment quality assessment

    Typical usage ratio

    • 2–6% relative to other aromatic amine or aldehyde co-reactants; quantity depends on target pigment class, hue, and final concentration in dye blend.

    Downstream process integration

    • Added at the nucleophilic aromatic substitution stage; process includes pH and thermal control; in-line colorimetric analysis used for yield determination and downstream filtration.

    Final product types

    • Azine-structured azo dyes
    • Specialty organic pigments for plastics
    • Textile dyes with high stability
    • Inkjet pigment concentrates

    4. Analytical Reagent Formulations

    Producers of laboratory analytical reagents rely on Salicylaldehyde Azine as a constituent for creating highly specific colorimetric and complexometric detection agents. The compound acts as a chelating agent or indicator in trace metal or organic analyte quantification, supporting rigorous QA for lot-to-lot consistency and analytical grade purity. Our industrial partners operate under ISO/IEC 17025 accreditation, maintaining traceable formulation records and stability data for all batches supplied to leading testing laboratories and research institutes.

    Industry compliance standards

    • ISO/IEC 17025 Laboratory Accreditation
    • ASTM D1193 for Reagent Water Quality
    • Analytical Reagent (AR) grade specification by ACS
    • GLP requirements for reagent manufacturing

    Typical usage ratio

    • 0.1–2% in final reagent composition, tailored to detection sensitivity and analyte concentration range; end users specify precise ratios during method development.

    Downstream process integration

    • Material introduced at the formulation stage in high-purity vessels; QC includes spectrographic purity analysis, moisture, and trace metal screening before filling and packaging.

    Final product types

    • Colorimetric assay kits
    • Complexometric titration reagents
    • Trace element test solutions
    • Analytical indicator blends for water testing
    Free Quote

    Competitive Salicylaldehyde Azine prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Salicylaldehyde Azine: Delivering Reliability Through Decades of Experience

    Every Batch, Every Time: Manufacturing Confidence Into Salicylaldehyde Azine

    Manufacturing chemicals isn’t about chasing volume or riding trends. In our line of work, every production run means more than process metrics or cost calculations. It comes down to trust—trust in what leaves the reactor, and trust from the user who builds a process on that very product. Salicylaldehyde azine, with its unique chemical profile, sits right in a space where that trust matters more than most. Our years of hands-on experience in organic synthesis have shaped how we approach every aspect of its production and delivery.

    Where Quality Counts: Purity and Reliable Specifications

    Salicylaldehyde azine, chemical formula C14H12N4O2, forms a solid yellow powder with properties chemists value for both fundamental research and manufacturing applications. The product we supply consistently meets a purity of at least 99% by HPLC, with melting ranges that stand up to repeated scrutiny—because one lab’s synthesis can determine another lab’s output down the supply chain.

    Every process step, from initial condensation and extraction to final drying and packaging, gets a close look from people who’ve worked these vessels and glass columns for decades. We recognize that products stuck in a cycle of re-crystallization or endless troubleshooting slow everyone down. So we follow up every batch with full spectral analysis—NMR, IR, and, when needed, mass spectrometry—ensuring the identity and purity match real-world requirements, not just numbers on a spec sheet.

    Why Demand This Molecule?

    Salicylaldehyde azine’s structure gives it a knack for complex synthesis, especially as an intermediate or ligand in coordination chemistry. Our customers put it to work synthesizing heterocycles, fine-tuning metal ion selectivity, and generating organic frameworks for advanced material studies. Some labs rely on it for fluorescence sensing of transition metal ions, while others exploit its functional groups as pivots for downstream modifications. In these cases, impurities or degradation can introduce serious noise, and controlling variables matters most.

    Over the years, direct feedback from researchers has taught us which contaminants cause trouble—whether unreacted salicylaldehyde, trace amines, or side-products like hydrazones. These details guide our tightening of protocols. Implementing low-temperature filtrations and extending washing sequences have directly reduced detectable impurities, based on real batch trouble tickets and customer calls.

    How Experience Shapes Every Drum We Ship

    Our production doesn’t lean on generic protocols. We’ve seen how moisture can cause lumps, how excess solvent can lead to unpredictable crystal formation, and how time in storage impacts stability. We found that storing azine in air-tight double-layer bags, within nitrogen-flushed barrels, has consistently kept product free-flowing and reduced clumping. That’s not a textbook fix—it’s the kind of procedural change that only comes from working through shipping delays or sudden changes in seasonal humidity.

    During the drying phase, ramping temperature too high encourages partial decomposition, producing colored byproducts and an off-smell caught by sharp-nosed operators. Careful thermal profiling, combined with batch sampling at intervals, led us to a slower but gentler process. This ensures the powder remains crisp and golden, without the tinge that signals something went wrong.

    Real-World Applications: Salvaging Time, Reducing Hassle

    In one collaborative project with a university lab focused on coordination polymers, batch inconsistencies almost derailed an entire semester’s worth of results. By adjusting the precipitation solvents and refining pH controls, we provided salicylaldehyde azine that dissolved fully and cleanly, minimizing filtration losses and shortening reaction set-up times by nearly 30 minutes per run. Timing matters when every instrument hour carries a budget impact or public grant accountability.

    Feedback from small pharmaceutical outfits has also shaped our logistics. Some require only a few kilograms a year, while others call for repeated shipments within tight windows. We respond in real time—batch splitting, adjusting drying, and pre-testing unusual lot sizes—ensuring everyone gets the same material characteristics, regardless of order scale.

    Comparing Our Salicylaldehyde Azine to Other Options

    We’ve looked at various commercial sources—offshore, local, and specialty providers. Differences that jump out include inconsistent granularity, batch-to-batch purity swings, and unpredictable delivery timelines. Lab reports from outside vendors show a wider range of melting points and persistent traces of starting materials. Some products arrive grey or brown, pointing to overstressed synthesis or poor packaging.

    Our focus—keeping specifications tight, responding fast, and prioritizing transparency—means researchers and buyers avoid those pitfalls. By supplying clear documentation, including lot-specific COAs with actual chromatograms and spectra, we offer more than a simple commodity. Through open-door feedback sessions (and, occasionally, troubleshooting in person with customers), we adjust our process, not just our paperwork.

    Addressing Storage and Stability Concerns

    Salicylaldehyde azine doesn’t tolerate sloppy storage. We’ve seen what ambient moisture can do, from caking to subtle hydrolysis, which impacts both yield and reproducibility. Customers once reported that after six months in open-lidded containers, tiny but troublesome color changes appeared—signaling partial breakdown. In response, we tightened our packing, added humidity indicators to bulk shipments, and, by listening to storage-room feedback, guided users to keep their stocks cool and dry, preferably under nitrogen or desiccant.

    We’ve studied decomposition profiles at different light and oxygen exposures, balancing thorough sealing with practical handling. Our on-site stability testing, which sometimes means storing material under simulated worst-case lab conditions, continually updates our shelf-life guidance. This builds confidence for customers who don’t always turn over inventory every few weeks.

    Handling and Safety: Lessons Learned from the Field

    On the factory floor and in partner labs, we’ve seen how accidents start—minor spills, dust clouds, or confusion about PPE. For salicylaldehyde azine, inhalation risk is low, but skin sensitivity can trip up those unfamiliar with its properties. We make sure every container leaves with clear, practical handling advice—no jargon, just lived experience. Eye protection, gloves, and basic dust masks remove most risk.

    We’ve participated in industry groups to share lessons, and whenever incident reports trickle in, they spark immediate review of both our internal and external communication. Efforts go beyond one-way warnings; we work with users to adjust signage, trial better dispensing tools, and, in some cases, revise the geometry of shipping drums to minimize awkward manipulations.

    Supporting Innovation in Synthesis and Materials Science

    Our salicylaldehyde azine began as a niche product for academic organics. Over time, researchers uncovered new possibilities—in chemosensor design, in macrocycle templating, in supramolecular assembly. Each new direction pushes us to rethink what characteristics actually matter. Some applications need higher batch purity for photophysical studies; others demand more granular, dust-free powder for automated feeders.

    R&D collaborations have introduced us to edge-case requirements. For instance, certain synthetic flows need azine with ultra-low iron content, pushing us to overhaul old reactor linings and switch to high-purity intermediary solvents. Some materials researchers wanted traceable isotopic content, leading us to investigate custom syntheses at pilot scales. Our close-knit technical team keeps pace with these needs, drawing on both academic partnerships and the hard-won flexibility of a longtime manufacturer.

    Traceability and Transparency: Earned, Not Assumed

    In an era where supply chain disruption and fraud can upend entire research projects, we take a simple, old-fashioned stance—track every lot from raw material to final package, with records open for question and review. Our QC managers sign off not just electronically, but through real-world batch witnessing. This way, we catch the subtle differences in color, grain, or odor that analytical tools sometimes miss.

    Years ago, a run of salicylaldehyde from an outside supplier arrived with an off-taint, invisible to instruments but not to human senses. That lesson reshaped our receiving and supplier-vetting. Today, we sample and verify every drum of every input, maintaining a record that can be traced back months, even years, should a customer need to unravel a downstream hiccup.

    Addressing Challenges in the Industry

    The global chemical supply system moves faster than ever, but outsourcing brings new headaches—variability, untracked impurity profiles, and unexpected regulatory challenges. As a manufacturer who shoulders risk every time a drum leaves our loading dock, the only answer is to build resilience through redundancy and direct communication. We never rely on just one source for a critical reagent, and every production operator carries the authority to halt batches for cause, without fear of reprisal.

    External disruptions—natural disasters, transportation shutdowns, or sudden sectored demand swings—can stress logistics. We counter this by maintaining strategic inventories and direct relationships with trusted forwarders and distributors. Before any crisis escalates, we’re dialed into customer supply chains, offering alternatives or flexible scheduling to keep their work running.

    Listening, Not Just Shipping: Growing With End-Users

    Feedback isn’t a box-checking exercise for us. Many of the advances in our salicylaldehyde azine have come straight from candid post-project reviews or troubleshooting phone calls. One customer flagged minor but persistent dustiness as an issue for automated handling robots. Our process team retooled the milling line, fine-tuned sieving, and eliminated almost all of the problematic fines. Every tweak makes a difference when dozens of runs hinge on a stable powder.

    By supporting customers as partners rather than transactions, we open ourselves to learning—sometimes uncomfortably—about field realities. Requests for specialized particle sizes, ultra-high purities, or custom packaging aren’t treated as a nuisance but as a challenge to grow our skills. In our experience, the products that last in the market are shaped far more by user input than by boardroom targets.

    Building a Future on Solid Foundations

    There’s no shortcut around attention to detail or a rush-job mentality that yields reliable chemical quality. We see salicylaldehyde azine as more than just a catalog entry. It’s a representation of our company’s commitment to enduring, responsible manufacturing. Every improvement, every process adaptation, springs from years of cumulative experience—failures included.

    If you’re looking for a manufacturer who stands behind their product not through marketing gloss, but through a proven record of delivered results, that’s what you’ll find in every drum of our salicylaldehyde azine. By focusing on how it gets made, shipped, and used in real labs, we make sure your next project starts with a product you can count on—from first contact to final application.