Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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Safrole

    • Product Name Safrole
    • Alias 4-allyl-1,2-methylenedioxybenzene
    • Einecs 204-535-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    736790

    Chemicalname Safrole
    Iupacname 5-(prop-2-en-1-yl)-1,3-benzodioxole
    Molecularformula C10H10O2
    Molarmass 162.19 g/mol
    Casnumber 94-59-7
    Appearance Colorless to slightly yellow oily liquid
    Odor Sweet, spicy (similar to sassafras)
    Boilingpoint 232-234 °C
    Meltingpoint -11 °C
    Density 1.096 g/cm3 at 20 °C
    Solubilitywater Insoluble
    Refractiveindex 1.535
    Flashpoint 112 °C (closed cup)
    Vaporpressure 0.1 mmHg at 25 °C
    Pubchemcid 5144

    As an accredited Safrole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A one-liter amber glass bottle labeled "Safrole, 99% purity, 1L". Features hazard pictograms and warnings, securely sealed for transport.
    Shipping Safrole is a regulated chemical due to its use in the synthesis of controlled substances. Shipping safrole requires compliance with international and local regulations, including secure packaging, proper labeling, documentation, and often permits. Only authorized entities may ship or receive safrole, with strict tracking and reporting throughout the transportation process.
    Storage Safrole should be stored in a tightly sealed container, away from light, heat, and sources of ignition. Store in a cool, well-ventilated, and dry area, ideally in a flammable chemicals cabinet. Keep it separate from oxidizers, acids, and bases. Ensure proper labeling, restrict access to authorized personnel, and comply with regulatory requirements, as safrole is a controlled substance in many countries.
    Application of Safrole

    Applications of Safrole in Industrial Manufacturing

    Safrole serves as a specialty chemical intermediate for various industrial sectors, supporting compliant, large-scale production where process precision and traceability are mandatory. Our manufacturing expertise ensures material supply in alignment with international documentation and production frameworks.

    1. Fragrance and Perfume Intermediate Synthesis

    Fragrance compound manufacturers utilize safrole to produce piperonal and heliotropin derivatives, essential components in formulation of aromatic bases. Safrole enters multi-step oxidation and condensation processes leading to high-purity aldehyde compounds. Controlled conditions and defined dosing maintain fragrance note consistency and regulatory thresholds.

    Industry compliance standards

    • IFRA (International Fragrance Association) Guidelines
    • EU Cosmetics Regulation (EC) No 1223/2009
    • REACH Registration (EC) No 1907/2006
    • ISO 9235: Natural Aroma Chemicals

    Typical usage ratio

    • 5–12% by weight in initial synthesis step, adjusted by conversion yield to piperonal or other intermediates

    Downstream process integration

    • Safrole introduced post-fractionation into oxidation reactors; followed by purification and condensation in aroma component workflows

    Final product types

    • Fine fragrance bases
    • Soap and detergent scent additives
    • Personal care perfumes
    • Industrial flavor preparations (trace levels in non-food)

    2. Piperonyl Butoxide (PBO) Synthesis for Agrochemical Formulations

    Agrochemical producers convert safrole into isosafrole, then proceed with oxidation and further synthesis to produce piperonyl butoxide (PBO), a key insecticide synergist. The process requires high-conversion reactors, solvent control, and certified safe handling protocols due to strict government oversight of production and distribution channels.

    Industry compliance standards

    • FAO/WHO Food and Agriculture Organization Specifications for PBO
    • EPA (US Environmental Protection Agency) PBO Technical Grade Standards
    • EU Plant Protection Products Regulation (EC) No 1107/2009
    • ISO 1750: PBO ID Numbering

    Typical usage ratio

    • 8–15% by weight in base-stage synthesis, adjusted for batch purity and final PBO content beyond 90%

    Downstream process integration

    • Initial safrole batch addition after primary cleaning; isomerization and oxygenation pre-final blending; QC for residual aromatic content

    Final product types

    • Insecticide synergists
    • Agricultural pesticide formulations
    • Stored grain protectants
    • Veterinary topical products

    3. Synthesis of Piperonal for Pharmaceutical Intermediates

    Pharmaceutical manufacturers select safrole as a precursor for certified piperonal synthesis, adhering to validated GMP process routes. The compound undergoes multi-phase oxidation, distillation, and fine purification to achieve pharmacopoeial requirements for subsequent application in API and flavoring agent production. Documentation and batch traceability support downstream audit needs.

    Industry compliance standards

    • USP-NF (United States Pharmacopeia–National Formulary)
    • Ph. Eur. (European Pharmacopoeia)
    • Good Manufacturing Practice (GMP) – ICH Q7
    • EDQM CEP (Certificate of Suitability) if applied in European finished APIs

    Typical usage ratio

    • Up to 10% by weight in stage one; adjusted based on required piperonal purity above 99.5%

    Downstream process integration

    • Safrole addition at start of oxidation chain; isolated after crude piperonal separation, followed by fine purification for API-use compliance

    Final product types

    • Pharmaceutical-grade piperonal (heliotropin)
    • Active pharmaceutical ingredient intermediates
    • Certified medicinal flavors
    • Diagnostic chemical reagents

    4. Manufacture of Safrole-Based Surface-Active Agents

    Specialty surfactant producers leverage safrole for preparation of ether and amine derivatives destined for use in textile and leather processing. Accurate control during alkylation and ethoxylation governs surfactant balance, while end-use performance testing validates application-specific behavior under various pH and temperature regimes.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile chemicals)
    • REACH compliance for surfactant raw materials
    • FDA 21 CFR 176.170 for paper and textile additives (if relevant)
    • ISO 9001:2015 (process management)

    Typical usage ratio

    • Typically 3–8% by weight as a starter molecule, adjusted for surfactant chain length requirements and target HLB

    Downstream process integration

    • Safrole introduced at initial phase of etherification; ethoxylation and neutralization steps finalize active surfactant production

    Final product types

    • Textile wetting agents
    • Leather degreasing aids
    • Emulsifiers for finishing baths
    • Industrial cleaning surfactants
    Free Quote

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    Certification & Compliance
    More Introduction

    Safrole: Bringing Precision to Chemical Manufacturing

    Connecting Quality with Experience

    Working directly with raw chemicals every day, I understand that every molecule in the process matters. Safrole stands out from the crowd because, for us as the manufacturer, production goes well beyond pumping out liters. We know the clear, colorless to pale yellow liquid by its subtle sweet-spicy aroma—a dead giveaway to anyone with enough time in the plant. You hear stories about safrole in trade circles, but handling and making it speaks louder than any rumor.

    Description and Physical Characteristics

    Safrole’s chemical structure—1,3-benzodioxole-5-(2-propenyl)—gives it the backbone for a range of applications. In our plant, it rolls off the line with purity levels above 99%. Once you see its clarity under the lights and catch its distinct smell, you know it’s not another generic aromatic oil. Specific gravity ranges between 1.096 and 1.103, and we keep moisture levels below 0.1% to sidestep downstream headaches for processors.

    We use only rigorously tested raw materials. Each batch is checked for acid value, impurity content, and refractive index, always in line with published technical expectations. Fresh safrole pours with a viscosity familiar to anyone working with essential oils—neither watery nor sticky. If the batch doesn’t meet our internal standards on color or odor, it never leaves the floor. Confidence starts with pride in one’s own output, not blind reliance on documents.

    Where Does Safrole Come From?

    We extract safrole the old-fashioned way, mainly from Sassafras albidum root bark and occasionally from camphor trees. This matters more than ever, as forests shrink and genuine material becomes scarce. Direct extraction separates our product from synthetic substitutes. You can spot the difference because synthetic material ends up with off-notes, even to an untrained nose. Genuine natural oil always wins in purity assays and longstanding reliability in downstream synthesis.

    Why Purity Makes All the Difference

    Purity isn’t an empty promise. During essential oil distillation, we monitor heating rates and fractional condensation with experienced hands. Our process trims down unknowns and typical contaminants. As a result, the safrole we supply avoids common trace residues—methylene chloride and other solvents never touch the product. Pharmacopeial testing proves it, but our real confidence comes from trouble-free performance in our own pilot runs.

    Other producers sometimes push out batches with higher moisture or off-ratios of isosafrole. We target these pain points directly so our partners don’t struggle downstream—mainly because we know the cost and frustration of a failed run. The careful approach to purity translates to less foaming and fewer unexpected byproducts in further synthesis. You get the full value of each liter, not a mix of unknowns waiting to complicate your day.

    Safrole’s Role in the Real World

    Plants don’t run on marketing materials; they run on results in the reactor vessel. Safrole plays a central role in the manufacture of fragrances, flavors, and—crucially—intermediate syntheses for industrial organic chemistry. Essential oil blenders and perfumery know safrole’s unmistakable character as a heart note in “root beer” accords, adding warmth and complexity that cheaper aromatics cannot replicate.

    The fragrance industry values safrole for its tenacity and sweet-woody undertones. It anchors heavier bases in a way that only true safrole manages. In our plant, demand often comes from formulators who have moved away from synthetic analogs and want the authenticity of a pure extraction. While legislation has changed how flavorists use safrole and related chemicals, the industrial need for precision remains.

    Industrial Synthesis and Derivatives

    Beyond aromatics, safrole’s greatest value comes from acting as a key building block. Its allyl side chain and methylenedioxy ring make it a prized intermediate. Our own teams rely on it to prepare piperonal, heliotropin, and other specialty aldehydes. These feed into the perfumery sector and specialty flavorings. Many pharmaceutical syntheses require exacting starting materials; safrole provides a consistent base for those reactions.

    Having supplied larger customers for decades, we share their frustration when impurities or batch-to-batch variation spoil consistency. Most downstream chemistry—like oxidation to piperonal—depends on minimal side reactions. Consistent feedstock means better yields and less waste. We designed our process flow to ensure each shipment behaves the same every single time.

    Handling and Safety—Manufacturer’s Perspective

    Handling safrole doesn’t take rocket science, but discipline matters. Direct exposure compounds long-term risk, so seasoned operators respect the usual personal protective gear—chemical gloves, splash goggles, and proper ventilation. We track each drum to avoid accidental mixing with incompatible materials.

    In our experience, the biggest safety lapses come not from the chemical’s nature but from trying to cut corners. Safrole oxidizes and darkens if stored in leaky containers or in direct sunlight. We use specialized lined drums and maintain strict inventory rotation. Each dispatch includes full traceability back to the batch, not because it’s required by regulation, but because we want every customer to track exactly what enters their facility.

    Regulatory Landscape and Real-World Pressures

    Safrole’s story is tangled with international regulation. Several years ago, shifting legal frameworks changed how our customers in North America and Europe order and use it as a precursor. Some regulatory authorities list it as a controlled substance based on concerns about diversion—especially given its historic use in producing illicit materials. The paperwork and security protocols have added layers to our routine, but our approach stays the same: full transparency and careful documentation.

    As a direct supplier, we respond to inspections and audits with open books. All our exports include the necessary customs compliance data. Customer inquiries range from production practices to certificate details and point of origin. These requests take time, but honest communication builds more trust than flashy branding ever could. We never push product toward channels where documentation feels dubious or where partners seem evasive about its end use.

    Comparisons: Safrole Versus Other Aromatic Compounds

    Anyone who has worked with safrole, isosafrole, and eugenol knows they all have their place. Safrole carries a characteristic warmth and lasting sweetness no matter how it’s diluted. Isosafrole—one isomeric cousin—leans more toward floral notes but loses some of the deep earthiness. Eugenol, which pops up in clove oil, smells sharper and turns spicy, denser, and more aggressive at higher concentrations.

    Some buyers try to cut costs by substituting cheaper analogs. We advise against it for any process where consistency matters. A fragrance designed with safrole as a key component quickly loses its harmony if replaced with another aromatic compound; this shows up both in stability tests and in the noses of end consumers. Our technical support has run side-by-sides with various replacements, and the difference is immediate—the original application usually requires tweaking to mask off-odors or restore the missing body.

    Sustainability and Natural Resource Management

    Raw material sourcing shapes the future of any chemical manufacturer. With safrole, resource management matters because overharvesting has already driven up prices and reduced forest stocks. We began moving toward more sustainable extraction and replanting programs long before it hit the headlines, simply because nobody with long-term vision wants to run their well dry. We partner with forest owners directly and regularly visit source regions to verify both legality and sustainability.

    From the factory perspective, any short haul in supply not only derails our operation but affects every partner down the line. This is why we track every kilogram from field to drum and use only material that meets our internal environmental criteria. No one wants to explain supply lapses or batch inconsistencies to long-term buyers. Being straight about the challenges of natural resource management wins confidence, especially when the market tightens.

    Market Trends and Production Capacity

    The market for safrole saw rapid changes over the past decade. Increased regulatory oversight and higher raw material prices squeezed out many smaller operations. As one of the few plants with both capacity and compliance history, we’ve seen large multinational customers consolidate their supply base. Volatility in source material prices runs up against fixed contracts, so customers rely more heavily on proven partners rather than spot-market vendors.

    We run medium-scale continuous distillation units capable of several tons per month, locking down both flexible scheduling and consistent output. Downstream buyers—whether in India, North America, or Europe—plan projects around long-term supply commitments, not unstable shipments. Regular capacity upgrades and a history of timely delivery set us apart from quick-turnover suppliers. Our reputation comes from decades of grinding out product, not short-term volume spikes or price games that come and go as quickly as the latest synthetic trend.

    Process Improvements and Innovations

    Innovation finds its place on every production floor. We’ve made significant changes to old extraction and purification lines based on practical experience and operator feedback. Reduced solvent handling and energy use, along with better impurity detection, have trimmed both costs and operational risks. New in-line sensors track batch purity and real-time temperature swings, allowing quick fixes to disruptions without compromising product quality. Each time we improve the process, the consistent feedback from our partners proves its value—fewer rejected shipments and faster integration into end-use systems every cycle.

    We share these advances willingly during technical discussions with partners. Why keep a trade secret that only creates headaches up and down the supply chain? Openness about process chemistry, potential side reactions, and aging characteristics has replaced the old days of close-guarded formulas. Our own technical crew regularly works hand-in-glove with customer plants to optimize their uses of safrole or troubleshoot mysterious batch hiccups.

    Customer Relationships and Traceability

    Accountability starts before the first drum ships. Each customer receives a full breakdown of batch data, and we retain samples for several years. Detailed traceability doesn’t just stave off regulatory problems—it protects both sides when there’s an unexpected issue. Routine audits and on-site technical visits cement long-lasting partnerships, built on shared success rather than transactional one-off sales.

    Sometimes, a customer stumbles across a problem no textbook anticipates—maybe a lumpy reaction or a strange color shift during downstream processing. Years of experience with real-world applications let us step in and share not just our chemical knowledge but practical troubleshooting that can only come from our position at the start of the chain.

    Moving Beyond Myths—Real Production Challenges

    Safrole draws more legends than almost any essential oil because of its dual identity—beloved ingredient and tightly watched chemical. You see whisper campaigns about ‘secret formulas’ or ‘untouchable suppliers’, but reality is far more straightforward. The hard truth is that reliable supply, precise delivery, and robust compliance aren’t glamorous, but they are the real mark of a manufacturer who takes pride in their operation.

    Shortcuts show up during quality checks, and corners cut—be it in sanitation, distillation, or documentation—eventually surface. Operating at scale means relentless focus on getting every part of the process right, day in and out. That’s the ethos that separates reputable makers from those just looking for a quick sale.

    The Path Forward and Customer Partnerships

    Our business doesn’t rest on single transactions. Growth has come from candor, a willingness to tackle hard production questions, and genuine support for partners both large and small. We see safrole not just as a line item, but as a touchstone for trust between producer and user. Sustainable sourcing, transparent process data, and ready support drive every decision we make.

    The next years bring new challenges—shifting regulation, evolving synthetic substitutes, and the ever-present need for natural resources. We face each hurdle with the same focus: professional pride, clear records, and the drive for the highest quality possible. Every batch that leaves our facility carries the weight of our reputation, earned from decades of doing the job right, not by chasing the market’s flavor of the month.

    Choosing a producer who understands these realities pays dividends with every order—consistent supply, straight answers, and the honest foundation for building something that lasts in an ever-changing world.