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(S)-Oxiranemethanol

    • Product Name (S)-Oxiranemethanol
    • Alias glycidol
    • Einecs 216-898-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    380752

    Chemical Name (S)-Oxiranemethanol
    Cas Number 5625-90-1
    Molecular Formula C3H6O2
    Molecular Weight 74.08
    Iupac Name (2S)-oxiran-2-ylmethanol
    Appearance Colorless liquid
    Boiling Point 193 °C
    Density 1.18 g/cm3
    Optical Rotation [α]D20 +38° (c=2, MeOH)
    Solubility Miscible with water
    Pubchem Cid 123375
    Ec Number 227-058-6

    As an accredited (S)-Oxiranemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing (S)-Oxiranemethanol is supplied in a 25 g amber glass bottle, securely sealed with a screw cap and labeled with hazard information.
    Shipping (S)-Oxiranemethanol is shipped in tightly sealed containers under cool, dry conditions to prevent degradation or contamination. It is handled as a hazardous chemical; appropriate labeling and documentation (such as MSDS) are provided. Transport complies with regulations for flammable, potentially irritant substances, ensuring safety and compliance during transit.
    Storage (S)-Oxiranemethanol should be stored in a tightly sealed container under cool, dry conditions and protected from light. Keep the storage area well-ventilated, away from heat sources, ignition points, and incompatible materials such as strong acids, bases, and oxidizers. Store at room temperature or lower, and avoid moisture exposure to maintain chemical stability and purity.
    Application of (S)-Oxiranemethanol

    Applications of (S)-Oxiranemethanol in Industrial Manufacturing

    As a specialized manufacturer of (S)-Oxiranemethanol, we provide high-purity material for key transformation steps in several complex downstream chemical production chains. This compound serves as an essential chiral building block and intermediate where tight quality control and regulatory compliance are critical. Below are distinct industrial applications with detailed integration, compliance, and finished product perspectives.

    1. Chiral Pharmaceutical Intermediate Synthesis

    (S)-Oxiranemethanol functions as a core chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients, such as selective beta-blockers and antiretrovirals. Many pharmaceutical companies utilize it to introduce stereochemistry in final API frameworks via enantioselective ring-opening and subsequent derivatization. Process requirements demand strict traceability and qualified analytical data, especially in cGMP-regulated environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP/NF and Ph. Eur. Monographs for Chiral Intermediates
    • 21 CFR Parts 210/211 (FDA Drug CGMPs)
    • Comprehensive Material Data Reporting (REACH/CLP)

    Typical usage ratio

    • 5–20 mol% relative to target API precursor
    • Adjustment based on enantioselectivity requirement and conversion efficiency
    • Process optimization via chiral purity assay (HPLC/GC)
    • Batch-to-batch usage varies per API route design

    Downstream process integration

    • Introduced post-glycidylation or at initial stereoselective coupling step
    • Subjected to further ring opening by specific nucleophiles or acylation
    • Controlled temperature and solvent protocols for maximum chiral integrity preservation
    • Integrated into GMP campaign production with validated cleaning and analytical protocols

    Final product types

    • Chiral beta-blockers (e.g., Esmolol, Nebivolol intermediates)
    • Nucleoside antiviral precursors (e.g., Lamivudine, Emtricitabine intermediates)
    • Non-steroidal anti-inflammatory precursor libraries
    • Custom enantioselective API scaffolds

    2. Fine Chemical Synthesis of Enantioenriched Building Blocks

    Chemical manufacturers use (S)-Oxiranemethanol as a starting point in the production of highly functionalized enantioenriched motifs for flavors, fragrances, and agrochemical actives. Its unique epoxide group and controlled stereochemistry facilitate downstream nucleophilic substitutions and alcohol/ester/amine conversion steps to yield value-added molecules with precisely defined chirality.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System
    • IFRA Standards for Fragrance Raw Materials
    • EU REACH Substance Registration (ECHA)
    • Global Product Stewardship Policies

    Typical usage ratio

    • 10–30 wt% of reactant batch
    • Adjusted for downstream nucleophile or reducing agent load
    • Scale varies from pilot to full commercial batch size
    • Real-time FTIR or in-line NMR for process control

    Downstream process integration

    • Introduced during nucleophilic attack/epoxide opening reactions
    • Integrated with asymmetric catalysis using organometallic or enzyme catalysts
    • Followed by in situ purification by continuous extraction or crystallization
    • Final building block transferred directly to compound library synthesis or final formulation

    Final product types

    • Enantioenriched alcohols and diols for aroma chemicals
    • Chiral intermediates for pheromonal agrochemical actives
    • Functional additives for fine fragrances
    • Precursor molecules for specialty coatings and cured resins

    3. Agrochemical Active Ingredient Production

    Crop protection and agrochemical companies incorporate (S)-Oxiranemethanol in the industrial synthesis of optically pure herbicides and fungicides. Processes using this raw material aim for strict impurity profiling and higher field performance via stereo-specificity. Application routes include epoxide ring-opening to generate allylic alcohols or amines, catalyzed by proprietary transition metal systems under batch and flow conditions.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Technical Grade Substances
    • ISO 17025 Analytical Testing Accreditation
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • EPA FIFRA Compliance (USA)

    Typical usage ratio

    • Up to 15 mol% per active ingredient batch
    • Dosage controlled by intended target molecule structure
    • Adjustment for yield optimization during pilot scaling
    • Continuous reaction monitoring to meet chiral profile specifications

    Downstream process integration

    • Inserted at early-stage intermediate conversion
    • Subsequent aminolysis or hydrolysis followed by functionalized group attachment
    • Process includes in-line impurity profile monitoring via HPLC-MS
    • Post-reaction phase separation and technical purification steps before formulation

    Final product types

    • Chiral herbicide intermediates (e.g., fluorinated phenoxyacetic acids)
    • Optically pure fungicide bases for formulation
    • Enantioselective insecticide scaffolds
    • Seed treatment actives for high-value crops

    4. Synthesis of Specialty Polymers and Curing Agents

    Advanced material manufacturers employ (S)-Oxiranemethanol as a reactive monomer for custom epoxy resin pre-polymers and curing agents. Its primary alcohol and epoxide group allow for incorporation into cross-linking chemistries, supporting fine-tuning of thermal and mechanical properties. End-users seek high optical purity to ensure performance in electronic encapsulants, adhesives, and protective coatings. Consistency in batch purity and documented traceability is essential for regulatory and customer audits.

    Industry compliance standards

    • ISO 14001 Environmental Management for Chemical Manufacturing
    • UL Environmental Claim Validation for Semi-conductor Materials
    • ROHS & REACH Substance Requirements (EU/Asia/US)
    • ASTM D1655 for Epoxy Material Grades

    Typical usage ratio

    • 1–10 phr (parts per hundred resin) as chain-extender or cross-linker
    • Ratio tailored by desired glass transition temperature and chemical resistance
    • Adjustment for specific downstream adhesive or dielectric property targets
    • Process validated by DSC/TGA thermal analysis

    Downstream process integration

    • Pre-mixed with bisphenol or aliphatic backbone systems in resin kettle
    • Forms reactive intermediates under base- or acid-catalyzed polymerization
    • Blended with functionalized hardeners during final formulation
    • Subjected to controlled curing under heat or UV, followed by QC gel time and mechanical testing

    Final product types

    • Custom epoxy adhesives for electronics assembly
    • Encapsulants for microelectronic device protection
    • Specialty coating prepolymers for industrial concrete flooring
    • High-performance laminates and composite matrices
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    Competitive (S)-Oxiranemethanol prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to sales7@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    Introducing (S)-Oxiranemethanol: Reliable Building Block for Specialty Chemistry

    Our Experience with (S)-Oxiranemethanol

    For decades, we have moved from pilot glassware to full-scale stainless steel reactors, making (S)-Oxiranemethanol on-site and continuously refining every batch. The hands-on experience with this molecule traces back to the early days when scaling chiral intermediates meant troubleshooting every pressure valve and chromatography column ourselves. Over time, we saw the chemistry world recognize and demand both the reactivity and selectivity built into the (S)-enantiomer. Down-to-earth innovation and laboratory problem-solving, plus a focus on reproducibility, have honed our process. The result now gives consistent quality demanded by fine chemical and pharmaceutical research labs.

    We pick raw materials that keep the stereochemistry tight and the impurity profile controlled. From our process you will meet material that stays clear, colorless, and well within the enantiomeric excess required for advanced syntheses. Several chemists have shared the same feedback—once they build their chiral epoxides or glycidol-based compounds with our (S)-Oxiranemethanol, handling goes smoother and purification takes less effort. Methods improve continuously: we reinvest successful lab routines directly into our production floors to minimize inconsistency batch to batch.

    Understanding the Chemistry

    The core of (S)-Oxiranemethanol lies in its structure—the oxirane (epoxide) ring connected to a primary alcohol. This combination unlocks selectivity and further functionalization. Chiral synthesis relies on precise, reproducible intermediates, and this molecule often kicks off more complex transformations. With the (S)-configuration, it becomes possible to build enantiopure products, which is indispensable in pharmaceutical and agrochemical development where stereo-specific outcomes matter. Our process puts a sharp focus on avoiding racemization and controlling by-product formation. We routinely analyze using chiral HPLC and GC, making sure that every delivery matches the promised stereochemistry.

    Most feedback we have received centers on the role of (S)-Oxiranemethanol as a building block for optically active glycols, epoxides, and specialized linker units. Experience has taught us to keep water content and heavy metals in tight check, as these can derail sensitive enantioselective processes. Workers on our line oversee every drum, and every kilogram maintains its chiral purity from source until it reaches the customer's bench. Operational continuity and rigorous QC come from hard lessons learned after hours on chemical floors, not from soft promises.

    Specifications That Matter

    We focus on purity and usability, not flashy labels or fleeting technical jargon. Typical batches register over 99 percent purity by GC, with enantiomeric excess regularly surpassing 98 percent by chiral HPLC. Color stays water-clear, no yellowing even after prolonged storage under inert gas. It carries a faint, sweet odor—a sign of cleanly distilled product and absence of burned or degraded residues. Each container ships sealed, with headspace purged using dry nitrogen, which our production staff verifies at the line before loading. This discipline avoids water ingress and oxidation, two major headaches for end-users in specialty and pharmaceutical applications.

    We refrain from generic grades; every order of (S)-Oxiranemethanol comes with hard data: NMR, GC, and chiral HPLC results traceable to batch. If a customer develops a formulation that needs even tighter specs on (for example) metal ions or residual solvents, our technicians fine-tune the finishing protocol. Many have called up asking for adjustments, and we've delivered tweaks ranging from solvent choices to packaging types. We listen to operator feedback—less static in transfer lines, better container handling, and documentation that tells the truth without jargon to hide behind.

    Uses: Direct Feedback from the Field

    Years of lab visits and customer calls have shaped our understanding about how (S)-Oxiranemethanol is actually put to use. Most demand comes from synthesis of advanced pharmaceutical intermediates and biologically active compounds. For instance, research teams rely on it to introduce chirality into active molecules—frequently making use of the epoxide ring’s reactivity with nucleophiles. Sulfide, amine, or carboxylic acid addition to the epoxide functionality easily generates substituted, optically pure alcohols or amines. Our (S)-isomer allows precise access to the required configuration in downstream synthesis.

    It often appears near the start of synthetic routes for beta-blockers, anti-viral drugs, and certain specialty pesticides. Contract researchers value the high stereospecificity; misassigned stereochemistry at this early stage can derail months of downstream testing and regulatory work. Clients in university and pharma R&D have reported shorter purification times and easier crystallization when they switched to our product versus competitors' lots. Overhead costs fall as less time must be spent in rework, column purification, or yields lost to side reactions triggered by trace impurities.

    On the practical side, many researchers appreciate our open access to production technologists who can advise directly on reactivity, work-up, and compatible solvents. Not many chemical manufacturers share direct bench notes, but for (S)-Oxiranemethanol, reproducibility means sharing what actually works—such as the benefit of using dry, non-coordinating solvents or the best storage practices to preserve chiral purity. Calls from process chemists have helped us tune our shipment sizes, leading to smaller containers when short-lifetime reactions are planned and eliminating material loss from repeated repackaging.

    What Sets (S)-Oxiranemethanol Apart from Similar Compounds

    Plenty of manufacturers offer 2,3-epoxy alcohols or glycidol derivatives, yet few provide (S)-Oxiranemethanol with rigorous chiral integrity, minimal batch-to-batch deviation, and accessible production support. Some competitors sell mixtures or racemic versions disguised through ambiguous labeling—leading to confusion and process troubleshooting that burns valuable development hours. Over the years, we’ve seen projects delayed or reformulated simply due to unrecognized racemization. Our attention to source material, secured supply chain, and unbroken cold storage keep every bottle within spec.

    Looking at similar molecules, glycidol or racemic oxiranemethanol lack that precise enantiomeric advantage. Unresolved stereochemistry stalls projects where enantiopure APIs (Active Pharmaceutical Ingredients) are non-negotiable for regulatory acceptance and biological efficacy. Many vendors set a low threshold for residual solvents, not accounting for toxic issues in downstream use. Our methodology drops typical residuals to parts-per-million range and stays open to adaptation if customers need even lower levels.

    In our workflow, small differences in production matter when it comes to stability and usability. For example, trace acid can catalyze ring opening and destroy the epoxide, so we routinely confirm low acid values and monitor color stability both after packaging and during transit. Repeated feedback from formulation teams suggests that these subtle differences save hours in process development and validation, leading not only to fewer failed pilot batches but also smoother regulatory filings.

    Lessons from Production—Mitigating Common Challenges

    Years of batch operation have taught us never to take the stability of (S)-Oxiranemethanol for granted. The molecule carries an active epoxide ring, and even slight exposure to heat or acid can open the ring and ruin enantiomeric integrity. To prevent this, we always cool product rapidly after synthesis and purge vessels with dry nitrogen, which stops atmospheric CO2 and water from creeping in. We’ve traced back shipping failures to inadequate seals or improper stacking, and we’ve overhauled packaging to prevent contamination and temperature spikes.

    Most manufacturers operate with generic packing protocols. Our team customizes the process for this compound—investing in tight-head drums and inert liners. Before shipping, each unit passes a set of rapid moisture and acid number tests, because slight errors in these parameters can invite disaster during long-haul transit. We do not cut corners by substituting cheaper, permeable plastics for solvent-resistant vessels. Risk-reducing infrastructure stems from seeing the real-life cost: when a research team loses precious weeks over a single tank leak or off-specification detection during incoming QC.

    On the lab scale, organic chemists sometimes underestimate the risk of base- or acid-catalyzed side reactions. To prevent these issues, we keep channels open: our staff will advise on storage under inert conditions and recommend use within a specific shelf life. Misuse or inattentive handling—like a shipment left uncapped or in sunlight—has been traced to rushed benchwork, not to product flaws. We document handling insights both from lab and warehouse and pass this knowledge on to our users.

    Applications That Drive Discovery

    Every year, we see (S)-Oxiranemethanol published in dozens of peer-reviewed academic articles and patent applications. Its role as a precursor in enantioselective synthesis remains central to both discovery and process-scale efforts. Typical applications span advanced chiral auxiliaries, ligand libraries for asymmetric catalysis, and modification of both natural product analogs and fully synthetic APIs.

    In industrial practice, this compound saves time in enantioselective ring opening and elaboration strategies, as the enantiopure alcohol moiety simplifies chiral pool approaches. Feedback points towards broad compatibility—users report that, in tandem with palladium- or copper-based catalysts, (S)-Oxiranemethanol delivers robust performance without need for repeated recrystallization.

    It also finds its way into bioconjugation chemistry, where the unique alcohol-epoxide interplay enables directed attachment of molecular labels, drug candidates, or sensory probes. Startups and academic labs alike have developed high-value probes and diagnostic tools that trace their core backbone to this molecule. They cite our consistency as key to reproducibility—nothing stalls an innovation faster than failing to repeat last year’s positive result because of batch drift.

    On the eco-impact front, researchers pushing for greener chemistry highlight the lower toxicity profile and easier downstream processing made possible by sharp control on residuals and enantiomeric composition.

    How We Back Our Product

    We do not take support lightly. Technical professionals answer questions—not salespeople. Years of making and troubleshooting this molecule have led to a wealth of real-world case studies. If a user experiences unusual retention times, unexpected downstream color, or yield loss, we investigate the parameters together—from shipping logs to solvent choices. Nobody gets handed off to a call center. Instead, our bench chemists relay notes directly from QC and scale-up teams, giving practical, not just theoretical, advice.

    Storage tips, preferred packaging, and direct handling guides are available for everyone who works with us. If a mistake happens—such as improper temperature storage at a customer site—recovery advice comes marching in; we have even shipped replacement batches overnight to avoid costly plant shutdowns. Lifetime relationships with labs and plants keep us accountable. Knowing how downstream regulatory filings can hang on a single impurity, we make all analytical data immediately available—not just on request, but proactively.

    Continuous dialogue means we have adjusted both our literature and labeling practices based on direct feedback about what researchers and engineers need. Information overload does not help, so we focus on actionable insights: ideal dilution solvents, appropriate PPE, most stable container types. We also log requests for special handling or challenging analytical puzzles, often working side-by-side with quality managers to resolve questions ahead of formal documentation cycles.

    Looking Forward: Keeping Pace with Evolving Needs

    Demand for (S)-Oxiranemethanol grows as chiral regulatory standards tighten and more biologically active compounds enter the pipeline. Staying ahead means adapting—not just at the bench, but throughout logistics, documentation, and follow-up. The future of this molecule extends beyond pharmaceuticals: newer applications in triblock copolymers, printable electronics, and biosensors already call for ultra-pure, traceable batches. Researchers request not only what sits in the drum, but the guarantee that each lot remains consistent, especially across scale.

    We see an ongoing evolution in how chemists worldwide think about supply chain security and QC transparency. Delays or inconsistencies in sourcing chiral building blocks stop a discovery dead. With every new batch we manufacture, process insight circles back: if a particular raw supplier or analytical standard slips, corrective action follows before a problem migrates downstream. Real-life audit and annual technical visits help us verify that best practice blurs the line between R&D and bulk shipping.

    No customer works in isolation; as chemistry grows more interdisciplinary, new applications challenge old process assumptions. Each client call, whether a multinational scale-up or a university postdoc, opens our eyes to how to do better next time. Our job means never resting on routine. Detailed recordkeeping, transparent QC snapshots, and a phone call away for troubleshooting can make all the difference between a smooth project and a delayed one. We keep the real-world lab bench in mind, not theoretical templates, shaping how we deliver materials, batch records, and solution-oriented support.

    Conclusion: Why Quality (S)-Oxiranemethanol Makes a Difference

    Our years manufacturing (S)-Oxiranemethanol have taught us that little things make the biggest difference—clean glassware, dry reagents, freshly certified analytical standards. We keep this in mind with every batch that leaves our site. Nobody wants to waste precious synthetic effort on poor material. Consistent stereochemistry, fast support, and practical, honest documentation define what we offer.

    Where other suppliers cut corners, we double down on reproducibility and direct client partnership. Our staff stand behind every shipment, sharing lessons learned at the bench and throughout the plant. Access to clean, reliable (S)-Oxiranemethanol opens new research directions, enables accurate regulatory filings, and prevents the kind of headaches that sap resources from already stretched laboratories.

    We remain committed to supplying chemists everywhere with the critical chiral building block their processes deserve, always focusing on integrity—from sample request to batch shipment. If there is a better way to help (S)-Oxiranemethanol benefit the next generation of chemical innovation, you will find us right there, refining and improving side by side with you.