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(S)-(-)-N-Benzyl-1-Phenylethylamine

    • Product Name (S)-(-)-N-Benzyl-1-Phenylethylamine
    • Alias (S)-(-)-BPPEA
    • Einecs 624-90-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    174438

    Chemical Name (S)-(-)-N-Benzyl-1-Phenylethylamine
    Cas Number 1443-77-6
    Molecular Formula C15H17N
    Molecular Weight 211.30
    Appearance Colorless to pale yellow liquid
    Purity Typically ≥98%
    Boiling Point 155-157°C at 3 mmHg
    Density 1.004 g/mL at 25°C
    Optical Rotation [α]D20 -58° (c=1, CHCl3)
    Solubility Soluble in organic solvents (ethanol, dichloromethane)

    As an accredited (S)-(-)-N-Benzyl-1-Phenylethylamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g bottle is amber glass with a tamper-evident cap, labeled “(S)-(-)-N-Benzyl-1-Phenylethylamine, 98%” and safety warnings.
    Shipping The chemical **(S)-(-)-N-Benzyl-1-Phenylethylamine** is shipped in a tightly sealed container to prevent contamination and degradation. Packaging complies with chemical transport regulations, including labeling for safety and hazard information. All shipments include documentation for tracking and regulatory compliance, ensuring safe and prompt delivery to the designated address.
    Storage (S)-(-)-N-Benzyl-1-Phenylethylamine should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, and well-ventilated area, preferably in a designated chemical storage cabinet. Avoid exposure to strong oxidizing agents and incompatible substances. Proper labeling and access control are recommended to ensure safe handling and storage of this amine compound.
    Application of (S)-(-)-N-Benzyl-1-Phenylethylamine

    Applications of (S)-(-)-N-Benzyl-1-Phenylethylamine in Industrial Manufacturing

    As an original manufacturer, we supply (S)-(-)-N-Benzyl-1-Phenylethylamine for advanced synthesis in several key sectors. Below, we outline specific industrial downstream applications, addressing regulatory standards, technical integration, and end-use product lines for each.

    1. Chiral Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical producers use (S)-(-)-N-Benzyl-1-Phenylethylamine as a chiral building block in small-molecule API manufacturing. The material acts as a key amine auxiliary during asymmetric synthesis and optical resolution steps, such as in the preparation of chiral amines, amino alcohols, and specific antihypertensive or psychoactive agents. Downstream formulation facilities incorporate our raw material by direct addition to enantioselective reactions, prioritizing traceability and batch consistency to meet international compliance.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF monographs for intermediates (where applicable)
    • European Pharmacopoeia 11th Edition
    • China Pharmacopoeia (ChP) standards for chiral auxiliaries

    Typical usage ratio

    • 5–20 mol% relative to target substrate, adjusted by desired chiral purity and conversion yield
    • Usage may increase for dual-resolution or excess chiral agent processes, maximized at 1:1 molar equivalence

    Downstream process integration

    • Direct addition to reaction vessels in the enantioselective step
    • Pre-mixing with solvent under nitrogen prior to catalytic hydrogenation or reductive amination
    • Raw material traced and sampled per GMP for in-process QC
    • Chiral integrity confirmed by HPLC or GC before downstream work-up

    Final product types

    • Chiral pharmaceutical intermediates
    • MDMA precursors for authorized research or controlled pharmaceutical synthesis
    • β-Blocker and antihypertensive agent intermediates
    • Enantiomerically pure amines for CNS drugs

    2. Ligand Synthesis for Asymmetric Catalysis

    Chemical manufacturers employ this amine as a key precursor in the preparation of enantioselective ligands used for transition metal catalysis. It serves as a chiral source in the synthesis of ferrocene and bisphosphine ligands, crucial for catalytic hydrogenations and transfer reactions in fine chemical and API production. Our facility ensures high optical purity and batch reproducibility for catalyst manufacturers.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for fine chemicals
    • REACH registration and reporting for manufacturing in the EU
    • Responsible Care program participation (where applicable)
    • Purity and chiral resolution confirmed by in-house NMR and optical rotation per specification

    Typical usage ratio

    • 0.1–5 mol% relative to catalytic metal center, tailored to ligand design and substrate
    • Lower ratios for high-efficiency or immobilized catalyst systems

    Downstream process integration

    • Integrated at ligand assembly step using coupling or reductive amination
    • Amines protected or deprotected as per synthesis route (e.g., Cbz or Boc steps)
    • Ligand solution filtered and directly charged to catalyst assembly reactors
    • Stringent chiral analysis before transfer to catalytic batch production

    Final product types

    • Asymmetric hydrogenation ligands (e.g., BINAP derivatives)
    • Phosphine-functionalized chiral ligand libraries
    • Chiral catalysts for API intermediate synthesis
    • Specialty catalysts for fragrance compound production

    3. Intermediate for Agrochemical Synthesis

    Producers of advanced crop protection actives utilize this compound as a chiral amine source in the syntheses of certain herbicide and fungicide intermediates. The enantiopure structure enables regioselective transformations, particularly for arylamine or benzylamine-bearing agro actives targeting fungal or broadleaf species. Our product integrates seamlessly with multi-step synthesis lines focused on high specificity and reduced process impurities.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • ISO 14001 Environmental Management in agrochemical production
    • REACH pre-registration (where exported to EU)
    • China National Standards (GB/T) for agricultural chemical intermediates

    Typical usage ratio

    • 10–30 mol% in asymmetric addition or alkylation steps, depending on target selectivity
    • Ratio reduced when amine is recycled or recovered in process loop

    Downstream process integration

    • Charged during amidation or amination stage of intermediate synthesis
    • Often introduced after nitration or halogenation steps for selective amination
    • Batch and continuous flow lines adapted for controlled addition
    • Excess amine removed by distillation or crystallization unit

    Final product types

    • Chiral precursors for triazole fungicides
    • Pyridine-based herbicide intermediates
    • Benzylamine-derived insecticide components
    • Specialty intermediate blends for proprietary crop protection agents

    4. Fine Chemical Synthesis for Chiral Fragrance and Flavor Ingredients

    Manufacturers of chiral aroma chemicals employ (S)-(-)-N-Benzyl-1-Phenylethylamine to introduce specific stereochemistry into key perfume and flavor intermediates. Its role is pivotal during reductive amination and chiral auxiliary steps, where scent and taste profiles depend on enantiomeric purity. Regular output includes intermediates for optically active alcohols and aldehydes used in luxury fragrance compositions and high-value flavors.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • ISO 9001 for specialty chemical production
    • European Regulation (EC) No. 1334/2008 on flavorings
    • FEMA GRAS list conformance (for flavor materials in US)

    Typical usage ratio

    • 2–15 mol% in initial chiral induction stage, modulated by desired optical yield
    • Batch-specific ratio based on analytical feedback from GC-MS and chiral HPLC

    Downstream process integration

    • Added as chiral auxiliary in reductive amination with aldehydes and ketones
    • Fed inline to reaction vessels under inert gas with continuous monitoring
    • Downstream fractionation ensures optical purity before blending or formulation
    • Residual amine removed by acid-base extraction or crystallization

    Final product types

    • Chiral alcohol intermediates for fine fragrances
    • Stereopure aldehydes and ketones for synthetic flavors
    • High-purity aroma compounds for personal care
    • Optically active ingredients in boutique flavor houses

    5. Specialty Chemical R&D and Custom Synthesis

    R&D groups at custom synthesis companies source this amine for small-scale development of novel chiral chemicals. Its well-defined stereochemistry facilitates exploratory projects in sectors such as advanced materials, specialty polymers, and pilot pharma. Our QC-tested batches support applications from high-throughput screening to kilogram-scale route validation for new biologically active molecules and advanced synthetic targets.

    Industry compliance standards

    • ISO/IEC 17025:2017 for analytical laboratories
    • GLP (Good Laboratory Practice) for research-grade chemicals
    • Custom synthesis contracts may stipulate project-specific documentation
    • Material Safety Data Sheets (MSDS) and transport in line with GHS/UN regulations

    Typical usage ratio

    • 0.5–10 mmol scale for screening, up to 50–500 g batch for pilot validation
    • Ratio tailored to reaction scope, target molecule complexity, and method development protocols

    Downstream process integration

    • Pre-weighed addition in glovebox or inert-atmosphere hoods
    • Integrated in multiple-step synthetic sequences (amide coupling, Grignard reaction, reductive amination)
    • Extensive analytical profiling (HPLC, NMR, chiral GC) performed on isolated intermediates and finished materials
    • Leftover material logged for traceability and further optimization cycles

    Final product types

    • Experimental pharmaceuticals for preclinical trials
    • Chiral auxiliaries and analytical standards
    • Advanced polymers featuring asymmetric linkers
    • Functionalized monomers for custom material science applications
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    Certification & Compliance
    More Introduction

    Introducing (S)-(-)-N-Benzyl-1-Phenylethylamine: Precision Chemistry for Research and Industry

    Crafting Reliable, Enantioselective Intermediates: Our Approach to (S)-(-)-N-Benzyl-1-Phenylethylamine

    On the manufacturing floor, every product that leaves our facility represents months of meticulous attention to process quality, raw materials, and customer feedback. (S)-(-)-N-Benzyl-1-Phenylethylamine, one of our key chiral amine products, reflects this approach. With years of dedication to chiral chemistry and enantioselective synthesis, we've developed a reliable, reproducible route for producing this material at scale—minimizing batch-to-batch variation and focusing on the underlying chemical value.

    Our (S)-enantiomer targets customers who require a dependable building block for asymmetric synthesis. Whether the end use lies in fine chemicals, pharmaceutical development, or academic research, this compound's purity and optical activity matter more than impressive marketing. By maintaining strict quality checks and investing in top-grade chiral resolution methods, we deliver a product that supports real innovation in the lab and on the production line.

    Model and Physical Properties: What We Supply and Why It’s Different

    This product carries the structural formula C15H17N, with the (S)-configuration providing a reliable handle for enantioselective transformations. Experienced researchers know that stereochemistry cannot be left to chance—so each batch undergoes chiral HPLC to confirm enantiomeric excess above industry-accepted thresholds. Average melting point and appearance data, like most chiral amines, vary slightly due to crystalline packing and batch scale. We monitor these parameters, flagging any outliers so you only receive materials with clean, predictable properties. Typical deliveries include a white to pale-cream crystalline solid, exhibiting strong, characteristic amine and aromatic infrared peaks.

    Where many suppliers might mix (S)- and (R)-enantiomers or allow racemization during synthesis and workup, our facility uses dedicated glassware, specific reaction conditions, and a closed loop of quality feedback. We keep contamination low, limiting cross-reaction and ensuring you are working with a single enantiomer. Our staff considers this a core skill rather than a value-added feature, and customers often return for reliable results in scale-up runs. From the first kilogram to regular multi-ton lots, this hands-on approach tallies with the requirements of regulated pharmaceutical manufacturing and demanding research labs.

    Direct Applications and User Experience: How We See Chemists and Engineers Work With It

    Many chemists and engineers searching for enantiomerically pure amines already understand their role as intermediates in creating pharmaceutical API candidates and in synthesizing advanced organic ligands. Our experience aligns with this: researchers using (S)-(-)-N-Benzyl-1-Phenylethylamine often follow two paths. Some employ it as a versatile precursor for further functionalization—N-alkylation, acylation, or reductive amination, for example. Others use it directly as a chiral auxiliary, introducing stereoselectivity into subsequent synthetic steps.

    Customers regularly comment on batch uniformity and the ease of downstream purification. Because each drum or bottle comes with clear documentation, analytical results, and a certificate of analysis, their planning stays precise. Academic partners developing new catalyst systems use our material for screening, while process R&D teams trust it for larger demonstration runs. The predictable handling profile, especially solubility and reactivity, reduces wasted time spent troubleshooting. Real feedback circles back to us: requests for alternative solvents, adjusted packaging, and concentration options. We take these suggestions seriously, adjusting procedures wherever practical.

    Comparing to Other Products on the Market

    We started manufacturing chiral amines to address the gap between boutique, high-spec laboratory samples and unpredictable commodity lots. With (S)-(-)-N-Benzyl-1-Phenylethylamine, you get full traceability and support before and after purchase. This separates us from traders who may source from multiple plants or relabel drums without confirming batch origins. Since traceability adds cost and complexity, some competitors cut corners by offering only racemic mixtures or material of uncertain optical purity.

    We've invested in developing a proprietary route where excessive racemization does not occur. Plant staff receive hands-on training in recognizing small deviations in the workup, and no batch moves to shipment before meeting predefined QC criteria: enantiomeric excess typically surpasses 99 percent in target applications, and residual solvents remain within tightly-held limits. Our internal process gives confidence for audits or compliance reports, especially when upstream documentation and batch data must be provided for regulatory filings. This lets our industrial clients submit clearer paperwork and move to new synthetic steps with minimal risk of out-of-spec intermediates.

    Besides compliance, scale keeps coming up in conversations with our largest partners. Where others may falter scaling synthesis beyond pilot size, our reactors, distillation columns, and purification systems handle multikilogram orders without quality erosion. We’ve seen how rushed scale-up or inconsistent crystallization can undermine the stereochemical integrity of chiral amines. Tight control over temperature, pH, solvent mixtures, and isolation steps preserves the enantiomeric purity and overall yield. This attention at the plant floor—combined with in-house analytical chemistry—lets us promise batch repeatability batch after batch.

    Safety, Handling, and Documentation—A Manufacturer’s Promise

    Years of supplying research and production groups taught us that reliable chemical supply never stops at the drum's edge. Active communication around hazards, recommendations for PPE, and transport packaging comes standard. Common sense practices—grounding containers, limiting exposure to air and moisture, ventilating workspaces—help manage the low but real risk posed by aromatic amines. On request, our documentation team issues Safety Data Sheets, customs or compliance paperwork, and detailed handling recommendations for all regional standards.

    Quality documentation is only as strong as the practices behind it. Every member of our analytical group understands the need for up-to-date methods and how small errors—an under-dried sample, a misaligned autosampler, an infrequent calibration—undercut customer trust. Only material passing each QC checkpoint reaches your bench or warehouse. If issues arise, direct feedback from your technical team, not a call center, addresses questions and resolves concerns.

    Sustainability, Waste, and Process Development: Learning From Each Batch

    Sustainability has become a real focus in the chemical manufacturing sector, and not just a box to check. Our process routes for (S)-(-)-N-Benzyl-1-Phenylethylamine center on maximizing atom economy and waste minimization. We design stage-wise purifications and recycle solvents wherever possible. That means less fossil-derived waste and safer working conditions for our plant team. Over years, we've refined the synthesis to cut byproduct load, using process analytics to confirm improvements.

    Neither customers nor regulators accept greenwashing. Third-party audits take place in our facilities, and we support efforts to detail our chemical inventory, waste outputs, and energy use. Feedback from industry partners prompted several upgrades in condenser design, nitrogen-permeable tubing, and automated solvent recovery—each contributing to a lighter environmental footprint. Smaller pilot runs help us trial new approaches before scaling up, learning what works through actual experience rather than hypothetical claims.

    Real Customer Scenarios: Problems Met and Solved

    Collaboration often starts with a straightforward inquiry and evolves as challenges emerge. One of our European partners reported material from a previous supplier yielding variable optical rotations in their synthesis. Our technical staff traced the issue to poor storage and batch blending, leading to racemization over time. Offering both storage protocol advice and expedited supply, we saw their downstream failures drop sharply. In-house chiral analysis let us guarantee enantiomeric purity from initial dispatch, and periodic checkups by our technical teams ensured continued reliability. Such cases underscore why seeing chemical supply as a partnership, not a transaction, matters in advanced synthesis.

    Another instance involved a North American pharmaceutical customer scaling an analog synthesis needing uninterrupted delivery of (S)-(-)-N-Benzyl-1-Phenylethylamine over a twelve-month window. Their internal QC flagged minor solvent residues in the first sample. Our analytical team, in direct communication with their quality group, adjusted post-crystallization drying in the next production cycle, reducing solvent carryover by over 90 percent. Such responsive feedback loops keep projects on track and build the trust critical in today’s competitive market.

    Universities and research institutes benefit as well. Early career chemists, sometimes new to the subtleties of chiral synthesis, receive both product and candid support. Guidance on storage, thawing, and handling helps avoid unwanted racemization or loss of activity. We see scientific output flourish as logistical headaches—improper storage, unclear labeling, or complicated customs procedures—get solved early in the process.

    Investment in Analytical Infrastructure: What Makes Quality Measurable

    Raw anecdote alone does not drive process improvement. Over the years, our site expanded capabilities for optical purity, impurity profiling, and solvent content testing. Sophisticated techniques—chiral HPLC, NMR, mass spectrometry, and Karl Fischer titration—help us stay ahead of increasingly stringent regulatory and technical demands. Inline process analysis means that deviations from established specifications rarely survive to final packaging.

    Certificates of Analysis are not generic copy-paste sheets. Each reflects the actual results on the batch you’ll receive: chiral purity, melting point, water content, and residual solvent data. Upon request, we provide augmented supplementary data on intermediates, trace metals, and spectral confirmation, giving your team exactly what you need for review or submission purposes. This granular data increases confidence, not only for routine synthesis but also for high-stakes development or validation of new APIs.

    Regulatory Support for Advanced Users and Scale-Up Projects

    Those working in fields where documentation, audit readiness, and regulatory submissions play a central role can expect a hands-on approach from our technical and compliance staff. We regularly assist with DMF submissions, regulatory queries, and import/export certifications, relying on a thorough, long-maintained documentation system for our (S)-(-)-N-Benzyl-1-Phenylethylamine production chain. As jurisdictions vary in their requirements for handling chiral amines and related aromatic structures, our regulatory team works alongside your staff to deliver targeted paperwork, easing the routine friction between manufacturing reality and paperwork requirements.

    Regular industry updates keep our procedures in step with shifting rules and expectations. Practical experience shapes our approach—reacting not just to current policies, but also to anticipated changes, such as updates to permissible impurity thresholds, environmental reporting standards, or hazardous goods labeling. Staying ahead of such changes means your projects do not stall due to avoidable regulatory hiccups.

    Collaborative Development for Customized Needs

    We rarely encounter projects that match the textbook case. Often, researchers or process engineers need a tailored approach to purity, concentration, or packaging. Our process chemistry group collaborates closely on alternative workups, solvent systems, or purification steps—sometimes at sub-kilogram scale, other times with hundreds of kilograms at stake. Each new case brings lessons, improvements, and—occasionally—wider process upgrades across the plant.

    Customers looking for custom labeling, mixed solvent systems, or additional analytical work benefit most from direct, clear conversations between technical teams. By documenting solutions, we avoid repeating mistakes, supporting those who push technological boundaries or regulatory frameworks. The habit of learning as we go, backed by decades of technical experience, lets us anticipate needs rather than simply react.

    Trust Through Transparency—What Sets Our (S)-(-)-N-Benzyl-1-Phenylethylamine Apart

    Transparency does not mean advertisements or claims; it involves granting access to real details, from production methods to analytical readouts. Our approach to (S)-(-)-N-Benzyl-1-Phenylethylamine manufacturing keeps customer requirements at the forefront. Whether supplying a small batch for method development or offloading a full-scale shipment for a validated process, we offer direct technical support to ensure expectations are met. All requests for technical clarification, troubleshooting, or method adaptation go straight to in-house chemists, not intermediaries.

    Long-term supply contracts and regular shipments reinforce trust-based relationships, and we offer informative, detail-driven updates on order status, quality results, and any observed anomalies throughout each campaign. Many of our partners operate with regulatory audits or competitive deadlines; we remain mindful of the stakes, keeping process documentation accurate and response times rapid.

    The Road Ahead: Continuous Improvement in Chiral Amine Production

    The world of enantioselective intermediates will only grow in complexity, and we intend to keep pace—upgrading process routes, analytical equipment, and customer-facing support as new needs arise. Continuous process improvement forms part of our company’s DNA: every experience, from inquiry to repeat business, informs refined procedures and investments on the plant floor. By operating as more than a commodity supplier, we strengthen our role as a manufacturing partner invested in your scientific and commercial progress.

    Every kilogram of (S)-(-)-N-Benzyl-1-Phenylethylamine produced at our site reflects both discipline and learned experience. We strive for the rare combination of reliable manufacture and hands-on support that helps customers, both new and established, tackle advanced synthetic challenges, scale up innovative ideas, and maintain compliance in an ever-demanding regulatory climate. We invite you to reach out with new product needs, development ideas, or questions, knowing you’ll receive direct, informed answers rooted in real-world chemical manufacture.