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HS Code |
647042 |
| Cas Number | 1821-95-4 |
| Molecular Formula | C10H8O3 |
| Molecular Weight | 176.17 g/mol |
| Iupac Name | 2-(3-oxo-2,3-dihydro-1-benzofuran-1-yl)acetic acid |
| Appearance | White to off-white crystalline powder |
| Melting Point | 138-141°C |
| Solubility In Water | Slightly soluble |
| Purity | Typically ≥98% |
| Storage Conditions | Store in a cool, dry place and keep container tightly closed |
As an accredited Phthalide-3-Acetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of Phthalide-3-Acetic Acid is packaged in a sealed amber glass bottle with a screw cap, labeled with product details. |
| Shipping | Phthalide-3-Acetic Acid is shipped in tightly sealed containers to prevent moisture and contamination. It is packed in accordance with chemical safety regulations and labeled appropriately. The shipment is handled as a non-hazardous material, but care is taken to avoid exposure to extreme temperatures, direct sunlight, and physical damage during transportation. |
| Storage | Phthalide-3-acetic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from moisture and incompatible substances such as strong oxidizers. The storage area should be protected from direct sunlight and sources of ignition. Proper chemical labeling and safety precautions, including the use of personal protective equipment, are essential when handling and storing this compound. |
Applications of Phthalide-3-Acetic Acid in Industrial ManufacturingPhthalide-3-acetic acid serves as a specialized intermediate in several advanced chemical manufacturing sectors. Our material is produced to meet stringent quality and regulatory benchmarks, ensuring reliable integration into downstream industrial processes. Below are key application scenarios highlighting differentiated industrial uses, relevant compliance regimes, formulation ratios, entry points in production, and illustrative end products. 1. Synthesis of Cardiovascular Active Pharmaceutical Ingredients (APIs)Leading pharmaceutical manufacturers utilize phthalide-3-acetic acid as a building block in the synthesis of certain calcium channel blockers and antihypertensive APIs. Downstream processes incorporate this compound during stepwise organic syntheses, often through condensation and cyclization reactions. Material addition at this stage provides critical molecular structures necessary for pharmacologically active finished substances. Industry compliance standards
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2. Agricultural Plant Growth Regulator (PGR) Intermediates ProductionAgricultural chemical companies employ phthalide-3-acetic acid as a precursor for synthesizing advanced analogues of phthalide-based plant growth regulators. This intermediate enters the esterification stage, contributing to the required chemical backbone for active agrochemical ingredients, which influence cell division and plant growth modulation in downstream crop applications. Industry compliance standards
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3. Fine Chemicals for Fragrance and Flavor IntermediatesPhthalide-3-acetic acid finds specialized application in the production of fragrance and flavor intermediates, particularly for synthesizing notes based on phthalide structures. Downstream manufacturers introduce the compound during the initial formation of aromatic ring systems, where it participates in condensation and lactonization steps, resulting in unique olfactory active agents. Industry compliance standards
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4. Dye and Pigment Intermediate ManufacturingDye formulation industries employ phthalide-3-acetic acid as a key intermediate in synthesizing phthalide-based dye components. The compound is essential in constructing certain chromophore-containing intermediates. During pigment production, manufacturers add the compound at the coupling reaction stage, enabling the transformation of substrate molecules and producing high-purity colorants for subsequent blending. Industry compliance standards
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5. Specialty Resin and Polymer Modifier SynthesisPhthalide-3-acetic acid is introduced as a co-monomer or chain modifier in the specialized production of phthalide-modified resins. Entering the process during esterification or polycondensation stages, the compound contributes to the enhancement of resin properties such as thermal stability and flexibility, valued in advanced polymer system formulations. Industry compliance standards
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Factory floors never forget a tough molecule, and Phthalide-3-Acetic Acid belongs on that list. We take every batch seriously because this compound often serves as a linchpin for fine chemical synthesis. In the world of active pharmaceutical ingredients, fine ceramics, agrochemical intermediates, and material modifications, expectations sit high. Our team knows what it means to deliver purity, handle the quirks of crystallization, and partner with customers who don’t just want product—they want reliability at scale.
Over years in the lab and on the plant floor, we’ve refined our approach to this white to slightly off-white powder. Our Phthalide-3-Acetic Acid typically boasts a purity above 99% by HPLC, tight moisture control, and consistent crystalline form for downstream process stability. Each batch is checked regularly for color, melting point, solubility, and trace impurities such as heavy metals to ensure compliance with modern standards—including those for pharmaceutical and specialty chemical use.
Our product leaves the reactor in free-flowing form with particle sizes tailored to customer reactions—whether slurry, suspension, or solid pack. It carries a CAS number specific to the molecule, not a generic intermediate. Isolating and packaging it absent of dust and static, we keep cross-contamination negligible and shelf lives long. Strict temperature logs and reproducible batch records mean we don’t lose track of the process for a single drum.
In our shop and those of our clients, Phthalide-3-Acetic Acid stands out for the way it builds complex molecules step by step. Synthetic chemists use it as a key intermediate for manufacturing antihypertensive drugs, several non-steroidal anti-inflammatory agents, and certain plant growth regulators. Routine feedback shows that our lot-to-lot stability saves researchers time and money otherwise spent troubleshooting batch failures upstream. The uniformity in melting points and solubility translates into more predictable crystallizations and extrusions.
Process engineers at specialty material companies tap the acid for precision syntheses—making use of its predictable reactivity and compatibility with modern coupling reactions. Textile and pigment formulators also recognize it for specialty dye synthesis, where color consistency and trace impurity content determine results. We often field requests for custom packaging, from fiber drums to double PE-lined aluminum pouches designed to travel overseas without clumping or degrading.
Demand for this compound keeps growing due to the expanding pipeline of advanced chemicals. Processors who once depended on small-batch supplies now count on industrial partners like us to guarantee uninterrupted scale. Reliable sourcing means pharmaceutical start-to-finish projects can avoid stockouts and periodical recertification. Agrochemical companies can plan their production campaigns around assured raw material flows.
Out on the blending floor where dust, heat and time pressure never wait, the last thing anyone wants is an inconsistent feedstock. Every time a customer’s QC team pulls a sample, they expect consistency. Suppliers who fudge specs or cut corners set entire supply chains back. We’ve watched this story play out over the years, so we keep our documentation transparent and batch samples archived for full traceability. When customers face urgent audit requests or regulatory queries, we aim to deliver honest batch histories and lots released with full COA backing—no hand-waving, no ambiguity.
Sourcing from the actual producer must feel different. Unlike traders or intermediaries, we control each variable from raw material sourcing through to the drying oven and the final packout. Our staff lives through every QA checkpoint; process deviations never get lost in translation. Instead of passing the buck when questions arise, we open our books, walk you through our documentation, and work out solutions at a level that only the original manufacturer can provide.
We have collaborated on route redesigns to reduce processing waste, troubleshoot solubility bottlenecks, or debottleneck scale-up reactions that push existing plant capacity. Recurring feedback tells us that labs and plants reach quicker regulatory filings on the back of a robust manufacturer certificate, and they avoid revalidation headaches because of documented, stable production history. This reduces the risk profile for everyone in the value stream—especially for regulated uses.
Molecules with similar backbone structures sometimes overlap in catalogues, but Phthalide-3-Acetic Acid brings a unique blend of functional handles and manageable reactivity. Compared to phthalide derivatives bearing other substituents, this compound provides three access points: the lactone ring, the acetic acid side group, and the aryl framework—all useful for building complexity into target molecules.
Other acetic acid-modified aromatics tend toward higher reactivity, unwanted polymerization, or undesirable odor. Phthalide-3-Acetic Acid resists these pitfalls. Our product won’t yellow or cake in standard storage. From a crystal engineering standpoint, its form resists moisture up to standard warehouse conditions, and bulk drum packaging can withstand moderate shocks without collapse or bridging.
Our team saw time and again that competitors relying on semi-batch or less controlled processes introduce high batch variability, not to mention trace impurities that affect synthesis reliability downstream. When the application context is high-value APIs or specialty coatings, there’s little tolerance for hiccups. Our production leverages reactor clean-in-place systems, segmented transfer zones, and barcode tracking for every lot, not just the flagship SKU.
As a manufacturer, the buck stops with us—planning, QC, packaging, and logistics. We have custom options to support different scales, including pilot plant quantities for R&D or multi-ton lots for campaign manufacturing. The difference becomes clear in emergency restarts, out-of-spec alerts, or regulatory audits. In the rare case a batch sits outside of a spec, we catch and quarantine it before any shipment leaves the loading dock.
Traceability also carries through our logistics chain. We train transportation partners on temperature and humidity guidelines documented over dozens of successful shipments. Product achieves consistent delivery quality after weeks at sea or in variable climates because we learned what holds up and what fails. Our warehouse teams maintain rotating buffer stock so production never finds itself idle while waiting on materials.
Direct customer feedback shapes our product roadmap. One pharmaceutical group needed minimal solvent residues for their tablet formulation; we modified our drying protocol and now the solvent test returns far below thresholds. An agrochemical start-up wanted to understand raw material lifecycle carbon footprints, so we built site- and batch-level data to support their climate impact reporting. Every field team knows that open dialogue with customers produces innovations we could never plan for on spreadsheets.
Our staff engineers stay available for troubleshooting or brainstorming process tweaks using Phthalide-3-Acetic Acid. They’ve contributed to flow chemistry optimizations, green solvent switchovers, and even in-line monitoring methods so clients can gain faster assurance of conversion rates. While we pride ourselves on reliability, we also learn plenty from end-users who stress-test our product’s limits and suggest improvements.
Meeting modern regulatory demands takes more than analytical finesse. Inspection teams, both domestic and overseas, have walked through our operations line by line. Trace element analysis attests to batch purity; our environmental monitoring routines confirm there’s no unreported contamination making its way into finished goods. Each batch of Phthalide-3-Acetic Acid contains a full set of documentation, matching both customer project codes and regulatory grade standards.
Some clients face unpredictable market swings that test even the best production schedules. We’ve handled seasonal spikes in demand, new application launches, and global transport bottlenecks. Our inventory tracking and robust supplier network bring resilience to the table, so projects don’t grind to a halt waiting for key intermediates. This approach has earned us long-term supply agreements and trust from top-tier end-users.
Modern chemical manufacturing can’t ignore its own environmental impact. Across our facilities, we invest in solvent recycling, closed-loop wastewater treatment, and energy efficiency upgrades. Our staff receives regular training on green chemistry principles, so we minimize yield loss and waste from raw input to finished lot. Over the years, these investments reduced atmospheric discharges, improved worker safety, and controlled water use—without sacrificing product consistency.
We seek out greener raw material options and maintain open dialogue with global partners who test emerging technologies for renewable inputs. This initiative extends to our packaging. When clients require biodegradable drum liners or lighter-weight secondary packaging, we bring our suppliers to the table to engineer new solutions—tested in actual field conditions.
Relying on direct relationships with producers matters most when a critical intermediate forms the backbone of multiple projects. Chemical supply lines operate at the mercy of intermediaries who rarely understand how today’s process deviation affects next month’s API launch. We spend the time teaching our teams about client needs, visiting facilities on short notice, and integrating feedback into monthly operational reviews.
The investment in relationships doesn’t just pay off for us—it arms customers with more confidence to innovate, invest in long-term research, and accelerate regulatory filings, since documentation and support arrive straight from the factory source. The benefit runs both ways: our development pipeline adapts faster to user insights and shifting regulatory expectations.
The realities of chemical manufacturing rarely resemble textbook cases. Shifting input costs, geopolitical trends, and regulatory shifts create volatility, even for established products like Phthalide-3-Acetic Acid. We thrive in these conditions by keeping communication open—regular forecasts, shipment tracking, and contingency planning come standard for our partners.
Each drum leaving our docks carries more than our logo—it's backed by dozens of person-years in R&D, production, and logistics, shaped to withstand real-world stresses. Clients don’t just get a sack of powder; they gain direct access to people who live their craft daily. The loyalty we build this way means we don’t just serve orders; we become trusted contributors to the next wave of scientific progress.
Our vision for Phthalide-3-Acetic Acid stretches beyond short-term contracts. We aim to anticipate customer needs, promote transparent supply chains, and raise the standard for purity, consistency, and sustainability. We’ll continue deploying new analytical technologies and partnering with regulatory agencies so that whenever our product makes its way into a new therapy, material, or formulation, it exceeds expectations.
Being the actual manufacturer means we see the whole picture—the legacy of reliable production, the responsibility for environmental stewardship, and the satisfaction of seeing our material drive forward new discoveries. We thank our long-time and new partners alike for placing trust in our team and our standards. Whenever your process depends on the real Phthalide-3-Acetic Acid, know there’s a factory team and a continuous improvement mindset standing behind every kilogram.