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Phenylacetic Acid Isobutyl Ester

    • Product Name Phenylacetic Acid Isobutyl Ester
    • Alias Isobutyl phenylacetate
    • Einecs 252-546-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    787828

    Cas Number 104-69-8
    Molecular Formula C12H16O2
    Molecular Weight 192.25 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Floral, honey-like, fruity
    Boiling Point 286°C (547°F)
    Density 1.014 g/cm³ at 25°C
    Refractive Index 1.492 - 1.496 at 20°C
    Flash Point 124°C (255°F)
    Solubility Insoluble in water; soluble in alcohol and most organic solvents
    Melting Point -28°C
    Purity Typically >98% (by GC)

    As an accredited Phenylacetic Acid Isobutyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle with tamper-evident seal, labeled "Phenylacetic Acid Isobutyl Ester" and relevant safety warnings.
    Shipping Phenylacetic Acid Isobutyl Ester is shipped in tightly sealed, chemically resistant containers to prevent leakage or contamination. It must be protected from heat, sunlight, and moisture. All shipments comply with local and international transport regulations and include proper labeling and documentation. Handle with care, using suitable protective equipment during transport.
    Storage Phenylacetic Acid Isobutyl Ester should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents. Protect it from heat, flames, and direct sunlight. Store at room temperature and avoid moisture to prevent hydrolysis. Ensure labeling and safety procedures are in place to avoid accidental exposure or spillage.
    Application of Phenylacetic Acid Isobutyl Ester

    Applications of Phenylacetic Acid Isobutyl Ester in Industrial Manufacturing

    Phenylacetic Acid Isobutyl Ester serves as a key chemical intermediate across several specialized sectors. Below, we detail real-world downstream scenarios, providing unique compliance guidance, integration points, formulation ratios, and common end-product types per segment. We highlight manufacturer-driven topics drawn from actual customer projects and regulatory standards.

    1. Fine Fragrance Compounding for Luxury Perfume Manufacturing

    High-purity ester grades enhance fragrance bases in fine perfumery, offering long-lasting floral and honey-like notes. In the blending stage, formulations require exact dilution to maintain olfactory profiles and regulatory limits. Perfume compounders rely on stability and low impurities to meet IFRA-related product safety. Our material enters as a high-purity essence, which we supply with batch traceability and analytical documentation supporting fragrance compliance worldwide.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Amendments
    • EU Cosmetics Regulation (EC) No 1223/2009 Annex III/IV
    • California Prop 65 for fragrance allergens
    • ISO 9235:2013 Natural Aromatics—Terminology compliance reference (for mixed compositions)

    Typical usage ratio

    • 0.01–1.8% in the aromatics phase of perfume compounds, adjusted for blend complexity and stability needs

    Downstream process integration

    • Entry point: Stepwise addition into fragrance concentrate during headspace balance, often in solvent-alcohol base
    • Homogenized using high-shear mixers prior to dilution with ethanol and water for final batch
    • Quality Control checkpoints for odour purity and impurity residues
    • Bottling as part of finished perfume or eau de toilette

    Final product types

    • Luxury eau de parfum
    • Floral perfume concentrates
    • Blended niche fragrances
    • Limited-edition scent compositions

    2. Aroma Chemicals Intermediate in Flavour and Fragrance Houses

    The ester functions as a key intermediate in multi-step syntheses for aroma chemicals, often used for conversion into higher-value aldehydes or for customized esterification. Producers require materials to comply with food and fragrance additive guidelines, with strict residual solvent and purity specifications. Our batches meet inspection protocols for major global F&F customers, supporting traceability and secondary transformation in enclosed systems.

    Industry compliance standards

    • US FDA 21 CFR 172.515 (Synthetic flavoring substances and adjuvants)
    • FAO/WHO JECFA Flavouring Group Evaluation
    • REACH Annex XVII (restrictions on certain chemicals in consumer aromas)
    • ISO 22000:2018 (Food Safety Management for F&F ingredient manufacturers, where applicable)

    Typical usage ratio

    • 1–5% in reaction charge for aroma intermediates; adjusted for batch size and target conversion rates

    Downstream process integration

    • Feedstock for acid catalyzed condensation or oxidation reactions in aroma chemical synthesis
    • Incorporated in closed reactor systems under nitrogen blanket
    • Monitored for side-product limits prior to distillation or crystallization
    • QC testing for GC purity and retention indices matching reference standards

    Final product types

    • Specialty aldehydes for fruit or floral accords
    • Custom esters as fragrance ingredients
    • Intermediates for high-value linalool derivatives
    • Base notes for personal care fragrance masks

    3. Solvent and Modulating Agent in Pharmaceutical Synthesis

    This ester finds use as a process solvent and polarity modulator for the pharmaceutical sector, especially in reactions demanding selective solubilization of reactants. Key API manufacturers employ it in compliance with pharmacopeial purity criteria and ICH impurity thresholds. Material enters cGMP or ISO 9001-certified environments with validated cleaning and segregation for minimal cross-contamination. We provide extensive CoA, batch-level documentation, and stability supporting DMF and regulatory filings.

    Industry compliance standards

    • USP/NF (United States Pharmacopeia—National Formulary) excipient monographs, if applicable
    • ICH Q3A/B: Impurities in New Drug Substances and Products
    • EU GMP Guidelines Part II (Active Substance Manufacture)
    • ISO 9001:2015 (Quality Management for pharmaceutical intermediates)

    Typical usage ratio

    • 3–12% by volume as a cosolvent or extracting agent, depending on solubility and selectivity requirements in the protocol

    Downstream process integration

    • Introduced during active ingredient synthesis (e.g., Grignard or Friedel–Crafts reactions), as well as purification step
    • Requires strict batch monitoring and in-process residual solvent analysis
    • Removal by vacuum distillation or crystallization before API isolation
    • Batch documentation maintained as part of DMF (Drug Master File) appendices

    Final product types

    • API intermediates in antihistamine production
    • Chiral pharmaceutical building blocks
    • Complex organic intermediates for CNS-active ingredients
    • Fine chemicals for research and development

    4. Additive for High-Stability Industrial Lubricants and Metalworking Fluids

    Formulators use this ester as an odor-masking agent and lubricity modifier in select metalworking fluids and high-stability lubricants. Compliance with occupational and environmental health guidelines ensures safe usage, especially regarding vapour exposure and biodegradability. Material is integrated after base oil blending and prior to performance additive inclusion, necessitating close control of dosage for anti-wear and odor management functionality.

    Industry compliance standards

    • OSHA 29 CFR 1910.1200 (Hazard Communication for handling lubricants with esters)
    • EU REACH Regulation (EC) No 1907/2006 (Registration, Evaluation and Authorization for industrial chemicals)
    • ASTM D6078 (Standard for mark-up lubricants bench testing)
    • OECD 301 biodegradability test methods (for environmental safety claims)

    Typical usage ratio

    • 0.1–0.7% of total formulation, adjusted according to base oil type and intended protective function in the blend

    Downstream process integration

    • Added to blending kettle post base stock mixing; agitation to homogenize prior to anti-wear additive addition
    • Monitored for compatibility with other esters and biocides
    • Lubricant samples tested for evaporation residue and odour threshold
    • Final batch filtered and filled into service containers under industrial hygiene controls

    Final product types

    • Metalworking cutting fluids
    • Odor-masked industrial lubricants
    • Machinery protection fluids
    • Plant environment-friendly lubricants

    5. Modifier in High-Performance Plasticizer Formulations for Polymers

    Manufacturers incorporate this ester to adjust flexibility, volatility profile, and odour in custom phthalate-free plasticizer blends for specialty polymers. All batch production complies with major chemical safety and migration standards, especially for packaging and non-food contact plastics. We monitor residual impurity signatures closely, maintaining batch records for customer audits and regulatory filing.

    Industry compliance standards

    • REACH Annex XVII (Restrictions on substances in plastics for EU market)
    • US FDA 21 CFR 177.1680 (Indirect food additives—olefin polymers, for non-food-contact plasticizer uses)
    • EN 71-3:2019 (Safety of toys—Migration of certain elements, for flexible toy parts)
    • GHS/CLP (Globally Harmonized System / Classification, Labelling and Packaging)

    Typical usage ratio

    • 0.5–6% blended with base plasticizer; ratio set by flexibility, volatility, and odour targets for the finished polymer

    Downstream process integration

    • Fed to melt-blend lines or extrusion mixers together with main plasticizer agents
    • Dosage monitored by automated or manual feed depending on batch scale
    • Homogenization at 100–150°C for optimal fusion, then cooled and pelletized or calendered
    • Final QC checks for migration, volatility, and odour character

    Final product types

    • Flexible PVC profiles (non-food contact)
    • Odour-controlled rubber coatings
    • Soft polymer molded components
    • Functionalized floor mat compounds
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    Certification & Compliance
    More Introduction

    Introducing Phenylacetic Acid Isobutyl Ester: Purpose-Driven Performance from a Chemical Manufacturer

    Experience Shaped by Decades in Synthesis

    At our facility, day-to-day work with esters shapes how we approach production and problem-solving. Phenylacetic acid isobutyl ester (CAS: 102-14-3) sits among our offerings as a reliable, high-purity product that emerges from hands-on chemical synthesis, not outsourcing or speculation. Every batch we prepare benefits from a close-up understanding of material behavior, be it during fractionation under reduced pressure, or during raw material checks. Over years of refining method and plant practices, the strengths of this single ester unfold across several industries. Our technicians draw on routine physical testing and real product feedback. This transparency enables careful stewardship of every lot—each gram reflects awareness of both occupational and market expectations.

    Understanding the Product on a Practical Level

    Phenylacetic acid isobutyl ester belongs to the family of aromatic esters. It appears as a clear, colorless liquid under normal laboratory and production conditions. In the plant, sharp attention to odor and boiling point serves as both a quality control lens and an early check on process drift. Staff know the signature floral and honey-sweet scent of a fresh batch—this sensory profile explains why flavor and fragrance markets come to us for consistent deliveries. The molecular structure, a fusion of phenylacetic acid and isobutanol, lends a balance of volatility and stability. This makes it desirable among flavor chemists developing fine fragrances, confectionery notes, and personal care aromas. Past experience shows that the tactile side—from handling in stainless processing lines to filtration details—shapes downstream use. Our approach sets quality from the moment raw phenylacetic acid enters our stores through to the way finished ester flows or pours from drums during customer receiving.

    Usage Built on Delivering Results

    Its primary draw in the flavor and fragrance industry roots in its nuanced, steadfast aroma profile. Perfume houses often request this ester in batch production—especially for blends that require hints of honey, jasmine, or narcissus. Our experience supplying for gourmand and floral formulations demonstrates strong feedback on shelf stay and odor reliability. Outside fine fragrances, food application technicians procure this ester for sweet, berry-like, or pastry-inspired notes in confections or baked goods. Each order demands purity, so we run repeated gas chromatography to verify batch consistency. Working in close coordination with finished product makers, we’ve seen how just minor variations in this ester dramatically affect a finished aroma’s top or heart notes.

    Many customers also bring questions about reactivity and compatibility for specialty chemical synthesis. In these segments, we’ve collaborated to optimize this ester as a reactive intermediate for various downstream molecules. Our lab team backs up its performance with tailored protocols—solubility in ethanol, stability alongside acids, or non-reactivity in certain bases. Reproducibility is essential, whether formulators use this ester for direct olfactory effect or as a building block toward more complex chemistries. What enables this reproducibility isn’t just good SOPs on paper—it's a learned discipline in temperature control, solvent selection, and even in the small talk at shift handover about the “feel” of a distillation run. These lessons build a product that suits real-world plant and formulation challenges.

    Specifications that Reflect Real User Needs

    We manufacture phenylacetic acid isobutyl ester under controlled conditions, aiming for the highest possible assay by GC, typically in the range of 98% or higher. Water content stays low, usually under 0.2%, because many customers process it alongside moisture-sensitive materials. Technicians perform density and refractive index checks batch by batch, not only to comply with standard ranges but to confirm process regularity. Odor purity comes high on the priority list, since the sensory industry grades every component by nose before it ever enters a formulation. In our experience, even trace off-notes introduce batch rejection risks in these markets. Our packaging staff uses closed-system fills and vapor barrier containers to retain sample integrity for as long as possible during shipping. Each aspect faces closer scrutiny due to the niche, high-value role this ester carries in finished goods. Over time, input from experienced customers sharpens our attention to what really matters in daily production use, making every parameter a practical, not just a theoretical, need.

    Key Differences from Other Esters—A Practitioner’s Take

    Phenylacetic acid isobutyl ester holds its own character—markedly different from more common analogs like the ethyl or benzyl esters of phenylacetic acid. Comparing sensory, physical, and application data, isobutyl ester tends much sweeter and slightly heavier on the nose than its ethyl equivalent, with less volatility but greater persistence. This gives formulators a flexible option when seeking longer-lasting, more substantial body in fragrances or flavors. The presence of the isobutyl group stretches out the aromatic complexity, making it less prone to quick evaporation. In the production plant, operators notice that isobutyl ester flows with lower volatility—allowing safer headspace management during drum or tank openings, especially in warm weather. For end users, the less reactive, heavier structure reduces unwanted byproduct formation in secondary syntheses. This technical side-by-side isn’t just a datasheet matter; it’s grounded in years of customer troubleshooting and side trials, where performance emerges as function, not just chemical structure.

    Processors and flavorists familiar with related esters—like the methyl, ethyl, or propyl versions—often switch to the isobutyl counterpart when they seek better masking of sharp or solventy undertones, or when regulatory thresholds require limits on more volatile analogs. In cosmetic and personal care, the difference shows up in how the ester remains gentle on skin contact, with lower chances of irritation, based on controlled in-house trials. Our ongoing data collection from customers points to reduced migration in plastic packaging, giving further differentiation in sensitive product matrices. Practical lab and plant notes underscore that every ester group change shifts solubility, boiling point, and safety profile. Formulators often compare several esters head-to-head, and in these real-world comparisons, isobutyl ester earns its place thanks to performance features that show up not on paper but in finished products on shelves.

    Challenges in Consistency: Lessons and Improvements

    Making high-purity phenylacetic acid isobutyl ester means watching for inconsistencies at every stage, not just end-point batch testing. Over time, we identified that impurities, especially from residual isobutanol or phenylacetic acid, can spoil entire batches for the fragrance industry. These off-notes often come from short-cuts in distillation, or small temperature drifts—even by a few degrees. As we refine our process, every step from weighing to splitting up final drums gets checked for cross-contamination using rapid GC sniff tests and side-by-side odor assessment. Only hands-on process education can teach how a slight change in cooling water flowrate, or a rushed transfer, leaves a trace solvent that trained noses pick up later. We train new technicians not just on the chemical mechanisms, but also on the reality that sloppy cleaning between esters ruins both efficiency and product confidence down the line.

    Storage and packaging bring further challenges. We noticed in early years that open-fill systems led to headspace oxidation, which made for rapid scent deterioration. Moving to vapor-barrier IBCs and shifting sampling protocols reduced customer complaints nearly to zero. When shipping to hot climates or long-haul destinations, we recommend temperature-controlled transit because excess heat tends to push trace byproducts beyond their olfactory threshold. These aren’t abstract rules—they are the result of observing complaints and feedback from formulators working with sensitive finished goods.

    Industry Expectations Drive Quality

    Flavor and fragrance customers have little patience for variable batches. We learned long ago that even minor deviations in phenylacetic acid isobutyl ester’s sensory character—or color hints from thermal decomposition—drive requests for replacements or credits. The escalation in natural flavor and clean label trends adds more scrutiny, since downstream processors request ever-cleaner odor profiles. Compliance testing, such as allergen thresholds, means zero room for undeclared carryover from other esters or solvents. Our line workers know these standards from first-hand communication with R&D departments in major flavor houses. Batch repeats, real odor panels, and unannounced third-party audits form part of the standard cycle each quarter. Customers expect transparency—from precursor sourcing to final certificate of analysis—making traceability from our synthesis records a regular discussion during site visits or on video calls.

    Local and international regulators take a close look at aromatic esters. Our compliance team grapples with updates on food additive status, safe use levels, and evolving requirements for food-grade or cosmetic use. This means ongoing batch documentation—analytical profiles, possible residual solvents, and detailed logbooks tracking every process step. Years of engagement with standard-setting bodies, from food safety agencies to international transport protocols, shapes each step of our process. The goal remains the same: a consistent, traceable, and fully documented product meeting both the letter and intent of regulation.

    Direct Manufacturer’s View: Real Feedback Drives Continuous Change

    Earning repeat orders for phenylacetic acid isobutyl ester calls for staying alert to industry shifts and keeping open lines with both power users and smaller formulators. Lab teams link up with customer R&D regularly to discuss not just technical data sheets, but actual production and formulation outcomes. For example, some fine fragrance mixers highlighted how minor water traces shifted the aging profile of their blends. We ran parallel water removal trials, changing drying agent grade and column design, and invited those clients to compare side-by-side test samples. Practical improvements in drying took months of repeated experimentation—one more detail only a disciplined, production-level focus brings forward.

    We also receive requests for customization—different drum sizes, transfer under inert gas, direct-tank delivery, even minor variations in ester concentration to cover specific flavor regulatory limits. Meeting these needs does not fall to back-office responses. Operators and production planners weigh feasibility based on plant layout, shipping schedules, and raw material inventories. Our ability to customize batch size or delivery timing has often saved customers from expensive production gaps or awkward line shutdowns. We don’t just sell a product; we join the ongoing effort to fit that product to machines, protocols, and packaging requirements that shift as industry demands change.

    Supporting Claims with Concrete Data

    In the lab, objective physical parameters serve as regular checkpoints during every campaign. Purity is tracked using GC with flame ionization detection, and presence of core byproducts remains well below sensory impact thresholds. We routinely check density and refractive index—parameters that indicate correct reaction pathways and unmodified product. Sensory panels, made up of trained staff and external reviewers, smell test samples at multiple stages. Customers have shared chromatograms and analytical data showing how our product holds up to established reference standards, even after months under warehouse lighting and heat. In customer audits, side-by-side blending trials compare our batches with both local and global suppliers; on the back of that, our retention rate on annual contracts outpaces regional competitors.

    We support our claims on stability with temperature and light-exposure tests managed inside our facility. Data loggers record batch storage conditions—both at our end and, for some partners, across shipping networks. Field returns or claims undergo cross-analysis with retained reference samples so that disputes can be resolved transparently. Many buyers bring their own sophisticated GC-MS or sensory panels. The fact that repeat business grows, not just from flagship buyers but also from small, independent blenders, strongly supports the real-world value of our production quality.

    Solutions to Current and Future Industry Issues

    The markets absorbing phenylacetic acid isobutyl ester place increasing importance on traceability and sustainability. This brings challenges for a direct manufacturer. We’re shifting sourcing for both phenylacetic acid and isobutanol toward origins with verifiable, documented trace chains. Our teams explore green process improvements—not just to chase marketing trends, but to address the practical reality of more expensive and less predictable raw material streams. By recycling process solvents on-site and capturing unreacted isobutanol, we cut waste output and ease fluctuations in input costs. We evaluate plant energy consumption by campaign, tuning reaction and distillation steps to reduce peak demand while preserving product integrity.

    For customers pressed by allergen status or clean-label regulation, our documentation protocols include batch-level allergen, GMO, and vegan declaration forms, with supporting analytical documentation open for direct review. Across product shipments, we supply material safety and compliance documents tuned to the target application—whether for food contact, fragrance, or cosmetic use. Each year, new inquires demand faster turnaround on regulatory responses; we staff a team fluent in real-world compliance, able to resolve these new requirements, not just quote standards out of context. Plant and lab staff trade lessons with global partners to keep documentation standards current and practical.

    The Road Ahead—Adaptation Built on First-Hand Experience

    More than a formula or a catalog entry, phenylacetic acid isobutyl ester represents a living, evolving product embedded in production culture, customer feedback, and practical chemistry. Our facility remains driven by real-world process knowledge—lessons learned on the job, tested against both equipment limitations and market realities. Every inquiry, every difficult customer batch, and every tweak in plant operation informs the next production run. Unlike distant traders or middlemen, we experience firsthand the cost of a minor deviation—and the pride in a perfect batch. As demand cycles shift and standards grow stricter, our forward path depends on this earned expertise—where talk lines up with measurable outcomes, and every finished drum reflects both science and craft. Phenylacetic acid isobutyl ester, in our workshop and warehouses, stands as a proof-point: substance and accountability matter most in chemical manufacturing.