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Phenyl Acetate

    • Product Name Phenyl Acetate
    • Alias Acetate de phenyle
    • Einecs 203-483-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    584596

    Chemicalname Phenyl Acetate
    Casnumber 122-79-2
    Molecularformula C8H8O2
    Molecularweight 136.15 g/mol
    Appearance Colorless liquid
    Odor Pleasant, floral
    Boilingpoint 195-198°C
    Meltingpoint -25°C
    Density 1.08 g/cm3 at 20°C
    Solubilityinwater Slightly soluble
    Flashpoint 93°C (open cup)
    Refractiveindex 1.501-1.504 at 20°C
    Vaporpressure 0.138 mmHg at 25°C
    Purity Typically ≥99%

    As an accredited Phenyl Acetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phenyl Acetate, 500g, is supplied in a sealed amber glass bottle with a secure cap and chemical hazard labeling.
    Shipping Phenyl acetate should be shipped as a hazardous material in accordance with local, national, and international regulations. It must be securely packed in tightly sealed containers, clearly labeled, and protected from heat and ignition sources. During transport, appropriate safety documentation and emergency procedures should accompany the shipment to ensure safe handling.
    Storage Phenyl Acetate should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Ensure proper labeling, and store at room temperature. Use containers made of compatible materials, such as glass or specific plastics, to prevent contamination or degradation.
    Application of Phenyl Acetate

    Applications of Phenyl Acetate in Industrial Manufacturing

    Phenyl Acetate serves as a high-purity intermediate with established roles in several targeted downstream industries. Our manufacturing expertise ensures quality, compliance, and supply security for clients using this compound in regulated and performance-driven sectors.

    1. Pharmaceutical Intermediate for Penicillin Derivatives

    Pharmaceutical plants use Phenyl Acetate as a key intermediate in the synthesis of semi-synthetic penicillins, particularly ampicillin and amoxicillin. This raw material participates in side chain modification, offering necessary structural features for antibacterial action. Production demands rigorous control over purity and residual solvents to meet active pharmaceutical ingredient (API) criteria and regulatory filings. Lot-to-lot quality consistency affects downstream crystallization and yield.

    Industry compliance standards

    • USP, Ph.Eur. monographs for API intermediates
    • 21 CFR 210/211 for cGMP manufacturing
    • ICH Q7 for Active Pharmaceutical Ingredient (API) starting materials
    • DMF (Drug Master File) supporting documentation

    Typical usage ratio

    • 0.95–1.15 molar equivalents per antibiotic batch; ratio adjusted based on desired side chain introduction and target volume

    Downstream process integration

    • Reaction with 6-APA (6-Aminopenicillanic Acid) via enzymatic or chemical acylation
    • Incorporated during early-stage fermentation purification and subsequent chemical synthesis
    • Purity impacts subsequent crystallization, isolation, and formulation steps

    Final product types

    • Ampicillin trihydrate API
    • Amoxicillin trihydrate API
    • Finished oral dosage forms (tablets, capsules, suspensions)

    2. Solvent and Precursor in Perfume Manufacturing

    Perfume houses and aroma chemical producers employ Phenyl Acetate both as a direct fragrance compound and as a solvent for floral or fresh olfactory notes. Its sweet, rose- and honey-like scent enables blending into fine fragrances and personal care products. Consistent volatility and color stability are required for integration within controlled batch blending and QC routines. Manufacturers monitor allergen content and residue profiles to comply with fragrance safety standards.

    Industry compliance standards

    • IFRA (International Fragrance Association) guidelines
    • REACH registration (EC 1907/2006)
    • EU Cosmetics Regulation (EC 1223/2009)
    • Allergen declaration under EU 76/768/EEC

    Typical usage ratio

    • 0.1–5.0% by weight in finished fragrance oils or bases; perfumers adjust based on desired profile and stability

    Downstream process integration

    • Dilution into ethanol or carrier oils during concentrate blending
    • Incorporation using closed-system dosing to minimize loss and allergen exposure
    • QC checked via GC and olfactory panels before final bottling

    Final product types

    • Eau de parfum, eau de toilette, cologne
    • Fragranced lotions and creams
    • Fine fragrance bases for personal care

    3. Raw Material in Agrochemical Synthesis

    Agrochemical facilities apply Phenyl Acetate as a building block for certain systemic herbicide and pesticide formulations. The aromatic ester structure provides a substrate for further halogenation, nitration, or condensation in multi-step synthesis schemes. Careful sourcing and specification testing help ensure the absence of prohibited impurities and residual solvents, which could carry over to finished crop protection products and regulatory filings.

    Industry compliance standards

    • FAO/WHO specifications for pesticide active ingredients
    • EU Regulation (EC) No. 1107/2009 concerning the placing of plant protection products on the market
    • ISO 9001:2015 QMS certification for process traceability
    • REACH registration and SDS requirements

    Typical usage ratio

    • 0.5–2.0 molar equivalents per batch, depending on downstream transformation and targeted synthesis route

    Downstream process integration

    • Introduced at the initial condensation/esterification stage for custom active ingredient precursors
    • Reacted under monitored temperature and pH to control by-products
    • Residual analytical checks for final crop protection registration

    Final product types

    • Systemic herbicide active ingredients (e.g., specific phenoxyacetic acid derivatives)
    • Industrial insecticide intermediates
    • Commercial crop protection formulations

    4. Intermediate for Plasticizer Production in Polymer Industry

    Specialty plasticizer manufacturers rely on Phenyl Acetate as an intermediate in the derivatization processes for high-performance esters. The molecule’s structure allows selective esterification or transesterification, which adjusts the compatibility and migration resistance within flexible polyvinyl chloride (PVC) and related resins. Plants implement strict specifications on moisture and color during bulk transfer and blending, ensuring batch reproducibility and final plasticizer stability.

    Industry compliance standards

    • ISO 9001 management systems for chemical plant operations
    • CONCAWE guidelines for plasticizer composition and traceability
    • RoHS Directive (EU 2011/65/EU) for restricted substances
    • ASTM D1755 for specification in PVC applications

    Typical usage ratio

    • 5–15% of total esterification reactants by weight; ratio chosen based on targeted ester functionality and plasticizer compatibility

    Downstream process integration

    • Used in the synthesis reactor feedstock for phthalate or non-phthalate plasticizer esters
    • Mixing and conversion under catalytic conditions with polyols or other acids
    • Continuous quality analysis for acid value and residual reactant

    Final product types

    • High-solvency plasticizers
    • PVC coating additives
    • Flexible vinyl flooring and cable insulation compounds

    5. Precursor in Dyes and Pigment Synthesis

    Colorant manufacturers utilize Phenyl Acetate as a specialty intermediate in the production of select azo and anthraquinone dyes for textile printing and industrial inks. The compound introduces essential aromatic groups that influence chromophore stability and solubility. Batches undergo pre-approval testing to verify sulfonation level and metal ion contamination, factors that impact final dye strength and fastness properties. Entry occurs through automated weighing and charge systems, and late-stage modifications enhance batch consistency.

    Industry compliance standards

    • OEKO-TEX Standard 100: limitations on specific aromatic amines and intermediates
    • EU REACH Annex XVII for restricted dye classes
    • ISO 14001 environmental management for effluent controls
    • ZDHC (Zero Discharge of Hazardous Chemicals) chemical inventory reporting

    Typical usage ratio

    • 1–10% of total dye precursor mass; ratio varies with chromophore class and solubility profile

    Downstream process integration

    • Incorporated into primary aromatic coupling or diazotization reactions for pigment development
    • Controlled addition at color synthesis, before neutralization and drying
    • Residual monitoring for AIQ and color index compliance

    Final product types

    • Synthetic dyes for polyester fabrics
    • Industrial inkjet printing colorants
    • Textile dye dispersions
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    Certification & Compliance
    More Introduction

    Phenyl Acetate: A Manufacturer’s Perspective

    Putting years on the production floor has shown us the value of transparency. Phenyl acetate, a clear and sweet-smelling liquid, stands as one of those versatile compounds that prove their worth time after time. In our facility, we work with phenyl acetate under the model PA-001, achieving high purity with specifications that reliably test above 99.5 percent. The chemical structure here is simple—phenyl group linked to an acetate—but this simplicity belies its usefulness across several industries.

    Production and Consistency

    Our reactors handle phenyl acetate synthesis through esterification, where we bring together acetic acid and phenol under controlled conditions. Years ago, slight deviations in reaction conditions often led to problems such as excess phenol or colored byproducts. Equipment upgrades and diligent process monitoring now allow us to produce phenyl acetate with a minimum of color and with a moisture content typically below 0.2%. We never cut corners on raw material purity since trace impurities can travel along and disrupt downstream uses, especially in pharmaceutical applications. Final product is kept in steel drums, under nitrogen, minimizing hydrolysis and preventing water absorption—which matters if storage extends for weeks at a time.

    Solubility, Handling, and Shelf Life

    Phenyl acetate wants to mix with most organic solvents but shows little interest in water. Technicians know that spills can be mopped up with standard absorbents but, left exposed, the material can evaporate rather quickly. The sweet odor is notable at surprisingly low concentrations in the air, which can be a blessing or a curse—many of the staff start associating that scent with a job well done, yet it reminds everyone not to leave containers cracked open. If proper care is taken to seal drums and limit exposure to light, the shelf life can easily extend over a year without any detectable change in purity. The most common analysis we run for aging is gas chromatography; a quick check can resolve questions and stave off unnecessary disposal.

    Applications in Industry

    Pharmaceuticals and Fine Chemicals

    Lab researchers regularly place orders for phenyl acetate because it fits so well into synthetic routes for pharmaceuticals. The ester group acts as a fleeting protecting group in complex syntheses, allowing easier management of multistep reactions. Certain intermediates, where phenyl acetate serves as a precursor, feed into medical compounds and fragrances, both fields where trace contaminants can matter as much as the main molecule.

    Fragrances and Flavors

    Looking closer, the strong, sweet scent of phenyl acetate is no accident; perfumers and flavorists learned early on that its aroma profile brings floral and fruity top notes. Our production runs regularly feature a dedicated batch, reserved for these industries, guaranteeing low levels of undesirable aldehydes and avoiding sulfur-based flaws that can spoil an entire fragrance blend. Consistency makes or breaks a formulation, and the recurring orders from large and small perfumeries alike show that users can rely on our product’s character.

    Solvents and Chemical Synthesis

    People often overlook phenyl acetate’s function as a solvent. Some specialty resins and coatings benefit from its solvency power, solubilizing polymeric chains that struggle with more common esters. In smaller quantities, synthetic chemists use it to adjust boiling points in reaction mixtures, where its 196°C boiling point plays a strategic role—higher than ethyl acetate, lower than benzyl benzoate. These subtle differences reveal themselves only to those who tinker regularly with reaction scales and conditions.

    Regulatory Insights and Market Evolution

    Manufacturers pay close attention to regulation, and phenyl acetate claims an interesting spot. Decades ago, most government agencies viewed it as a simple industrial chemical. Changing times—especially concern regarding illicit drug synthesis—have reshaped how it’s monitored. Many jurisdictions classify phenyl acetate as a controlled precursor, which places an obligation on us to maintain transparent paperwork, ship only to vetted customers, and store records for years. These extra steps may feel like nuisance, but they have become part of everyday operations and actually help maintain credibility with legitimate downstream users. We comply not out of fear, but because the industry’s reputation rides on responsible stewardship.

    Quality: Beyond the Certificate

    Specs matter. Buyers routinely call for GC assay numbers, water content, acidity, or color in Hazen units. Yet, as producers, we know an unchecked batch error can undermine all the paperwork. That is why teams confirm specifications at multiple stages—post-reaction, after solvent removal, and when finished drums line up for shipment. Careful control of cooling rates can impact crystal formation in cold climates; we had shipments in winter where some crystallization occurred, a headache for customers expecting a pourable liquid. These stories stick, and we now warm batches before filling drums in cold weather, adding another point of reassurance for buyers who don’t want surprises.

    Distinguishing Phenyl Acetate from Similar Compounds

    Inquiries often land in our inbox from customers unsure whether to use phenyl acetate, ethyl acetate, or benzyl acetate. The simplest distinction comes from their boiling points and odor profiles. Ethyl acetate boils low and flashes off quickly—great for paint thinners, too volatile for high-temp syntheses. Benzyl acetate makes a much thicker, heavier note in perfumes, and sits stubbornly in water-based systems. Phenyl acetate hits a sweet spot, literally and figuratively. Its mild volatility matches up with specific needs in fragrance layering, and the relatively stable ester bond resists hydrolysis under mild conditions. Direct comparisons only go so far—getting hands-on with the material reveals the subtle but crucial differences that shape outcomes in synthesis or product development.

    Sustainability and Environmental Footprint

    We see questions about greener processes with increasing frequency. Traditionally, phenyl acetate derives from petrochemical sources, but over the last decade, new syntheses using renewable feedstocks have moved from pilot scale to full production. Our pilot plant trialed a process using biobased phenol, sourced from crop side-streams, and acetic acid made from fermentation. The process runs cleaner with lower greenhouse gas emissions, although the market price still runs a premium. Some sectors, especially in food and fragrance, have started to prefer this renewable version and show willingness to pay a little more for documented sustainability.

    Waste management ranks as another operational focus. The most common byproduct is water, but off-spec phenyl acetate requires careful incineration in approved facilities. Our team collaborates with licensed disposal partners, and we favor process improvements that boost reaction yields, cutting down waste at the source. Each process tweak might save a few hundred kilograms of raw material per year, which adds up to real economic and environmental impact across multiyear production runs.

    User Experience: Challenges and Feedback

    Feedback from those actually running phenyl acetate in their plant matters more than any spec sheet. One example—a customer troubleshooting an unanticipated haze in a specialty resin—prompted us to investigate minute water content. Turns out, a tiny leak in our condenser allowed environmental humidity into a couple of drums. Fixing that taught us to double-vacuum all drums in summer months, a practice we now keep as standard. Such practical feedback loops between production and end-use have shaped our working methods more than raw textbook knowledge ever could.

    Handling Recommendations and Lessons Learned

    The experienced warehouse crew knows phenyl acetate can irritate skin with extended contact. Gloves and simple goggles do the job for everyday transfers. On a few occasions, operators absent-mindedly uncapped drums only to catch the sharp scent—motivation enough to stick with best handling practices. Fire risk stays low, as phenyl acetate won’t ignite as easily as lighter esters, but we still group it away from oxidizers and maintain spill kits within easy reach.

    Lessons keep coming. Over a decade ago, a drum stored near an overhead heater aged faster than expected, leading to a shift in odor profile. That taught us not to store near heat sources, which applies as much to warehouse layouts as to lab-scale projects. We encourage buyers and downstream users to keep the material cool, dry, and sealed, a simple habit that prevents most avoidable issues.

    Market Shifts and Customer Expectations

    Changes in the global supply chain have shaped demand for phenyl acetate. Fluctuating prices for raw phenol or acetic acid directly influence not just our costs, but decisions by end users on formulation and sourcing. A recent spike in feedstock pricing brought more questions from customers exploring long-term supply contracts. We offer periodic market insights, explaining likely trends rather than making false assurances. Being upfront with customers when we see clouds on the horizon helps both sides plan instead of lurching from shortage to shortage.

    Expectations from buyers have steadily risen, especially regarding documentation. Material traceability gets requested by ever more clients, with some wanting to track every step from raw feedstock to finished drum. We keep molecular batch logs and raw material receipts for years, enabling audits and reinforcing confidence. Such attention to detail helps maintain strong relationships, especially where projects stretch over many production cycles or involve sensitive end uses like food or pediatric medicines.

    Future Directions and Continuous Improvement

    The pressure to innovate is always present. Our R&D group continues to pilot new catalysts and green chemistry approaches to shaving down waste, improving yields, and refining product purity. Last year, a tweak to residence time and a change in distillation column design brought purity gains of nearly 0.2%, with some batches testing at 99.7%. These small increments may look trivial but mean fewer purification steps for end users and fewer complaints about off odors or trace discolorations.

    Collaboration with end users shapes much of our direction. Requests from perfumery houses to hold sulfur content below 1 ppm led us to increase routine elemental screening. A pharmaceutical client flagged a nitrosamine risk in their downstream process, prompting us to add another stage of pre-shipment quality checks. Changes in customer expectations rarely feel like a burden—they reflect a mutual interest in delivering safe, reliable, effective products.

    Conclusion: Experience as Guide

    After years in chemical manufacturing, we view phenyl acetate as more than a line on a balance sheet. It represents the accumulation of hard-won know-how, close engagement with both regulatory and market shifts, and ongoing improvements shaped by direct user feedback. From fine chemicals to fragrances, each lot produced speaks not just to technical skill but also to a philosophy of open communication and steady progress. Every improvement, every customer conversation, every shipment handled with care builds trust—something not captured in mere specifications, but evident in every drum leaving the plant.