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Phenoxyacetamide

    • Product Name Phenoxyacetamide
    • Alias Acetamide, 2-phenoxy-
    • Einecs 221-867-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    634877

    Chemical Name Phenoxyacetamide
    Molecular Formula C8H9NO2
    Molecular Weight 151.16 g/mol
    Cas Number 103-84-4
    Appearance White to off-white solid
    Melting Point 98-101 °C
    Boiling Point 335.6 °C at 760 mmHg
    Density 1.204 g/cm3
    Solubility In Water Slightly soluble
    Smiles O=C(N)COC1=CC=CC=C1

    As an accredited Phenoxyacetamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phenoxyacetamide is supplied in a 500g high-density polyethylene (HDPE) bottle, sealed, with a tamper-evident cap and clear hazard labeling.
    Shipping Phenoxyacetamide is shipped in tightly sealed containers to prevent moisture and contamination. The packaging complies with chemical safety regulations, using strong, leak-proof materials. Labeling includes hazard information and handling instructions. The chemical is transported under ambient conditions, with care to avoid excessive heat and physical damage during transit.
    Storage Phenoxyacetamide should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and moisture. Keep it away from incompatible substances such as strong oxidizing agents. Store at ambient temperature and protect from light. Ensure proper labeling and follow all applicable safety and regulatory requirements for chemical storage.
    Application of Phenoxyacetamide

    Applications of Phenoxyacetamide in Industrial Manufacturing

    As a direct manufacturer of phenoxyacetamide, we serve downstream industries that leverage the unique properties of this intermediate for specialized production processes. Below are the primary application segments where our material is actively used, with detailed insight into compliance, dosage, process integration, and resulting finished products.

    1. Pharmaceutical Intermediate for Antipyretic-Antiinflammatory Agents

    Major pharmaceutical companies utilize phenoxyacetamide as a critical intermediate compound during synthesis of certain antipyretic and non-steroidal anti-inflammatory drug (NSAID) actives, including phenacetin derivatives. Our material enters highly regulated synthesis chains, where stringent control over impurity profiles and traceability is mandatory. Batch release supports high-volume and pilot-scale drug precursor manufacturing, ensuring reproducibility and consistent reactivity during condensation or amide coupling steps.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • US FDA CFR Title 21 Part 210/211
    • EU EudraLex Volume 4 GMP
    • Pharmacopoeial requirements (USP, EP) for related substances in APIs

    Typical usage ratio

    • Ranges from 0.2 to 0.5 moles per mole of target API, depending on multi-step reaction design and yield optimization; adjustment based on stoichiometry of condensation or substitution routes.

    Downstream process integration

    • Integrated into early or mid-stage synthetic steps, usually in the amide bond formation phase; input is via controlled feed tanks under nitrogen.

    Final product types

    • Intermediate and final pharmaceutical APIs such as acetaminophen analogues and other phenoxy group-bearing NSAIDs.

    2. Agrochemical Synthesis: Herbicide and Fungicide Intermediates

    Agrochemical manufacturers employ phenoxyacetamide as a precursor molecule in the design of phenoxy-based herbicide and systemic fungicide actives. Its introduction contributes specific electron-donating properties required during the derivatization of phenoxyacetic acid frameworks. Product suitability rests on residue threshold controls and trace contaminant levels, vital for compliance in major crop protection markets.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for chemical production
    • OECD Guidelines for the Testing of Chemicals
    • REACH Annex II Safety Data Sheet Requirements (EU)

    Typical usage ratio

    • Utilized between 5% and 15% by mass relative to total batch charge, adapted as per synthetic target and process scale-up; ratios selected based on conversion efficiency and downstream purification steps.

    Downstream process integration

    • Fed directly during the initial amide formation stage in multi-step batch synthesis; followed by acylation or halogenation to achieve final bioactive structures.

    Final product types

    • Phenoxyalkanoic herbicide technical concentrates, systemic fungicide precursors for agricultural formulation.

    3. Specialty Dye Intermediate for Textile and Leather Processing

    Producers of high-performance dyes for textile and leather sectors use phenoxyacetamide to introduce both stability and specific chromophoric properties into azo and anthraquinone dye molecules. Its reactivity profile supports synthesis steps that require strong coupling and minimal byproduct formation. Regulatory compliance on residual amides and azo intermediates underpins all supply agreements to major textile chemical houses.

    Industry compliance standards

    • OEKO-TEX Standard 100
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals - Manufacturing Restricted Substances List)
    • REACH Regulation (EC) No 1907/2006 Annex XVII
    • ISO 9001:2015 for batch traceability

    Typical usage ratio

    • Added at 3%–8% of the total mass in dye intermediate synthesis, tuned to color depth and stability requirements; percentage set after small-scale reactivity screening.

    Downstream process integration

    • Incorporated during dye coupling or condensation reactions, prior to salt formation, and often purified by solvent extraction before final crystallization.

    Final product types

    • Reactive textile dyes, azo pigment intermediates, leather finish coloring agents.

    4. Fine Chemical Synthesis: Custom Polymers and Monomers

    Manufacturers in the custom synthesis segment leverage phenoxyacetamide as a precursor for specialty monomers and as a chain modifier in polymer production. The amide linkage provides targeted flexibility and thermal stability profiles in engineering polymers, influencing end-use properties in a predictable fashion. Careful adherence to global chemical control regulations ensures acceptability for export-oriented supply chains.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management
    • REACH registration for monomers and intermediates
    • TSCA (Toxic Substances Control Act, US) Inventory Requirements
    • Industry-specific customer audit parameters for polymer purity and trace residues

    Typical usage ratio

    • Ranging from 1%–5% by weight of the total monomer charge dependent on target polymer architecture; load level optimized after pre-polymerization trials and mechanical performance testing.

    Downstream process integration

    • Charged into the monomer mix before polymerization initiation, with active monitoring of incorporation rates via in-process analytics (GPC, NMR).

    Final product types

    • High-performance polyamides, phenoxy-functionalized thermoplastic elastomers, specialty coatings precursors.
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    Certification & Compliance
    More Introduction

    Phenoxyacetamide: Direct from Our Production Line

    A Closer Look at Our Phenoxyacetamide

    Every batch of Phenoxyacetamide coming from our facility reflects an approach shaped by years in the chemical manufacturing sector. We have watched this compound shift from a specialty chemical for research to an ingredient recognized for its consistency and reliability in agrochemical, pharmaceutical, and intermediate applications. Much of that reputation is earned on the production floor, not in advertising copy or repeated buzzwords.

    Understanding Phenoxyacetamide’s Qualities

    Phenoxyacetamide, which we produce under model PA-12, carries the CAS number 103-81-1. In practice, purity matters more than just a number printed on a label. We consistently reach a minimum purity of 99%. Making that happen isn’t just about technical capability—it comes down to process discipline, real-world experience troubleshooting on the line, and a refusal to cut corners when raw material quality fluctuates.

    Once, when a supplier’s phenol feedstock failed to meet our specs, it triggered a review of batchwise impurity profiles. Our operators caught the shift because they know phenoxyacetamide's physical behavior in the reactor—subtle changes in crystallization, even in color shade after drying. They stopped an entire day’s run to prevent any material with an off-odor or trace contaminants from leaving the plant. For end users, whether you are blending in an herbicide formulation or running it forward in a pharma intermediate process, this is the difference between consistent performance and a bad surprise.

    How Performance Connects with Real Manufacturing

    We supply Phenoxyacetamide mainly in fine, white crystalline form. Over time, we found the optimal granule size for our clients sidesteps issues like caking during storage or excessive dust during transfer. We package it in lined fiber drums to prevent moisture pickup, using a process that avoids excess pressure on the crystals so they don’t compact. This seemingly simple handling detail came only after years of dealing with customer calls about poor flowability in their feed systems. A manufacturer’s job doesn’t stop at batch release—shipping, storage stability, and compatibility in your process all start on our side of the wall.

    Application Stories from the Plant Floor

    Our teams spend a lot of time learning how actual users run Phenoxyacetamide through their processes. One partnership, for a regional crop-protection producer, centered on surfactant compatibility. They’d had trouble with co-precipitation when introducing generic phenoxyacetamide from less controlled sources into a tank-mix concentrate. After some back-and-forth, it turned out trace impurities—hydroxyacetic acid mainly—pushed their pH balance just enough to destabilize the blend. By carefully managing synthesis temperatures and reactant addition rates, we managed to keep that impurity below 0.02%, clearing up their tank-mix issues and earning them tighter control over hydrolysis.

    On the pharma side, our material routes directly into some non-steroidal anti-inflammatory drug syntheses. We’ve seen customers trim reaction times in amide bond formation by several hours just by switching to our product. Some of them had previously sourced from a trader who blended materials from multiple origins, leading to erratic yields. We’ve pushed for hands-on technical feedback, and in one case, shared real-time HPLC traces to help a customer solve a mystery yield drop when a competitor’s material left high residual solvent.

    What Sets Phenoxyacetamide Apart from Other Amides

    The chemical world is full of amides, but not many slot into so many diverse roles. Naphthylacetamide and benzamide, for example, share similar backbone chemistry but behave differently in both reactivity and handling. In our experience, customers choosing Phenoxyacetamide often need something with lower toxicity and higher thermal stability. Phenoxyacetamide’s structure gives it resilience in aggressive process conditions—mid-range pH, moderate heat, and even some oxidants—which opens up options not available with less robust amides.

    During large-scale filtration, phenoxyacetamide crystals don’t collapse or compress into cakes nearly as easily as some of the bulkier substituted amides. This doesn’t just make life easier for a plant operator—it also means customers see lower solvent retention, translating directly to better drying energy usage and reduced costly solvent loss.

    Quality Control: Real Experience Behind Each Batch

    Our Q.C. lab doesn’t rely only on standardized analytical routines. Over the years, the team has built a logbook of real-life case notes—like the time a subtle discoloration indicated trace oxidation, or when a faint off-smell led us back to an upstream ethanol supplier who had delivered drums with slightly elevated aldehyde content.

    For customers, this can show up as improved traceability. We provide detailed CoA sheets for each batch, including not only purity but also color value, individual impurity levels (not a total impurity number), and residual solvent content. During export inspection, we sometimes go so far as to test multiple drums in a chosen lot—especially for long-sea shipments prone to temperature fluctuations—because not all stories are told by a single drum sample.

    We field regular requests for specific impurity profiles. For a Japanese agrochemical customer, residual methylphenol below 0.01% was demanded not just for regulatory reasons but to prevent odor issues in their finished product. That drove us to tweak drying conditions and improved fume handling, ultimately raising the entire line’s standard.

    Handling, Shelf Life, and Real-Life Storage Realities

    Few things break a plant manager’s confidence like material that loses quality after just a few weeks in storage. We’ve seen issues where drums stored close to a heat source clumped up, while others sitting in high humidity absorbed moisture. Switching to lined fiber drums helped, but just as important was how we close drum liners during packing.

    A while back, a shipment delayed at a coastal port ended up with moisture spots—our plant made the call to immediately quarantine the lot and dry the affected drums ourselves, rather than pushing risk onto the customer. A small detail, but avoiding headaches later is worth more than pushing volume out the door faster.

    Consistent Supply Backed by Plant-Level Investment

    Securing enough raw phenol and monochloroacetic acid can be tricky during market squeezes. In past cycles, prices for phenol spiked. Some suppliers responded by switching to off-spec or secondary origin material. We saw several downstream customers complain about haze in solutions or odd melting behaviors. Rather than chase speculators, we negotiated long-term supply contracts, and we keep a raw material buffer stock.

    When competitors started fielding cheaper, brown-tinted phenoxyacetamide derived from recycled streams, we stuck to our process, even if that kept our cost slightly higher. Getting repeat orders from customers who need their process to run day in and day out matters more than dealing with the fallout from failed blends.

    Technical Support: It Actually Makes a Difference

    We learned early to offer more than a datasheet. One customer upgraded their headspace GC protocol to track possible volatile byproducts, seeking to avoid contamination of their final API during scale-up. They found our support team onsite within a week—not just sending an MSDS, but walking through their pilot facility, reviewing their chromatograms, and suggesting tweaks on pH and agitation that ultimately improved their yield.

    Real-world troubleshooting isn’t glamorous but it’s what forges reliability between a manufacturer and its partners. We keep technical engineers and chemists on call, not in a distant office but on our plant floor, because every strange odor or off-test can come back to the actual folks running the reactors.

    Comparisons that Matter: Beyond the Chemical Datasheet

    The world’s technical datasheets can make many things look like apples-to-apples choices on paper. In our experience, any two batches of Phenoxyacetamide from different makers tell a different story under an FTIR scan or in a continuous crystal filter. Material from traders, bulk resellers, or re-blenders often ends up with trace levels of unrelated isomers or non-phenoxy byproducts.

    Customers who care about process reliability look for a producer who understands not just chemistry but the impact of physical changes in the product. In one large-scale crystalline formulation, we ran side-by-side blends using two sources. Our in-house product kept a uniform melt range and no discoloration, while the cheaper competitor’s started to brown near the melting point. This small difference avoided downstream rework worth several days of lost production and became the deciding factor for that customer to switch exclusively to direct-from-manufacturer supply.

    Environmental and Regulatory Consistency

    Over the years, regulations on process waste and permitted trace substances in chemicals have tightened. We invested in closed-system handling, in-vent scrubbers, and safer effluent controls. This came after learning, through experience, that even small environmental slip-ups can lead to production shut-downs or lengthy regulatory reviews. Several customers—especially those marketing internationally—insist not just on a REACH-compliant material, but on a transparent, auditable supply chain. We keep archived samples and documentation stretching back several years to give buyers confidence in traceability.

    A few customers have approached us after regulatory audits flagged unregistered contaminants or incomplete supply records from their previous sources. We walk them through our compliance procedures, show them actual batch records, and demonstrate that traceability starts inside our site, not after the product is already bagged for shipment.

    Why Phenoxyacetamide Remains a Key Choice for Formulators

    Formulators keep coming back to this compound because it does what it says in the application, with fewer surprises year after year. Its stability lets process engineers sleep at night, knowing their blends won’t degrade or react with other components unexpectedly. Our consistent physical profile eliminates wasted time troubleshooting insoluble residues, and every percentage point of purity translates into a smoother, more controlled process downstream.

    Many of our customers have tried working with repackaged or third-party materials, dealing with sporadic issues that cost more in lost batch time than the pennies saved up front. Switching back to source-manufacturer supply solved quality headaches. Communication lines stay open—one call gets a live update, not a runaround or finger-pointing between middlemen.

    Building Solutions Beyond Product Alone

    We believe manufacturing chemical intermediates should be as much about the relationship with the processor as the chemistry itself. Seeing customers improve throughput, avoid shutdowns, or hit new regulatory standards because of a minor tweak in our production sails further than just shipping another ton. The best product still needs reliable hands and sharp eyes behind it.

    If your team faces a recurring challenge—whether it’s blending, reaction speed, or even unloading after a long-haul sea shipment—reach out. Our approach is to treat feedback as the main source of improvement. We’ve altered particle sizing, tweaked rinsing protocols, and even built custom drum liners based on issues customers flagged. Chemical supply isn’t static, and neither is our way of improving.

    Facing the Future: Responsible, Reliable Production

    Data from industry groups predicts demand for high-purity phenoxyacetamide will rise steadily—especially as new applications in fine chemicals, crop management, and specialty intermediates take root. We expect innovation, but also respect that the basics never lose value: clean chemistry, clear records, honest communication. If your line depends on stable, consistent quality, there is no shortcut. We keep our process transparent, traceable, and always open to evolving with end-user needs.