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Phenethyl Caffeate

    • Product Name Phenethyl Caffeate
    • Alias Caffeic acid phenethyl ester
    • Einecs 649-535-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    785295

    Cas Number 104594-70-9
    Molecular Formula C17H16O4
    Molecular Weight 284.31 g/mol
    Iupac Name 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    Synonyms Caffeic acid 2-phenylethyl ester
    Appearance Yellowish to brownish solid
    Solubility Slightly soluble in water, soluble in ethanol and DMSO
    Melting Point 110-115°C
    Source Major component of propolis
    Structure Type Phenolic ester
    Logp 3.1 (estimated)
    Uses Antioxidant, anti-inflammatory, anticancer research
    Storage Store at -20°C, protected from light and moisture
    Stability Stable under recommended conditions

    As an accredited Phenethyl Caffeate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Phenethyl Caffeate is supplied in a 1-gram amber glass vial with tamper-evident cap, clearly labeled for laboratory use.
    Shipping Phenethyl Caffeate is shipped in tightly sealed, chemically-resistant containers to prevent contamination and degradation. It is protected from light, moisture, and extreme temperatures. Proper labeling and documentation are included for safe handling. Shipment complies with relevant regulations for laboratory chemicals. Immediate inspection upon receipt is recommended to ensure product integrity.
    Storage Phenethyl Caffeate should be stored in a tightly sealed container, protected from light and moisture, at a cool temperature (preferably 2–8°C, in a refrigerator). It should be kept away from strong oxidizing agents and acids. Ensure ventilation in the storage area and avoid prolonged exposure to air, as the compound may degrade under unsuitable conditions.
    Application of Phenethyl Caffeate

    Applications of Phenethyl Caffeate in Industrial Manufacturing

    Phenethyl Caffeate is a specialized compound widely recognized for its antioxidative, anti-inflammatory, and preservative properties in several high-value industrial manufacturing sectors. As an original chemical producer, we provide consistent supply to downstream processes that demand precision formulation and rigorous quality compliance, supporting product differentiation and regulatory alignment across multiple markets.

    1. Functional Food and Dietary Supplement Formulation

    Functional food and dietary supplement producers utilize this compound to address oxidative stability challenges in ingredient-intensive products such as energy bars, soft chews, and capsules rich in unsaturated oils. By integrating it during batch blending phases, manufacturers boost shelf life and support regulatory labeling for antioxidant activity, especially in products marketed towards active and wellness-oriented demographics.

    Industry compliance standards

    • U.S. FDA 21 CFR Part 111 Dietary Supplement cGMP
    • EU Regulation (EC) No 1925/2006 on food supplements
    • GB 16740-2014 National Food Safety Standard for Health Foods (China)
    • CODEX STAN 192-1995 General Standard for Food Additives

    Typical usage ratio

    • 40–200 mg per kg of total formulation; nutrition bar and capsule applications require titration based on matrix and desired antioxidant load.

    Downstream process integration

    • Incorporation during final blend phase after thermal processing to safeguard compound activity and ensure homogeneity, followed by QC spray-drying or granulation for dosage control.

    Final product types

    • High-protein bars, vitamin-fortified gummy chews, nutritional drink powders, oil-based softgels, botanical extract capsules

    2. Cosmetics and Personal Care Formulation

    Personal care manufacturing has adopted this material to address the volatility of bioactive ingredients in skin serums, lotions, and anti-aging creams. By integrating the ingredient into emulsion systems, formulators achieve increased resistance against oxidative degradation, supporting claims for skin barrier protection in line with established cosmetic safety norms.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • U.S. FDA 21 CFR Subchapter G for cosmetics
    • ISO 22716:2007 Cosmetics — Good Manufacturing Practices (GMP)
    • ASEAN Cosmetic Directive (ACD)

    Typical usage ratio

    • 0.01–0.2% by weight, with concentration adjusted to the total lipid or aqueous phase stability requirements.

    Downstream process integration

    • Dispersion in heated oil or aqueous phase during pre-emulsion, followed by addition to cooled bulk during homogenization to prevent in-process degradation.

    Final product types

    • Facial serums, antioxidative creams, sunscreen emulsions, recovery balms, scalp treatment lotions

    3. Pharmaceutical Intermediate and Topical Formulation

    Pharmaceutical producers use this material in topical semi-solid dosage forms capitalizing on its anti-inflammatory and antioxidant action, especially for dermatological gels and ointments. It is added during the compounding of non-sterile products, targeting improved shelf stability and patient adherence by maintaining active component levels during intended shelf life periods.

    Industry compliance standards

    • USP–NF Monographs (where permitted as an active or excipient)
    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for topical formulations
    • Japanese Pharmacopoeia general requirements for non-sterile topical products

    Typical usage ratio

    • 0.05–0.15% by weight in gel or ointment base; dosing set to match clinical safety threshold and desired topical antioxidative capacity.

    Downstream process integration

    • Addition to the cooled, post-sterilization phase of ointment or gel mixing to preserve integrity of the molecule, with subsequent thorough dispersion for dose uniformity.

    Final product types

    • Anti-inflammatory dermatological creams, transdermal gels, topical patches for antioxidative skin care, wound recovery salves

    4. Food Preservation and Shelf-Life Extension

    Processed food operations, especially those producing high-fat bakery items, spreads, and ready-to-eat meals, rely on this compound's antioxidative mechanism to stabilize unsaturated oil matrices. During automated mixing lines, formulators incorporate it to extend product freshness and delay rancidity development, aligning with national food additive laws while catering to brands demanding clean-label natural preservative claims.

    Industry compliance standards

    • EU Regulation (EC) No 1333/2008 on Food Additives
    • U.S. FDA GRAS Policies (where permitted as a natural antioxidant)
    • GB 2760-2014 National Food Safety Standard for Use of Food Additives (China)
    • Codex Alimentarius General Standard for Food Additives

    Typical usage ratio

    • 15–60 mg/kg of total fat phase; adjusted to total fat content, water activity, and product intended shelf life under ambient conditions.

    Downstream process integration

    • Dosing into emulsified fat blends at pre-packing stage or addition to dough prior to baking, followed by additional quality checks post-cooling and prior to packaging.

    Final product types

    • Premium baked goods, margarine and butter blends, nut spreads, shelf-stable meal kits, confectionery coatings

    5. High-Value Animal Feed Additives

    Producers of specialty animal feeds apply this ingredient for its antioxidative support, helping stabilize vegetable oils and bioactive micronutrients in compounded feeds aimed at performance livestock, aquaculture, and companion animals. Integration during post-extrusion spraying ensures preservation of nutrient profiles under high-throughput and extended storage timelines.

    Industry compliance standards

    • EU Feed Additives Regulation (EC) No 1831/2003
    • AAFCO Ingredient Definitions for Animal Feed Ingredients
    • China GB/T 13078-2017 Hygienic Standards in Feed Industry
    • ISO 22000:2018 Food Safety Management Systems

    Typical usage ratio

    • 12–35 mg/kg total feed mass, with adjustments based on oil/fat loading, animal species target, and environmental storage risks.

    Downstream process integration

    • Atomized application onto cooled feed pellets after extrusion, ensuring retention of antioxidative property during storage and throughout the intended feeding cycle.

    Final product types

    • High-energy aquafeed pellets, performance livestock mash, canine specialty diets, ornamental fish foods
    Free Quote

    Competitive Phenethyl Caffeate prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Phenethyl Caffeate: A Commitment to Quality from a Dedicated Manufacturer

    Understanding Phenethyl Caffeate Through Production Expertise

    For those who value substance over salesmanship, the work behind phenethyl caffeate deserves to be seen through the eyes of someone who’s spent years amid the raw materials, reactors, trials, and continuous improvement that shape a proper active ingredient. Our journey developing phenethyl caffeate—model number PEC-99, purity 99% minimum—reflects more than just chemistry. It tracks the search for genuine quality, lot after lot, with a clear focus on safety, consistency, and performance in every sector that relies on reliable source material.

    You won’t find this compound made to spec by chance. Over many batches, we’ve learned to control parameters such as solvent choice, reaction temperature, and purification steps to produce product that stands up to rigorous third-party HPLC assay and organoleptic review. Ordinary origins often lead to variable consistency and doubts about batch-to-batch equivalence, two issues that always complicate downstream usage—especially in demanding research or specialty formulations for health and personal care. Anyone who has suffered from buying intended “high-purity” compounds only to call lab support after discovering strange hues or off-target melting points knows the cost of cut corners.

    Building from the Basics: Model PEC-99 Specifications from an Operator’s Perspective

    Rolling up our sleeves in the plant, our team starts from naturally derived caffeic acid, applying controlled esterification with phenethyl alcohol. There’s more to the story than the reaction equation. Care must be taken to avoid side reactions such as oligomerization or incomplete ester formation. Strict finishing, washing, and low-temperature drying lock in a bright, fine crystalline powder—a product that passes visual inspection under daylight, not just in the glow of HPLC graphs. Average particle size lands near 60-100 microns, targeting markets where fast dissolution in polar solvents is needed and fine control over excipient blending pays off in both laboratory and production environments.

    Understanding the natural variance in the global supply chain for plant-derived caffeic acid, we source only premium-grade material from longstanding partners. This reduces the risk of pesticides, unknown isomers, or unexpected impurities leaking into the line. Our documentation contains plenty of chromatography overlays comparing each imported lot to our in-house standards before a single batch begins. Such hands-on vigilance minimizes the risk of surprises and raises overall yield.

    Phenethyl caffeate leaves our reactors typically as >99% pure, but it’s not a marketing term. This means on every COA and with every drum, you’ll see trace impurity data, residual solvent records, and both melting point (usually reported near 80-81°C) and water content analysis. Moisture control ranks high on our checklist, especially since excessive humidity leads to caking and slower dissolution downstream. Each drum ships with nitrogen backfilling as routine—one of those small details many skip but which maintains stability over months of storage.

    Why Phenethyl Caffeate Has Earned Its Reputation

    Manufacturing expertise matters most to those with skin in the game. Phenethyl caffeate stands out not just by what it is, but by what careful handling enables. In antioxidant applications, such as test kit formulations or nutritional prototypes, purity dictates both shelf life and bioactivity. Any hint of oxidized byproducts or isomer contaminants leads to off-notes and decreased performance, risking downstream rejection and wasted capital. We manage this by employing closed-loop inert gas flows during synthesis and packaging—an investment that pays off in stable product months after manufacture.

    For customers in cosmetics, phenethyl caffeate’s mild profile and neutral hue adapt well to formulations seeking naturally inspired phenolic ingredients. Here, a manufacturer’s responsibility extends to sensory and microcrystalline analysis. Our testing labs screen for off-odors, examine color under daylight grade LED, and log photographic records on every batch, so a formulator or technician can expect zero surprises on arrival. These are not check-the-box procedures but front-line quality control that saves time and headaches for everyone in the value chain.

    The pharmaceutical world demands even more. Phenethyl caffeate used in novel excipients or advanced delivery research must clear thresholds for residual metals, microbiology, and solvent traces. We maintain validated procedures for ICP-MS metal screening, and our site regularly undergoes internal audits for GMP precursor conformance, though many phenethyl caffeate applications still fall outside pharmacopeial monograph requirements. More than once, researchers have told us their results depend entirely on consistent feedstock—something only possible with proper upstream controls.

    Day-to-Day Use: Experience Guides Each Step

    Over years supporting clients through pilot-scale scale-ups and production runs, we’ve seen practical issues arise—ones rarely discussed in dry technical bulletins. One example: once, a client’s staff stored bulk phenethyl caffeate in an area with variable humidity. In a matter of weeks, samples from the bottom of the drum clumped and lost the free-flowing crystal structure that makes handling easy. Our own best practice is to keep material tightly sealed, out of direct sunlight, at under 25°C, with a desiccant pouch if ambient humidity regularly exceeds 60%. The stable product stays free-flowing and easy to handle for over a year. If others say their material is stable “under standard conditions,” we ask for details—they matter more than the label.

    Preparation for solution-making is another task that rewards discipline. Phenethyl caffeate dissolves quickly in ethanol and DMSO at concentrations up to 100 mg/mL. Occasionally, clients ask about use in aqueous systems. We’ve found that pre-dissolving in a small aliquot of alcohol, then diluting, retains the compound in solution for longer periods—a small step, but crucial in analytical testing workflows. No one wants precipitation mid-experiment, so method details are always on hand and ready to share.

    Disposal and cleanup also come from experience gained, not just standard directions. Operators washing down glassware at the end of the shift know phenethyl caffeate leaves behind invisible traces, so we recommend sequential ethanol and hot water washes to clear residues completely. Miss that step, and the next run could see minor cross-contamination, something we avoid by habit and constant retraining. Facilities taking in our product for the first time appreciate these details, especially after a few cycles confirm the advice works.

    Comparing with Other Phenolic Compounds: Lessons from the Line

    Plenty of phenolic esters sit alongside phenethyl caffeate in specialty ingredient catalogs. The differences aren’t just technical; they show up all the way from manufacturing effort to end-use success. Take ethyl caffeate or octyl caffeate as examples. Ethyl caffeate, with its lightly shorter chain, tends to dissolve faster but oxidizes more easily if not protected rigorously from air. Octyl caffeate provides some added lipid solubility but can introduce unwanted fatty off-notes if used at higher concentrations. We have produced all three, and phenethyl caffeate repeatedly finds favor due to its unique balance of solubility and stability, plus a flavor and aroma profile that remains neutral in mixtures.

    Amping up antioxidant action with polyhydroxylated phenols often sounds attractive at first. Later, formulators discover that trace metals or reactive color bodies can form if chemistry isn’t tightly controlled. With phenethyl caffeate, our pilot-scale teams pushed multiple stabilization and chelation studies, finding that our regular inert processing prevented the usual fading or color shifts seen in pantry-grade alternatives. These are hard-won lessons: one slight tweak to catalyst or pH, and the resulting product drifts away from the bright, clean profile needed for sensitive blends.

    From a technical standpoint, phenethyl caffeate’s mid-length phenethyl chain allows for reasonable partitioning between water and oil phases. It won’t segregate as fast as longer alkyl esters in layered systems, making batch homogenization far simpler. For those using automated dispensing or larger-scale mixing, this reliability saves countless stops and recalibrations. Our own in-process QC records have repeatedly tracked this property, and we tailor batch release criteria based on these operational advantages, not just static “data sheet” numbers.

    Safety and Integrity: Operating Beyond Compliance

    A responsible manufacturer’s concern always runs past basic regulatory compliance. In-house, our safety team conducts frequent risk reviews—not just for operator exposure, but environmental controls during waste handling and effluent treatment. The spent solvents from phenethyl caffeate synthesis are collected, neutralized, and then either recycled or sent for proper incineration. We don’t let shortcuts threaten workplace or community safety. For each raw material shipment, we require up-to-date safety data, and an on-site chemist inspects container seals—risking an extra shift if any questions arise.

    Each month, dedicated quality auditors collect representative samples for ongoing stability studies. Finished batches get stored in temperature- and humidity-monitored environments, with logs open for auditor review. About once per quarter, we run accelerated aging studies to confirm the product holds its spec in terms of purity, color, and handling characteristics over time. Results thus far have confirmed robust stability when our guidance is followed, a point that reassures major buyers and research groups placing multi-year standing orders.

    Security and traceability matter just as much. Batches get coded down to process operator, date, and even reactor number. That way, even years later, we can trace any irregularity to its root, retraining staff and improving protocols as needed. Of course, confidentiality applies to all customer-specific requests or modifications. Some research partners have requested us to screen for extra parameters, such as specific endotoxin or allergen risks; our high-resolution analytics and transparent documentation make these special controls possible without sacrificing workflow.

    Serving the Requirements of Global and Local Clients

    Experience working with both multinational buyers and small labs means recognizing varied needs and constraints. Bulk shipments for industrial blenders go out on heavy-duty pallets, lined with food-grade polyethylene, while gram-scale vials for specialty research projects leave our weighing lab double-sealed and coded against tampering. We keep clear records of every shipper and packer, allowing traceability from our floor to the customer’s bench.

    Feedback from international logistics specialists has shaped our approach to transport, too. Our logistics coordinator monitors transit humidity and route temperature patterns, particularly for sensitive loads heading to regions with dramatic weather swings. If any hint of damage or deviation crops up, we work with both carrier and end-user immediately, sending replacement material at no extra charge. Long-term users who’ve weathered these mishaps tell us the difference between a real manufacturer and a middleman shows up in crisis—and the relationships we’ve built over time have all grown stronger from direct, honest response.

    From time to time, requests come in for different forms based on unique project goals: microgranulated, micronized, or pre-dissolved phenethyl caffeate for use in specific test systems or continuous production lines. Our process team evaluates the request, tests on our own bench, and only after confirming stability and performance does any new format get released. We draw on our own experience, not just a catalog promise, to guide these choices—and that’s one reason most of our custom form batches become regular products over time.

    Sustainability and the Drive for Better Chemistry

    No story about manufacturing quality ingredients is complete without addressing sustainability. The world is right to focus on environmental impact, waste reduction, and responsible sourcing. Taking this seriously, we maintain direct partnerships with upstream growers and processors of natural caffeic acid, rejecting material that fails regular screening for pesticides or overharvesting. Year on year, we’ve increased solvent recycling rates by updating distillation units and switching to lower-impact alternatives where reactions allow. Our plant’s emissions and energy consumption get tracked against set benchmarks, which guides investments in lighting retrofits, insulation, and heat-recovery systems. These improvements benefit everyone connected to the line, from growers to end-user researchers.

    Wastewater is another focus. Rather than sending all post-reaction streams off-site, our team operates bench- and pilot-scale water treatment units tuned to handle the residues generated from esterification and washing. By neutralizing and filtering residual phenolics and organics in-house, we minimize the impact on municipal systems and remain accountable for the life cycle of our products. Over time, the investment pays off through reduced discharge fees and a clear conscience knowing the local ecosystem remains protected.

    Real-World Impact: Supporting Innovation and End-Use Success

    In the trenches with our users, we’ve watched ideas move from benchtop prototypes to successful launches. One startup began working with phenethyl caffeate to stabilize a novel emulsion for food preservation—they hit a wall with inconsistent thermal stability using off-brand supplies. After switching to our material, their production runs held up over time, winning them confidence and a path to wider adoption. Such stories repeat every year across different industries, and they confirm that hands-on manufacturing skill really does affect commercial outcomes.

    Senior researchers from biotech incubators call us for verification tests or advice on complex solubilization routines. Every custom request, whether for a new blending experiment or extra-sensitive impurity profile, gets taken as seriously as our largest volume orders. We make it a habit to gather feedback, spot recurring needs, and adapt our procedures, updating both internal processing and customer-facing guidance beyond the current batch.

    Some of the proudest moments come from universities and consortiums who communicate their results without reservations about raw ingredient quality. Our reference samples have underpinned research published in peer-reviewed journals spanning antioxidant action, inflammation studies, and more. Knowing our material supports genuine discovery and innovation gives equally strong motivation as any commercial incentive.

    Focusing on What Matters: Reliability, Purity, and Trust

    After years making phenethyl caffeate, we measure our work in the consistency of what leaves the plant, the ongoing success of our customers, and the returns from our team’s discipline. Each batch reflects deliberate choices, hard-won improvements, and a steady refusal to take short cuts. We answer questions from all manner of industries, acting not as salespeople but as operators who know the risks and solve problems before they escalate. Proving our commitment day in and out turns repeat buyers into partners—something that never happens when purity claims are just a line on paper.

    Real manufacturers live in the details, sweating over every step from sourcing through processing and shipment. The story of phenethyl caffeate includes investment in the plant, guidance in the field, and transparent communication across the supply chain. That’s the perspective we bring—honest about challenges, proud of the progress, and always ready to improve.