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Pentyl Isothiocyanate

    • Product Name Pentyl Isothiocyanate
    • Alias Amyl isothiocyanate
    • Einecs 206-890-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    338653

    Cas Number 110-01-0
    Molecular Formula C6H11NS
    Molar Mass 129.22 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Pungent, horseradish-like
    Boiling Point 191-193 °C
    Density 0.952 g/cm³ at 20 °C
    Flash Point 66 °C (151 °F)
    Solubility In Water Insoluble
    Refractive Index 1.479-1.482 at 20 °C

    As an accredited Pentyl Isothiocyanate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Pentyl Isothiocyanate is supplied in a 100 mL amber glass bottle with a secure screw cap and hazard warning labels.
    Shipping Pentyl Isothiocyanate should be shipped in tightly sealed containers, kept cool and well-ventilated, away from heat, flames, and incompatible substances. The package must comply with local and international regulations for toxic and flammable chemicals. Proper labeling and hazard documentation are required to ensure safe handling during transit.
    Storage Pentyl isothiocyanate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizing agents. It should be kept away from direct sunlight and moisture. Use appropriate chemical-resistant containers and ensure proper labeling. Always follow local regulations and safety guidelines for storage of hazardous chemicals.
    Application of Pentyl Isothiocyanate

    Applications of Pentyl Isothiocyanate in Industrial Manufacturing

    Pentyl Isothiocyanate serves as a targeted specialty intermediate in organic synthesis, flavor and fragrance production, pharmaceutical ingredient routes, agrochemical formulation, and polymer modification sectors. As the direct manufacturer, we support downstream partners in process optimization, compliance alignment, and quality management through precise material control and validated application data.

    1. Flavor and Fragrance Synthesis

    Pentyl Isothiocyanate functions as a crucial backbone in the synthesis of specific aroma compounds, notably in creating tropical fruit, horseradish, and wasabi notes. Formulators employ it in controlled reactions with alcohols and amines to build desired esters, thioesters, and related precursors. Reaction processes require precise control of stoichiometry and pH, with particular attention to minimizing off-notes and unwanted byproducts. End-use flavors integrate into food, beverage, and oral care sectors, requiring analytical traceability and batch-to-batch consistency.

    Industry compliance standards

    • FEMA GRAS designation (Flavor and Extract Manufacturers Association of the United States)
    • 21 CFR 172.515 – Flavouring substance regulation (US FDA)
    • Commission Regulation (EU) No 872/2012 on flavoring substances
    • IFRA Code of Practice for use in fragrance mixtures

    Typical usage ratio

    • 0.01%–0.5% in finished flavor concentrates; specific ratio determined by intensity targets and regional regulatory limits

    Downstream process integration

    • Introduced at the stage of esterification or amidation synthesis; post-reaction distillation ensures removal of excess isothiocyanate; QC verifies odor profile and residual levels prior to compounding in master flavors or fragrances

    Final product types

    • Beverage flavors (e.g., tropical fruit base)
    • Savory food flavors (e.g., horseradish, wasabi, mustard type)
    • Oral care mint-type flavors
    • Fine fragrance concentrates for perfumery

    2. Pharmaceutical Intermediate Synthesis

    Pentyl Isothiocyanate acts as a building block for heterocyclic scaffolds, including thiazoles and thioureas, in small-molecule API manufacture such as certain anti-infectives and cardiovascular actives. Reaction procedures typically employ the isothiocyanate in nucleophilic addition with primary amines or activated heterocycles under inert conditions. Strict control on starting material purity, moisture, and residual solvents is essential to ensure yield and analytical conformity in downstream steps. Downstream manufacturers conduct full traceability and validation per GMP protocols.

    Industry compliance standards

    • ICH Q7 – Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP Pharmacopoeia monographs on related intermediates
    • EDQM CEP standards (where applicable)
    • ECHA REACH registrations for chemical intermediates

    Typical usage ratio

    • Stoichiometric to 20% molar excess per amine substrate; optimization based on side reaction minimization in scale-up

    Downstream process integration

    • Added during heterocyclization or thiourea formation steps; purity monitored by HPLC or GC-MS; residual isothiocyanate controlled by in-process quenching and solvent washes as required for API compliance

    Final product types

    • Pharmaceutical intermediates (e.g., alkylthioureas, thiazole derivatives)
    • APIs for anti-infective agents
    • APIs in antihypertensive drug classes
    • Biologically active intermediate stocks for contract synthesis

    3. Agrochemical Synthesis

    Agrochemical producers incorporate pentyl isothiocyanate as an intermediate for sulfur-containing herbicides, fungicides, and soil treatment agents, particularly as a core reagent in syntheses involving carbamate and thiourea coupling reactions. Synthesis parameters include controlled temperature, nitrogen blanketing, and continuous removal of volatiles. Downstream batch records and field-use approvals mandate full disclosure of precursor origin and impurity profile. Material traceability documentation accompanies all deliveries to authorized production plants.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides
    • EPA registration requirements (US FIFRA regulations)
    • EU Regulation No 1107/2009 (Plant protection product approval)
    • ISO 9001:2015 Quality Management (agrochemical production)

    Typical usage ratio

    • 5%–30% by weight in intermediate synthetic streams; final dosage controlled by downstream crop safety and environmental fate testing

    Downstream process integration

    • Charged into reaction vessels during carbamoylation or thiourea-coupling stages; reaction progress monitored by TLC and LC-MS; unreacted isothiocyanate neutralized to minimize EC and workplace exposure

    Final product types

    • Sulfur-containing herbicidal actives
    • Fungicidal intermediates for further derivatization
    • Soil treatment agents
    • Specialty pesticides composite blends

    4. Polymer Modification and Specialty Additives

    The isothiocyanate group undergoes controlled grafting onto polysiloxanes, polyolefins, and epoxy polymers to introduce reactive sites in high-performance material applications. Industrial users select this chemistry for modification of surface properties, crosslinking, or initiation in specialty coatings, adhesives, and sealants. Application workflows typically use batch reactor dosing with inert blanketing and controlled temperature ramping. Downstream QC focuses on FTIR, mechanical, and migration testing according to end-use certification standards. Waste management follows local environmental standards for volatile sulfur-containing reagents.

    Industry compliance standards

    • ISO 10993, ISO 9001 for polymer processing
    • RoHS and REACH compliance for electronics and automotive applications
    • FDA 21 CFR §177 for indirect food contact polymers (as applicable)
    • ASTM methods for migration and toxicity testing of cured materials

    Typical usage ratio

    • 0.1%–2% by weight based on base resin content; levels adjusted for end-use mechanical and crosslinking properties

    Downstream process integration

    • Introduced into prepolymer or oligomer melt phase; monitored for uniform dispersion and degree of grafting by FTIR; post-reaction venting and cure schedule managed to drive off free isothiocyanate; extraction tests run for safety certification

    Final product types

    • Functionalized silicone coatings
    • Crosslinked epoxy adhesives
    • Modified polyolefin composites
    • Specialty elastomer and sealant masterbatches
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    Certification & Compliance
    More Introduction

    Introducing Pentyl Isothiocyanate: Our Perspective as the Manufacturer

    Drawing from Real-World Production

    Pentyl isothiocyanate, known also as amyl isothiocyanate, has become one of those specialty chemicals that often surprise newcomers with its range of uses and punchy properties. In our experience, producing this compound involves a hands-on process—precise temperature control, carefully sourced raw materials, and constant vigilance to ensure purity in each batch. From the moment we start the synthesis, our team stays focused on keeping moisture and impurities out of the system, as the presence of water can quickly ruin yield and compromise consistency. In our facility, we work with the molecular structure C6H11NS, forming a clear, pale yellow liquid with a distinctly sharp, pungent aroma—a hallmark of quality for this isothiocyanate.

    Specifications, Pure and Uncomplicated

    For customers asking about specifications, we focus on what matters most: high assay, low moisture, and minimal byproducts. We produce pentyl isothiocyanate at greater than 98% purity, verified by gas chromatography right off the reactor line. The boiling point sits around 201-202°C, and we typically measure the density at roughly 0.95 g/cm3 at room temperature. Chemists and formulators looking for certainty can trust this compound won’t introduce unexpected noise into their analyses or downstream syntheses. Our batches consistently offer a refractive index near 1.484, another quick check for labs seeking reliable results.

    Putting Pentyl Isothiocyanate to Work

    Industrial clients most often come to us for pentyl isothiocyanate because it delivers both strength and selectivity. In our work with flavor and fragrance houses, the compound serves a dual role—building sharp, radish-like notes in complex blends, or, more rarely, as a potent intermediate for more refined aromatic components. Its characteristic stinging smell limits the quantity used, letting perfumers add backbone without overwhelming softer ingredients. We’ve watched our isothiocyanate transform otherwise muted formulations, granting boldness to finished products that would otherwise fall flat.

    Synthetic chemists and pharmaceutical researchers come to our door seeking a stable, reliable source for introducing the isothiocyanate functional group into small molecules. Pentyl isothiocyanate reacts cleanly with amines, phenols, and thiols, making it a go-to building block for complex organic synthesis projects. Our clients value the predictable reactivity, which helps take guesswork out of late-stage functionalization work. Those developing crop protection chemistries have also found its insecticidal and antifungal properties valuable in preparing test compounds, with our batch consistency reducing repeated troubleshooting.

    Production Know-How Sets Us Apart

    There’s no shortcut to quality when producing pentyl isothiocyanate. Our factory staff have spent years honing a balance between throughput and trace control of key reaction steps. Sourcing amyl alcohol of consistently high quality keeps sulfur-containing off-odors to a minimum. We run quality checkpoints at every junction, sampling each blend before and after distillation. Maintaining clear separation between small-batch custom orders and routine bulk runs avoids cross-contamination, a risk often overlooked by volume-focused operations. Each lot receives full documentation, with COAs reflecting actual readings—not vague assurances.

    Over the years, we’ve refined our process to cut down on reaction byproducts and handle waste streams responsibly. By working closely with equipment specialists, we minimize emissions and capture most of the off-gassing for safe treatment. The choice of catalysts and scrubbers comes from hands-on trials, not catalog recommendations. Laboratory data gets backed up by what we see on the plant floor—this real-world feedback loop has paid dividends both in reliability and in worker safety.

    Application Insights from the Factory Floor

    Working as the direct producer, we’ve fielded detailed requests from R&D teams who need subtle variations in product grade. Some labs specify strict limits on halogenated impurities, while fragrance houses request tighter controls on color and turbidity, since faint discoloration could disrupt final blending. Over time, we’ve built the capacity to offer micro-batch runs for these high-demand, niche applications. If a formulator wants pentyl isothiocyanate in a UV-stabilized container for long-term storage, we can adapt our bottling line to meet that specification. If there’s need for an extra filtration to achieve crystal clarity, our team stays prepared with the right glassware and expertise.

    Flavor chemists who need traceable product origins often lean on us for direct documentation—a paper trail from raw material arrival right through to final bottle. Unlike traders or resellers, we can open our doors to audits and share processing details, giving end users a closer look at where their starting materials begin life. This relationship builds trust, especially for those blending pentyl isothiocyanate into formulations where authenticity matters.

    How Pentyl Isothiocyanate Stands Out from Other Alkyl Isothiocyanates

    Over years of production, we’ve seen pentyl isothiocyanate distinguish itself from its shorter- and longer-chained relatives. Compared to the common butyl isothiocyanate, pentyl’s heavier structure mellows the acridness, cutting down on volatility and reducing the choking, tear-inducing effects in lab handling. This improvement means safer, more manageable processing—and fewer complaints from line workers. On the other hand, going up another carbon to hexyl shifts the odor profile past the “snappy” stage, with many fragrance and specialty chemical users finding the punch of pentyl to be just right for their needs.

    We’ve compared side-by-side analyses of volatility and solvent compatibility, with pentyl grades consistently offering a better tradeoff between strength and controllability. Those attempting to use ethyl or methyl isothiocyanate often struggle with rapid evaporation and persistent, stinging off-gassing—a headache for both environmental controls and end product consistency. The comparatively moderate boiling point for pentyl lends itself to improved stability through shipment and storage, extending shelf life under a range of climate conditions.

    Tailored Advice from the Manufacturer’s Standpoint

    As the ones formulating, blending, and bottling every batch ourselves, we encounter questions that span the entire life cycle of pentyl isothiocyanate. From bulk transport to custom packaging, real-world logistics bring out challenges that no desk-bound data sheet can prepare a buyer for. In humid regions, we recommend tamper-proof closures and inert-atmosphere bottling for customers expecting to store material beyond six months. Freezing temperatures can cause crystallization or leaks if packaging isn’t robust—hard-earned lessons that our team faced long before they ever appeared in the literature.

    Clients working in sensitive applications sometimes ask whether trace solvents or plasticizers could cause bottle leaching or subtle contamination. Over the years, we transitioned from generic jerry cans to lined, corrosion-resistant vessels specifically because we witnessed off-odor transfer—an expensive but necessary move when reliability came before penny-pinching. Our standard operating procedures now reflect those hard knocks; every package leaving our site has passed an internal inspection, often guided by real-world complaints and early-morning meetings rather than outside guidelines alone.

    Supporting Customers: From Small Labs to Heavy Industry

    Much of our knowledge comes from working directly with users who don’t always fit the “major industry player” mold. We’ve fulfilled multi-kilogram orders for small research groups, helping them troubleshoot vapor handling setups and offering technical phone support—something large commodity suppliers rarely have time for. Hobbyist chemists sometimes reach out for advice on safe scale-up or storage, and if we can advise on best practices, we do.

    On the opposite end of the scale, industrial customers want pallet-sized shipments sealed for minimal exposure and simplified receiving. Our logistics team has coordinated hazardous materials shipments around port closures and seasonal humidity spikes, double-checking paperwork and batch compatibility for every international order. Our on-the-ground experience in customs and regulatory documentation helps smooth out snags long before they grow into costly problems.

    Through these conversations, we stay aware of the practical needs and feedback that day-to-day users rarely get a chance to voice. Adjusting to regional regulations or specific application quirks—such as meeting stricter odor thresholds or addressing acute toxicity concerns—keeps us flexible, resourceful, and real about our role in the supply chain.

    Handling Safety and Compliance: A Manufacturer’s Commitment

    Producing pentyl isothiocyanate brings a weight of responsibility. The distinct odor may tempt some to underestimate the health and safety requirements, but our operators know just how critical it is to prevent direct inhalation or unprotected skin exposure. Our process lines run under negative pressure with local area exhaust to protect both staff and the wider environment. Mandatory PPE and periodic refresher training form a core part of our daily routine, whether handling full drums or running quality tests at the lab bench.

    Meeting hazard communication requirements takes real-world discipline. Every drum, every vial comes labeled with GHS pictograms and plain-language handling tips—because as manufacturers, we’ve seen how confusion at the point of use leads to costly mistakes. Integrated risk management forms not just a legal checkbox, but a living part of plant culture. Our on-site emergency systems tie directly into municipal response frameworks, grounded in regular drills and reviews after each incident, rare though they may be.

    Innovation and Process Refinement

    Continuous improvement shapes both our product and the way we approach process management. We review production data after every run, using feedback from both customers and technicians on the floor. In response to early issues with batch-to-batch color drift, we re-engineered our final purification step, introducing time-controlled distillation and improved filtration. Instead of static recipes, we track which tweaks yield measurable upgrades—documenting real-world differences, not theoretical gains.

    Waste minimization has proved a rewarding challenge. We recover organosulfur byproducts for sale into secondary markets when possible, and we’ve succeeded in reducing wastewater output by nearly a third over five years. Every upgrade gets measured for both environmental benefit and plant performance. Local regulators, familiar with our operating history, know we can demonstrate meaningful progress, not just pay lip service to compliance.

    Our long-term clients often participate in pilot upgrades or custom orders, providing feedback on analytical performance, odor profile, and package usability. This loop between production, application, and process improvement roots our expertise in lived reality.

    Product Authenticity: Assurance Only a Manufacturer Can Give

    Engaging directly with factory staff instead of third parties brings advantages that only insiders understand. We guarantee direct origin, full traceability, and deep knowledge of process variables—facility temperature shifts, minor lot-to-lot changes, and microscopic issues that traders simply overlook. Our technical representatives frequently join application teams on customer sites, interpreting subtle chromatographic peaks or troubleshooting why a batch “smells” off compared to last year’s lot. No data sheet can replace in-person expertise built over countless runs, scaled batches, and hands-on cleanup.

    Clients relying on supply chain transparency appreciate the direct link between our process logs and the product in their production line. Knowing the history of each drum, down to the ambient temperature and operator shift, cannot be replicated through anonymous intermediate warehouses. For those working in industries where authenticity and accountability matter—food and fragrance, specialty organics, advanced agrochemicals—these real-world assurances matter more than polished brochures or third-party guarantees ever could.

    Why Reliability in Pentyl Isothiocyanate Matters

    Failures in process chemistry have taught us the high cost of cutting corners. A minor lapse in purity during scale-up can mean entire R&D projects have to be rerun, wasting time and budgets. Fragrance specialists find that even trace impurities in pentyl isothiocyanate batches can destroy delicate blends, throwing carefully balanced notes completely out of alignment. Our role as manufacturer is to insulate users from these headaches. Over years, we have absorbed the hard lessons that only repeated batch production teaches—learning how ambient humidity or a stuck valve can spiral into bigger operational issues.

    Building this culture of reliability doesn’t happen overnight. It comes from hands-on investment in training, infrastructure, and process controls that many overlook. Even something as simple as timely maintenance schedules or investing in redundant storage protects both our clients and our own ability to deliver on schedule. Real reliability gets measured not in slogans, but in repeat orders, honest feedback, and long-term relationships that reward both parties for staying true to the craft.

    Looking Ahead: Practical Solutions to Industry Challenges

    Operating as a direct manufacturer brings both privilege and responsibility. Market volatility can test our supply chain and pressure us to trim costs, but our history makes it clear—long-term resilience beats quick gains. In the coming years, process optimization and continued communication with our customer base will play critical roles in keeping pentyl isothiocyanate relevant and reliable. As application fields evolve, our production line adapts—responding to greener synthesis requests, tighter regulatory environments, and shifts in what clients value most. Our door stays open to pilot collaborations and process development with end users willing to share their learning curve.

    Technological upgrades to monitoring and control systems remain a focus. Early adoption of batch analytics and real-time process adjustment reduces unplanned downtime and lets us detect minute problems before they cascade. Investing in this plant intelligence lets us produce not more marketing copy but more trust—one container at a time, year after year.

    Whenever customers need to chat about differences between alkyl isothiocyanates, best-in-class packaging, or ways to minimize process losses, we welcome the conversation. As direct producers, our goal goes beyond shipping product—we build partnerships and long-term solutions, striving to bring quality, safety, and reliability to every stage of pentyl isothiocyanate’s journey from our factory floor to your application.