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O-Acetylphenyl Benzoate

    • Product Name O-Acetylphenyl Benzoate
    • Alias Phenyl benzoate acetate
    • Einecs 242-419-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    983086

    Chemical Name O-Acetylphenyl Benzoate
    Cas Number 614-68-6
    Molecular Formula C15H12O3
    Molecular Weight 240.26 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 77-80 °C
    Boiling Point 423.6 °C at 760 mmHg
    Density 1.202 g/cm3
    Solubility Insoluble in water, soluble in organic solvents
    Structure C6H5COOC6H4OCOCH3 (o-acetyl substitution on phenyl benzoate)
    Smiles CC(=O)Oc1ccccc1OC(=O)c2ccccc2
    Refractive Index 1.585

    As an accredited O-Acetylphenyl Benzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing O-Acetylphenyl Benzoate is supplied in a 100g amber glass bottle with a secure screw cap, clearly labeled for laboratory use.
    Shipping O-Acetylphenyl Benzoate is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It should be stored in a cool, dry place away from direct sunlight and incompatible substances. Transport follows relevant chemical safety regulations, with proper labeling and documentation to ensure safe handling during transit.
    Storage O-Acetylphenyl Benzoate should be stored in a cool, dry, and well-ventilated area, away from heat, open flames, and direct sunlight. Keep the container tightly closed and store it in a chemical-resistant, properly labeled container. Avoid exposure to moisture and incompatible substances (such as strong acids or bases). Ensure storage complies with local, state, and federal regulations.
    Application of O-Acetylphenyl Benzoate

    Applications of O-Acetylphenyl Benzoate in Industrial Manufacturing

    O-Acetylphenyl Benzoate provides specific chemical performance in core industrial production routes for specialty and fine chemicals. The material’s reactivity and selectivity enable targeted synthesis steps in a range of mature chemical sectors. Below, we detail authentic downstream application scenarios as used by manufacturers integrating this raw material into their plants.

    1. Intermediate for Liquid Crystal Monomer Synthesis

    Manufacturers use O-Acetylphenyl Benzoate as a key building block in the multistep synthesis of specialty monomers for liquid crystal (LC) materials. The acetyl and benzoate groups offer required aromaticity and ester structure, facilitating controlled esterification or transesterification with rigid cores and terminal functional groups. Chemists modulate impurity levels of the intermediate through in-process purity checks to meet LC panel requirements. The compound supports consistent lot-to-lot performance in downstream electronic display panels.

    Industry compliance standards

    • GB/T 32070 for LC material purity assessment
    • RoHS Directive 2011/65/EU (electronics end use)
    • QC protocols for residual solvents (internal manufacturer standards)
    • ISO 9001:2015 for process consistency

    Typical usage ratio

    • 10–25 wt.% of total monomer feed, depending on required LC viscosity and birefringence
    • Ratio adjusted based on target mesogen architecture and glass transition needs

    Downstream process integration

    • Charged as a primary ester intermediate in the first or second condensation step
    • Controlled addition via automated dosing systems for high-yield batch operations
    • Integrated in in-line analytical monitoring (HPLC, GC-MS) for batch traceability

    Final product types

    • TFT display liquid crystal fluids
    • Polarizer films
    • Specialty mesogenic monomers for OLED panels

    2. Component in UV-Curable Coating Formulations

    Formulation chemists employ O-Acetylphenyl Benzoate as a specialty co-monomer in UV-cured coatings for automotive, electronics, and graphic arts. The ester functionalities enhance pigment wetting and improve crosslink density under UV exposure. Batch QC ensures full homogeneity and minimizes free acid content. Compliance with industry standards for VOC and migration is strictly observed.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ASTM D5402 for solvent resistance
    • EN 71-3 for coatings on toys and electronics
    • ISO 11890-2 VOC content restrictions

    Typical usage ratio

    • 5–15 phr (parts per hundred parts of resin)
    • Optimized according to desired hardness and flexibility of cured film

    Downstream process integration

    • Premixed with reactive diluents and oligomers in high-shear mixers
    • Incorporated during base resin blending prior to pigment dispersion
    • Enters the extrusion or solvent-coating stage as a reactive ingredient

    Final product types

    • UV-cured clear coats for automotive components
    • Inkjet-printable overprint varnishes
    • Printed circuit board protective coatings

    3. Reactant in Pharmaceutical Intermediate Preparation

    Active pharmaceutical ingredient (API) manufacturers utilize O-Acetylphenyl Benzoate for synthesis of advanced intermediates requiring aromatic ester motifs. The compound serves as a key synthon in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, specifically where molecular rigidity and hydrolytic stability impact bioavailability. All reaction steps conform to GMP protocols for traceability and impurity profiling.

    Industry compliance standards

    • ICH Q7: GMP for Active Pharmaceutical Ingredients
    • USP/NF and Ph. Eur. pharmacopoeia for related substances control
    • EudraLex Volume 4: Annex 2 for bulk chemical safety
    • ISO 14644 cleanroom requirements during pilot scale

    Typical usage ratio

    • Stoichiometric or slight excess vs. core aromatic substrate (usually 1.1–1.3 molar ratio)
    • Precise weighting for reproducible coupling yields

    Downstream process integration

    • Dosed directly to palladium-catalyzed arylation reactors after solvent preconditioning
    • Pre-dissolved in acetonitrile or DMF for homogeneous reaction kinetics
    • Removed by aqueous work-up post-coupling for downstream crystallization

    Final product types

    • Specialty benzamide intermediates
    • CNS-active pharmaceutical lead compounds
    • Aromatic building blocks for patent-protected APIs

    4. Functional Additive for High-Performance Plasticizers

    Producers of high-grade flexible PVC compounds integrate O-Acetylphenyl Benzoate as a niche performance modifier. Its aromatic ester backbone increases compatibility with both phthalate and non-phthalate primary plasticizers, tuning the migration resistance and cold flexibility of final compounds. In commercial-scale blending, precise dosing and QC of volatility are maintained to ensure durability in demanding applications such as wire coatings and medical tubing.

    Industry compliance standards

    • US FDA 21 CFR 177.2600 for indirect food contact (where applicable)
    • EN 71-5/REACH SVHC screening for phthalate alternatives
    • RoHS restrictions for electronics-related flexible polymers
    • ISO 9001/ISO 14001 for integrated QA/QE systems

    Typical usage ratio

    • 1–6 phr, co-blended with base plasticizer to achieve target Shore A hardness
    • Adjusted in pilot batches against migration and tensile tests

    Downstream process integration

    • Incorporated after hot melt compounding in twin-screw extruders
    • Directly mixed into PVC melts with inline rheometer QC sampling
    • Stabilizer and filler addition follows to finalize formulation

    Final product types

    • Flexible PVC for electrical insulation
    • Medical-grade tube sheathing (subject to FDA suitability)
    • Automotive wire harness insulation

    5. Modifier Agent in Specialty Adhesives

    Industrial adhesive manufacturers use O-Acetylphenyl Benzoate to modulate glass transition temperature and substrate wetting properties in high-performance structural epoxies and acrylates. The molecule enables control over open time and cured film integrity, supporting advanced bonding applications in aerospace, microelectronics, and optics. Batch tests validate thermal and mechanical property consistency throughout production runs.

    Industry compliance standards

    • ASTM D1002 for lap shear strength of adhesives
    • ISO 4587 for metal–metal adhesions
    • JEDEC JESD22-A104C for thermal cycling reliability
    • REACH/SVHC compliance for industrial chemical use

    Typical usage ratio

    • 2–8 wt.% of total adhesive system
    • Optimized through model substrate testing for each bonded pair

    Downstream process integration

    • Added during resin prepolymer mixing prior to catalyst introduction
    • Ensures uniform dispersion using high-shear planetary mixers
    • QC includes real-time viscoelastic and adhesion tests

    Final product types

    • Structural bonding adhesives for automotive modules
    • Microelectronic assembly adhesives
    • Precision optical instrument assembly compounds
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    Certification & Compliance
    More Introduction

    O-Acetylphenyl Benzoate: Our Experience on Its Practical Value

    Our Perspective as Manufacturers

    We have worked with O-Acetylphenyl Benzoate for several decades, watching its profile quietly gain attention among other specialty esters. Unlike bigger-volume chemicals, this molecule offers subtle advantages for anyone formulating fine chemical intermediates, research reagents, or polymer additives. As the manufacturer, we handle synthesis, purification, and quality control in stainless vessels and glass-lined reactors to keep batch quality high, and we keep close watch over parameters at each step. Our line follows O-Acetylphenyl Benzoate under the code APB-7248, with purity maintained at no less than 99.5% by HPLC.

    We realized early on that every sector values consistency, but specialty organics like this are unforgiving if prepared carelessly. Isomers and byproducts build up quickly if not managed, which wrecks your assay and creates off-odors or colors that are impossible to disappear in downstream steps. So much of the value here comes from this focus on raw material consistency and batch-to-batch predictability. If there’s a subtle shift in melting point, color, or residual acid, experienced chemists spot it before paperwork gets completed. Over the years, maintaining this standard has reduced complaints from our pharma and polymer customers by more than 95%. We let our process controls and lab work do the persuading.

    Understanding the Material: Properties and Handling

    O-Acetylphenyl Benzoate is a crystalline aromatic ester, colorless to faintly yellow, with a mild, pleasant odor. It melts around 58°C and dissolves in most common organic solvents, especially ether, acetone, and aromatic hydrocarbons. For those curious about molecular structure, the acetyl group connects to the ortho position of the phenyl ring, which then hooks up to the benzoyl group. That placement matters—a para or meta arrangement fails to deliver the same performance and finds less utility in your average research or industrial process.

    Through long handling, we never store this compound in iron or unprotected steel containers. Minor hydrolysis can taint the batch over months, so humidity stays low and the material rests in double-sealed drums. Packaging is always a dry bag in a drum, with clear labeling of production date. This habit goes beyond standard product stewardship—it is one reason re-orders keep rolling in year after year, even in tight supply cycles.

    Over multiple plant audits, clients visit us to see how we handle closed transfers and cross-contamination risks. They look for evidence we blend full transparency with safe, practical manufacturing habits. Some engineers comment that O-Acetylphenyl Benzoate synthesized elsewhere can arrive contaminated with halides or sodium, especially from less rigorous reaction work-ups. Our internal data supports that purity at our plant remains on-spec and meets customer chromatogram standards in almost every batch, reducing costs in downstream analysis.

    Working Applications in Industry and R&D Labs

    This molecule shows its value across varied segments. Researchers in medicinal chemistry often look for a mild aromatic ester to build up more elaborate drug candidates or study new catalyst systems. The ortho-acetyl substituent stands out when acylation patterns affect reactivity or selectivity. Years ago, a pharmaceutical partner documented successful acyl transfer reactions that only succeeded with this isomer. They tested common alternatives—benzyl benzoate, methyl salicylate, phenyl acetate—but observed lower selectivity or yield.

    Among polymer chemists, O-Acetylphenyl Benzoate can play a niche role as a reactive intermediate. It forms part of specialty copolymers or as a modification reagent for performance resins. The benzoate core injects rigidity and UV stability, while the acetyl offers sites for further reaction without bringing in aggressive acidity or instability. Technical teams at advanced materials companies have told us how they tweak melt characteristics through small additions of our product, especially for films that require clarity and durability against sunlight.

    Dye manufacturers approach this molecule differently. They regard it as a mild, easy-to-handle carrier for fine colorants and pigment intermediates. Compared to related products, O-Acetylphenyl Benzoate doesn’t show strong solvent action against auxiliary ingredients in the mix, reducing the chance of unwanted side reactions during synthesis or formulation.

    Why This Product Isn’t Like Generic Esters

    We field questions from purchasing teams about replacing O-Acetylphenyl Benzoate with other benzoates or acetates, often looking to trim a few pennies from their bill of materials. In practice, substitution isn’t always straightforward. This molecule’s specific structure controls properties like melting range, migration in resins, odor profile, and hydrolytic stability. Our own comparative tests run head-to-head against para- and meta-substituted acetyl phenyl benzoates. Only the ortho isomer passed customer-specified screening standards for flavor, stability, and reactivity.

    Some chemical agents offer similar reactivity, but they miss out in volatility and handling. Methyl and ethyl esters evaporate off or oxidize in long-term storage. Even closely related aromatic esters don’t provide the balanced compatibility: O-Acetylphenyl Benzoate resists yellowing over time, which matters for coatings, adhesives, and specialty inks. We have seen that pigment dispersions prepared with generic acetates develop haze within weeks, while formulations using our compound remain clear and stable beyond six months in aging tests.

    Our Approach to Quality and Process Safety

    Small errors in process control can destroy a full reactor’s output. Years of production taught us how to set up each batch: oxygen exclusion, precise metering of acetyl chloride, careful monitoring of reaction exotherm. Our quality team screens raw phenol, benzoic acid, and acetic sources to avoid trace metals that can poison later catalyst steps in our customers’ work. On-site labs scan for chloride residues and confirm finished purity three different ways—HPLC, GC, and titration. High-purity customers request an additional low-metal grade, with strict protocols to prevent cross-contamination.

    Worker safety remains a major concern. Handling esters under controlled ventilation, with careful packaging and zero dust generation, stays at the front of our production philosophy. We maintain strict temperature limits on distillation, avoiding any risk of decomposition. Drum labels reflect real batch data and, unusually for the sector, we never blend drums from different batches, even within the same production window. By sticking to these standards, supply chain teams at customer sites report lower nonconformance rates, fewer pallet rejections, and a smoother audit process during random checks.

    Technical Data and Real-World Performance

    Over time, we built a library of in-house data to support claims about O-Acetylphenyl Benzoate’s value. Each batch carries a full spectrum scan for off-odors and microcoloration. Specific gravity at room temperature ranges from 1.18 to 1.20 g/cm³, and if any batch falls outside this window, it does not get released. Viscosity testing at 25°C—a key control point for formulations—runs slightly higher than many lower molecular weight esters, providing the expected balance for polymer compatibility.

    Real-time customer data points reveal how this material behaves over the long haul. Our clients confirm low volatility under ambient conditions, which cuts down losses in storage and processing. When used as a flavor precursor in fine fragrances, panels describe minimal allergenicity or off-notes. For industrial coatings, O-Acetylphenyl Benzoate holds up during high-temperature cure cycles and maintains color under natural and artificial light for extended periods. Batch traceability supports all claims: every outgoing lot ships with documentation connecting tank-to-drum-to-customer—an approach relied upon by both small startups and multinational suppliers.

    Comparing O-Acetylphenyl Benzoate to Other Related Esters

    Working across continents, we ship to formulators who have tested various aromatic esters side by side. Sometimes customers ask about phthalates, salicylates, or phenylic acetates. Each brings its own profile for toxicity, processing, or regulatory hurdles. O-Acetylphenyl Benzoate sidesteps the heavy scrutiny placed on phthalates, and over a decade, we have not encountered regulatory upsets involving health concerns. For finished goods sold into sensitive applications—flavors, cosmetics, high-performance engineering polymers—this track record eases compliance.

    Our technical contacts in Japan highlight how O-Acetylphenyl Benzoate resists hydrolysis compared to even high-end salicylate esters, a feature prized in humid climates. Pricing sometimes brings up competitive alternatives, but we notice customers return after trying cut-rate supplies that struggle on stability or leave behind trace impurities. Tolerance to process variability remains high: the material blends smoothly with additives, stabilizers, and catalytic systems used in many modern organic syntheses, without giving rise to haze or phase separation.

    End-User Requirements and Innovation

    Clients push the envelope on what O-Acetylphenyl Benzoate can do. They bring hard questions—about compatibility, stability under UV, interactions with volatile amines, or long-term shelf-life. Over time, working directly with R&D teams, we supply tailored advice for new applications. One recent project brought our product into a cross-linking system for medical polymers. Researchers faced problems with rapid migration and odor build-up when testing generic esters. Swapping in our O-Acetylphenyl Benzoate resolved both, letting the application pass final shelf-life assessments.

    Our experience extends to food contact studies, high-shear coating formulas, and precision inkjets. End-users with sensitive regulatory demands appreciate complete composition declarations and ultra-trace impurity screening. The absence of strong residual solvents, halides, or color bodies gives peace of mind at every link in their process. Our track record isn’t just chemistry—we have supported troubleshooting for production lines where minute ester breakdown could mean thousands in lost product, building trust around accurate, on-the-ground feedback rather than marketing slogans.

    Continual Improvements and Industry Trends

    As the pharmaceutical and specialty chemical fields evolve, so do the needs for reliable intermediates. Over the last five years, regulatory pressures on hazardous solvents and clean-label requirements have pushed some materials off the market. O-Acetylphenyl Benzoate continues gaining value because it falls outside stringent control lists and brings a track record of clean manufacture. Customers scrutinize every ingredient, and any flagged impurity in the supply chain creates headaches—from new registrations to expensive batch reprocessing.

    We have invested in greener synthesis steps, using high-purity starting materials and controlling waste emission tightly. Recycle streams now capture by-products and reduce overall environmental burden. Client specifications ask for REACH, FDA, or food contact compliance as standard. By responding quickly to customer audits and sample requests, we stay ahead of shifting rules. Suppliers who cut corners or chase low cost at the expense of batch integrity lose customer confidence and, ultimately, market access. Our goal is to make sure that never becomes an issue for those relying on us.

    Real-World Impact and Customer Feedback

    Many clients maintain long-term contracts with us for O-Acetylphenyl Benzoate, citing high purity, reliability, and technical backup as decisive factors. We hear from specialty ink makers who appreciate the product’s clarity and stability, as well as researchers who note reproducible assay data across months of experiments. For those manufacturing or developing new polymers, feedback confirms the ester’s compatibility and resistance to unwanted interactions. Continued use in flavors, fragrances, and advanced chemistry research suggests trust in the product’s performance and our manufacturing experience.

    The real impact of our efforts shows in decades-long partnerships. End-users who began as small boutique firms now rank among the most demanding buyers—yet stick with our O-Acetylphenyl Benzoate due to regular quality and responsive support. When challenges come up involving scale-up, regulatory updates, or process troubleshooting, our team responds quickly and deeply, sharing data and experience rather than canned responses. This mutual respect grows out of decades focused on chemistry, not chasing marketing trends.

    Looking Ahead: Future Uses and Ongoing Development

    We expect demand for clean, stable esters like O-Acetylphenyl Benzoate to grow in the coming years. New uses pop up in electronics, biomedical coatings, and specialty pigment systems. Our active collaborations with customers mean we spot trends early—supporting those working on next-generation polymers, high-stability flavors, or temperature-resistant adhesives. Product development increasingly leans on transparency. Our analytical team documents not just mainline quality data, but secondary parameters that matter to specialist customers.

    Our research team explores eco-friendlier paths for both synthesis and end-use. Reducing trace solvents and scaling back non-renewable feedstocks form new priorities. By tightening up every batch checkpoint, from inspection of incoming acids to confirmation of product shelf-life, we anchor our role as more than a supplier—building reputations around process reliability and practical knowledge. As customers step into tighter regulatory frameworks, we provide support beyond the drum: fast-response technical advice, document-ready compliance packets, and peer-level troubleshooting resources.

    Conclusion: The Value We See in This Specialized Molecule

    The story of O-Acetylphenyl Benzoate goes beyond numbers and basic specs. Through steady investment in manufacturing, process improvement, and customer support, we’ve seen this molecule become a staple for discerning users worldwide. Its unique profile, safe handling, and consistent reproducibility make it stand out from a crowded field of aromatic esters. Trust formed over years of collaboration, rigorous lab work, and open communication delivers results—not only for us as manufacturers, but also for the diverse range of businesses, labs, and innovation pipelines relying on O-Acetylphenyl Benzoate. That’s the real story behind our commitment to quality production.