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Nonoxynol 9

    • Product Name Nonoxynol 9
    • Alias Nonoxynol-9
    • Einecs 204-812-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    870912

    Chemical Name Nonoxynol-9
    Common Use Spermicidal agent
    Chemical Formula C33H60O10
    Cas Number 26027-38-3
    Appearance Viscous liquid
    Odor Odorless or mild odor
    Solubility Soluble in water
    Melting Point Approximately 5°C
    Molar Mass 617.83 g/mol
    Mechanism Of Action Disrupts sperm cell membranes
    Application Forms Gels, foams, films, suppositories, condoms
    Color Colorless to pale yellow
    Storage Conditions Store at room temperature, away from light
    Stability Stable under normal conditions
    Synonyms N-9, Nonoxinol-9, Nonylphenol ethoxylate

    As an accredited Nonoxynol 9 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Nonoxynol 9 is packaged in a white, opaque 500 mL plastic bottle with a blue label detailing contents and safety information.
    Shipping Nonoxynol 9 should be shipped in tightly sealed containers to prevent contamination and moisture exposure. Transport it in accordance with local, national, and international transport regulations. Store and ship in a cool, dry place, away from incompatible substances. Proper labeling and documentation should accompany the shipment to ensure safe handling and compliance.
    Storage Nonoxynol-9 should be stored in a tightly closed container, away from heat, sparks, open flames, and incompatible substances. Store it in a cool, dry, well-ventilated area, protected from direct sunlight and moisture. The storage area should be clearly labeled and accessible only to trained personnel. Follow all local and regulatory requirements for safe chemical storage and handling.
    Application of Nonoxynol 9

    Applications of Nonoxynol 9 in Industrial Manufacturing

    As a direct manufacturer, we have supplied Nonoxynol 9 for decades to OEM clients across specialty sectors. Outlined below are key downstream industrial applications where Nonoxynol 9 plays a critical technical role, with detailed process, regulatory, and formulation specifics for each.

    1. Spermicide Formulation for Contraceptive Products

    Nonoxynol 9 serves as the primary active ingredient in spermicidal gels, foams, and suppositories. Its clinical function requires controlled dosing and precise formulation to achieve both safety and effectiveness for contraceptive use. GMP-compliant production lines blend the compound with stabilizers and delivery matrices at low thermal stress to protect activity and minimize impurities.

    Industry compliance standards

    • 21 CFR Part 330.5 (FDA OTC Monograph - Vaginal Contraceptive Products)
    • USP-NF monograph (Nonoxynol 9)
    • ICH Q7 Good Manufacturing Practice (GMP) guidelines
    • European Pharmacopoeia (Ph. Eur.) standards

    Typical usage ratio

    • Nonoxynol 9 concentration: 2%–12% by weight in finished formulation, based on desired contraceptive efficacy and product type
    • Formulation adjustment depends on delivery system (gel, foam, film), regulatory max limits, and clinical studies

    Downstream process integration

    • Manufacturers add Nonoxynol 9 during homogenous blending stage to aqueous or oil-based matrices before packaging
    • Critical QC includes assay, purity, and preservative compatibility tested per pharmacopeial requirements

    Final product types

    • Spermicidal gels and creams
    • Vaginal contraceptive foams and film strips
    • Spermicide-coated condoms
    • Single-use pre-filled applicators

    2. Nonionic Surfactant in Industrial Laundry Detergents

    Industrial and institutional laundry detergent formulators rely on Nonoxynol 9 for its powerful nonionic surfactant properties, targeting both proteinaceous and oily soils. Its excellent dispersing and emulsification capability allows its use in high-alkalinity, multi-phase blends typical of hospital and hospitality laundering. Process chemists optimize its inclusion for synergy with builders and other surfactants, considering foam control and rinseability.

    Industry compliance standards

    • OECD Guidelines 301/302 (Biodegradability and aquatic toxicity)
    • REACH Substance Registration (for EU sales and usage)
    • AISE Detergent Ingredient Guidelines
    • ISO 9001:2015 certified manufacturing QC systems

    Typical usage ratio

    • Active level: 2%–7% by weight in main detergent concentrate
    • Ratio adjusted based on presence of auxiliary surfactants and fabric types
    • Lower rates used for light-duty, higher for medical soiled loads

    Downstream process integration

    • Mixed in pre-neutralization or post-neutralization blending tanks under mild heat (below 60°C) to avoid degradation
    • Raw Nonoxynol 9 is filtered before homogenization with other actives and sequestering agents

    Final product types

    • Commercial liquid and powder laundry detergents
    • Industrial cleaning concentrates for hospitals and hotels
    • Heavy-duty institutional degreasers
    • Linen processing detergent boosters

    3. Emulsifier in Textile Processing Chemicals

    The textile finishing industry utilizes Nonoxynol 9 as an effective emulsifier for scouring agents, dye baths, and finishing oil systems. Its balanced hydrophilic-lipophilic profile enables stable microemulsions in both aqueous and solvent-based phases. Plant engineers select dosage according to fiber type, surfactant package, and dye/auxiliary system, factoring in temperature and shear during large-batch processing. The compound supports even dye distribution and promotes cleaning efficiency during pretreatment.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile chemical acceptability)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals – Manufacturing Restricted Substances List)
    • EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
    • GB 18401 (Chinese National Textile Product Basic Safety Technical Code)

    Typical usage ratio

    • Use level: 1%–5% in scouring and dyeing auxiliaries
    • Fiber and stage-specific: lower with synthetic fibers, higher for natural cellulosic batch scouring

    Downstream process integration

    • Integrated during scouring, wetting, or emulsification stages, prior to dye application or finishing
    • Blended at 40–60°C with other auxiliaries for optimal emulsification and wetting performance

    Final product types

    • Textile wetting agents
    • Pre-treatment scouring chemicals for cotton and blends
    • Emulsified dye carrier formulations
    • Finishing agent emulsion concentrates

    4. Solubilizer and Emulsifier in Agrochemical Formulations

    Nonoxynol 9 acts as a key solubilizer and emulsifier in the production of agricultural pesticide and herbicide concentrates. Formulators leverage its ability to disperse oily actives and stabilize emulsions for water-dilutable EC (emulsifiable concentrate) and SC (suspension concentrate) systems. Dosage is optimized for active ingredient compatibility, environmental safety profiles, and desired application methods, following strict agrochemical registration and environmental codes.

    Industry compliance standards

    • FAO/WHO specifications for pesticide products (e.g., FAO/WHO REG CMC 87/Rev.2)
    • US EPA inert ingredient tolerance regulations (40 CFR 180.910/930)
    • BPR (Biocidal Products Regulation, EU Reg. No. 528/2012) as applicable for biocidal actives
    • China ICAMA (Institute for the Control of Agrochemicals, Ministry of Agriculture) product registration requirements

    Typical usage ratio

    • Surfactant level: 3%–10% within total formulation, varying by specific active ingredient and emulsion type
    • Lower levels used for SC formulations, higher for EC or EW (emulsion-in-water) types

    Downstream process integration

    • Nonoxynol 9 is pre-mixed with adjuvants and solvents before active addition
    • High-shear emulsification and homogenization applied to ensure dispersion and droplet stability

    Final product types

    • Herbicide emulsifiable concentrates (ECs)
    • Suspension concentrates (SCs) for pesticides
    • Crop protection tank-mix adjuvants
    • Insecticide wettable powders and granules requiring emulsification

    5. Wetting and Dispersing Agent in Metalworking Fluids

    Manufacturers of metalworking fluids use Nonoxynol 9 for its stable wetting properties and ability to disperse particulate and lubricant oils uniformly during cutting, grinding, and machining operations. The agent enables improved cooling and chip residue removal in water-miscible and semi-synthetic fluid systems. Dosing is optimized for emulsion stability, operator safety, and downstream filtration performance, taking into account equipment and application parameters.

    Industry compliance standards

    • ASTM E2525 (standard practice for evaluating the environmental, health, and safety hazards of metalworking fluids)
    • OSHA 29 CFR 1910 (occupational exposure limits for chemical mixtures)
    • REACH compliance for European manufacturing
    • ISO 14001:2015 Environmental Management Systems

    Typical usage ratio

    • Added at 0.5%–4% by weight in ready-to-use or dilutable systems
    • Exact rate determined by base oil type, required wetting action, and fluid stability targets

    Downstream process integration

    • Blended in main fluid concentrate during cold-mixing, before addition of biocides and extreme pressure agents
    • Homogenized under low shear to prevent emulsion breakage and maintain clarity

    Final product types

    • Water-based metal cutting, grinding, and cooling fluids
    • Semi-synthetic and synthetic coolant emulsions
    • Industrial lubricating fluid concentrates
    • Machine tool maintenance fluid systems

    6. Demulsifier Component in Oilfield Chemical Blends

    Oil and gas processing companies apply Nonoxynol 9 as a secondary demulsifier in crude oil-water separation. Its role is to disrupt water-in-oil emulsions in produced fluids, enhancing dehydration and oil recovery efficiency at production sites and refineries. Blending engineers dose it in combination with cationic and anionic surfactants tailored to well fluid compositions, viscosities, and crude characteristics, ensuring that residual content meets environmental discharge limits.

    Industry compliance standards

    • API RP 45 (Recommended Practice for Analysis of Oilfield Chemicals)
    • OECD 306 (Biodegradability in seawater)
    • US EPA NPDES effluent limitations for oil & gas extraction
    • ISO 14254 (Crude oil testing - emulsified water determination)

    Typical usage ratio

    • Active dosing: 0.1%–1.0% demulsifier content by crude volume
    • Rate varies with emulsion strength, temperature, and separation equipment type

    Downstream process integration

    • Pumped into field batch tanks or combined with primary demulsifiers before injection
    • Performance validated via jar testing and online water separation monitoring

    Final product types

    • Oilfield demulsifier chemical blends
    • Crude oil dehydration additives
    • Emulsion breaker packages for upstream processing
    • Downstream refinery water treatment coagulant formulations
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    Certification & Compliance
    More Introduction

    Nonoxynol 9 Manufactured with Precision and Experience

    Consistent Quality Matters in Surfactants

    Nonoxynol 9 stands out among nonionic surfactants, not because it’s new or flashy, but because experience has proven its reliability for a range of industrial and personal care uses. Our team has worked hands-on with this chemical for years. Every batch is measured for performance—foam, solubility, and stability—long before it moves out of the facility. Nonoxynol 9, with an average of 9 ethylene oxide units per nonylphenol molecule, brings exactly the right degree of hydrophile-lipophile balance for emulsification and dispersion in even the most demanding applications.

    Different nonoxynols carry numbers that mark the average count of ethylene oxide units in the molecule—this number defines the surfactant’s essential character. We manufacture the Nonoxynol 9 model with the specific molecular structure customers have requested when they want assured wetting action and clean rinse-off across a variety of pH ranges. Detergents, spermicidal gels, agricultural emulsifiers, and industrial cleaning concentrates all draw value from this formulation, as do textile treatments and specialty lubricants.

    Experience Shows the Key Differences vs Alternatives

    Years of experimentation have made it clear that the differences between Nonoxynol 9 and lower- or higher-numbered nonoxynols are not minor details—they are the difference between instant separation and stable emulsion, or between a safe consumer formulation and a batch that doesn’t meet specs. Our Nonoxynol 9 shows an HLB value that’s optimal for oil-in-water emulsifying, giving a cleaner break than Nonoxynol 4 or 6. Higher-numbered versions, such as Nonoxynol 15 or 30, push the hydrophilicity too far for many of the classic tasks our customers demand.

    Our customers follow strict tolerances on pH stability, viscosity, and low-odor requirements. Reproducible polymerization is not negotiable, and Nonoxynol 9’s molecular size and balance set a clear line in how the active ingredient behaves in an actual mix tank. From our view as direct chemical manufacturers, those who choose a different surfactant only do so because they have a very unique application—otherwise, Nonoxynol 9 often lands as the more versatile and predictable choice.

    In Practice: Trusted Use Across Industries

    We have shipped Nonoxynol 9 in everything from multi-ton lots for large-scale formulation to precise containers destined for pharmaceutical assembly lines. Our observations from direct user feedback and co-formulation work show that pharmaceutical and personal care manufacturers often rely on Nonoxynol 9 for its proven spermicide effect and exceptional protein solubilization. There is no lack of research here—its action as a surfactant and emulsifying agent has been documented for decades.

    The food processing industry, by contrast, rarely uses Nonoxynol 9 given stringent direct-contact safety rules. Detergent and metalworking customers, on the other hand, value the chemical’s ability to remove stubborn residues and maintain clear solutions under heavy load. From laundries using it as an additive in fabric processing to electronics firms using it in cleaning processes, we have resolved formulation hurdles through trial, error, and analysis that only come from hands-on production experience.

    Performance and Batch Integrity from First Principles

    Every lot of Nonoxynol 9 is only as good as the precision invested at each stage. We draw raw material from trusted suppliers with a record of supplying high-purity nonylphenol and tightly controlled ethylene oxide. Operators and engineers in our line review chain-of-custody forms and material safety data before each run. Modern reactors monitor temperature and pressure on a moment-to-moment basis. Our QC staff know the failure points—off-odor, incomplete ethoxylation, excess free glycol—that mark the difference between a useable and a discardable batch.

    Lab technicians analyze final product for active matter, pH, color, and water content. Experienced eyes, not just automated instruments, crosscheck infrared spectra for signal patterns that don’t match historic samples. Batch records note every detail because customers expect the same fluid, the same functionality, every shipment, no matter how many tons they order.

    Responsible Handling and Environmental Concerns

    Manufacturers face steady pressure in surfactant chemistry to reduce environmental impact. Decades ago, nonylphenols as a group drew scrutiny due to persistent environmental residues, especially in wastewater. Our facility invests in closed-loop water systems, air emissions control, and waste-stream analytics because these concerns are real. We engage with regulators and industry groups, not as a public relations move, but because our own staff want to minimize risk and maximize safety.

    Nonoxynol 9’s role in finished goods varies by regulation. In some regions, it faces stricter limits; in others, it remains authorized for pharmaceutical and cleaning applications. Experience in the field shows that effective waste treatment, coupled with source control, minimizes risk downstream. We don’t shy from transparency: full composition disclosures and handling protocols travel with every shipment.

    Safety and User Protocols: Real-World Practices

    Our work as manufacturers means we don’t read safety sheets in the abstract. Workers suit up, manage pumps and valves, and sense when a formulation’s behavior signals a problem. For all its utility, Nonoxynol 9 can cause skin and eye irritation in concentrated form. Customers who visit our production facility see wall postings and live demonstrations about exposure control. Our own plant adopted vapor capture and double-washing for valves after seeing where leaks or drips were most likely.

    On the user end, personal care manufacturers typically dilute Nonoxynol 9 below thresholds set by regulatory agencies to limit contact risks. Cleaning product and industrial users consult with us directly for best storage, transfer, and disposal practices. We provide insights on compatibility—what tanks and gaskets show swelling, where batch separation may emerge, and which ancillary additives solve foaming or settling.

    Formulation Insights: What Decades in Production Teach

    More chemists and process engineers have learned on Nonoxynol 9 than almost any other nonionic surfactant. Our conversations with formulation scientists, R&D directors, and contract blenders have shaped improvements in our own processes. Mixing Nonoxynol 9 with anionic or cationic surfactants, for instance, can fine-tune cleaning or emulsification behavior. In high-alkaline or high-calcium systems, we recommend blending with sequestering agents or specific cosurfactants to maintain clarity and performance.

    In high-value cosmetic or pharmaceutical applications, purity and color take on outsized importance. So, we implemented advanced filtration and in-line color monitoring on our dedicated Nonoxynol 9 line. Our staff work with customers changing formulation parameters to stay ahead of market shifts—whether it’s a new low-foam requirement, reduced sensitivity to hard water, or compliance with the latest restrictive list.

    Technical Specifications: Reliable Data from Manufacturing Floors

    Direct control over every step—raw material intake, ethoxylation reactor efficiency, downstream upgrades—lets us deliver Nonoxynol 9 that meets stated ranges for APHA color, percent active, and water content. Typical batches register a pH between 6.0 and 8.0 in 1% solution form, and viscosity generally exceeds that of lighter nonoxynols. We discourage customers from comparing specification sheets alone. A bottle’s label does not reveal batch-to-batch consistency, trace contaminant levels, or the record of process upsets. Years spent working in this business show that true product consistency comes from direct oversight and rigorous documentation, not a printed certificate.

    Advantages Only Direct Manufacturers Know

    There is a temptation to generalize about surfactants, but as the team who sees the raw material, the process, and the finished chemical up close, we know that every shift in source, every tweak in process, shows up in final performance. As a manufacturer, we have worked with downstream users adjusting their formulas: sometimes due to a change in oil feedstocks, sometimes due to regional compliance shifts or simply a need for tighter foam control. We can change the degree of ethoxylation slightly, cut reaction time, or swap filtration protocols because we are not handing off third-party barrels—we see and control every detail.

    Clients looking for an industrial emulsifier or a well-documented component for approved health formulations rely on the traceability that only direct factory records can provide. Every batch shipped comes with full documentation, including reactivity histories and performance testing. Our facility, staffed by people who have built their careers on hydrophilics, never ships unknown mixes or off-specification blends to fill a gap in the inventory. Customers know to expect more than what they see on paper. Regular lot-by-lot consulting, transparent manufacturing records, and on-site validation visits are part of our everyday routine.

    Meeting Evolving Customer Demands Directly

    As end-use markets face new restrictions and sustainability pushes, manufacturers like us take an active role, not a reactive one. Our process control engineers continuously monitor advances in catalyst systems and heat-recovery for greener production. Zero-discharge aspirations push every aspect of our wastewater handling to higher standards. Years spent shipping Nonoxynol 9 across international lines led us to invest in multi-level packaging, updated material declarations, and seamless supply chain tracking.

    Customers in North America want reassurance their products comply with local chemical inventories and registration requirements. Manufacturers in Europe track evolving eco-label and restriction lists. Emerging market users call with unique formulation challenges—like tight foam control under high-contaminant loads or compatibility with indigenous raw materials. By running a live facility and listening to users in hundreds of sectors, we adapt each process, shipment, and support call to the current landscape.

    Navigating Supply Chain Pressures and Volumes

    Recent years have seen supply disruptions in key raw materials for ethoxylates, including access to nonylphenol and ethylene oxide. Direct control of sourcing and forward planning in inventory means Nonoxynol 9 leaves our facilities only after meeting in-house certification. Orders from regular customers, especially those scaling up, receive priority access from dedicated tank storage. Bulk shipments and custom drum packaging reflect changing order patterns across regions and industrial sectors.

    We track every shipment batch, manage transportation according to product properties, and solve logistical issues before they reach the dock. In some regions, special delivery protocols and temperature-controlled storage are essential. Decades of on-site experience show that packaging failures, not process errors, usually cause downstream problems—so we double-check every label, cap, and seal before release.

    Continuous Improvement: Lessons Learned Over Decades

    Many technologies and trends have claimed to replace nonionic surfactants like Nonoxynol 9, but practical results win out. We continuously test new competitors: sugar-based surfactants, alkyl polyglucosides, specialty block copolymers. Their environmental benefits are real, but they don’t always match the surfactant’s efficiency in emulsification, residue removal, or microbial action.

    Each new challenge from customers feeds into our cycle—more pilot runs, more QA checks, and further operator training. Our senior engineers review every process deviation, feeding back lessons into the system, making each new run that much more reliable than the last. Our ongoing investments in plant safety, process control, and real-time chemical monitoring are not marketing slogans, but responses to lessons earned the hard way in live production.

    True Product Confidence Comes from Real-World Experience

    Nothing replaces seeing the raw materials loaded, the reactors running under blue light, or the QC staff verifying each sample under the spectrometer. Customers don’t get to see the rhythm of in-plant communication or the accumulated lessons in sample logs and batch histories. What they get, instead, is a product built on decades of experience—delivered with the advice and consultative insights only working manufacturers can offer.

    We listen to every concern, challenge every complaint, and use every new data point—from detergents to pharma to plant floor feedback—to keep our Nonoxynol 9 at the highest standard possible. Our pride in the product and the discipline to improve each step come from the knowledge that real businesses and people count on our choices. As manufacturers, we look forward to supporting every new inquiry or process challenge, armed not just with Nonoxynol 9 but with a body of practice built from making, testing, and standing behind the product every day.