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Nicotinanilide

    • Product Name Nicotinanilide
    • Alias Nicotinamide
    • Einecs 222-763-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    282661

    Chemical Name Nicotinanilide
    Cas Number 132-85-4
    Molecular Formula C12H10N2O
    Molecular Weight 198.22 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 166-169°C
    Solubility Slightly soluble in water; soluble in organic solvents
    Iupac Name N-phenylpyridine-3-carboxamide
    Pubchem Cid 12585
    Structure Contains a pyridine ring substituted with an amide group at the 3-position

    As an accredited Nicotinanilide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Nicotinanilide, 100g, is packaged in a sealed amber glass bottle with a tamper-evident cap and clear labeling for safety.
    Shipping Nicotinanilide should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It requires labeling in accordance with chemical safety regulations. During transport, it should be kept at ambient temperature and handled by trained personnel, ensuring compliance with local and international shipping guidelines for laboratory chemicals.
    Storage Nicotinanilide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Protect it from light and moisture. Keep it at room temperature and avoid exposure to excessive heat. Ensure containers are clearly labeled and comply with local regulations for chemical storage.
    Application of Nicotinanilide

    Applications of Nicotinanilide in Industrial Manufacturing

    Nicotinanilide offers reliable performance advantages for several specialized chemical industries, serving as a functional additive, intermediate, or processing aid. All scenarios below reflect widely adopted and technically validated markets, each with distinct integration protocols and compliance considerations.

    1. Agrochemical Intermediate Manufacturing

    In the crop protection sector, manufacturers utilize nicotinanilide as a synthetic intermediate for multiple pyridine- and pyrimidine-based active substances. Its structure supports fine-tuned substitutions that enable production of both herbicide and insecticide actives. The material typically enters at early or mid-stage coupling, where its chemical compatibility avoids by-product contamination and minimizes downstream purification. Stakeholders must align processes with pesticide certification and impurity controls throughout batch synthesis, monitoring for compliance under shifting global norms. Continuous updates to technical documentation support transparent evaluation during regulatory audits and new registration applications.

    Industry compliance standards

    • ISO 9001:2015 certified QC system for raw materials and intermediates
    • Compliant with EU Regulation (EC) No 1107/2009 for plant protection product synthesis
    • Meets US EPA requirements for chemical intermediates in pesticide manufacturing
    • China GB 2763 MRL framework for downstream active ingredient traces

    Typical usage ratio

    • 3–8% by mass in the synthesis step, varying depending on the target pyridine backbone and yield optimization; process chemists adjust ratio according to purity and conversion rates

    Downstream process integration

    • Added in the early-stage amide coupling or condensation reactions for active substance intermediate production; stability maintained under controlled temperature and pH
    • Often followed by chlorination, alkylation, or cyclization steps specific to downstream agrochemical’s molecular scaffold

    Final product types

    • Selective herbicide actives (pyridine-based compounds)
    • Nitrogen-containing insecticide active ingredients
    • Fungicidal intermediates for export formulation packs
    • Bulk pesticide technicals for formulation blending

    2. Pharmaceutical API Synthesis

    Within API synthesis lines, nicotinanilide functions as a foundational intermediate for the production of several classes of therapeutic agents, including certain anti-tuberculosis and anti-diabetic drugs. GMP process control and thorough validation of input purity are essential, given the sensitivity of downline reaction pathways. The placement of the material within reaction schemes often aims to facilitate ring closure or targeted functional group insertion, both of which are critical for the desired pharmacological activity. QC teams subject incoming batches to full traceability audits, ensuring batch-to-batch reproducibility and supporting regulatory submission files across multiple healthcare jurisdictions.

    Industry compliance standards

    • Complies with ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • Documentation aligned with US FDA 21 CFR Part 211 for finished pharmaceuticals
    • Incoming controls adapted to EP, USP, and JP pharmacopoeia reference standards for intermediates
    • Full traceability per EudraLex Volume 4 Chapter 17 (EU guidelines on APIs)

    Typical usage ratio

    • 1–5 mol % relative to final pharmaceutical backbone, adjusted for different molecule sizes and purity specifications

    Downstream process integration

    • Uses include condensation and coupling steps preceding key heterocycle formation (notably, for certain pyridine-based active substances); process adjustments for controlled impurity profile
    • Subjected to repeated recrystallization or chromatographic purification depending on target medicinal specifications

    Final product types

    • Anti-tuberculosis API intermediates (e.g., prodrugs with nicotinic acid derivatives)
    • Anti-diabetic precursor agents used in further synthesis
    • Contract manufacturing supply to pharmaceutical formulators
    • Research-grade intermediates for specialty pharmaceutical development labs

    3. Dye and Pigment Intermediate Production

    Colorant manufacturers leverage the stable aromatic structure of nicotinanilide to introduce specific color wash properties and enhance chromophore rigidity in select azo and heterocyclic dye classes. Its amide functionality provides a key coupling node for subsequent diazotization, impacting hue saturation and product weather resistance. The integration point directly influences downstream colorfastness and substrate compatibility, requiring precise formulation and multilayer QC throughout the reaction cascade. Restricted substance compliance continues to evolve, affecting both raw material incoming inspection and final batch disposition for textile and ink sector customers.

    Industry compliance standards

    • Adheres to EU REACH Registration and SVHC regulations for dye intermediates
    • Oeko-Tex Standard 100 criteria for restricted amides in textile chemicals
    • China GB/T 21866 and GB 18587 for pigment and dye additives
    • Compliance with AP(89)1 Council of Europe Resolution for colorants in food-contact articles (if relevant)

    Typical usage ratio

    • 0.2–1.5% by weight, balanced against primary aromatic amine content and desired dye shade; color chemists may further fine-tune according to batch dyeing yield and fixation efficiency

    Downstream process integration

    • Introduced during the generation of key azo or heteroaromatic dye precursors via amide functionalization reactions
    • Often follows a sequential nitration or sulfonation process for specialty pigment manufacture

    Final product types

    • Disperse dyes for polyester fiber processing
    • Acid dyes for wool and nylon applications
    • Specialty organic pigments for industrial coatings
    • Printing ink colorants for packaging and labeling

    4. Electroplating Bath Additive Formulation

    Electroplating workshops incorporate nicotinanilide as a grain-refining additive in select copper and nickel bath chemistries, particularly where uniform coating microstructure and minimized dendrite formation are critical. Its inclusion modifies cathodic polarization, suppresses unwanted crystal growth, and enables tighter control of deposited layer thickness. The efficiency of this additive depends on multiple process factors, including current density and bath pH, so engineers optimize dosage based on real-time thickness and roughness measurements, while maintaining full traceability of additive sourcing for environmental audits.

    Industry compliance standards

    • Complies with ASTM B322-99 for cleanliness in metal finishing
    • Observes RoHS Directive 2011/65/EU for restricted substances in electroplated products
    • Aligned with China GB/T 5237.4 for metal surface treatment alloys
    • Subject to regular internal QC per ISO 14001:2015 for plating process environmental management

    Typical usage ratio

    • 0.01–0.08 g/L in working electrolytic solution, adjusted based on desired grain size, cathodic efficiency, and final deposit thickness; operators confirm ratio by lab-scale panel trials before full-bath addition

    Downstream process integration

    • Added directly to freshly prepared electrolyte bath just before plating cycle begins
    • Monitored through periodic bath analysis and adjusted incrementally to account for additive consumption over large production runs

    Final product types

    • High-gloss copper-plated automotive connectors
    • Electronics-grade nickel contacts for circuit assembly
    • Precision electroformed metal mesh and screens
    • Consumer hardware coatings with controlled microstructure

    5. Specialty Polymer Modifier Synthesis

    Engineers in specialty plastics production sometimes utilize nicotinanilide as a reactive modifier during polyamide and copolymer synthesis, targeting enhancements in chemical resistance and thermal stability. Its amide group co-polymerizes with nylon or specialty engineering resin backbones, introducing secondary functionalities that tailor molecular structure for demanding industrial applications. The addition point and ratio are chosen for specific end-use certification requirements, often dictated by automotive, electrical, or medical device standards.

    Industry compliance standards

    • Adheres to ISO 9001 and ISO 14001 for manufacturing process control
    • UL 94 for flammability of plastic materials in electrical applications
    • RoHS and REACH compliance for restricted substances
    • Automotive OEM technical specifications (e.g. VW TL 52682, GM GMW303306 where applicable)

    Typical usage ratio

    • 0.3–2% by total resin mass, based on target mechanical properties and migration limits; R&D labs determine loading during pilot runs aligned with final product testing

    Downstream process integration

    • Introduced during pre-polymer compounding along with other chain modifiers
    • Followed by high-temperature extrusion and pelletization, with in-process monitoring for gel content and melt-flow stability

    Final product types

    • Nylon engineering plastics with enhanced chemical durability
    • Copolymers for automotive under-hood components
    • Specialty wire insulation compounds
    • Medical device housings requiring certified extractables profiles
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    Certification & Compliance
    More Introduction

    Introducing Nicotinanilide: Crafting Reliability for Modern Chemistry

    Real Experience with Nicotinanilide Production

    Producing Nicotinanilide over many years gives a front-row view to how small decisions on the manufacturing floor shape the outcome of a fine chemical's characteristics. In our own manufacturing plant, each step, from sourcing raw materials to final packaging, leaves its mark on purity, consistency, and handling of Nicotinanilide. Many in the industry see this compound as just another building block, but experience shows subtle differences in synthetic routes change real-world usability. Engineers in our plant work directly with operators to optimize yield and minimize contaminants, especially those that could limit its effectiveness for pharmaceutical or crop protection applications. During each batch synthesis, temperature control and solvent choice demand constant attention, and small process changes have taught us which refinements truly pay off in the end product.

    What Is Nicotinanilide and Why We Make It This Way

    In our facility, Nicotinanilide stands out for its dependable structure and chemical reactivity. Composed of nicotinic acid and aniline, it marries the benefits of both components. Our approach blends hands-on production experience with the calm discipline of tight quality checks. Technicians notice the color change of intermediates; chemists oversee analytical profiles after each stage. Some competitors automate nearly the whole process, but manual oversight catches process drift that can cause subtle impurities. Products leaving our site fall within a narrow melting point and HPLC range because the team watches over every critical step.

    Our keys for Nicotinanilide production involve direct oversight of the reaction pathway. We rely on batch syntheses under controlled conditions, regularly validating starting material identity and moisture content. The process generates a solid crystalline product, and our filtration and drying areas run under low-humidity air with regular checks for organic volatiles. This minimizes residual solvents—important for customers targeting highly regulated markets like active pharmaceutical ingredients, high-end coatings, or analytical standards.

    Model and Specifications From the Shop Floor

    We produce Nicotinanilide as a white to off-white crystalline powder suitable for sensitive laboratory uses or as an ingredient in larger reaction chains. Each batch runs with a narrowly specified melting point and strict impurity profile due to repeated learning cycles. Initially, lower melting fractions showed up before we controlled solvent system pH more tightly and implemented staged crystallization. Packing the powder in double-lined drums protects it from outside moisture and stops caking, which keeps even aging inventory easy to use. Operators spot check cartons for physical integrity—a habit that comes from too many years seeing powders compromised by poor warehouse practice.

    Each specification sheet, built from cumulative plant data not just textbook values, includes ranges for purity verified by HPLC, loss on drying, and trace metal content. Earlier batches sometimes failed due to trace chlorides—later rounds with adjusted cleaning ensured clean glassware and solvent lines. The data on each batch spring not from marketing promises but from hands-on daily practice and chemical analysis tied to the actual equipment we use.

    The Nicotinanilide we ship has batch identification tracking back to vessel logs and laboratory records. Customers receive material matching our actual production parameters, not just generic numbers, so each shipment reflects the workflow actually used and monitored by real staff on the ground.

    Practical Usage in the Field

    Researchers and industrial operators trust Nicotinanilide for more than just its name—dependability under real conditions means everything. In pharmaceutical research, only consistent purity keeps experimental results believable and production lines trouble-free. Variability in reactivity, crystal size, or trace contamination directly causes headaches for chemists and engineers. Our plant focuses on stable supply since even minor inconsistency in melting point widens product impurity in downstream synthesis. These practical details have driven how we build out and operate our plant, right down to running parallel lines for sensitive customers who have their own unique analytical requirements.

    We have seen end users apply Nicotinanilide as a coupling reagent, a starting material, or an intermediate in synthesis pathways ranging from specialty aromatics to biochemistry reagents. Some rely on its amide linkage to improve reaction compatibility in complex molecule assembly. Research customers often come back with practical observations—reaction rates differ with trace residual water content or with subtle batch-to-batch changes in crystalline habit. To keep feedback positive, we adjust everything from drying times to micronization steps in response to their real usage, not just passing QC on paper.

    Sales staff don’t just push out orders. They record feedback from bench chemists and pilot plant engineers so we can adapt both equipment maintenance and process parameters. If a customer’s batch reacts slower or picks up impurities downstream, technical staff work with our own team—sometimes rewriting old instructions, sometimes ordering new stockroom glassware, and sometimes changing purification solvents altogether.

    Why This Nicotinanilide Is Different

    Plenty of Nicotinanilide comes from bulk plants that focus on volume over control. Our years in the trenches taught us that speed and cost-cutting only work until someone needs reproducible results. Sometimes upstream vendors swap materials or install new reactors and never tell customers, causing ripple effects in purity and behavior. In our plant, operators, shift leads, and engineers treat every deviation as a potential lesson—someone reads the trend log, double-checks the product, and fixes process drift at the source.

    Differences appear not just in test results but in how the powder flows, how it handles in the customer’s hands, and how the product ages in storage. Technicians have caught early caking issues in the drum before they turned into full returns from users. Some outdoor storage delays material integrity; we switched to smaller batch packaging at the urging of a customer who reported moisture pick-up after several months in a non-airconditioned warehouse.

    What sets our Nicotinanilide apart is not just a tighter spec sheet but a willingness to work with people—hearing complaints, visiting plants, and digging into real usage patterns instead of pushing out more generic goods. Over years, feedback from hands-on users shaped both the physical characteristics and test criteria for every outgoing lot.

    Competitors’ products sometimes drift outside critical control points—moisture, aggregate size or residual solvent levels—when supply chains stretch. We keep a shorter, more transparent sourcing network for both safety and supply reliability. Every employee on the line knows that their work impacts a customer’s process, so accountability stays strong day and night. Technicians scrutinize every blend, record each discrepancy, and sign their names to logs. Production staff know our customer base includes firms with both high-volume and high-integrity requirements—mistakes have real consequences for end applications in regulated industries.

    Upstream and Downstream Impacts

    Our control over all the steps, from choice of starting aniline and nicotinic acid right down to filtration and drying, lets us troubleshoot quickly if issues ever arise. Some raw material suppliers have changed their own synthetic approaches—sometimes the trace metal content or side reactions shift as a result, which might go unnoticed by distributors that only repack bulk shipments. Because we operate our own synthesis facility, those shifts show up quickly in our own analytical triggers, and real-time batch logs let us trace each issue.

    Downstream users feel these small changes acutely. A trace impurity causing color shifts in intermediates can stall an entire pharmaceutical synthesis chain. Our responsiveness not only shortens troubleshooting time for our customers but also builds trust with partners managing stringent regulatory requirements.

    Customers using Nicotinanilide in crop protection actives or high-value dyes bring unique feedback about product stability. Formulators find even small differences in crystallinity or bulk density change how material disperses or dissolves in carrier liquids. We respond by adjusting roll-milling and packaging schedules, at times inventing custom solutions within our plant—fine-tuning our equipment where others would simply press for higher throughput.

    Lifecycle management happens not as an afterthought but as a daily pursuit. Our batch records, retained for many years, help customers with regulatory audits or unexpected technical queries. By maintaining traceability from initial raw material receipt to shipment, teams can pinpoint and fix oddities rather than leaving customers in the dark.

    Supporting Advanced R&D and Industrial Synthesis

    Nicotinanilide serves as an anchor in the labs that design the molecules of today’s advanced therapeutics, dyes, pesticides, and materials. Some R&D firms insist on analytical support beyond mere proof of purity, so our in-house team works alongside theirs to study baseline impurity profiles or support documentation for pilot submissions. The site’s technical services team regularly receives samples from customers who run exploratory syntheses and need help with side product identification. This approach, learned from years of open conversation with hands-on chemists, plays a real part in advancing their discoveries.

    Industrial-scale assemblers focus more on throughput than on bench-scale quirks, but we still listen to those running pilot plants. Their equipment, often somewhat jury-rigged or prone to scale-related hiccups, exposes subtle differences in chemical behavior missed in small vials. Practical issues like stickiness, varying powder flow, or inconsistent solubility at scale crop up—matters addressed best by walking the customer line, not just emailing spec sheets.

    Some years back, an automotive coatings supplier flagged crystal clumping as they scaled up. Trials and adaptation of our drying process, followed by improved anti-caking protocols in packaging, solved the trouble and enabled their production run to complete smoothly. These lessons stick—they don’t make flashy marketing stories, but they cement relationships and build steady improvements for future batches.

    Real Comparisons With Other Products

    Years of feedback show clear differences between high-purity, closely monitored Nicotinanilide and cheaper, bulk versions. Many traders push generic stock, but deep relationships with end users reveal some sellers blend fractions from different lots, leading to performance issues. We stay away from that—it never results in dependable product. Batches from tightly controlled plants cost more to make, but research and production customers with tight margins appreciate fewer failed synthesizes and less downtime chasing inconsistent results.

    Repeated use confirms the importance of chemical integrity, especially in downstream use where side reactions from minute impurities create major expense in purification and yield loss. We have seen clients switch after trouble with low-cost suppliers—the headaches of inconsistent melting point, batch variable residues, and uncertain trace element content always outweigh the initial price savings. Sometimes we receive urgent requests to airfreight replacement material after a competing batch fails a critical test. Traceability, reliability, and customer service start at the manufacturing line but get proved out in customers’ facilities around the world.

    Bulk-packaged Nicotinanilide, shoveled wholesale without close inspection or end-use observation, cannot hope to respond to user demands on purity or stability. The smaller the batch, the closer we watch, and the faster we respond when end users flag issues in real-world operation. Because most distributors and resellers have never run a pilot reactor or cleanroom synthesis, they miss the subtle but critical differences that come from day-to-day challenges on the production floor.

    Our plant’s staff presence—real people, real logs, real interventions—prevents common pitfalls like cross-contamination or unidentified out-of-spec drifts. Because the plant leadership values feedback loops, every technician carries the knowledge that their eye for detail changes customer outcomes. This lived experience gives our Nicotinanilide its reputation—less as another commodity, and more as a true building block for the next generation of fine chemicals.

    The Human Element: Experience Guides Every Lot

    Over decades, plant supervisors have built a practical culture for Nicotinanilide handling and production. Chemists spend time in both lab and plant to understand limitations—adjusting crystallization rates after identifying off-spec particle distributions, redesigning dust collection when the product showed minor static cling in summer humidity. Operators spot material flow shift and step in to correct packing routines. The technical team’s reward comes not from speculative improvements but from fewer customer complaints and more positive remarks from returning buyers.

    This people-driven cycle, backed by years of experience correcting both recurring and surprise problems, puts real dependability into the product. Training matters—we do not hand over process controls to those who do not know why each step matters for outcome. Even with advanced automation, human judgment remains at the core—anomalies need eyes and intuition, not default programming. This approach keeps us learning, listening, and improving the Nicotinanilide reaching the hands of those building tomorrow’s chemistry.

    Continuous Improvement Driven by User Results

    Each year, updates to our process come from user results, not just internal goals or academic papers. After one customer identified an issue with analytical interference from a batch, the team ran side-by-side tests with their actual instrumentation. These collaborative exercises, repeated across multiple applications and partners, shaped both quality control routines and final packaging protocols. Updates get made on the basis of demonstrated gains in customer satisfaction and technical reliability, not only on cost or output numbers.

    Quality assurance, for us, sits at the intersection of trained staff, open communication, and customers willing to share their setbacks as well as successes. Operators in both synthesis and handling look for trouble before it appears—leaks, trace contamination, or logistics problems get flagged and fixed as soon as signs emerge, minimizing downstream fallout. Each improvement on the line comes from a real case: a sticky powder, a color drift, a packaging tear, or a failed bench reaction. This hands-on, improvement-focused culture keeps the standards for Nicotinanilide rising incrementally every year.

    Environment and Safety in Daily Operations

    Handling Nicotinanilide production never stops at simple compliance. Teams monitor dust levels, ventilation, and solvent exposure all shift long. Factory safety officers train all staff to manage spills, run detailed waste segregation, and properly use personal protective equipment. Cut corners bring lasting trouble, so honest and regular coaching remains a mainstay.

    Each shipment leaving the plant is the product of teams that care about both their own health and the long-term safety implications for those down the line. Documentation reflects actual plant protocols, not just regulatory minimums, so the real-world risks get managed on the ground. Reducing waste, running cleanly, and maintaining safe conditions goes hand-in-hand with technical excellence.

    Looking Forward With Nicotinanilide

    We view Nicotinanilide as both a chemical in its own right and a marker of broader change in specialty chemical manufacturing. Demands grow sharper each year—not only for higher purity, but for genuine traceability, staff training, and forward-looking batch management. Our plant adapts by keeping close tabs on both global trends and the specific, practical, often unglamorous requirements of end users in chemical, pharmaceutical, and specialty industries.

    Through ongoing investment in equipment, training, and feedback-based process improvement, we remain confident that our Nicotinanilide stands ready for both existing and new applications. The stories and successes of our long-term users make the difference, and over time, the plant’s own lessons compound into reliability and technical assurance for all who rely on this unique compound.