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N-Phenylethylenediamine

    • Product Name N-Phenylethylenediamine
    • Alias N-Phenylenediamine
    • Einecs 202-870-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    902304

    Cas Number 136-35-6
    Molecular Formula C8H12N2
    Molar Mass 136.19 g/mol
    Appearance Colorless to light yellow liquid
    Melting Point -10 °C
    Boiling Point 255-257 °C
    Density 1.015 g/cm3
    Solubility In Water Slightly soluble
    Flash Point 120 °C
    Refractive Index 1.589
    Synonyms N-Phenylethane-1,2-diamine
    Structure Phenyl group attached to ethylenediamine

    As an accredited N-Phenylethylenediamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing N-Phenylethylenediamine is packaged in a 100g amber glass bottle with a screw cap, labeled with hazard and safety information.
    Shipping N-Phenylethylenediamine should be shipped in tightly sealed containers made of compatible materials, away from strong oxidizers and acids. Transport in accordance with local, national, and international regulations. Clearly label packages with hazard warnings and handle with care. Protect from moisture, excessive heat, and direct sunlight during transit to ensure stability and safety.
    Storage N-Phenylethylenediamine should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect from light, moisture, and sources of ignition. Proper labeling and spill containment are essential. Personal protective equipment should be used when handling. Store in accordance with all local, regional, and national regulations.
    Application of N-Phenylethylenediamine

    Applications of N-Phenylethylenediamine in Industrial Manufacturing

    As a registered manufacturer, we supply N-Phenylethylenediamine to established downstream sectors employing advanced integration and quality control systems. This material’s reactivity and selective amination profile support specific synthesis routes across regulated chemical industries. Below, we detail main application sectors, relevant compliance measures, formulation considerations and process integration in line with actual industrial practices.

    1. Synthesis of Heterocyclic Pharmaceutical Intermediates

    N-Phenylethylenediamine serves as a core substrate in the development of key heterocyclic intermediates, including substituted imidazoles and benzimidazoles for active pharmaceutical ingredient (API) manufacture. Pharmaceutical synthesis requires precise introduction of the diamine for ring closure or alkylation stages under GMP-compliant conditions. Process engineers often employ this molecule at controlled temperatures to ensure selectivity and reproducibility. Batch records track input quantities and reaction endpoints, with all intermediates undergoing rigorous impurity profiling in accordance with pharmacopeial specifications.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP, EP, JP relevant monographs for related intermediates
    • 21 CFR Part 211 (US FDA cGMP for finished pharmaceuticals)
    • EU EudraLex Volume 4 GMP Guidelines

    Typical usage ratio

    • 0.85–1.2 molar equivalents based on targeted intermediate yields and route optimization
    • Ratio adjustments depend on downstream impurity limits and catalyst loading

    Downstream process integration

    • Charged into closed reactors during condensation and cyclization steps
    • Integrated after in-line raw material dispensing, followed by continuous stirring under inert atmosphere
    • Residual diamine monitored and neutralized before extraction stages

    Final product types

    • Benzimidazole-based antihypertensive intermediates
    • Heterocyclic building blocks for anti-infective APIs
    • Pharmaceutical process chemicals for solid and liquid formulations

    2. Color Developer Precursor for Analytical Reagents

    The material acts as a color reagent precursor in diagnostic formulations, enzyme assays, and water analysis kits. Laboratories require precise dosing of the diamine with diazonium salts for rapid chromogenic detection. Laboratory and industrial reagent manufacturers control input ratios to tune sensitivity, meeting internal and regulatory quality benchmarks. Reactions typically proceed in buffered media with temperature control and batch records for traceability. Finished kits undergo verification for batch-to-batch color consistency.

    Industry compliance standards

    • ISO 13485:2016 for medical devices and IVD reagent production
    • OECD Guidelines for the Testing of Chemicals (chromogenic reagent validation)
    • CLSI EP17-A2: Protocols for detection limits in diagnostic devices
    • REACH registration if used in European IVD manufacturing

    Typical usage ratio

    • 0.02–0.1% w/v in final diagnostic reagent batches
    • Optimized by substrate and application detection threshold

    Downstream process integration

    • Added post-buffer preparation during reagent compounding
    • Mixed in closed vessels before sterile filtration and aliquoting into kit vials
    • Monitored for purity and absence of unreacted diamine via QC checks

    Final product types

    • Enzymatic test kits for clinical chemistry
    • Environmental water analysis strips
    • Custom colorimetric solutions for laboratory diagnostics

    3. Corrosion Inhibitor Synthesis for Industrial Cooling Systems

    This diamine compound forms part of multi-component formulations in the in-house synthesis of organic corrosion inhibitors. Specialty chemical producers use the molecule as a bridging agent for imidazoline or quinoxaline-based inhibitors, supporting metal surface protection for large-scale heat exchangers and recirculation systems. Each batch undergoes chemical compatibility and metal passivation panel evaluation to comply with site-specific requirements outlined in technical standards.

    Industry compliance standards

    • ASTM D1384: Standard Test Method for Corrosion Testing in Engine Coolants
    • ISO 8044: Corrosion of metals and alloys – Terminology
    • REACH SVHC regulations for hazard classification
    • API 682: Pumping systems mechanical seal corrosion testing (for process integration)

    Typical usage ratio

    • 3–8% in concentrated corrosion inhibitor formulations
    • Adjusted based on evaluation of corrosion rate and system water chemistry

    Downstream process integration

    • Reacted in blending reactors with fatty acids and saponifiers
    • Dispersed in the final inhibitor matrix before product standardization
    • QC teams conduct titration and spectral analysis post-blending

    Final product types

    • Closed-system corrosion inhibitor concentrates
    • Formulated scale/corrosion inhibitor tablets
    • Custom-designed inhibitor solutions for power plant cooling towers

    4. Rubber Antioxidant Production

    Major rubber additive producers use N-Phenylethylenediamine as an intermediate to synthesize certain aromatic amine-type antioxidants. These antioxidants extend the life of synthetic and natural rubber by preventing oxidative degradation, especially under dynamic load and thermal exposure. Industrial production requires precise diazotization and coupling pathways for maximizing conversion and purity before compound blending into elastomers. Quality control teams analyze finished batches for residuals and migration potential in line with regional regulation.

    Industry compliance standards

    • GB 9651: Rubber Antioxidant Product Standards (China)
    • ASTM D4676: Classification of Rubber Compounding Additives
    • EN 2000/53/EC (ELV Directive—limits on amines in automotive elastomers)
    • ISO 9001 certified production and batch release QC

    Typical usage ratio

    • Employed at 6–10% of total antioxidant batch mass pre-polymerization
    • Formulation ratio varies by polymer type and end-use durability requirements

    Downstream process integration

    • Synthesized in dedicated reactors as part of amine antioxidant production
    • Purified intermediate incorporated into masterbatch or compound lines
    • Physical property tests (aging, volatility) conducted on final rubber additives

    Final product types

    • Amine-based rubber antioxidant additives (e.g., DPPD/6PPD analogues)
    • High-durability tires and industrial rubber belting
    • Seals and gaskets for automotive and heavy equipment

    5. Stabilizer Preparation for Photographic Chemicals

    N-Phenylethylenediamine is integrated as a reducing and stabilizing agent in the manufacture of color developing solutions and photographic stabilizers. Producers leverage its ability to form stable complexes with metal ions and to maintain image clarity during exposure and processing. The molecule supports the manufacturing process for color developer concentrates, tailored for strict uniformity during large scale photographic emulsion production. Final stabilization packages undergo consistency, longevity and safety verification.

    Industry compliance standards

    • ISO 18902: Imaging materials – Processed photographic films
    • ANSI IT9.11: Stability standards for photographic chemicals
    • EU REACH conformity (Annex VII–IX data requirements for downstream users)
    • RoHS/ELV regulations for non-hazardous, consumer-grade photographic goods

    Typical usage ratio

    • 0.1–0.3% in color developer concentrate formulations
    • Ratio refined by image density profiling and solution shelf-life targets

    Downstream process integration

    • Integrated after primary developer compounding, under temperature-controlled mixing
    • Subjected to final filtration and chemical stability validation before packaging
    • Spot-checked for residuals and solution clarity per lot release criteria

    Final product types

    • Photographic color developer kits
    • Stabilizer solutions for film processing labs
    • Archival-grade photographic treatment blends
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    Certification & Compliance
    More Introduction

    N-Phenylethylenediamine: Quality and Consistency from the Manufacturing Floor

    What Sets Our N-Phenylethylenediamine Apart

    Working every day on our production lines, we see the direct link between quality of raw materials and the final, functional reliability of N-Phenylethylenediamine we ship out. Our team has built up years understanding how a product like this makes a real difference for users, especially in demanding synthetic routes. The product doesn’t just come from our facility—it reflects our hands-on approach to every step, from raw materials screening and batch control, to packaging details. The material we produce, whether as pale to off-white crystals or powder, comes free from physical contaminants and with a purity level that rarely strays below 99.5% (GC)—a figure borne from down-to-earth process control, not catchy marketing or formulaic claims. Take a closer look at ours under a microscope, and the particle consistency—fine, non-caking—speaks to how we listen to our own operators and lab techs more than what catalogs suggest.

    A pure N-Phenylethylenediamine delivers value as a direct intermediate in specialty organic synthesis, especially where clear, high-yield reactions without persistent byproducts matter. Our customers, often chemists with decades of practical troubleshooting behind them, bring us challenging target molecules. The reliability they get back leads to tighter process windows, greater downstream yields, and less risk of inlet system contamination. Such qualities show in chromatography profiles or consistent endpoint titrations, not in promises. That doesn’t come by switching traders or shopping spec sheets; it comes from crews who understand the subtle differences raw material origins make and aren’t afraid to reject a batch that lands outside trusted parameters.

    Model Variants and Batch Consistency

    Over the years, we’ve seen customers referencing our batch numbers well beyond the order paperwork. Most repeat users have settled on our model SDX-117-PED, which balances ease of manipulation—for those working at lab scale or multi-kilo production—without introducing extra moisture or statically clumping. The particle size rarely exceeds 300 microns, as confirmed by regular sieving and visual inspection. Some syntheses call for a slightly different morphology, and our plant line can shift toward finer or slightly denser grading, though the chemistry itself never shifts unless process reviews demand it.

    Rather than offering hollow "tailored" solutions, we concentrate our skills on ensuring the main model meets or exceeds what experienced chemists already expect based on their years in synthetic benches. That means a material melting point consistently between 60-62°C, as confirmed by repeated DSC (differential scanning calorimetry), and limits on total heavy metals and moisture content set well below what most published regulatory specs require. Reproducibility from drum to drum is tracked not only by QC paperwork but by keeping lines of conversation open among lab, floor, and customer teams.

    How Our Manufacturing Experience Drives Confidence

    We don’t approach N-Phenylethylenediamine as just another commodity. On our production floor, operators regularly deal with the quirks of each lot of precursor raw materials—learning the lessons that technical bulletins often miss. For example, the oxidative stability of the ethylenediamine backbone means continual testing on each feedstock lot is necessary. Even temperature and humidity on the packing floor make a difference, and our team keeps digital logs of every deviation. Small pressures lead to changes in flow—so even the way the powder settles in bags lets our staff trace back to specifics of filtration and drying cycles.

    Years of batch logs and root-cause investigations taught us that stability hinges on process standardization above all else. Operators adjust reaction temperatures in real time when subtle signs—such as vapor phase pressure or coloration—demand it. Training across the team focuses on recognizing these day-to-day variations, leading to fewer failed runs and more predictable, high-purity output. Finally, chemical identity is confirmed with modern analytical methods: FTIR for bond profiles, NMR for primary amine integrity, and titration to reveal even faint contamination from ortho or meta regioisomers which can sabotage downstream syntheses. Analysis seldom ends when paperwork checks out—our leads constantly review spectra to ensure no new artifact creeps in.

    Application Insights from Real Synthesis Workflows

    We supply N-Phenylethylenediamine mostly to customers working at the intersection of pharmaceutical synthesis, heterocyclic chemistry, and precision dye intermediates. Our work doesn’t end at shipping. We’ve collaborated with both university researchers and private pilot plants attempting scale-up; the practicalities surprise many on their first runs. Drying the compound correctly, for instance, makes or breaks a hydrogenation or acylation step. Slight excess of moisture—often left unchecked by resellers—can quench sensitive catalysts, especially in metal-catalyzed pathways for assembling pharmaceutical scaffolds.

    In dye chemistry, the balance between reactivity and selectivity matters. Our long-form N-Phenylethylenediamine avoids problematic isomers, which otherwise interrupt color formation or produce inconsistent quality for downstream pigments. Customers chasing novel ligands or coupling intermediaries, such as those used in high-performance coatings or active pharmaceutical ingredients, attest to fewer side chain artifacts compared to what they find from bulk-trader deliveries. Our feedback loop, built off chromatography traces and in-process yield records, lets us identify trouble points and refine our specifications for subsequent batches.

    Key Differences from Similar Products

    After several decades of commercial synthesis, the subtle but real differences between direct-from-manufacturer N-Phenylethylenediamine and the diverse secondary-market products become obvious. Many distributors rebottle and relabel the compound after sourcing from uncertain, often cross-contaminated, supply chains. The consistency drops—chromatographic impurities increase, and in-field users wind up dealing with strange reactivity or altered product color. These differences might not appear in a quick spot test, but they surface fast during full-scale processing. Our site has never run parallel solvent recovery with distributor-sourced material without seeing a broader impurity envelope and longer purification steps, eating up time and labor.

    We don’t stretch technical specs to fit market buzzwords, nor do we hide behind generic "fine chemical" claims. Our N-Phenylethylenediamine maintains a defined, traceable production route, using only vetted raw materials with supplier audits to back the claims. Documentation matches the reality on the floor: no surprise peroxides, no excessive color formation during storage, and packaging that respects the material’s need for dry, airtight conditions. Quality checks don’t end at the drum gate; our shipping team inspects for moisture incursion in every outbound lot, not just as a checkbox but as a culture shaped by too many years fixing others’ preventable mistakes.

    Practical Handling and Safety Considerations

    At our facility, process safety depends on knowing the real hazards—right down to how a slip in storage temperature leads to subtle decomposition. Chemists on our team regularly review shelf-life data and test samples stored under worst-case warehouse conditions. Our packaging uses laminated barrier liners that actually make a difference in practice. Drums are loaded fast—minutes rather than hours outside controlled environments—and every shift logs ambient humidity and temperature. Such details might not seem significant until a customer’s pilot run slows from excessive decomposition or unexpected color shifts late in holding.

    Our lab carries out regular irritancy and incompatibility tests—not just relying on the textbook recommendations. This hands-on knowledge means we never suggest reckless shortcutting in waste neutralization or vented storage. Material safety data sheets offer a starting point, but real safety comes from operators who know how the material smells, reacts with minor trace oxidants, and even how it stains gloves or concrete. We’ve learned it's not about listing hazards in long technical terms—it's about calling the engineer directly if we spot something off in a sample pack shipped out.

    Supply Chain Integrity and Direct Communication

    Over time, we’ve found users appreciate the supply chain clarity that comes from working directly with a manufacturer. Our team shares shipment histories and can trace the origin of every basedrum, because all chemical transfers and packaging happen under our own oversight. No repackaging, no secondary storage. Every time a question comes up about batch specifications, impurity profiles, or even packaging resilience during transit, the response draws on direct experience rather than abstracted records from multiple vendors.

    We also work to avoid over-promising supply timelines. If an upstream supplier faces disruption—perhaps in the amine or benzene derivative sub-supplies—customers get immediate notification. We’ve found being forthright about any hurdles beats vague reassurances or hiding behind logistics jargon. Many chemists—especially those supporting critical production—rely on this level of detail to plan their own schedules and avoid cascading delays.

    Supporting Users in Complex Synthesis Campaigns

    Mid-scale synthesis jobs regularly reveal challenges hidden from view during routine lab-scale runs. Small deviations—glassware residue, subtle solvent mismatches—amplify at scale. We run periodic studies on how our material performs under scale-up, and when a customer shares a bottleneck, our senior chemists dive into possible causes with them. For instance, catalytic hydrogenations using our N-Phenylethylenediamine run clean for certain pharmaceuticals, with no persistent catalyst poisoners at ppm levels. We have invested time collaborating with process engineers, sharing chromatograms and advanced NMR datasets from troublesome steps. In multi-step routes, side-product formation from less pure diamines tends to cut far more into overall yield than most chemists would predict.

    Our technical service doesn't stop at the point of sale. If a synthetic target sees difficulty in ring closure or coupling chemistry, we review the customer’s actual setup—sometimes running shadow experiments in our own tech center to diagnose sources of unpredictability. This hands-on technical follow-up reduces risk for companies bringing new compounds to market, especially in industries where regulatory standards leave little margin for excusing odd analytical findings. Over time, we have noticed stronger relationships and fewer production halts when we join the troubleshooting directly.

    Minimizing Environmental and Regulatory Risks

    Modern chemical manufacturing faces tighter regulatory thresholds each year. Within our site, effluent from N-Phenylethylenediamine production goes through dedicated treatment. Regular audits and self-imposed standards—stricter than regional discharge limits—prevent future headaches with compliance. Our own internal checks spot changes in color, BOD, or trace amines so we can intervene early in wastewater treatment.

    We’ve also made it a point to keep documentation and labeling up-to-date, reflecting not just domestic rules but common requirements for industrial users working in pharmaceutical, electronics, or pigment fields in other continents. When regulatory parameters shift—such as updated REACH or EPA listings—we invest time retraining staff and reviewing procedures long before the official deadline. Several customers say this careful approach prevents disruptions to their downstream registrations or compliance audits.

    Advances in Manufacturing: From Practical Tales to Process Improvements

    Every improvement in our N-Phenylethylenediamine manufacturing comes from practical observation. Once, after resolving an unusual filtration challenge during an August heat wave, we diagnosed a subtle reaction of an intermediate with local humidity patterns. Rather than chasing fancy process modeling, technicians and engineers huddled together cross-checking logs and running hands-in-the-vat trials. That blend of experience and open communication shapes both our QA philosophy and the drive to push impurity levels lower each quarter.

    Sometimes, a batch flagged by an experienced packer for off-color variance leads us to re-examine a catalyst aging routine or pre-cleaning sequence. Over time, we eliminated specific bottle necks linked back to basic habits: checking line clearance twice, segregating filter media by delivery age, and keeping honest batch records rather than paperwork fiction for regulatory sign-off. Sharing stories across shifts—rather than relying only on supervisor memos—means more heads watch for trends and act on minor process slips before they spiral into product defects.

    What Customers Say—and Teach Us—About Performance Gaps

    Real feedback comes from chemists facing unexpected solubility issues, stuck reactions, or odd impurity spikes. We see value in every complaint, often sending internal samples to match exactly the conditions reported by outside users. Our technical support logs track more than basic troubleshooting; they contain the context behind why our N-Phenylethylenediamine performs in some applications better than others. By digging into both the practical reports and analytical data, we've refined how quickly we blend, dry, and pack the product. Regular customer audits keep us honest, pushing us to marry speed with accuracy, rather than turning production into an arms race for the lowest per kilo price at the cost of trust.

    Experienced users catching early-stage issues, like off-profile residue buildup in reactors, often drive tweaks in our process. In return, they get a manufacturer who values partnership over volume. These cycles—report, review, correct—feed into each new campaign and establish real-world reliability. The outcome is chemistry that needs less rework, less unplanned downtime, and less wasted effort managing subpar batches.

    The Road Ahead for Our N-Phenylethylenediamine

    Chemical manufacturing stays competitive because those closest to the process keep learning and refining. We stay in front by capturing problems as they occur and staying honest about shortfalls—never hiding them behind minimum passing specs. Our N-Phenylethylenediamine, made by hands as much as by systems, works because teams with direct experience keep moving the line forward. Down the line, as new uses and advanced syntheses emerge, we focus on expanding only at the pace our controls, experience, and people can master. The reputation we earn comes batch by batch, and every customer challenge shapes the next improvement to product and process alike.