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N-(P-Aminobenzoyl)Glutamic Acid

    • Product Name N-(P-Aminobenzoyl)Glutamic Acid
    • Alias PABA-glutamate
    • Einecs 211-484-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    165744

    Chemical Name N-(p-Aminobenzoyl)glutamic acid
    Molecular Formula C12H14N2O5
    Molar Mass 266.25 g/mol
    Cas Number 59-30-3
    Appearance White to off-white powder
    Melting Point 227-229 °C
    Solubility In Water Soluble
    Storage Temperature 2-8 °C
    Ph Approximately 6.5 (1% solution in water)
    Synonyms p-Aminobenzoylglutamic acid, PABGA
    Iupac Name (2S)-2-[(4-Aminobenzoyl)amino]pentanedioic acid
    Pubchem Cid 6037

    As an accredited N-(P-Aminobenzoyl)Glutamic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a 100g amber glass bottle, sealed, labeled “N-(P-Aminobenzoyl)Glutamic Acid,” with hazard and storage instructions.
    Shipping **Shipping Description:** N-(p-Aminobenzoyl)glutamic acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and degradation. The package is clearly labeled with the chemical’s identity and hazard information. It should be transported under ambient conditions and handled according to standard safety protocols for laboratory chemicals.
    Storage N-(p-Aminobenzoyl)glutamic acid should be stored in a tightly sealed container, away from light, moisture, and incompatible substances. Keep at a controlled room temperature, generally between 15–25°C (59–77°F). Store in a dry, well-ventilated area, and protect from strong oxidizers. Ensure proper labeling and access restricted to trained personnel. Avoid sources of ignition and follow all standard chemical safety practices.
    Application of N-(P-Aminobenzoyl)Glutamic Acid

    Applications of N-(P-Aminobenzoyl)Glutamic Acid in Industrial Manufacturing

    N-(P-Aminobenzoyl)Glutamic Acid supports several critical processes in pharmaceutical and specialty chemical manufacturing. The following industrial applications demonstrate its specialized roles, compliance frameworks, and technical integration in real downstream production environments.

    1. Antifolate Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical producers use N-(P-Aminobenzoyl)Glutamic Acid as a structural intermediate during the synthesis of antifolate compounds, mainly for oncology and antimicrobial products. The molecule enters multistep API processes, often coupling with pteridine or related scaffolds to build out drug substances like methotrexate or related analogues. Strict batch controls monitor its purity, as minor impurities may impact the pharmacological profile of the end molecule. Producers focus on precise stoichiometry and coupling efficiency to prevent excess impurities during the coupling and cyclization stages.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) standards: ICH Q7, EU GMP Part II, US FDA 21 CFR Part 211
    • USP, EP, JP monographs for related antifolates
    • ICH Q3A/B for impurity and residual limits
    • Process validation and batch traceability documentation

    Typical usage ratio

    • Equimolar to 1.05:1 molar excess against the pteridine substrate (adjusted for coupling conversion rates in scale-up)

    Downstream process integration

    • Loaded during protected amide formation and coupling reaction sequence in antifolate assembly
    • Undergoes hydrogenation or deprotection post-coupling, with subsequent purification steps
    • Strict temperature and solvent control to maintain regioselectivity and purity

    Final product types

    • Methotrexate API
    • Pralatrexate API
    • Pemetrexed API
    • Other antifolate drug substances used in oncology and infectious disease

    2. Laboratory Reference Standard Preparation

    Specialty reference material producers utilize N-(P-Aminobenzoyl)Glutamic Acid to create impurity markers and analytical standards for pharmaceutical development and regulatory filing. These standards must meet trace composition and purity criteria. Solutions are produced on small batches, with highly characterized material for chromatographic systems or reference mapping. Maintaining crystalline integrity and absence of secondary isomers is critical for these purposes.

    Industry compliance standards

    • ISO 17034 Reference Material Producers Accreditation
    • International Council for Harmonisation Q6A/B quality standards
    • FDA and EMA requirements for submission reference materials
    • Ph. Eur. general test methodology for chemical reference substances

    Typical usage ratio

    • Used as 100% pure analyte; dilution to 0.1–10 mg/mL for solution standards (adjusted for target analytical sensitivity and matrix compatibility)

    Downstream process integration

    • Integrated in controlled solution preparation or solid standard batch for HPLC or LC-MS reference runs
    • Stored under inert conditions to retain stability
    • Material traced and certified by lot for reproducibility

    Final product types

    • Chemical reference standards for API analysis
    • Impurity profile markers for regulatory submissions
    • Analytical spike solutions used in pharmaceutical QC labs
    • Characterization tools for structural elucidation

    3. Synthesis of Folic Acid Derivatives for Nutritional Supplement Manufacturing

    Manufacturers of high-purity folic acid and custom folate vitamin formulations employ N-(P-Aminobenzoyl)Glutamic Acid as a key intermediate. It reacts with pterin derivatives through heterocyclic formation reactions to generate advanced folic acid intermediates. Downstream operations remove protecting groups and adjust pH to ensure correct folate isomer formation. Every lot must achieve strict biosynthetic pathway mimicry to ensure bioavailability of the endpoint supplement.

    Industry compliance standards

    • Food Chemicals Codex (FCC) folic acid standards
    • US FDA 21 CFR Part 111 Dietary Supplement GMP
    • EU Regulation (EC) No 1333/2008 for permitted vitamin fortificants
    • ISO 22000:2018 Food Safety Management Systems

    Typical usage ratio

    • 1.0–1.2 equivalents relative to pteridine input, optimized for yield (final dietary folate conversion rate up to 90%)

    Downstream process integration

    • Added at the coupling stage with dihydropteridine derivatives
    • Monitored for complete conversion by HPLC; excess neutralized or removed by chromatography
    • Purification and crystallization follow to ensure food-grade compliance

    Final product types

    • Folic acid crystalline powder (USP food grade)
    • Vitamin B9 tablet cores and premixes
    • Custom multivitamin blends containing folate derivatives
    • Infant nutritional formulations fortified with bioactive folates

    4. Photometric Reagent Formulation in Analytical Chemistry

    Certified reagent companies integrate N-(P-Aminobenzoyl)Glutamic Acid for the preparation of colorimetric and photometric test kits, primarily for characterization of folic acid and p-aminobenzoate analytes in biological and food matrices. The compound forms specific absorbance complexes when coupled with oxidized environmental samples or marker substrates. Producers control batch homogeneity and extinction profiles to guarantee analytical sensitivity and regulatory reliability for accredited labs.

    Industry compliance standards

    • ISO 9001:2015 for reagent quality management
    • ISO/IEC 17025:2017 laboratory accreditation
    • REACH Annex IV regulations for reagent safety
    • EN ISO 7899-2:2000 for water and food analysis kit requirements

    Typical usage ratio

    • 0.05–0.2% (w/v) in buffered photometric reagent systems; adjusted for molar absorptivity and sample matrix interference

    Downstream process integration

    • Incorporated during final buffer formulation and stabilization steps
    • Mixed with oxidative cofactors and stabilizers prepackaged into test cartridge systems
    • Systematically validated for lot-to-lot spectral response within certified kit production

    Final product types

    • Colorimetric test kits for folic acid analysis in food and serum
    • P-Aminobenzoic acid detection reagents for research labs
    • Photometric assay kits for diagnostic platforms
    • Commercial environmental analytics cartridges
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    Certification & Compliance
    More Introduction

    N-(P-Aminobenzoyl)Glutamic Acid: Manufacturer’s Insight

    Delivering Precision in Every Batch

    Every step in chemical production brings its own set of hurdles and breakthroughs. Over decades of scaling up fine chemicals, teams at the plant have learned the subtle differences raw material sources and reactor conditions can make to batch outcomes. N-(P-Aminobenzoyl)Glutamic Acid demands care at every junction, from handling temperature-sensitive intermediates to preserving functional group integrity. Our technical crew keeps an eye on details that would seem trivial to outsiders but mean everything for the purity of the finished product.

    The heart of N-(P-Aminobenzoyl)Glutamic Acid production lies in achieving reliable quality over many production runs. A lot happens between initial crystallization and final packaging, including thorough analytical testing. Modern high-performance liquid chromatography and advanced spectroscopic methods measure each batch for composition and purity. This approach is more than a box-ticking exercise, as any deviation can shift the utility or reactivity of what we ship. Customers in research and pharma expect this consistency. Confidence in the final product flows from how closely specifications are monitored daily.

    Model and Specifications: Beyond a Catalog Number

    Inside the plant, workers know that a model number is only the beginning. Our N-(P-Aminobenzoyl)Glutamic Acid has earned its reputation from how tightly we hold specifications—controlling moisture, minimizing trace contaminants, and ensuring particle distribution. Teams regularly test for purity exceeding 98 percent, with recorded moisture levels below 0.5 percent during optimal runs. These metrics aren’t just statistics; they matter for those using this compound in synthesis or formulation, where even slight impurities can alter the downstream process or final product performance.

    Granule size, solubility profile, and yellowish hue form part of the identity of every batch. In-process technicians document each lot’s physical and chemical features. Clumping gets tackled at the drying step. Color is checked against a series of in-house standards. Material destined for usability studies always undergoes a further round of filtration. No step is redundant because every custom application demands strict attention to these qualities.

    Purpose and Use in Real Applications

    Research teams and industrial partners use N-(P-Aminobenzoyl)Glutamic Acid in a remarkable variety of projects. Some apply it as an intermediate in developing new pharmaceuticals, particularly antifolates and related compounds. It plays a central role in pathways that build up more complex molecules. In the plant, we find a sense of purpose in enabling chemists to tackle problems that impact public health—be it in oncology, anti-infective treatments, or nutritional studies.

    Formulators appreciate how well this compound dissolves in polar solvents and its stability under common lab conditions. Teams who operate in specialty chemical manufacturing note its compatibility with a wide spectrum of reagents. The careful crafting at our end ensures that it does not introduce unexpected side-reactions, which keeps yields high and waste to a minimum during multi-step syntheses.

    Downstream customers often tell us how critical a single component is to their output. Our production teams hear about timelines cut short or regulatory submissions delayed by inconsistent supply or material that fails even one parameter. As a manufacturer, direct feedback like this drives us to strengthen quality control and engagement. Since many pharmaceutical synthesis routes cannot tolerate variable input, we aim to de-risk every shipment from our end.

    Process Improvements and Employee Experience

    Material such as N-(P-Aminobenzoyl)Glutamic Acid brings the plant floor together. Operators train for weeks on the critical steps, and process engineers perpetually fine-tune procedures based on the last run’s data. We never assume old ways are best—if drying time fluctuates due to humidity, maintenance steps change. Routinely, staff meetings include feedback from quality control, pointing out even small off-odors, subtle specks visible under a lamp, or shifts in bulk density that could indicate upstream issues.

    Process upgrades don’t land overnight. They require care, input from people up and down the line, and an acceptance of rigorous validation before changes become permanent. GMP (Good Manufacturing Practice) compliance forms the backbone of our workflow, but the collective experience of shop-floor operators who have worked on dozens of these campaigns matters just as much. Success builds over years of missed targets, revised SOPs, and close calls that inspired safer, leaner, and cleaner manufacturing.

    Navigating Differences from Other Products

    Experience shows that while the chemistry of N-(P-Aminobenzoyl)Glutamic Acid shares kinship with related folic acid analogs, its unique p-aminobenzoyl substitution changes everything—reactivity, solubility, chromatographic behavior, and compatibility with other functional groups. That single change can affect how a downstream step unfolds and what isolation challenges researchers face. Plant staff keep up with customer feedback each year, noting pain points chemists and analysts encounter in their workflows.

    Synthetic routes for similar analogs might use the same type of reactions, but our N-(P-Aminobenzoyl)Glutamic Acid process evolved over time in response to market and regulatory needs. We eliminated certain reagents as better options became available and optimized neutralization conditions to minimize byproducts. Each time we introduce a variation—such as a change in solvents or tweak in the order of addition—the impact goes beyond the lab notebook, translating into higher consistency and less variability for users.

    As a molecule, N-(P-Aminobenzoyl)Glutamic Acid stands out from most standard amino acids and bulk intermediates, mainly because it brings targeted value for those modifying pteridine analogs or constructing custom ligands. The synthetic skills of our employees, and the persistence of our analytical group, get channeled into achieving results that general fine chemical suppliers find hard to reproduce batch after batch. Our team measures its performance not against distant averages, but by the conversations with labs and companies relying on repeat deliveries from our facility.

    Challenges and Solutions Across Production Cycles

    Managing raw material fluctuation has shaped our approach from the ground up. Sourcing key starting materials calls for steady relationships with dedicated suppliers, not just spot buying. Each time a lot shifts in quality, operators are alerted and samples get screened before entering the main synthesis line. Sometimes, subtle differences in water content or impurity profiles can mean hours lost, so we enforce redundant checks before any reaction scales up.

    From time to time, unexpected challenges arise in handling exothermic steps, which carry risks for unwanted side products. Experienced supervisors work with operators to monitor temperatures minute by minute, adapting resourcefully when process conditions veer from the norm. Rather than simply doubling down on automated systems, we train personnel to read process cues and keep lines of communication open at every handoff. These habits, built over hundreds of runs, create a safety net that protects product quality.

    Sterility and contamination risks never truly go away, especially for compounds heading toward regulated sectors or clinical trials. Our investments in closed-system transfer, regular environmental monitoring, and robust cleaning cycles keep microbial and cross-product residues in check. Employees cycle through annual retraining to keep their skills sharp, and management leads regular root cause analysis sessions each time an out-of-spec result shows up.

    Trust Built on Transparent Processes

    Buyers sometimes ask to visit the plant, wanting to see first-hand how N-(P-Aminobenzoyl)Glutamic Acid comes off the line. We’ve welcomed academic researchers, regulatory inspectors, and partners from around the world to observe batch tracking, analytical lab work, and warehouse handling. Transparency counts here, because every shipment carries our reputation. We document process flows and trace materials from the point of delivery through to packaged product, and provide authenticated certificates for each lot.

    Instead of hiding mistakes or near-misses, engineering and operations teams walk clients through everything from batch records to deviation reports, showing how issues were resolved or improvements added. Our openness builds real partnerships, feeds into customer innovation, and influences regulatory acceptance. The expectation isn't perfection, but a willingness to meet challenges head-on and work collaboratively with clients who count on reliable chemical supply.

    Future Directions and Continuous Improvement

    Demand for compounds like N-(P-Aminobenzoyl)Glutamic Acid keeps rising as research teams explore next-generation antifolates, novel imaging agents, or catalytic ligands. Every new project increases the requirements for purity, reliability, and environmental responsibility. Plant engineers now look to incorporate energy efficiency upgrades and waste-recovery techniques across process steps. Teams actively trial renewable solvent systems, setting tight benchmarks for rollback if product quality moves outside customer-defined limits.

    Joining industry consortia and technical networks helps keep production staff updated with best practices. Operators and analysts rotate through external training on green chemistry, process intensification, and advanced analytical methods. Real progress comes from blending the old—tried and true practical know-how—with new tools from process modeling and real-time analytics. This ongoing evolution enables the plant to adapt to shifting market landscapes, pick up early signals from R&D partners, and future-proof our product offering.

    What Matters for End Users

    Labs and manufacturers value consistency. For them, switching suppliers often brings risk, as new material can upset reaction balances or fail established protocols. Our process is built around minimizing those disruptions. Direct engagement with formulators and R&D teams allows for batch customization, special packaging formats, and rush orders when research deadlines loom. The combination of personal accountability by our site staff, and a culture of hands-on customer support, translates to peace of mind for scientists tackling critical projects.

    Often, requests surface for tailored solvent blends, modified particle sizes, or documentation supporting regulatory filings. Our manufacturing set-up allows tight control over these variables, thanks to modular process trains and in-house analytical capability. This direct channel between production and application means turnaround can be fast, and solutions can be implemented without involving layers of intermediaries.

    Standing Apart in a Crowded Field

    N-(P-Aminobenzoyl)Glutamic Acid attracts attention not just because of its chemistry, but because end users want a reliable connection between their goals and our ability to deliver. The path from order intake to product shipment runs through many hands and insights, guided not by one-size-fits-all protocols but by the actual needs of each customer. Staff at all levels understand this philosophy, owning every stage of the process—whether it’s correcting an off-color batch or tracing an impurity back to upstream handling.

    Reputation cannot be bought by listing specifications or performance data alone. Our plant’s standing in the community rests on more than years in business; it grows from our willingness to admit flaws, share insights, and walk through each challenge along with our partners. N-(P-Aminobenzoyl)Glutamic Acid stands as both a result of this collective experience and a starting point for ongoing collaboration with the innovators, problem-solvers, and builders in the chemical and life sciences worlds.