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N,N'-Diacetyl-1,6-Diaminohexane

    • Product Name N,N'-Diacetyl-1,6-Diaminohexane
    • Alias N,N'-Diacetylhexanediamine
    • Einecs 221-854-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    388160

    Iupac Name N,N'-diacetylhexane-1,6-diamine
    Cas Number 20474-22-2
    Molecular Formula C10H20N2O2
    Molecular Weight 200.28 g/mol
    Appearance White to off-white solid
    Melting Point 112-116 °C
    Solubility In Water Slightly soluble
    Smiles CC(=O)NCCCCCCNC(=O)C
    Inchi InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
    Synonyms 1,6-Bis(acetamido)hexane

    As an accredited N,N'-Diacetyl-1,6-Diaminohexane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is packaged in a 100g amber glass bottle with a secure screw cap, labeled with product details and hazard information.
    Shipping N,N'-Diacetyl-1,6-Diaminohexane should be shipped in tightly sealed containers, clearly labeled, and protected from physical damage. Store in a cool, dry, well-ventilated location. Comply with local, national, and international transport regulations. Avoid contact with incompatible materials. Handle with care, following standard chemical shipping protocols and including safety data sheets in the shipment.
    Storage N,N'-Diacetyl-1,6-Diaminohexane should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Label containers clearly. Always follow appropriate safety procedures, including using personal protective equipment (PPE) when handling or transferring the chemical.
    Application of N,N'-Diacetyl-1,6-Diaminohexane

    Applications of N,N'-Diacetyl-1,6-Diaminohexane in Industrial Manufacturing

    N,N'-Diacetyl-1,6-Diaminohexane supports multiple advanced industrial processes as a specialty intermediate. This section outlines its deployment in authentic downstream sectors, focusing on application specificity, usage standards, quantitative ratios, and integration in established manufacturing workflows.

    1. Polyamide and Nylon Engineering Resin Additives

    Manufacturers incorporate N,N'-Diacetyl-1,6-Diaminohexane into polyamide blends to adjust molecular weight, improve crystallinity, and tailor melt-processing behavior. It serves as a controlled-chain terminator or modifier, allowing fine-tuning of polymer chain ends during resin synthesis. Accurate dosing into melted lactam or hexamethylenediamine-based reaction mixtures enables adjustment for desired polymer performance in technical engineering applications.

    Industry compliance standards

    • ISO 1874-2: Polyamide technical specifications
    • REACH Annex XVII (EU): Restrictions on certain amine chain extenders
    • GB/T 1633-2000: China standard for synthetic resin testing
    • UL Yellow Card: Flammability and mechanical properties for engineering polymers

    Typical usage ratio

    • 0.25–1.5 wt% of monomer mass, adjusted for target viscosity and end-group content

    Downstream process integration

    • Dosed directly into melt polymerization step
    • Added before pre-polymerization to regulate condensation rate
    • Intensive mixing with lactams and diamines before high-temperature baking
    • Inline quality control for molecular weight distribution

    Final product types

    • High-modulus nylon pellets for automotive parts
    • Glass-reinforced PA6 and PA66 resins
    • Specialty engineering plastics used in power tools
    • Precision-molded connectors and gears

    2. Custom Polyurethane Elastomer Prepolymer Synthesis

    N,N'-Diacetyl-1,6-Diaminohexane functions as a chain extender in one-shot or prepolymer polyurethane processes that require balanced flexibility and heat resistance. Its secondary amide groups impart improved phase separation and compatibility, especially in high-stress elastomer parts. Manufacturers use the compound for thermosetting systems where dynamic performance and low-temperature flexibility are key.

    Industry compliance standards

    • ISO 9001: Quality management for PU manufacturing
    • EN 71-3: Safety requirements for elastomeric toy parts
    • ROHS Directive (EU): Limits on restricted substances in molded PU
    • ASTM D412: PU tension and elongation testing

    Typical usage ratio

    • 1.5–5.0 wt% relative to total diisocyanate and polyol feed, adjusted by target Shore hardness and expected end use

    Downstream process integration

    • Fed into prepolymer reactor following polyol dehydration
    • Used in isocyanate-terminated prepolymers before chain extension
    • Metered by automated dosing pumps for batch or continuous PU lines
    • Monitored by FTIR for complete incorporation

    Final product types

    • PU rollers for conveyor equipment
    • Wear-resistant seals for hydraulic machinery
    • Elastomeric wheels for automated guided vehicles (AGV)
    • High-flexocushion end uses in mining and printing equipment

    3. Epoxy Curing Agent Modification in Composite Materials

    Composite material producers employ this diamide to regulate crosslink density and toughness in advanced epoxies for aerospace and electronics. Its bifunctional structure modifies curing agents, enhancing heat resistance and microcrack prevention in carbon fiber laminates and circuit board encapsulants. Real-world usage is prominent where microstructure precision is vital over long-term performance cycles.

    Industry compliance standards

    • AS9100D: Aerospace manufacturing quality
    • IPC-4101: Requirements for base materials in PCB lamination
    • UL 94: Flammability rating for cured epoxy parts
    • REACH Registration (EC 1907/2006): Safety in additives handling

    Typical usage ratio

    • 0.3–2.0 wt% based on total resin and hardener mix, adjusted for glass transition target and mechanical stress requirements

    Downstream process integration

    • Pre-mixed with curing agents under controlled temperatures
    • Introduced before addition to high-shear reactors
    • Used as a modifier during resin prepreg processing
    • Quality checked using DSC/DMTA for crosslink validation

    Final product types

    • Carbon fiber aerospace pannels
    • PCB insulation layers for telecommunications
    • High-impact electrical encapsulants
    • Heat-resistant composite structural parts

    4. Intermediate for Specialty Organic Synthesis in Agrochemical Actives

    Agrochemical manufacturers utilize N,N'-Diacetyl-1,6-Diaminohexane as an intermediate in multi-stage synthesis of certain pesticide and herbicide molecules. Its acetyl functionality introduces protected amino groups essential for further coupling or cyclization reactions under precise process controls. The use falls under tightly regulated manufacturing conditions, involving careful compliance with residue and impurity limits on the final crop protection products.

    Industry compliance standards

    • FAO/WHO Specifications for agricultural pesticides
    • ISO 17025: Laboratory accreditation for residue assessment
    • China GB 2763: MRLs for agrochemical residues
    • EU Regulation (EC) No. 1107/2009: Authorization of plant protection products

    Typical usage ratio

    • Stepwise—fed stoichiometrically, 0.7–1.2 molar equivalents per targeted synthesis, adjusted for route yield and impurity profile

    Downstream process integration

    • Added in amidation or protection steps before key cyclizations
    • Purified at intermediate stage before final formulation
    • Batch monitored by HPLC for process traceability and purity
    • Residue managed to meet global export compliance

    Final product types

    • Selective herbicide technical concentrates
    • Systemic pesticide actives
    • Early-season crop protection agents
    • Integrated pest management formulations

    5. Pharmaceutical Intermediate for Controlled-Release Drug Conjugates

    API manufacturing utilizes our material as a building block for certain advanced drug conjugates and targeted release agents. Its protected amide linkages support prodrug synthesis strategies, especially for oral and parenteral sustained delivery systems. The process must adhere to strict cGMP requirements, in which the purity, traceability, and process validation are paramount throughout the multi-stage synthesis.

    Industry compliance standards

    • ICH Q7: GMP for Active Pharmaceutical Ingredients
    • USP/NF Monograph controls for intermediates
    • FDA 21 CFR 211: Finished pharmaceuticals
    • EDQM CEP for European registrations

    Typical usage ratio

    • Dosed 1.0–1.3 molar equivalents in coupling or linker steps—variance depends on conjugation strategy and purity targets for the final API

    Downstream process integration

    • Charged in activation steps for drug-linker synthesis
    • Incorporated under inert atmosphere to minimize byproduct formation
    • Purified by preparative chromatography at intermediate stage
    • Subjected to full analytical release before API finishing

    Final product types

    • Sustained-release oral or injectable drug APIs
    • Anticancer small-molecule drug conjugates
    • Biosimilar peptide-drug conjugate intermediates
    • Precursor building blocks for advanced pharmaceutical delivery systems
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    Certification & Compliance
    More Introduction

    N,N'-Diacetyl-1,6-Diaminohexane: An Introduction from the Manufacturer’s Floor

    Building Value with Reliable Chemistry

    At our facility, the aisles fill with the unmistakable smell of chemical innovation — a place where batches of N,N'-Diacetyl-1,6-Diaminohexane begin as raw fundamentals and move through a careful process. Our team has spent years adjusting production routes to meet real demands instead of hypothetical claims. With each cycle, our staff handles N,N'-Diacetyl-1,6-Diaminohexane’s transformation from base precursor to a fine, consistent product, always noting changes in reaction quality and yield.

    Customers come to us not because a catalog lists a model, but for the deep relationship between performance and reliability. This compound, also known by chemists for its acetylenediamine backbone, stems from acylating 1,6-diaminohexane under strictly monitored conditions, giving the molecule remarkable consistency batch after batch. Its appearance settles most often as a pale solid, one that flows without caking and reveals true purity in every drum or bag.

    Transparent Specifications Born from Experience

    Our manufacturing logs track all key physical characteristics. Purity always exceeds 98% on HPLC thanks to close oversight at every stage. Melting ranges maintain well within recognized bounds, an important trait when the end-application demands absolute reliability. Production stability ensures low moisture content and controlled particle size — factors that arise from air-controlled drying bays and solid transfer protocols.

    Rigorous monitoring removes guesswork. Every container is filled under the eyes of those who have watched this compound change the shade of a batch over several hours, learning to recognize true end-points by color rather than numbers alone. No batch leaves without a full profile — not just a COA, but QC sign-offs held to higher-than-usual benchmarks, because we know small inconsistencies multiply downstream. Tight controls over precursor inputs remain in place, and every raw feed arrives with evidence of chain-of-custody back to the primary supplier. These steps avoid midstream contamination, lowering the chances of any mid-process impurity spikes.

    Uses that Drive Real Industry Progress

    N,N'-Diacetyl-1,6-Diaminohexane stands apart by finding its way into the hands of those building useful things: curing agents for epoxy formulations, stabilizers for specialty resins, intermediates in high-end plastic synthesis. Large-scale producers of ion-exchange resins and specialty coatings trust this chemistry, because every ton delivered translates into stability for their mixes during every run.

    One of the more practical uses lies in its performance as a cross-linker. The molecule’s well-chosen acetyl groups ensure tight, reliable reactions with isocyanate systems, improving the wash-out resistance and performance ceiling of engineered resins. In applications demanding high resistance to migration or yellowing, chemists prefer this diamide structure after direct comparison. Years of field feedback confirm improved final-product properties, including superior thermal stability in resin blends compared to alternatives that cut corners on precursor quality or synthesis method.

    Producers of functionalized elastomers value this compound for its ability to step up properties not easily achieved with simple diamines. In systems where long-chain amides matter, the double acetylation unlocks performance gains without harsh side reactions or the need for heavy metal catalysts. For polycondensation and polymer modification processes, those same properties help engineers and scientists widen the available window for downstream reactions.

    Why Industry Chooses Our Process

    Having grown from a hands-on manufacturing background, we’ve put ourselves in our customers’ places. No engineer wants a phone call at 3 a.m. because a charge of curing agent crystallized wrong, or a blend failed a critical test. We saw early on that cheap shortcuts during acylation or inadequate purification echo down the production line, so we invested in large, jacketed vessels, vacuum driers, and in-line analytic tools.

    Many suppliers can ship a product that ‘meets spec’ on paper, but practical demands run deeper. End users gain the most from a diaminohexane derivative that avoids seasonal variability. For manufacturers serving automotive, aerospace, or electrical industries, product drift leads to line shut-downs or unreliable products in the field. By refining batch chemistry and fixing process bottlenecks, our team delivers chemical reproducibility that saves both time and reputation. Few things travel so far down a value chain, where a minor impurity can disrupt a multi-million dollar production run.

    What Distinguishes N,N'-Diacetyl-1,6-Diaminohexane from Other Choices?

    In the polyamide intermediates market, a sea of similar-sounding compounds circulate among various suppliers. Not all perform equally or have the same chemical backbone. N,N'-Diacetyl-1,6-Diaminohexane distinguishes itself both in reactivity profile and in its physical handling. With its deliberate molecular structure, each end group reacts in a predictable, clean way, minimizing side product generation during curing or polymerization.

    Compared to simple diamines, double acetylation offers extra shelf life and improved storage safety. Those acetyl modifications block premature oxidation, so the product holds up in storage and doesn’t draw excess water from the air. In practical shop-floor conditions, this means fewer surprises — a drum opened weeks later behaves the same as a freshly packaged one. By avoiding chloride-based promoters in synthesis, our process keeps heavy metal and halide impurities at levels measurable only by lab instrumentation.

    Technicians working on high-performance resin blends notice the difference. With standard hexamethylenediamine, resin mixtures often suffer from batch-to-batch color drift, unplanned viscosity shifts, and unpredictable cure rates. N,N'-Diacetyl-1,6-Diaminohexane delivers smoother resin mixing, repeatable reaction timing, and a neutral color profile right through to the finished part. The product delivers value not listed in a spec sheet: greater uptime, simpler logistics, and a lower overall scrap rate.

    Long-Term Industry Trust Built through Results

    Many relationships with longtime customers began after a failed production run with a lower-cost substitute. The learning curve with N,N'-Diacetyl-1,6-Diaminohexane isn’t the shape of the vessel or setting on a drier, but recognizing the compound’s ability to tolerate real-world handling stress without degradation. In large plants, line stability trumps theoretical properties, and the feedback we get is clear: product reliability outweighs promise. Over several years, customers have taken data from laboratory tests and put it to work in pilot and full-scale manufacturing, returning time and again for a product that solves actual pain points rather than hypothetical ones.

    Beyond manufacturing, our team visits client plants to see the product put to work in tough conditions — in resins that endure wide temperature swings, chemicals that get packed and unloaded in humid climates, blends exposed to rigorous industrial cross-linking. Real-world results inform every process update or formulation tweak we make. Clients trust us not for marketing, but for sharing the unvarnished truth: what N,N'-Diacetyl-1,6-Diaminohexane can do, where it’s vulnerable, and how non-obvious changes in process variables can shift outcomes.

    Quality, Safety, and Environmental Responsibility

    Every advancement in production comes with heightened duties toward workplace safety and environmental stewardship. Many specialty intermediates raise occupational safety concerns — with N,N'-Diacetyl-1,6-Diaminohexane, our priority rests firmly on closed-loop transfer, reduced fugitive emissions, and high-efficiency scrubbing of process air. Formulation and blending take place in areas specifically designed for both worker and product protection. Audit teams track residual solvent content not simply for compliance, but because experience has taught us that ignoring such details leads to bigger problems downstream.

    Sound chemical management requires insistent documentation: from raw material arrival, through processing, to outbound logistics. Our operators operate with checklists not as a bureaucratic shackle, but as a daily part of how reliable and safe output is built. Even as we engineer larger batch sizes for efficiency, we maintain the same tight controls over waste capture and disposal, always working to minimize environmental footprint. Operating close to regional and national authorities improves oversight; regular independent inspection brings a level of transparency customers deserve.

    Resolving Real-World Production Challenges

    Production managers often grapple with resin instability, storage hurdles, or unpredictable blending outcomes. Many operators assume that all N,N'-Diacetyl-1,6-Diaminohexane is functionally identical — trial and error proves otherwise. During a major project with an automotive supplier, a minor formulation change caused inconsistent cure times. By auditing their line together, we traced the problem to a tightly related diamide but with uncontrolled water content, which resulted in unpredictable reactivity. Our in-house dehydration and stabilization steps, supervised by skilled hands, eliminated these fluctuations on subsequent runs, restoring both consistency and customer confidence.

    Shipping conditions add another layer of complexity. Some intermediates lose reactivity or take up water en route to distant plants, especially during summer heat or uncontrolled storage. Our facility’s packaging method — combined with multi-layer moisture barriers and in-plant storage at controlled temperature — protects product value until it gets used by the end customer. This attention to detail means reaction performance stays as expected, not just on lab scales but in the unpredictable realities of day-to-day large batch processing.

    Investments in Technology for Better Outcomes

    Enhancing product utility isn’t accomplished solely by new equipment; it involves commitment to raw material selection and staff expertise. Process automation helps, but the trained eye of a technician still catches telltale color shifts or subtle texture changes that signal potential deviation. In-line spectroscopy and controlled vacuum driers back these human judgments, helping refine cut points, ensuring each lot matches every published figure.

    Increased attention to downstream product quality led us to invest in GC-MS and LC-MS methods, verifying that minor side products remain below tight thresholds. These steps cost more, but reduce customer complaints and build trust over many cycles of use. Batch-release logic ties each shipment to real, traceable data — a practice learned from both regulatory demand and the desire to protect customer lines from unplanned batch variability.

    Operators and QC professionals partner closely with R&D to track data, solve cross-plant variation, and feedback process improvements based on true outcomes, not just lab models. This integrated approach bridges the theoretical and the practical so that every kilogram delivered performs the way our customers expect.

    Market Realities and Customer Conversations

    Buyers today operate under tighter economic and regulatory pressure than ever. Lowering batch failure rates, reducing product hold time, and avoiding regulatory disruptions drive purchasing decisions. Those in high-volume blending or casting gain additional peace of mind knowing that N,N'-Diacetyl-1,6-Diaminohexane from our plant consistently clears inspection up and down the supply chain. Many of the questions we field cut past price and look for assurances on product stability, impurity profile, and technical support in the field.

    Customers don’t measure value purely by tons delivered but by how much downtime or scrap the order saves. Several long-term clients have shifted entire product lines to our chemistry after discovering fewer interruptions, more consistent final product properties, and faster troubleshooting support. Instead of generic call-center scripts, we base technical discussions on detailed production logs, real-case histories, and site visits.

    Product traceability links every shipment to a process history — not just at our end but all the way to the plant using the compound. This approach strengthens supply chain visibility and empowers users to track and mitigate production variation before it affects delivery.

    Continually Raising the Bar

    We view every production report or quality call as an opportunity to make the next run better. Even after decades in chemical manufacturing, improvement opportunities present themselves daily. New equipment comes in only if it raises throughput without sacrificing our hard-won reputation for solid, stable output. Customer feedback shapes every alteration, from small tweaks in particle size to the addition of extra QC steps for high-sensitivity applications.

    As global demand rises, our strategy favors deliberate expansion. Rather than taking speculative orders, we scale up capacity with an emphasis on stable energy supply, raw material certainty, and trained staff. Gaps in raw material chains or unstable power threaten more than just timelines; they undermine the very reliability customers depend on. Planning for stable, repeatable manufacturing isn’t an academic exercise in our world — it’s the way we protect the real-world utility of each drum we fill.

    Looking Ahead

    The landscape of specialty intermediates will always shift — customer requirements evolve, regulations grow more rigorous, and expectations from end-users only tighten. N,N'-Diacetyl-1,6-Diaminohexane continues to play a crucial role for those committed to field-tested quality and durability in challenging environments. By listening closely to the needs of our partners and keeping an open line between plant floor, lab, and R&D team, our manufacturing practices become a living response to what industry truly demands.

    For users in resin synthesis, advanced coatings, or specialty plastics, every kilogram of N,N'-Diacetyl-1,6-Diaminohexane from our plant reflects a chain of decisions grounded in the hands-on realities of chemical manufacturing — careful about the details, mindful of safety and sustainability, and always focused on the needs of those who put the chemistry to work.