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N-Ethyl-P-Menthane-3-Carboxamide

    • Product Name N-Ethyl-P-Menthane-3-Carboxamide
    • Alias WS-3
    • Einecs 227-813-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    232656

    Chemical Name N-Ethyl-p-menthane-3-carboxamide
    Cas Number 39711-79-0
    Molecular Formula C13H25NO
    Molecular Weight 211.35 g/mol
    Appearance White crystalline powder
    Odor Odorless
    Melting Point 60-63°C
    Solubility In Water Slightly soluble
    Cooling Strength Approximately 2.5 times that of menthol
    Main Application Cooling agent in food, cosmetics, and pharmaceuticals
    Stability Stable under normal conditions
    Boiling Point Unknown (decomposes before boiling)
    Logp 3.2 (approximate)
    Flash Point 113°C
    Synonyms WS-3

    As an accredited N-Ethyl-P-Menthane-3-Carboxamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of N-Ethyl-P-Menthane-3-Carboxamide is packaged in a sealed amber glass bottle with a screw cap and tamper-evident seal.
    Shipping Shipping of N-Ethyl-P-Menthane-3-Carboxamide requires secure, tightly sealed containers to prevent leakage. The substance should be protected from moisture, heat, and sunlight, and shipped in compliance with local chemical transport regulations. Use appropriate hazard labeling and documentation, and ensure handling by trained personnel to maintain safety during transit.
    Storage N-Ethyl-p-menthane-3-carboxamide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect from direct sunlight, heat, and moisture. Ensure proper labeling, and keep away from food and drink. Use personal protective equipment when handling the chemical.
    Application of N-Ethyl-P-Menthane-3-Carboxamide

    Applications of N-Ethyl-P-Menthane-3-Carboxamide in Industrial Manufacturing

    N-Ethyl-P-Menthane-3-Carboxamide serves as a highly effective cooling agent across several specialized industrial production chains. As the direct manufacturer, we support scale production and quality consistency, ensuring compliance and product integrity throughout complex downstream processes. This section details the established industrial application segments where our material delivers value through performance, product safety, and adherence to international and sector-specific regulatory frameworks.

    1. Topical Pharmaceutical Preparations

    Formulators in the topical drug sector incorporate this compound to deliver long-lasting cooling sensations without the drawbacks of volatility or skin irritation associated with menthol. It enables precise temperature response in formulations: cream, gel, and patch producers rely on this material to address over-the-counter (OTC) demand for local anesthetic and soothing effects in products ranging from analgesic balms to anti-itch solutions. Its contribution is tightly linked to meeting patch kinetics, emulsion stability, and sensory reproducibility standards mandated for large-scale pharmaceutical release.

    Industry compliance standards

    • USP Monograph Topical Nonsterile Preparations requirements
    • 21 CFR Part 330 (OTC External Analgesic Products)
    • ICH Q7 (GMP for Active Pharmaceutical Ingredients)
    • EMA Guidelines for Dermal Medicinal Products

    Typical usage ratio

    • 0.1–1.5% w/w; formulators select lower dosages for leave-on products and higher ranges for intensive or occlusive patch systems based on area of application and targeted cooling duration

    Downstream process integration

    • Introduced during the semi-solid compounding stage, post-emulsification but pre-homogenization, to ensure even dispersion without phase separation in gels and ointments
    • Incorporated with other actives during the mixing phase for patch matrices to optimize diffusion rate

    Final product types

    • Topical analgesic creams and gels
    • Anti-itch ointments
    • Medicated cooling patches (transdermal systems)
    • After-sun skin relief lotions

    2. Oral Care Formulations

    Personal care manufacturers have established its role as a key sensory modifier in oral care products, notably toothpastes, mouthwashes, and dental chewing gum, to achieve sustained, non-irritating cooling. This material allows controlled flavor release and masks bitterness in active pharmaceutical, fluoride, or herbal ingredient blends, supporting the development of end uses that must comply with global food-grade and oral safety standards. Its solid-state stability enables safe microencapsulation during high-temperature processing, preserving functional properties throughout distribution and shelf-life.

    Industry compliance standards

    • US FDA 21 CFR 172.515 (Flavoring Agents)
    • EU Regulation (EC) No 1334/2008 (Flavorings and Certain Food Ingredients)
    • ISO 9001:2015 (Quality Management for Personal Care Manufacturing)
    • GB 2760 (China Food Additives Standards)

    Typical usage ratio

    • 0.02–0.1% w/w in toothpaste and mouthwash bases; up to 0.2% in concentrated flavor premixes or encapsulation blends for bottled oral care products, fine-tuned to minimize interference with sweeteners and actives

    Downstream process integration

    • Added to flavor pre-mixes before high-shear blending
    • Dosed into aqueous phase for homogeneous dispersal prior to final filling and packaging
    • Microencapsulated and released at tableting or gum molding stage

    Final product types

    • Therapeutic and whitening toothpastes
    • Alcohol-free mouthwashes
    • Dental chewing gum
    • Breath-freshening tablets

    3. Food and Beverage Flavor Additives (Sensory Cooling)

    Within modern food engineering, N-Ethyl-P-Menthane-3-Carboxamide functions as a specialty additive to impart a cooling effect distinct from menthol, without flavor overlap or bitterness, supporting sugar-reduced or mint-free product launches. It finds application in confectionery, functional beverages, and nutraceuticals requiring thermal sensory differentiation. Application demands focus on global food safety, allergen, and labeling rules, with process compatibility in hot-fill, UHT, and cold-process environments.

    Industry compliance standards

    • US FDA GRAS Status (self-affirmed for flavoring use)
    • EU Regulation (EC) 1333/2008 (Food Additives)
    • FSSC 22000 Certified Facility Processing
    • Japan Ministry of Health Additive List (Flavors)

    Typical usage ratio

    • 0.001–0.05% w/w depending on product matrix sensitivity, desired cooling intensity, and synergistic application with other cooling or flavor compounds

    Downstream process integration

    • Direct mixing into sugar syrups prior to candy molding or extrusion
    • Included in microencapsulated blends for heat-stable performance in pelletized or powdered beverage premixes
    • Blended at the beverage post-pasteurization step for cold-fill drinks to retain volatile profile

    Final product types

    • Hard and chewy candies
    • Nutritional bars with cooling elements
    • Functional sports drinks
    • Instant drink powders and lozenges

    4. Cosmetic and Personal Care Formulations

    The ingredient supports innovation in cosmetics requiring prolonged sensory cooling, such as post-sun gels, shave balms, and antiperspirants. Large-scale production benefits from its thermal and hydrolytic stability during multiple blend phases, while its non-volatile nature ensures sustained skin perception, important for high-volume, fast-moving consumer goods. Regulatory mandates direct sourcing from GMP-audited and allergen-screened production lots, with batch traceability and quality control at every stage up to retail fill.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • US FDA Voluntary Cosmetic Registration Program (VCRP)
    • ISO 22716 (Cosmetics GMP)
    • ASEAN Cosmetic Directive Compliance

    Typical usage ratio

    • 0.05–0.3% w/w, typically dosed lower for daily lotions and higher for targeted effect in antiperspirant sticks or aftershave gels

    Downstream process integration

    • Added at the cool-down phase post-emulsification for lotions and creams, maintaining integrity through temperature-sensitive batching
    • Incorporated into wax-oil matrices for stick and solid cosmetic formats before molding

    Final product types

    • Aftershave and post-sun gels
    • Deodorant and antiperspirant sticks
    • Facial masks with cooling features
    • Soothing body lotions
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    Certification & Compliance
    More Introduction

    N-Ethyl-P-Menthane-3-Carboxamide: Cooling Sensation Innovation from the Production Floor

    Understanding N-Ethyl-P-Menthane-3-Carboxamide

    Through years of hands-on experience with menthane derivatives, our team sees first-hand how advances in cooling compounds shift expectations in oral care, cosmetics, and food industries. N-Ethyl-P-Menthane-3-Carboxamide keeps surfacing as a standout among modern cooling agents. This crystalline white powder delivers a pronounced sense of freshness while leaving out the burning or numbing sideways effects traditionally linked with menthol. This ingredient comes with a molecular structure that fine-tunes the ability to interact with the cold receptors in the skin and mucous membranes. Our customers repeatedly highlight the balanced cooling it provides and the precise control one can achieve in their products.

    Proven Specifications and Model Consistency

    Every batch starts with the right foundation: high purity standards and strict technical controls. In our typical manufacturing runs, we achieve a purity above 99% through repeated recrystallization and testing via gas chromatography and HPLC. Particle size remains consistent, supporting smooth blending and accurate dosing. The melting point, usually hovering around 68-72°C, confirms the material is genuine and free from by-products that might cloud performance. Moisture content stays below 0.5%, confirmed by Karl Fischer titration—never an arbitrary number but set from repeated practical feedback showing this level keeps caking away and ensures shelf-life stability. Odor checks and organoleptic assessments take place batch-by-batch, reflecting the reality that a textbook-perfect batch doesn’t always cut it in real-world application labs.

    Applications with Real-World Impact

    Not every synthetic coolant works the same in every application. Decades ago, mint had the scene wrapped up—the unmistakable chill, that strong taste in gums and toothpaste. Then came the complaints about burn, flavor clashes, and lingering bitterness. N-Ethyl-P-Menthane-3-Carboxamide solutions began to change the conversation. In toothpaste, our customers use it to deliver a lingering, controlled freshness that doesn’t distract. Chewing gum applications benefit from a longer-lasting, more predictable release: instead of spiking cold and dropping away, this compound draws out a gentle, satisfying cool arc over several minutes. Lip balms take advantage of the elegant sensory lift, minus the risk of dermal irritation. In flavored beverages, especially low- or sugar-free types, formulators choose this compound to provide the same cooling effect but avoid aftertaste that can tank otherwise promising SKUs. The contrast becomes even clearer in functional foods and confections, where ingredient restrictions and off-notes make gentler cooling agents indispensable.

    What Sets N-Ethyl-P-Menthane-3-Carboxamide Apart

    On paper, many modern cooling compounds might look interchangeable. In the plant, subtle differences in chemical backbone make all the difference in usability and product performance. For example, basic menthol has been reliable but comes with regulatory, health, and sensory limits. Stronger synthetic coolers, especially WS-3 and WS-23, can offer intensity but often lack finesse and can cause oral numbness or mask intended flavor profiles. N-Ethyl-P-Menthane-3-Carboxamide hits a sweet spot: the cooling starts fast, peaks gently, and sustains itself without numbing or bitterness. This matters a lot in personal care goods–nobody needs a toothpaste or a lip balm that hits like an ice storm. Skin-contact products (lotions, aftershaves, gels) benefit from its mellow onset and compatibility with both water-based and oil-based carriers.

    Traditionally, production teams struggled balancing intensity versus comfort. Stronger coolers could satisfy those looking for “impact,” but overuse led to ingredient drift or complaints of harshness. Formulators ran repeated panels and consumer tests and found that this carboxamide provided a high success rate—people came back for more. In the food sector, regulatory clearances and flavor neutrality make a massive difference. Its low odor really proves itself in flavor layering scenarios, where you want clean, persistent cool with no grassy or minty interference. In plant batch runs, we often hear from R&D staffers relaying field feedback; they report smoother blending and almost no hot spots or separation in finished product matrices.

    Reliability of Supply—A Manufacturer’s Perspective

    Talking to fellow manufacturers, reliability stands out as a constant challenge. Big swings in base menthane supply or sudden quality dips from upstream plants can create havoc. Years ago, we realized that relying on irregular intermediates just couldn’t sustain the consistent quality that end customers demand. Today, our own production line runs integrated synthesis steps out of necessity, not luxury. We monitor reactors for pressure, temperature, and purity in real time, so every lot ticks specification boxes. Unrecorded fugitive emissions, process residues, or untraceable by-products only show themselves when batches end up rejected at customer labs. By maintaining a full hands-on approach—staffing our own QA/QC operators, keeping on top of preventive maintenance—we keep wastage low and complaints from downstream processing at an absolute minimum. The end result: Chemists, product developers, and quality managers keep seeing repeat results, season after season.

    Differences Made Tangible in Production

    Comparing N-Ethyl-P-Menthane-3-Carboxamide to older or alternative coolants isn’t a paper exercise—it plays out in mixing tanks, extrusion lines, and packaging lines every day. Menthol volatilizes, and residual off-notes often bleed out, tripping up multi-ingredient systems. Heavy-duty synthetics might cloud up emulsions or clash with preservatives. This compound keeps its head: low volatility protects aroma profiles, even in hot-fill or extrusion processes. In compressed tablets (think breath mints), the fine powder disperses with virtually no dusting. In clear beverages, it brings a lasting ice-cool finish, sidestepping annoying sediment or flocculation challenges.

    For years we got calls about “clumping” or “off” batch notes from downstream filling halls. Our switch to a tighter mesh specification and low moisture control stopped most of those complaints in their tracks. Feedback from line workers in chewing gum plants guided us to fine-tune the crystalline form so it doesn’t threaten wear and tear on blending machinery. Precision matters—from the time a product arrives at our dock, all the way to final sensory QA panels. If an ingredient chews up filters, pipes, or nozzles, we hear about it fast. N-Ethyl-P-Menthane-3-Carboxamide has proved trouble-free across decades of pilot and full-scale manufacturing.

    Supporting Clinical and Regulatory Demands

    With global movement on ingredient safety and consumer transparency, documentation and compliance have never been casual affairs. Our QA and regulatory teams spend weeks every year making sure every certificate, analysis report, and documentation set matches evolving needs—not just a GHS label tucked on a drum. Toxicology studies support its use in rinse-off and leave-on personal care formulas. With food-grade variants, we validate purity by using food contact-safe starting materials and confirming every step traceable for audits. Our site’s regular customer and third-party audits keep the pressure on; few things motivate better than an inspector lifting a lid and demanding a thorough walk-through.

    Global regulatory status means something beyond just paperwork. In some markets, menthol faces concentration limits or flavor restrictions. N-Ethyl-P-Menthane-3-Carboxamide’s profile lines up with global flavor standards, including acceptance for use in sugar-free mints, gums, and oral care. Importers and finished product makers lean on our documentation when facing local authorities or end-market buyers with tough ingredient approval lists. We maintain archived batch samples for years, keeping every retained record accessible for traceability checks—an everyday routine, not a paperwork chore.

    Unique Performance Stories from the Field

    A flavor house approached us with flavor “muting” complaints in a fast-dissolving candy application. Their prior menthol-based cooler spiked early, overshadowed fruit flavors, and faded unevenly. After months of iterative sampling, they settled on a blend using our N-Ethyl-P-Menthane-3-Carboxamide, reporting a sharp boost in consumer preference for a “clean, rolling” cool without aftertaste. Separately, a personal care brand started using it in their aftershave balm, citing the end-user feedback: smooth non-irritating freshness, no redness, and no mask over base notes. Their R&D director said they’d “given up” on menthol for this line because of consistency problems.

    In a mass-market chewing gum plant, the engineering lead noted that their mixers and compression molds needed cleaning less often due to the finer, more manageable particle size—something we’d tweaked following end-user feedback sessions. Not every technical “improvement” translates in practice, but in this case, the downtime savings spoke volumes. These stories echo through the plant and office: lifetimes of minor adjustments, rooted in real-world user feedback, shaping each successive batch.

    Handling Challenges in a Changing Market

    Nothing ever sits still in the world of cooling compounds—consumer trends mean more than a pat on the back or a marketing claim. Years ago, nobody asked about “clean label” claims or allergen testing for something used at low ppm levels. Now, buyers want explicit, documented absence of GMOs or animal-derived raw materials. Our sourcing choices shifted as a result. We lock down supply of pharma- and food-grade intermediates, run dual screenings for allergens, and include finished product traceability on every batch summary. As microplastics, allergens, and contaminant headlines grew, our lab shifted from periodic to lot-by-lot testing and invested in advanced analytical tools for trace impurity detection.

    A few years back, smaller flavor houses struggled to meet large customer volume requests when supply chains buckled. In response, we built buffer stocks and staggered production cycles for N-Ethyl-P-Menthane-3-Carboxamide, making sure annual contract holders keep their seasonal lines on supermarket shelves. Meeting surge demands isn’t a marketing slogan. It meant scaling runs, adding process automation, and training more hands on deck. We did away with batch-level lot inconsistencies through long-term process improvements, not just document fixes.

    Environmental and Safety Realities

    Proper handling of carboxamides requires rigor on the plant floor. Even “non-irritating” compounds turn hazardous with careless storage or overexposure. Our bulk material storage closely monitors external heat and humidity to prevent clumps and maintain flow. Workers gear up with gloves, goggles, and work clothing regardless of perceived compound safety—plant norms arise from experience, not just paperwork. Quarterly safety and spill drills ensure that accidents rate low, even on the busiest production weeks.

    On the wastewater front, exhausted rinses and off-spec residues flow to in-house waste processing and not straight out to municipal lines. Local regulators audit regularly. N-Ethyl-P-Menthane-3-Carboxamide’s chemical stability helps, reducing volatile releases that can set off neighbor complaints or regulator alarms. Neighbors and partners alike keep an eye out for any change—so every process tweak or improvement runs through environmental impact reviews. Missteps on this front never stay quiet for long, so we keep ahead with old-fashioned vigilance.

    Customer Support Rooted in Experience

    Real support doesn’t mean sending a spec sheet and hoping for the best. Our team fields queries from product developers, flavorists, and production engineers, whether by video call or an onsite visit. Sometimes a beverage formulator needs help dialing in the cooling sensation at a fraction of a percent and balancing sweetener choices; sometimes a confectionery workshop faces unexpected clumping during hot-fill. We go beyond the lab: trial runs, plant visits, troubleshooting line issues side-by-side. Genuine answers and ongoing support arise from running these ingredients in our own plants, seeing what can go wrong, and building honest guidance from hard-won experience.

    Whether in a multi-national R&D center bench-testing new formulas or in a local chewing gum line mixing tanks at full tilt, the product’s strengths and quirks become understood only through regular user feedback, not just one-off customer calls. We keep our FAQ sheets alive based on genuine plant queries: fixing a blend issue, improving flow, dialing back intensity for a new market. Often, decades-long ingredient users ring up with new project requests or suddenly different regulatory documentation needs—every new market and every reformulation brings its trickle-down surprises.

    Looking Toward Ongoing Cooling Innovation

    The cooling agents market keeps building on incremental, not revolutionary, change. Our own production line keeps exploring small improvements: tighter particle sizing, even purer starting materials, gentler drying regimes. Every small tweak trickles out into easier line setups, fewer product recalls, and happier downstream blending. We keep collaborating with suppliers of both intermediates and finished food or cosmetic products, picking up on trends like vegan formulation, microencapsulation, and alternative delivery forms.

    As the market expects more transparency, faster launch cycles, and greater label clarity, N-Ethyl-P-Menthane-3-Carboxamide stands out by matching performance with reliability. A major beverage customer told us last year the real draw is not just technical merit, but the ability to promise predictable, positive mouthfeel across production runs—even as formulations change. Clean finish, minimal bitterness, and manageable regulatory profile mean fewer surprises down the line.

    Building on Consistent Results

    Our story with N-Ethyl-P-Menthane-3-Carboxamide doesn’t rely on a single technical breakthrough or flashy innovation. Long-term competitive edge stays rooted in consistent application feedback, practical improvements, and reliable results over thousands of tons. Product developers trust that what came in last quarter’s shipment won’t shift next month, and QA teams know their calibrations and sensory panels won’t need to reset with each new lot. That kind of reliability can’t get engineered overnight—it comes from staying hands-on, responding to operator feedback, and keeping production grounded in the practical realities of everyday manufacturing.

    Through tightening quality controls, dialing in flexible batch sizes, and maintaining one foot in the lab and the other in the warehouse, our manufacturing journey with this ingredient keeps evolving. The landscape keeps changing with consumer trends and regulatory waves, but the day-to-day dedication to quality and the spirit of collaboration with every partner and line worker makes every batch of N-Ethyl-P-Menthane-3-Carboxamide more than a product—it’s the sum of shared practical experience from plant to shelf.