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N-Benzyloxycarbonyl-6-Aminohexanoic Acid

    • Product Name N-Benzyloxycarbonyl-6-Aminohexanoic Acid
    • Alias Z-6-Ahx-OH
    • Einecs 241-271-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    926412

    Chemical Name N-Benzyloxycarbonyl-6-Aminohexanoic Acid
    Synonyms Z-6-Aminohexanoic acid, Z-ε-Aminocaproic acid
    Molecular Formula C14H19NO4
    Molecular Weight 265.31 g/mol
    Cas Number 7524-52-9
    Appearance White to off-white crystalline powder
    Melting Point 94-98 °C
    Solubility Slightly soluble in water, soluble in polar organic solvents
    Storage Temperature 2-8°C
    Purity Typically ≥98%
    Smiles C1=CC=C(C=C1)COC(=O)NCCCCCC(=O)O
    Inchi InChI=1S/C14H19NO4/c16-13(17)9-5-4-7-11-15-14(18)19-10-12-8-2-1-3-6-12/h1-3,6,8,15H,4-5,7,9-11H2,(H,16,17)

    As an accredited N-Benzyloxycarbonyl-6-Aminohexanoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25-gram amber glass bottle, sealed with a screw cap, labeled with chemical name, purity, batch number, and safety information.
    Shipping **Shipping Description:** N-Benzyloxycarbonyl-6-Aminohexanoic Acid is shipped in tightly sealed containers under dry, cool conditions. The chemical is handled as a non-hazardous substance but should be protected from moisture and direct sunlight. Standard safety and labeling procedures apply. Rapid shipment is recommended to preserve product integrity and ensure safe delivery.
    Storage N-Benzyloxycarbonyl-6-Aminohexanoic Acid should be stored in a tightly sealed container in a cool, dry, and well-ventilated area. Protect it from light, heat, and moisture. The preferred storage temperature is 2–8°C (refrigerator). Avoid exposure to incompatible materials such as strong oxidizing agents. Always label the container clearly and keep it away from sources of ignition.
    Application of N-Benzyloxycarbonyl-6-Aminohexanoic Acid

    Applications of N-Benzyloxycarbonyl-6-Aminohexanoic Acid in Industrial Manufacturing

    N-Benzyloxycarbonyl-6-aminohexanoic acid serves as a key protected intermediate in advanced peptide and pharmaceutical synthesis. Its unique protective function enables precise control during the assembly of complex molecules. This section outlines established industrial scenarios where this compound underpins critical production, with details on regulatory standards, precise formulation levels, application in production lines, and final downstream outputs.

    1. Peptide API Manufacture for Antiviral and Antibacterial Drugs

    Pharmaceutical companies utilize this acid as a building block in solid-phase peptide synthesis (SPPS) routes, especially when constructing APIs for targeted therapeutic drugs. Its benzyloxycarbonyl group acts as an orthogonal protective moiety during fragment coupling, which minimizes side reactions throughout elongation. Manufacturers rely on careful, stepwise deprotection and subsequent elongation for the production of regulated drug substances.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia and United States Pharmacopeia requirements
    • FDA cGMP, 21 CFR Parts 210/211
    • EDQM CEP route mapping for registered peptide APIs

    Typical usage ratio

    • 0.8–1.2 mol equivalents relative to growing peptide segment; adjusted based on sequence complexity and protecting group removal profile

    Downstream process integration

    • Fed into automated or manual Fmoc-/Boc-SPPS reactors during protected lysine or caproic acid incorporation steps

    Final product types

    • Custom peptide APIs for infectious disease, metabolic disorder, and oncology drug products
    • GMP-grade oligopeptide intermediates for further functionalization

    2. Enzyme Inhibitor Synthesis for Biopharma Research Tools

    Manufacturers in the biopharmaceutical R&D sector employ N-benzyloxycarbonyl-6-aminohexanoic acid for the preparation of specific lysine-mimetic inhibitors, notably within protease or lysine-specific demethylase inhibitor programs. The compound’s protective group ensures high-fidelity coupling and prevents premature side chain modification, which is especially critical for batch reproducibility in catalog inhibitor synthesis.

    Industry compliance standards

    • ISO 9001:2015 certified quality management for biochemical reagents
    • REACH registration for supply to the EU market
    • GLP guidelines for non-clinical batch preparation

    Typical usage ratio

    • 1.0–1.5 equivalents relative to nucleophilic fragments; optimized per proprietary compound synthesis protocol

    Downstream process integration

    • Incorporated during the alkylation or amidation stage ahead of final deprotection and purification for inhibitor scaffold assembly

    Final product types

    • Research-grade selective protease inhibitors
    • Small molecule tools for epigenetic and signal transduction pathway studies

    3. Intermediate for Functionalized Polymer Additives in Medical Device Coatings

    Specialty polymer manufacturers use this compound to create monomers and oligomers with protected amine groups, which are later deprotected during surface modification processes such as hydrophilic or antimicrobial coating for medical devices. It ensures precise placement and stable storage of reactive sites until terminal steps, reducing variability in functional group density on device surfaces.

    Industry compliance standards

    • ISO 13485:2016 for Quality Management in Medical Devices
    • USP Class VI Biological Reactivity Tests
    • ISO 10993-1 for Biocompatibility Evaluation
    • FDA 21 CFR 820 – Quality System Regulation for device component suppliers

    Typical usage ratio

    • 3–10% by weight in prepolymer mixtures, ratio tailored by desired surface functionality and device class specification

    Downstream process integration

    • Introduced into polyamide or polyurethane backbone synthesis, with deprotection performed during post-polymerization coating operations

    Final product types

    • Anti-fouling and anti-thrombogenic coatings for catheters, stents, drainage tubes
    • Custom medical-grade polymer dispersions for surgical instrument surfaces

    4. Synthesis of Linkers in Antibody-Drug Conjugate (ADC) Manufacturing

    Biotech companies involved in the development of targeted oncology therapeutics employ this acid as a protected backbone for linker molecules. This strategy limits undesired crosslinking during linker activation/conjugation steps and allows for precise cleavage under physiological conditions in vivo.

    Industry compliance standards

    • ICH Q11 for drug substance development and manufacture
    • GAMP 5 software validation (process monitoring)
    • FDA guidance on ADC quality control (2015)
    • USP <823> for radiopharmaceuticals if applicable to labeled ADCs

    Typical usage ratio

    • Variable: 1–2 equivalents relative to antibody hinge region, adjusted based on desired drug-to-antibody ratio (DAR)

    Downstream process integration

    • Used for synthesis of cleavable linkers, introduced during solution-phase assembly before final antibody coupling

    Final product types

    • Targeted ADC products for late-stage clinical or commercial use
    • Preclinical linker-payload libraries for cancer therapeutic discovery

    5. Custom Amino Acid Derivative Supply for Peptide Material CROs

    Contract research organizations (CROs) synthesizing custom peptides for structural biology or therapeutic screening request this compound as a highly purified, protected lysine substitute. This allows CROs to introduce site-specific labeling for downstream protein conjugation or imaging studies, while enabling straightforward deprotection protocols.

    Industry compliance standards

    • ISO 17025 accreditation for analytical testing of custom peptides
    • Chemical control regulations such as TSCA (US) and REACH (EU)
    • Sachverständigenrat Prüflabor (Germany) for purity and contamination

    Typical usage ratio

    • 0.9–1.1 equivalents relative to activated amino acid, fine-tuned to minimize epimerization

    Downstream process integration

    • Fed into multi-step solution-phase peptide assembly or fragment condensation lines, often followed by mass spectrometry-based QC prior to delivery

    Final product types

    • High-purity protected amino acid derivatives for custom peptide libraries
    • Building blocks for FRET-labeled peptides, protein–dye conjugates, and immobilized affinity tags
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    Certification & Compliance
    More Introduction

    N-Benzyloxycarbonyl-6-Aminohexanoic Acid: A Closer Look from Our Factory Floor

    Craftsmanship in Chemical Manufacturing

    Every year, as labs seek new ways to assemble peptides and improve molecular design, our team feels the pressure and pride of delivering the intermediates that keep research and production lines moving. We don’t approach this business as a faceless manufacturer churning out generic compounds. Our work with N-Benzyloxycarbonyl-6-aminohexanoic acid stands as a prime example—every batch carries the weight of customer trust and the collective experience of our chemists and engineers.

    Understanding the Compound

    This specialty acid carries both a protective benzyloxycarbonyl (Cbz) group and a six-carbon amino acid backbone. People often ask, “Why not just use a cheaper six-carbon amino acid directly?” The real answer lies in selectivity. Our product includes a Cbz-group, and that detail makes a huge difference for peptide researchers. The Cbz-group shields the amino functionality, letting operators run coupling reactions without cross-reactivity. We add the Cbz-protecting group right at our own facility, running every synthesis under carefully controlled pressure, temperature, and pH.

    A technical advantage grows from the purity of raw starting materials. Our acetic acid and sodium carbonate come in with strict COAs and batch records, so we know we aren’t introducing trace metal contaminants or unwanted moisture. For Cbz-protection, low-moisture and gentle agitation preserve the molecule’s integrity. If someone wants to follow up on the actual machinery, we run jacketed glass reactors for temperature uniformity and fast phase separation. This isn’t just theoretical; our technicians have spent years finessing the details so customers open a drum and find that small crystals or free-flowing powder every single time.

    Why It Matters to Real-World Users

    Peptide chemists have tough standards. Every extra impurity creates a purification headache. Over the past five years, we’ve worked closely with contract research labs and scale-up pharmaceutical sites, responding to their requests not just for chemical purity, but for consistent particle size and batch-to-batch color. Too yellow means oxidation or decomposition. Too clumpy means excess moisture. The consistency of our N-Benzyloxycarbonyl-6-aminohexanoic acid means fewer surprises in an already tough business.

    Each order goes through analytical testing: HPLC for purity, IR for functional group verification, and water content by Karl Fischer. In practice, our shipments routinely show purity above 99 percent and moisture less than 0.3 percent. We do this because we remember the stories shared from customers—one missed target value translates to lost days in peptide assembly, and that costs thousands in wasted reagents downstream.

    Customers running solid-phase peptide synthesis (SPPS) benefit most. When anchoring amino acids onto a resin, users need the side chains and end-groups protected. The benzyloxycarbonyl group handles that job better than most. During removal using hydrogenation, the Cbz-protected lysine analog doesn’t give off problematic side products, and users get sharper results in mass spec and HPLC after cleavage.

    Distinctives Against Other Options

    Compare our N-Benzyloxycarbonyl-6-aminohexanoic acid with classical amino acids like regular lysine. Standard lysine reacts easily at both its α-amino group and its ε-amino side chain. For advanced peptide assembly, this can produce unwanted byproducts or require extra steps to mask and unmask the amino functionality. The Cbz-protected molecule avoids that.

    We’ve run method validation side-by-side with other sources, comparing Cbz-protected hexanoic acid from general chemical houses against our own. The difference shows up not just in purity or melting point, but in solubility behavior and crystallinity. Poorly crystallized material can gum up feed hoppers or cause bridging in conveyors. We addressed these pain points early, switching to slow recrystallization and low-temperature drying even though it costs more to operate. Fewer customer calls for “blocky” material or slow dissolution have followed.

    Specifications That Matter—More Than a Certificate

    People in product development sometimes fall into a trap of chasing stats. Purity, water content, color—these numbers matter, but what really matters is how the product performs in the customer’s hands. For example, even if a lot tests 99.5 percent pure, it’s worthless if it clumps inside a synthesis robot or dissolves too slowly for their pumps. We watch trends from dozens of trials, seeing how each tweak in reaction pressure or solvent ratio signals a downstream change in handling. Troubleshooting a single bad batch from a competitor once led to a two-week delay at a peptide outfit in Europe. We reformulated our isolation steps afterward and switched filter media, guaranteeing that level of control.

    Handling, Packaging, and Storage From Experience

    We package N-Benzyloxycarbonyl-6-aminohexanoic acid with attention to detail—no skimping on liners or seals. Cardboard barrels do the job for most, but humidity spells disaster. Every batch gets double bagging in polyethylene, and we include low-dust desiccants based on the season. For repeat customers in damp regions, we learned after a couple complaints that extra care keeping the material bone dry in transit saves everyone headaches. Our warehouse sits at a controlled temperature, so thermal degradation doesn’t sneak in over weeks between synthesis and delivery.

    Over time, one thing we’ve learned—if your amino acid powder comes out sticky or forms clods mid-summer, storage got overlooked. Years ago, monitoring climate within our plant and courier trucks was a novelty; now, it’s protocol. If a drum of N-Benzyloxycarbonyl-6-aminohexanoic acid ever moves past 30 degrees Celsius without proper seals or sits near open loading bays, we catch it on tracking logs to prevent spoilage before it reaches a partner’s dock.

    Credibility in Manufacturing: Why Source Directly?

    Some buyers venture through a maze of brokers, hoping to save a few cents per kilo. We often hear, months later, about mismatched specs or the wrong polymorph showing up from an unknown producer. Trust builds with regular performance, and direct sourcing from a manufacturer means tighter feedback loops. If a CRO project pivots or an R&D team requests a tailormade impurity profile, only a real plant with custom reactors and in-house QA can adjust. Our customers know which line made their batch, which operator signed the log, and how to trace every step of production from lot records.

    Our team works with the kind of transparency needed for regulated markets. Drug synthesis teams sometimes bring us audit questions: How do we validate trace metals? How granular are our cleaning protocols? What energy sources drive our main lines? We open up process documentation because there’s nothing hidden—efficiency and cross-contamination checks are as much a part of our process as reaction chemistry. This attitude means regulatory agencies and GMP auditors deal with facts, not platitudes.

    Lifelong Learning in Fine Chemical Synthesis

    Manufacturing specialty amino acids and protected intermediates takes relentless updates. A decade ago, simple SPPS routes dominated; today, combinations with click chemistry, isosteric substitutions, or multi-site functionalization are normal. Our plant’s R&D team pursues collaborations with university labs and industrial partners, making sure our N-Benzyloxycarbonyl-6-aminohexanoic acid stays up to date for fresh synthetic methods or modifications. For instance, one recent project demanded a specific counterion for downstream coupling—no catalog product offered it. We retooled purification columns to deliver it within weeks, getting it just right by working directly with the customer’s scientists.

    Continuous training extends through our workforce. Technicians conduct regular workshops on new crystallization techniques, moisture control during transfer, and troubleshooting for handling large or small volumes. This culture of steady improvement flows directly to our product. As more customers shift toward automated or miniaturized peptide synthesis, we adapt particle size and fill methods accordingly.

    Environmental Responsibility

    Every fine chemical factory faces criticism for waste management and chemical emissions. We can’t ignore the impact, and our approach isn’t just about optics. Solvent recovery systems, phase separation units, and controlled venting all matter for the neighbors as much as the bottom line. During Cbz-group introduction, we recycle much of the organic solvent and filter cake, and our byproduct benzyl alcohol finds a second life as a feedstock elsewhere. This cuts down not only on haulage fees but on the environmental load of the plant as a whole. Our aim: ensure the only thing leaving the site with N-Benzyloxycarbonyl-6-aminohexanoic acid stamped on the drum is exactly what customers ordered—never the runoff into local water tables.

    Addressing Market Gaps

    A recurring complaint from R&D groups concerns long lead times and small batch inflexibility. Oversized multinational suppliers can leave smaller labs in a bind. We keep inventories flexible, producing N-Benzyloxycarbonyl-6-aminohexanoic acid at scales from a single kilo up to tons as needed. Scaling up or down requires rebalancing reactors and supply chains, but our willingness to run “off-cycle” batches on demand speaks to our roots as responsive problem-solvers, not just commodity vendors. Regular feedback surveys and real-time order tracking let partners set expectations upfront.

    There’s satisfaction in seeing our acid go from these batch tanks into hundreds of different customer syntheses—used for building peptide chains, probing new biological mechanisms, or making research molecules never seen before. Consistent, tailored output keeps science moving forward, one shipment at a time.

    Safety in Handling and Transport

    From our training and experience in-house, we know safety isn’t something to bolt on after production. N-Benzyloxycarbonyl-6-aminohexanoic acid, like many synthetic intermediates, requires care for operators and end-users. Clear labeling, robust packaging, and explicit batch records offer more than regulatory box-ticking. We batch test for peroxide content and ensure the absence of dust-forming fines, reducing exposure risk in enclosed facilities.

    Shipping rules from IATA or ADR overlap, but real lessons come from experience. One summer, a batch delayed on the tarmac moved through a heatwave, triggering customer alarms over product integrity. Following that incident, our logistics team implemented new summer cold-chain protocols for global exports. Customer peace of mind is built not just on paperwork, but on lived lessons turned into standards.

    Looking Forward: Niche Needs and Specialty Grades

    Not every order fits the textbook. Some scientists want atypical derivatives, special particle morphology, or custom labels for high-traceability peptide production. Our factory team recognizes that innovation in life sciences moves fast, and generic materials won’t always keep up. Custom Cbz-protected intermediates take extra work, but maintaining laboratory and pilot lines in parallel helps bridge the gap. Every new project, no matter the size, begins with clarity—a frank discussion of use case, test regimes, and data expectations. For scholars proposing a new synthetic route, turnaround can mean the difference between publication and a missed deadline.

    Feedback loops directly into plant operations. A customer’s request for a tighter melting point range pushed us to experiment with cooling rates and monitor residual solvent down to the ppm level. Each such iteration extends the product family, with N-Benzyloxycarbonyl-6-aminohexanoic acid forming a reliable core.

    Why Our Product Stands Apart

    Other suppliers might offer similar labels, but the quality of a product—especially in chemical synthesis—traces directly back to consistent process control and an engineering culture grounded in customer success. Peptide synthesis remains one of the fastest-moving areas in biotech. Any shortcut in upstream intermediate quality threatens whole downstream campaigns. From sourcing to post-shipment support, we own the process end-to-end, and that distinction carries weight.

    Feedback from labs worldwide tells us that the most important measure comes not just from a purity figure but from the cumulative absence of issues—no recrystallization needed, no sticky powder, no unexplained color in the bottle. These are not accidents. They are the result of continual investment in both our staff and our facilities, with technical expertise built over years and the flexibility to solve problems on the fly.

    Conclusion: Building Trust Batch by Batch

    For every shipment of N-Benzyloxycarbonyl-6-aminohexanoic acid, our relationship with the scientific community grows. Our value echoes in the reliable, transparent way we handle customer feedback, enforce internal process checks, and innovate both in chemistry and logistics. We supply more than a chemical—we support discovery and extend the reliability of science itself. The product stands as a testament to what direct factory engagement, rigorous standards, and a customer-first mindset achieve in modern chemical manufacturing.