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N-Acetylcaprolactam

    • Product Name N-Acetylcaprolactam
    • Alias N-Acetylcaprolactam
    • Einecs 248-298-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    733289

    Cas Number 3396-80-1
    Molecular Formula C8H13NO2
    Molecular Weight 155.19 g/mol
    Iupac Name 1-Acetylazepan-2-one
    Appearance White to off-white solid
    Melting Point 92-95°C
    Boiling Point No data available (decomposes)
    Solubility In Water Slightly soluble
    Density 1.12 g/cm³ (approximate)
    Chemical Structure C1CCCCC(NC(C)=O)=O

    As an accredited N-Acetylcaprolactam factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing N-Acetylcaprolactam, 500g, is packaged in a sealed, amber glass bottle with a tamper-evident cap and clear labeling.
    Shipping N-Acetylcaprolactam should be shipped in tightly sealed containers to prevent moisture absorption and contamination. Store and transport it in a cool, dry, and well-ventilated area, away from incompatible substances. Proper labeling and adherence to all relevant shipping regulations, including appropriate hazard communication, are essential for safe handling and transport.
    Storage N-Acetylcaprolactam should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and direct sunlight. Protect from moisture and incompatible substances such as strong oxidizing agents. Ensure proper labeling and keep away from food and beverages. Follow all relevant safety and regulatory guidelines for chemical storage.
    Application of N-Acetylcaprolactam

    Applications of N-Acetylcaprolactam in Industrial Manufacturing

    Our production of N-Acetylcaprolactam supports high-demand downstream sectors that rely on precise chemical performance and consistent batch-to-batch quality. This section details verified application fields with focus on formulation accuracy, regulatory fit, and integration into customer operations.

    1. Synthesis of Pharmaceutical Intermediates

    Pharmaceutical synthesis uses N-Acetylcaprolactam as a building block in selective amide and lactam transformations for active pharmaceutical ingredient (API) intermediates. Its controlled reactivity adds value in stepwise pharmaceutical syntheses, particularly for small-molecule APIs where ring-functionalization is needed in a GMP-controlled environment. Manufacturers value its low impurity profile in multi-stage flow chemistry or batch reactors, especially for analgesic or anti-infective drug intermediate synthesis lines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF and Ph. Eur. reference standards (where applicable to intermediates)
    • 21 CFR Part 211 (U.S. FDA GMP regulations)
    • EU Directive 2001/83/EC on medicinal products

    Typical usage ratio

    • 5–20% w/w depending on target API intermediate and stoichiometry; chemists adjust based on molar equivalents required for amidation or lactam opening steps

    Downstream process integration

    • Added at condensation or cyclization stage, preceding isolation or downstream purification; employed in continuous or batch synthesis using jacketed glass-lined reactors

    Final product types

    • Pain management API intermediates
    • Cephalosporin core intermediates
    • Specialty heterocyclic compounds for further functionalization

    2. Polyamide Modifier for Engineering Plastics

    The polyamide compounding industry uses N-Acetylcaprolactam to fine-tune crystallinity, melt flow, and mechanical strength in nylon-6 composite pellets. By modifying the caprolactam monomer stream, formulators can control chain structure and tailor polymerization kinetics. This approach is critical in the production of engineering plastics for automotive, electrical, and consumer parts, where dimensional stability and surface finish quality must meet rigorous industrial QC programs.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management for polymer compounds)
    • REACH Regulation (EC) No 1907/2006
    • UL 94 for flammability (where relevant)
    • ISO 1874-1/2 (Polyamide materials specification)

    Typical usage ratio

    • 0.5–3% by weight in nylon resin formulations; precise percentage varies with desired final melt viscosity and crystallization speed

    Downstream process integration

    • Direct addition to caprolactam melt prior to polymerization in autoclaves; process control via inline blending or pre-mix, monitored by melt viscosity analysis

    Final product types

    • Injection-molded automotive brackets and housings
    • Electrical connector casings
    • Mechanical gears for appliances

    3. Specialized Coating Resins and Additives

    Advanced coatings manufacturers employ N-Acetylcaprolactam in specialty resin synthesis as a co-monomer or chain modifier, often to produce low-emission, high-adhesion polyurethane or epoxy systems. This application is critical in formulating resins where precise amide content controls film formation, flexibility, and adhesion properties for industrial paints or anti-corrosive coatings on metal substrates.

    Industry compliance standards

    • ISO 9001:2015 (Resin production)
    • VOC limits per EU Directive 2004/42/EC
    • ASTM D16 (Standard Terminology for Paint, Related Coatings and Materials)
    • RoHS 2011/65/EU (for electrical coatings)

    Typical usage ratio

    • 1–8% by resin weight; manufacturers adjust based on resin backbone structure and required film thickness or flexibility

    Downstream process integration

    • Blended during pre-polymerization phase via controlled monomer feed; QC sampling takes place prior to chain extension and curing stages

    Final product types

    • Protective industrial enamels
    • Powder coating resins for metal hardware
    • Solventborne primer bases for OEM equipment

    4. Performance Additive in Specialty Adhesive Formulations

    Manufacturers of industrial adhesives use N-Acetylcaprolactam as a functional additive to achieve tailored open times and adhesion profiles in structural, hot-melt, and reactive adhesives, particularly where resistance to thermal or environmental degradation is needed. Its amide structure enables improved compatibility with polyurethane or polyamide-based adhesive backbones, supporting production lines that demand controlled viscosity and cure rates for automated dispensing.

    Industry compliance standards

    • ISO 14001:2015 (Environmental management)
    • FDA 21 CFR 175.105 (for adhesives in indirect food contact, as applicable)
    • ASTM D1002 (Lap Shear Strength of Adhesively Bonded Metal)
    • REACH registration

    Typical usage ratio

    • 1–5% by adhesive formulation weight; percentage determined by required open/cure time and targeted substrate adhesion level

    Downstream process integration

    • Incorporated during pre-polymer or compounding phase; solubilized at elevated temperatures using high-shear mixers, with downstream QC tracking viscosity and cohesion metrics

    Final product types

    • Hot-melt adhesives for automotive interior assembly
    • Structural adhesives for electronics encapsulation
    • Industrial packaging hot-melts

    5. Controlled Release Agent in Agrochemical Formulations

    Agrochemical formulators incorporate N-Acetylcaprolactam in encapsulation technologies for fertilizers and crop protection agents. By leveraging its hydrolytic stability and tailored release kinetics, manufacturers design granules or film coatings that provide extended nutrient or pesticide availability in soil, which supports efficient field application and reduces runoff concerns.

    Industry compliance standards

    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • EPA PRN 96-1 and PRN 93-10 (U.S. EPA policy for inert ingredients)
    • ISO 17025 (Laboratory test methods for release rates)
    • National Institute of Standards and Technology (NIST) references on encapsulated agrochemicals

    Typical usage ratio

    • 0.3–2% by weight in formulation, based on target active loading and desired release period

    Downstream process integration

    • Dispersed or pre-polymerized during encapsulation or coating step, often using fluidized bed or spray-drying equipment at controlled thermal profiles

    Final product types

    • Slow-release nitrogen fertilizers
    • Encapsulated herbicides
    • Granulated systemic insecticides
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    Certification & Compliance
    More Introduction

    N-Acetylcaprolactam: Efficiency Born from Precision Chemistry

    The Product at a Glance

    N-Acetylcaprolactam stands out as a specialized lactam derived from the acetylation of caprolactam using pure, food-grade reagents. With our model—produced under strict controls for consistency—purity levels register above 99.5% by HPLC. Production takes place in atmospherically controlled reactors using raw materials from our own vertically integrated supply lines. Batch records trace every step and maintain the history from raw input through finished lot, supporting full transparency for product traceability and regulatory reviews.

    Physical presentation remains white and powdery, with water content below 0.05% as measured by Karl Fischer titration. Particle size distribution—optimized through precise crystallization—avoids aggregation that clogs hoppers or causes loss during transfer. Our Q.C. teams have observed the importance of tight control at this stage, since variations produce handling headaches in actual plant conditions. Every lot leaves our facility sealed and accompanied by full documentation: COA, test reports, and MSDS. No short-cuts, no substitutions.

    Where N-Acetylcaprolactam Works Best

    N-Acetylcaprolactam serves both as a specialty intermediate in fine chemical manufacturing and as a functional building block for research and development. Teams at several polymer modification plants choose it when they require an acetyl group protection route during synthesis of polyamides or specialized nylon variants. The introduction of the acetyl function lets process engineers selectively block reactions or tune melting points, a feature unattainable with plain caprolactam or its simple salts.

    Some customers in the dye and pigment field report that the compound’s unique structure enables them to access chromophores otherwise blocked by typical ring modifications. From our observation and feedback, this edge translates to lower downstream purification burdens and less waste. The material also sees use as a reagent for custom organic syntheses in academia. Chemists value its predictable reactivity and limited by-product profile. To those end users, reducing purification work up means less solvent, energy, and labor hours.

    Differences That Matter in Real-World Production

    Often, customers contact us after trialing raw materials from competitive sources. The difference appears most dramatically in batch reproducibility. In synthetic operations that scale from flask to reactor, any hidden impurity, moisture, or inconsistency will reveal itself by higher rejection rates and inconsistent yields. Manufacturing with N-Acetylcaprolactam of lesser quality compromises downstream reactions, which leads to time-wasting rework and extra quality checks. Over the years, our operators have run side-by-side tests with third-party lots; the contrast in finish purity and line cleanliness becomes obvious right on the production floor.

    Compared to basic caprolactam, this acetylated derivative gives process chemists a unique handle for tuning molecular pathways. The acetyl protection avoids over-activation or uncontrolled ring opening under typical reaction systems, especially where stepwise synthesis is required. That control isn’t possible with caprolactam alone, which reacts aggressively in polymerization. For every lot, our lab confirms acetyl substitution levels, using NMR and mass spectrometry. If the batch falls outside standard, we never ship—it goes right back for adjustment or disposal.

    In contrast to partially purified bulk offerings, our practices achieve contaminant profiles below 0.1%, minimizing the formation of tars or colored side-products downstream. When even trace iron or sodium ions sneak through, color, viscosity, and filterability of end products suffer. By controlling for these non-obvious parameters, our material makes a direct difference in customer yields and end-product marketability. The proof comes from production stories: one client in the pharmaceutical sector cut their purification steps from five to three simply by choosing our N-Acetylcaprolactam over generic sources sourced from unsecured supply chains.

    Lessons Drawn from Decades of Chemically Intensive Manufacturing

    Modern chemical manufacturing depends on trust in the reliability of building blocks. Experience shows that a perceived small deviation—a few tenths of a percent in water or a minor contaminant—quickly turns into lost hours and expensive recalls when multiplied over hundreds of batches. In our earliest days, inconsistent raw inputs led to shutdowns, costing many days each year. Reinvesting in tighter upstream controls, in-house analytical testing, and batch feedback cycles has kept production on schedule and minimized customer complaints.

    Investments in automated drying lines and improved vacuum sealing led to consistent moisture control, a factor that contributes directly to powder flow, packing, and shelf-life. Engineers monitor every parameter, from crystallization rate to filter drier temperature, which began after we traced a quality issue to a faulty control valve on one dryer line. Failures from skipping attention to these details lead to snagged equipment and cross-contamination, which always cost more in the long run than proper quality management upfront.

    We have faced customer concerns about possible off-odors or unidentified extractables during accelerated aging trials. In response, we extended headspace-GC/MS screening of each production batch, flagging compounds down to the parts-per-million level. Customers in regulated markets such as medical devices or food contact materials benefit directly—batch after batch passes their own incoming inspections with no rejections reported. When regulatory standards changed, we modified traceability methods to make batch data exportable for third-party compliance audits.

    Operators at the plant level apply lean manufacturing practices learned from cumulative experience. Every shift participates in active quality circles. Suggestions such as rotating shallow tray depths mid-drying or pre-screening each lot for fine particulates before final drum packing have led to steady improvements year after year. Each improvement grew from firsthand troubleshooting—observing how lumps affect automated feeders or how small changes in sieve mesh boost downstream efficiencies.

    Impact on Downstream Product Quality in Polyamide Synthesis

    In nylon production, N-Acetylcaprolactam modifies morphologies and end-group profiles, enabling manufacturers to precisely set tensile properties or melting points. The compound’s acetyl function blocks undesired ring opening and lets process engineers set up kinetic controls in their polymerization steps. That flexibility vanishes with unprotected caprolactam or low-purity byproducts, which contribute only to unwanted side reactions and excessive gel formation.

    Those working with high-value monomers, where end-use applications touch food contact or medical-grade polymers, avoid contaminants at every stage—down to sub-ppm. We guarantee no external process aids or solvents carry over to finished product, because any trace of foreign chemical can later trigger regulatory scrutiny or end-use failures. Over time, plants that transitioned to our material found that filter fouling, polymer yellowing, and viscosity drift diminished—issues routinely linked to hidden contaminants or hydroscopic impurities in generic acetylated lactams.

    Feedback from customer technical teams revealed that better starting material reduces not just labor, but also wear on reactors and gear pumps. Polyamide producers running at scale noticed reduced batch-to-batch adjustments on gear pump settings, which directly correlates to enhanced line throughput. As polymer lines reach higher automation, the value of reliable, contamination-free N-Acetylcaprolactam grows even more significant. The product works as both a facilitator of innovation—allowing unique polyamide grades—and a cost-saver in minimizing unplanned shutdowns.

    Troubleshooting and Real-World Integration with Customer Operations

    Every industrial partner comes with their own process quirks. In introducing N-Acetylcaprolactam to new lines, we’ve worked side by side with customer engineers, troubleshooting unplanned foaming, exotherm spikes, or variable filtration rates. These sessions taught us the importance of pre-shipment particle size matching to customer expectations. A few test runs with earlier batches showed that crystallization at the wrong grain size led to bridging in dosing hoppers—solved by adjusting chiller ramp times in our process, on direct request from maintenance managers.

    Another frequent topic involves regulatory documentation. Years ago, a customer in the EU requested a full REACH data package for a new product development. We assigned our site compliance officer to walk them through our documentation trail, including chain-of-custody on every drum shipped. The outcome: trouble-free customs clearance and elimination of supply chain delays as their manufacturing scaled from bench to multi-ton. We learned to prepare this documentation proactively for future clients, saving all parties considerable back-and-forth on compliance questions. In every case, firsthand involvement and ongoing feedback led to small improvements that made a direct impact on throughput, downtime, and reporting.

    Risk management plays a key role when introducing any new intermediate. For N-Acetylcaprolactam, we maintain a rolling stockpile program, holding two months of batch- and lot-segregated material. This standard grew out of experience: several years ago, weather-driven disruptions stalled upstream logistics, but our safety stock kept downstream customer lines running uninterrupted. It cemented the importance of integrating supply and production schedules to real-world risk, not just theoretical inventory plans.

    Supporting Cleaner, Safer, and More Efficient Chemical Synthesis

    Product consistency has impacts far beyond immediate technical performance. Downstream, it serves as a signal: engineers know the difference between raw materials that require heavy reworking and products that allow smooth, safe operation. By eliminating off-specification batches and delivering reliable analytical data, we free researchers and process engineers from routine troubleshooting, letting them focus on higher-value tasks. Every improvement we introduce—whether through cleaner plant operations, better analytical checks, or smarter logistics—translates to reduced waste, energy savings, and better resource use across the chemical industry.

    Feedback loops stay open. Technical support teams log all customer reports—positive or negative—and feed those insights right back to production and R&D. At every quarterly review, we assess what worked, what slowed processes, or what surprised an engineer at a customer site. In the past, shared documentation and side-by-side testing let us co-develop new application routes for N-Acetylcaprolactam, yielding benefits that ripple through the entire manufacturing chain. That collaborative problem-solving approach makes all the difference between commodity supply and real, user-focused chemical manufacturing.

    We watch closely as trends in specialty materials and green chemistry evolve. Process managers continually study how small variations in molecular structure can cut energy consumption, prevent waste, or let customers reach new market segments. For N-Acetylcaprolactam, this drive shows itself in consistently improved isolation methods and more efficient purification protocols. Using lower temperatures for recrystallization, optimizing solvent recovery, and expanding our on-site analytical labs all contribute to greener and more responsible manufacturing. These steps find validation not just in customer satisfaction, but also in reduced regulatory interventions and lower environmental impact during internal and third-party audits.

    Several customers running closed-loop solvent recycling flagged that even trace impurities in input materials affect cycle purity. By providing lots with ultra-low trace contaminants, we ease solvent management and help clients reach their sustainability targets more quickly. Reducing both raw material and waste disposal costs underscores the direct link between manufacturing diligence and systemwide efficiency.

    Looking Forward in an Evolving Chemical Landscape

    The need for reliability and predictability in industrial chemistry only grows stronger as downstream uses become more specialized and regulated. We refine our approach based on accumulated experience, technical partnership, and honest feedback—never on speculation or cost-cutting at the expense of downstream performance. Delivering N-Acetylcaprolactam means more than meeting a technical specification. It means providing a foundation for industrial, academic, and R&D progress, batch after batch.

    Every decision made on the shop floor and in the technical office shapes the product that reaches customers, both in terms of final quality and the support structure backing it. In our experience, these efforts pay for themselves many times over, reducing long-term operational costs and strengthening customer confidence. The chemical sector faces ever tighter constraints—between regulation, sustainability, and performance benchmarks. Uncompromising focus on purity, physical control, and reliable documentation gives our customers a critical head start, turning a basic intermediate into a true asset for advanced manufacturing.

    With every lot leaving our site, we know exactly what goes into the drum—and, just as importantly, what doesn’t. That level of knowledge and care sends a clear signal to all downstream users: you can trust the inputs, focus on your end goals, and move ahead with confidence.