Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

N-(4-Methylphenyl)-3-Oxobutanamide

    • Product Name N-(4-Methylphenyl)-3-Oxobutanamide
    • Alias 4-Methylacetoacetanilide
    • Einecs 249-601-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    577448

    Cas Number 5466-77-3
    Molecular Formula C11H13NO2
    Molecular Weight 191.23 g/mol
    Iupac Name N-(4-methylphenyl)-3-oxobutanamide
    Appearance White to off-white solid
    Melting Point 110-113°C
    Solubility In Water Slightly soluble
    Smiles CC(=O)CC(=O)Nc1ccc(C)cc1
    Inchi InChI=1S/C11H13NO2/c1-8-3-5-10(6-4-8)12-11(14)7-9(2)13/h3-6H,7H2,1-2H3,(H,12,14)
    Storage Temperature Store at room temperature
    Synonyms 4'-Methylacetoacetanilide

    As an accredited N-(4-Methylphenyl)-3-Oxobutanamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a sealed amber glass bottle containing 25 grams of N-(4-Methylphenyl)-3-Oxobutanamide, labeled with safety and handling instructions.
    Shipping N-(4-Methylphenyl)-3-Oxobutanamide should be shipped in tightly sealed containers, protected from moisture and light. Ensure appropriate labeling and documentation as per regulatory requirements. Handle with gloves and goggles. Ship via ground or air using a reputable chemical carrier, adhering to all local, national, and international hazardous material shipping regulations.
    Storage **Storage Description for N-(4-Methylphenyl)-3-Oxobutanamide:** Store N-(4-Methylphenyl)-3-Oxobutanamide in a cool, dry, well-ventilated area, away from moisture, direct sunlight, and incompatible substances such as strong oxidizers. Keep the container tightly closed and labeled. Protect from physical damage, and follow appropriate chemical hygiene protocols. Use secondary containment to prevent accidental spillage and ensure proper disposal of waste materials.
    Application of N-(4-Methylphenyl)-3-Oxobutanamide

    Applications of N-(4-Methylphenyl)-3-Oxobutanamide in Industrial Manufacturing

    N-(4-Methylphenyl)-3-Oxobutanamide demonstrates targeted value in several specialized chemical processing sectors. As a direct manufacturer, we supply this intermediate for advanced organic synthesis, specialty coatings, crop protection compounds, pharmaceutical intermediates, and advanced materials development. Below, we detail the primary downstream scenarios, including specific compliance requirements, dosage ratios, integration points, and reference finished products.

    1. Pharmaceutical Intermediate Synthesis

    Many high-value pharmaceutical companies utilize N-(4-Methylphenyl)-3-Oxobutanamide for the preparation of complex APIs, specifically within the synthesis of substituted anilide or acetoacetamide derivatives. This material enters multi-step reactions as a key component forming active moieties for anti-inflammatory agents and specific CNS-active molecules. All downstream usage strictly aligns with ICH and pharmacopoeial compliance to ensure product integrity and consistency in batch production.

    Industry compliance standards

    • ICH Q7 GMP for active pharmaceutical ingredients
    • Ph. Eur., USP, and JP relevant monographs for intermediates
    • FDA 21 CFR Parts 210/211 for processing substances in finished dosage forms
    • EU EMA and China NMPA submission guidelines for synthetic intermediates

    Typical usage ratio

    • Generally 0.1–0.5 molar equivalents relative to the primary amine or ketone group. Adjustments depend on stoichiometry of target API synthesis chain.

    Downstream process integration

    • Typically introduced after initial condensation stages
    • Directly involved in acylation or amidation steps
    • Ensures precise molecular configuration for API core structure
    • Reacted under controlled temperature and solvent conditions for maximal yield

    Final product types

    • Nonsteroidal anti-inflammatory drug (NSAID) raw materials
    • Intermediates for CNS-active agents
    • Precursors for veterinary active compounds
    • Building blocks for market-authorized pharmaceuticals

    2. Advanced Agrochemical Intermediate

    Leading crop protection firms purchase this molecule as a selective intermediate for synthesis of substituted amide herbicides and targeted fungicides. Within agrochemical processing lines, the compound contributes to robust backbone construction for selective activity, passing through extensive compliance checks related to residue and environmental safety. Most users integrate this material within streamlined reaction chains that promote desired selectivity for modern field applications.

    Industry compliance standards

    • ISO 9001:2015 quality management
    • FAO/WHO specifications for technical-grade intermediates
    • REACH and global agrochemical registration dossiers
    • Chinese GB/T standards for crop protection inputs

    Typical usage ratio

    • 0.15–0.3 mole ratios based on target active concentration; defined by technical dossier requirements for each formulation batch.

    Downstream process integration

    • Fed into the core amide coupling phase for key agrochemical APIs
    • Combined via catalytic amidation or Claisen-type condensation
    • Integrated post-chlorination or methylation steps for required activity tuning
    • Utilized in pilot and scale-up schemes with full batch traceability

    Final product types

    • Modern amide-type herbicides
    • Fungicide matrix intermediates
    • Selective pre-emergence or post-emergence crop protection actives
    • Raw inputs for dual-function agrochemical blends

    3. Performance Coating Resins

    Specialty polymer and coating formulators employ N-(4-Methylphenyl)-3-Oxobutanamide in the synthesis of functional acrylic or polyurethane resin precursors. This compound enables development of coatings with improved adhesion, film flexibility, and durability, particularly in automotive, industrial metal, and marine environments. Stringent industry standards require full traceability, raw material control, and accurate ratio adjustment based on required resin performance.

    Industry compliance standards

    • ISO 14001 environmental management for coating inputs
    • ASTM D16 and D5402 for resin materials characterization
    • RoHS and REACH SVHC restrictions on additives
    • Certifications for heavy metal and VOC content (EU EN 13428)

    Typical usage ratio

    • Incorporated at 2–5% by weight of the total resin solids; minor adjustments based on viscosity and hardness targets.

    Downstream process integration

    • Added during initial monomer charging or pre-polymer stage
    • Participates in in-situ copolymerization or cross-linking reactions
    • Tailors the glass transition temperature for specific substrates
    • Processed in batch reactors with full in-process QC sampling

    Final product types

    • High-durability industrial coatings
    • Protective marine paints
    • Automotive repair and OEM finishes
    • Functional primer and undercoat resins

    4. Specialty Organic Synthesis

    Advanced material development laboratories use this raw material as a modular unit for constructing custom acetoacetamide scaffolds or exploring new functional molecules. Research-driven customers often require highly pure, reproducible intermediates matched to strict research protocols and global regulatory standards. The compound enters their workflow at defined synthetic nodes, contributing to the architecture of new material classes and enabling late-stage modifications.

    Industry compliance standards

    • ISO 9001:2015 for R&D handling and traceability
    • International Laboratory Accreditation Cooperation (ILAC) for purity validation
    • Material transfer and RoHS conformance for electronics R&D projects
    • REACH Annex XVII for lab use

    Typical usage ratio

    • Usually between 0.05 and 0.2 molar equivalents per custom synthesis batch; determined experimentally based on molecular design goals.

    Downstream process integration

    • Introduced as a building block in stepwise organic assembly
    • Supports scaffold diversification through functionalization
    • Utilized in solid-phase or solution-phase combinatorial synthesis
    • Integrated into route-scouting or scale-up feasibility studies

    Final product types

    • Library compounds for medicinal chemistry
    • High-purity scaffolds for material innovation
    • Organic LED (OLED) test structures
    • Functionalized monomers for experimental polymers
    Free Quote

    Competitive N-(4-Methylphenyl)-3-Oxobutanamide prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Introducing N-(4-Methylphenyl)-3-Oxobutanamide: A Versatile Ingredient From Experience

    Product Insight From the Manufacturing Floor

    Every batch of N-(4-Methylphenyl)-3-Oxobutanamide starts with an understanding that precision in chemical synthesis translates into value downstream. Our teams have designed and optimized the route for this molecule over years of daily production, guided by the feedback of clients working in fine chemicals, pharmaceuticals, and intermediates. We’ve watched N-(4-Methylphenyl)-3-Oxobutanamide earn its reputation not from brochures, but from results that repeat in real applications. This compound stands out thanks to strict adherence to chemical purity, reliable crystallization processes, and meaningful collaboration with R&D teams who demand the finest details from their input substances.

    Production Philosophy: More Than a Molecule

    There is always a difference between shipping barrels of chemicals and ensuring those contents match expectations for every end use. As a chemical manufacturer, responsibility does not end at reaction yields. Our focus stays on minimizing impurities from side reactions and controlling moisture to levels that fit sensitive syntheses. Over the years, working directly with chemists, we’ve seen N-(4-Methylphenyl)-3-Oxobutanamide selected not for catchy names, but because technicians rely on its predictable performance under varied lab and plant conditions.

    In our plant, every lot of this compound comes from reactors that run extensive checks for color, melting point, residual solvents, and particle size. If a pharmaceutical client asks for tighter controls on any parameter, we take their requests seriously and rerun checks, sometimes revising an entire batch protocol. From the first mixing of raw materials to the final drying stage, the workforce performs hands-on inspections. Small changes in handling or filtration can affect downstream yields for a customer, so continuous feedback shapes the conditions inside our facility.

    Specifications Rooted in Practical Application

    Specifications have meaning when they come from real-world use, not just paperwork. The N-(4-Methylphenyl)-3-Oxobutanamide we produce is defined by exact melting ranges and purity profiles, developed through ongoing conversations with users who measure these same traits in their own labs. Most standard batches reach a chemical purity of 99% and above, with trace solvents or moisture kept below universally accepted thresholds. Batch-to-batch variability grows smaller because we track every reaction and purification stage, refusing to cut corners when clients demand tight specifications.

    On the manufacturing side, robust analytical support covers routine checks — HPLC, NMR, melting point, and loss on drying among them. The material handles easily with routine containment measures, pours smoothly, and avoids caking even after months in storage, as we tweak drying and packaging based on real logistics and conditions found in warehouses or during transport. All this matters to the chemist who opens the drum and expects nothing less than a consistent solid — not an experiment in reprocessing.

    Fulfilling Roles in the Chemical Industry

    We’ve watched N-(4-Methylphenyl)-3-Oxobutanamide make its mark across several applications. Pharmaceutical development brings the most direct dialogue, especially in custom synthesis routes where reacting partners must be precisely characterized. A well-made batch of this amide allows process chemists to maximize step yields and cut costly rework. In agrochemicals and dye intermediates, consistent reactivity and low byproduct levels help downstream operators predict clean product isolation.

    Performance comes down not to paperwork, but to the real chemical behavior in coupling reactions, acylations, or condensations. In my experience, users of this product have called after trials with blends containing poorly controlled analogs from other suppliers. These brought headaches — delays from unexpected crystalline byproducts, reactivity drops, or mismatched solubility profiles. Our technical team responds with more than assurances: we detail every point of the synthetic path that can influence the final molecular structure.

    Differences Beyond the Label

    In an industry flooded with similar materials and unfamiliar producer names, what sets one batch of N-(4-Methylphenyl)-3-Oxobutanamide apart from the next? That question changes every year as manufacturers come and go, some using minimal controls or blending subpar raw inputs. What we see in the market are lots that look similar under a basic microscope but diverge when tested in actual processes. Results in a lab notebook do not lie — a genuinely refined product reduces scrap rates, lets clients scale up with fewer surprises, and directly saves on cost for rework or wasted time.

    We’ve had more than one case where a new customer arrived tired of process deviations caused by “almost pure” compounds from fly-by-night vendors. They describe materials with extra odor, off-white appearance, or shifting melting profiles. These are red flags for seasoned hands. Our N-(4-Methylphenyl)-3-Oxobutanamide sets itself apart by passing every critical quality metric. Trace impurity fingerprints run low; polymorphic issues remain controlled by optimized crystallization. Above all, long-term relationship building and ongoing technical service matter. Machines alone cannot deliver the kind of trust that comes when a chemist can talk directly to the people making their intermediates.

    Considerations for Bulk Supply and Logistics

    Supplying hundreds of kilos a week means constantly watching for bottlenecks in logistics and keeping communication open both internally and with clients. Seasonal humidity, variations in incoming raw materials, and shifting regulatory requirements have all taught us to never get complacent. Our shipments often travel far from the plant floor, so we track every drum, monitor for integrity, and routinely check warehouse conditions. Customers have called after weather changes or customs holdups, and we respond by helping troubleshoot on the ground — this means more than a tracking number, it means real follow-through.

    It is easy to underestimate the challenges faced by end users who scale up from gram to metric ton production. From our experience, scale-up surprises nearly always point back to material predictability or lot homogeneity. This is where rigorous batch record-keeping and traceability make the difference. Every shipment has a documented production story, and we keep samples for reanalysis in case any end user needs clarification months down the road.

    Addressing Issues: Consistency and Transparency

    Industry veterans know that process hiccups can cost more than the entire chemical input for a week. That is why every improvement in our N-(4-Methylphenyl)-3-Oxobutanamide comes from real discussions with chemists who share their wins and their pain points. We learned early that simply hitting a nominal purity spec means little if trace side products go undetected and show up in finished goods further along the process chain. That led us to invest in stepwise monitoring for possible contaminants that are nearly invisible in basic profiles.

    There’s a shared responsibility between the manufacturer and the user. We’ve applied lot-specific labeling, maintain archive samples, and respond with detailed certificates of analysis that are more than just regulatory paperwork. If a process chemist requests odd data from their batch, we pull our records, analyze retained samples, run new tests if needed, and report back honestly. That builds the confidence to stake your product’s success on a crucial input. It has kept old clients returning project after project — a fact that speaks louder than marketing language.

    Supporting Research And Development

    R&D teams often call for tighter tolerances, cleaner spectra, or new physical forms. Over the last decade, our product development group adapted crystallization, filtration, and drying steps to accommodate shifting needs. If a biotech client found our current form inconvenient for their synthesis, we explored different grain sizes, adjusted parameters, and sent out test lots for feedback. We won’t claim to hit the mark every single trial on the first try, but our openness to trial-and-error has led us to innovative process changes — often resulting in forms that simplify washes or improve handling under new protocols.

    Lab and plant chemists have asked for more granular insight into trace element content, or for assurances on elemental impurities as regulations advance. Because our own analysis labs are close to the plant, new requests move from question to real data quickly. We have even adjusted filtration pressures and recrystallization cycles based on experimental input from collaborating partners. All of this demonstrates that, for N-(4-Methylphenyl)-3-Oxobutanamide, the real value emerges through dialogue, careful control of processes, and a willingness to invest in user-driven improvements.

    Comparing To Other Offerings On The Market

    Not all N-(4-Methylphenyl)-3-Oxobutanamide sold worldwide is made to the same standard. Some manufacturers focus on bulk volume at the expense of performance characteristics important for research or critical industrial steps. We see the difference clearly in post-purchase surveys, where chemists note less predictable outcomes or find themselves repeating purification steps to attain the necessary reactivity. Our batch histories frequently outperform these competitors specifically in areas like polymorph stability, moisture control, and clarity of NMR profile.

    There is a temptation to accept any supply that looks right at a quick glance, especially when short-term price pressure looms. From experience, this approach brings risk: yields slip, timelines stretch out, and costs creep up from extra checks and re-work. We address these pain points directly, sharing our methodologies, documenting every intermediate, and maintaining open channels for troubleshooting in the field. That’s less common among facilities that only engage with customers from afar.

    Sustaining Quality For Tomorrow’s Challenges

    Long-term clients demand a level of predictability. They plan multi-step syntheses months in advance and need each piece in the puzzle to fit on cue. Our role is to ensure each batch of N-(4-Methylphenyl)-3-Oxobutanamide meets expectations as specifications tighten and regulatory scrutiny rises. Our internal training and continuous process improvement place a premium on reproducibility. The spirit of partnership with clients, whether for pharma, specialty intermediates, or academic research, guides daily procedures. End users often bring forward new requirements, such as finer monitoring for residual metals or adapting packaging to meet clean-room routines. We mobilize production and QA teams to document change steps, train line workers, and update process parameters in real time.

    From the original synthesis up to full-scale production, this compound’s journey reflects active problem-solving — not simply hitting production targets but providing a stable, transparent foundation for end users. We believe this kind of accountability ties directly to the success of anyone relying on our material for development or commercial manufacturing.

    Near-Term Industry Trends

    Trends in the chemical sector rarely leave raw material quality untouched. As green chemistry principles take hold and as new bioprocesses emerge, tighter sourcing standards follow. These trends have led us to reassess not just synthetic routes, but energy use, solvents, and waste profiles. By integrating eco-efficient methods alongside product performance, we ensure a supply chain that stays relevant for future generations of chemical innovation.

    We have participated in collaborations with academic groups and process optimization consultancies, learning from fresh perspectives how changes in intermediates like N-(4-Methylphenyl)-3-Oxobutanamide can scale up to major environmental gains. Practically, it means scrutinizing each element in our process for hazards or overconsumption, and it influences the way we package, label, and transport every unit of material.

    Real-World Value: The User Experience

    Feedback from plant managers and chemists in the field matters as much as inputs gleaned from the most advanced lab instrumentation. One client noted a step-change in purification times after transitioning to our product, with measurable impact on plant throughput. Others reported improved GC-MS profiles, reduced downstream carbon load, or more straightforward filtration characteristics when scaling up reactions.

    User stories like these inform our pursuit of continuous improvement. Data from lab and plant use cases shape the way we refine drying, monitor inbound starting materials, and document trace contaminants. A cycle of open reporting and resolution delivers more robust and reliable batches year after year.

    The Value of Direct Manufacturer Support

    Direct lines from the manufacturing team to the end user mean more than just technical troubleshooting. We routinely field technical calls, review analytical reports, and travel on-site to resolve handling or form issues. Practical support bridges the gap between theoretical specifications and real world use. Our chemists and engineers know that the best ideas arise through shared experience and sustained dialogue.

    We also recognize the limitations of printed data sheets. While analytical graphs matter, everyday problems — like stuck transfer lines, storage conditions, or compatibility with varied solvents — resolve faster when real-world advice from people who have spent years making the material is available. The difference reflects a mindset shaped by real experience, not just formal documentation.

    Common Questions and Solutions

    Over the years, certain questions arise repeatedly in conversations with users. Will the product stay free-flowing under high summer heat? Has the crystalline form ever changed due to supply interruptions in raw materials? Can the quality parameters withstand new application requirements in emerging synthesis methods? To each, we provide honest, detailed responses backed by actual lot records and by studies conducted over many production cycles.

    If a problem ever emerges in use — for instance, unexpected residue or reduction in activity — we handle it hand in hand with the user. Root cause analysis doesn’t stop at the plant gate. With no layers of distributorship between maker and user, real answers, corrections, and rapid turnaround remain possible. That commitment to direct engagement sets us apart in a market crowded with intermediaries.

    An Ongoing Commitment: Beyond Compliance

    Meeting regulatory obligations marks only the start. Real accountability means ongoing evaluation of every aspect of production. We actively reassess our processes and keep up with scientific literature and new environmental standards. Each time a new regulatory framework appears or an end market evolves, we gather plant and QA teams and match our practices to fresh standards. Many changes, such as phasing out specific solvents or adjusting for new impurity guidelines, launch after industry or client feedback.

    In practice, this means frequent investment in new testing equipment, ongoing staff training, and a tighter paper trail from raw material intake to finished drum. These standards may not make headlines, but they matter to every chemist handling material in a development project or process scale run.

    Conclusion: Proven Through Partnership

    N-(4-Methylphenyl)-3-Oxobutanamide represents more than a chemical name to those of us who make it. Decades of operational know-how, technical troubleshooting, and attention to the finest details have shaped a product that meets the reality of demanding industrial and scientific work. Where others trade in bulk quantities, we trade in relationships built on visible, tested reliability. Whether you develop new pharmaceutical compounds, support process improvements, or tackle research-grade syntheses, the commitment to quality we put into every lot means your project can progress with confidence. The experience gained through continuous partnership has proven its worth time and again, far beyond what any data sheet or third-party write-up could deliver.