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N-(4-Carboxyphenyl)Phthalimide

    • Product Name N-(4-Carboxyphenyl)Phthalimide
    • Alias N-(4-Carboxyphenyl)phthalimide
    • Einecs 243-624-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    151503

    Iupac Name 2-(4-carboxyanilino)isoindoline-1,3-dione
    Cas Number 1721-30-8
    Molecular Formula C15H9NO4
    Molecular Weight 267.24
    Appearance White to off-white powder
    Melting Point 318-322 °C
    Solubility In Water Insoluble
    Boiling Point Decomposes
    Purity Typically >98%
    Smiles C1=CC=C(C=C1C(=O)O)NC2=CC3=CC=CC=C3C(=O)N2
    Inchi InChI=1S/C15H9NO4/c17-14(18)9-6-7-11(8-10-9)16-12-4-2-1-3-5-13(12)15(19)20/h1-8,16H,(H,17,18)

    As an accredited N-(4-Carboxyphenyl)Phthalimide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White crystalline powder sealed in a 25-gram amber glass bottle with a tamper-evident cap and detailed chemical labeling.
    Shipping N-(4-Carboxyphenyl)phthalimide is shipped in tightly sealed containers, protected from moisture and light. It should be handled with gloves and proper PPE. The package is clearly labeled as a chemical substance. Shipping complies with local and international regulations for non-hazardous laboratory chemicals. Store in a cool, dry location upon arrival.
    Storage N-(4-Carboxyphenyl)phthalimide should be stored in a cool, dry, well-ventilated area, away from moisture, strong acids, and oxidizing agents. Keep the container tightly closed and protected from direct sunlight and incompatible materials. Store at room temperature or as specified on the safety data sheet. Avoid contact with skin and eyes, and ensure proper labeling for safe handling.
    Application of N-(4-Carboxyphenyl)Phthalimide

    Applications of N-(4-Carboxyphenyl)Phthalimide in Industrial Manufacturing

    N-(4-Carboxyphenyl)Phthalimide serves as a key intermediate that enables high-value downstream products in several specialized industries. The following application sectors reflect actual usage in industrial manufacturing, highlighting technical integration and requirements across related compliance environments.

    1. High-Performance Polyimide Resin Synthesis

    This intermediate acts as a crucial monomer in the synthesis of aromatic polyimide resins, which are sought after for their thermal stability and dielectric properties. Resin formulators select it for its contribution to imidization kinetics and final polymer rigidity. Engineers modify formulation ratios in line with design needs for coatings, films, and composites in microelectronics and automotive parts, requiring meticulous process control to achieve desired molecular weights and cross-linking density.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for products used in electronics
    • UL 94 Flammability Standards for plastics
    • IEC 61249-2-21 for base materials in printed circuit boards
    • REACH Regulation (EC) No 1907/2006 for restricted substances

    Typical usage ratio

    • 10–30 mol% as an aromatic monomer for polyimide backbone, chosen depending on flexibility/toughness target; adjust ratio to balance mechanical and thermal requirements.

    Downstream process integration

    • Polycondensation step during resin formation — typically, direct condensation with diamines using solution polymerization or thermal imidization.

    Final product types

    • Flexible printed circuits
    • Electronics-grade insulating films
    • High-temperature adhesives
    • Automotive wire coatings

    2. Specialty Pigment and Dye Precursor Manufacture

    N-(4-Carboxyphenyl)Phthalimide is used as a building block in the synthesis of phthalimide-based pigments and dyes, specifically for colorants requiring strong lightfastness and heat resistance. Laboratory and scale production harness its aromatic structure to create pigments for plastics, specialty inks, and performance coatings, facilitating stable chromophores that retain color integrity under prolonged exposure conditions.

    Industry compliance standards

    • EU Regulation (EC) No 10/2011 for food contact materials (for plastics colorants)
    • EN 71-3:2019 for toy safety (colorants in children's items)
    • OEKO-TEX Standard 100 for textile inputs
    • ASTM D476 for classification of pigments

    Typical usage ratio

    • 5–25% w/w in pigment intermediates, adjusted based on desired depth of color and thermal stability of the final pigment; lower loadings for transparent shades, higher for opaque.

    Downstream process integration

    • Condensation or coupling reactions during pigment synthesis — introduced after primary aromatic amine formation to build extended conjugated systems before precipitation and purification.

    Final product types

    • Engineering plastics colorants
    • UV-resistant textile dyes
    • High-performance printing inks
    • Industrial paints and coatings

    3. Pharmaceutical Intermediate for Antineoplastic Agents

    The compound’s imide function and carboxylate group provide a core scaffold in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly in antitumor agent research involving cyclic imide analogs. Medicinal chemists leverage this scaffold for derivatization toward molecules targeting chemotherapeutic action, following strict GMP controls and batch consistency verification as part of pharmaceutical QC protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidelines
    • EU GMP EudraLex Volume 4 for active substance production
    • USP–NF Monographs (where applicable for downstream APIs)
    • EDQM CEP Certification for intermediates in Europe

    Typical usage ratio

    • Core scaffold — typically 1:1 molar equivalent with other coupling partners in API synthesis; adjusted in medicinal chemistry depending on substitution steps and desired target molecule.

    Downstream process integration

    • Stepwise intermediate — introduced into N-alkylation and cyclization reactions, forming part of the key heterocyclic ring during late-stage API construction in process chemistry runs.

    Final product types

    • Antineoplastic drug molecules
    • Specialty imide-containing pharmaceutical candidates
    • Research-grade intermediates for drug discovery
    • Synthetic reference standards for oncology development

    4. Reactive Monomer for High-Temperature Epoxy Formulations

    N-(4-Carboxyphenyl)Phthalimide is incorporated as a reactive additive in production of high-performance epoxy resins used for structural composites. Its carboxyl group allows covalent incorporation via reaction with epoxide sites, enhancing curing speeds and cross-link density for aerospace and electrical encapsulation. The specificity of its incorporation requires precise stoichiometric balancing dependent on resin backbone structure and mechanical property targets in fabrication lines.

    Industry compliance standards

    • AS9100 for aerospace polymer matrix materials
    • RoHS Directive 2011/65/EU for restricted substances
    • IPC-4101B for composite base materials
    • UL 746C for polymeric materials — use in electrical devices

    Typical usage ratio

    • 2–12 phr (parts per hundred resin), depending on targeted modulus and glass transition temperature. Manufacturers fine-tune ratio by application — higher for structural, lower for potting compounds.

    Downstream process integration

    • Mixed directly into epoxy resin prepolymers during resin formulation; reacts during thermal or catalytic curing before material shaping or laying up in composite structures.

    Final product types

    • Aerospace composite panels
    • Electrical encapsulation compounds
    • High-voltage insulator coatings
    • Industrial bonding adhesives
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    Certification & Compliance
    More Introduction

    N-(4-Carboxyphenyl)Phthalimide: A Behind-the-Scenes Perspective from the Manufacturer

    Introducing N-(4-Carboxyphenyl)Phthalimide

    Walking through the production floor, the scent and sight of N-(4-Carboxyphenyl)phthalimide reminds us that not every specialty chemical comes with easy notoriety. Those grayish-white crystals hold a quiet significance for dye intermediates, advanced polymers, and high-grade electronics. In a market where trace purity and consistent results stand as the top priorities, our firsthand experience with this compound allows us to deliver not just the product, but also the reliability that only a manufacturer working from raw material sourcing to final packing can honestly guarantee.

    Decades in Synthesis: Understanding Structure and Performance

    The choice of N-(4-Carboxyphenyl)phthalimide often starts at the chemical structure — its fused phthalimide core with a carboxyphenyl group at the para position. From our perspective, handling each batch means careful temperature profiles during imidization and cautious addition of phthalic anhydride and p-aminobenzoic acid. Synthesis demands patience: skipping the correct pH control or slight shifts in heat throws the final assay off by more than just a few decimals. Over the years, adjustment in reaction kinetics or solvent selection has carved out subtle differences that skilled formulators quickly notice down the value chain.

    Spec-driven buyers usually look at melting points, particle size, and spectral purity. We run HPLC and FTIR tests on every lot, not simply to tick off a checklist, but to respond to polymer researchers and dye houses who occasionally back-calculate purity from end-use performance. If something doesn’t click in their QC lab, we track right back to the process line and assist in troubleshooting. You won’t get that follow-up from a faceless distributor.

    Getting Beyond a Simple Specification

    Model codes often flood the market with promises of “HQ” or “premium” gradings whose definitions shift with the seller. From a manufacturer’s vantage point, we point directly to the CAS registry: 5570-77-4. That single identifier anchors our product’s traceability. Every runaway “equivalent” or “replacement” on reseller shelves brings back stories — stories where a customer’s critical batch failed and the raw data peeled back to some subpar mimic.

    Through close partnership with upstream producers of primary aromatics, we select input lots based on consistent isomeric ratios. Seasonal variation in supply chain quality, especially for benzoic acid derivatives, means our QA team pauses incoming raw goods for testing before releasing them into batch kettles. Our laboratory logs document that consistent protocol; we open those records whenever clients visit for audits or certifications. That level of transparency doesn’t pass down from traders who simply freight in bulk bags.

    Uses that Drive Consistency — Not Just a Line on a Data Sheet

    Every kilogram we ship goes into critical functions. For those in polyimide manufacturing, N-(4-Carboxyphenyl)phthalimide enables the creation of high-temperature-stable films and fibers. A few clients use these derivatives in automotive or aerospace-grade materials, where the insulation must not degrade above 300°C. This compound’s unique carboxyl functionality improves bonding to other monomers—a detail often lost unless your team personally reviews failed tensile tests after a minor supplier swap.

    Dye producers use our material for specialty azo and anthraquinone colorants. Shifts in the purity profile change the hue of the resulting pigment just enough to cause costly interruptions in textile warehouses. We learned quickly never to skip the endpoint washing stage, as incomplete removal of side products can ruin a year’s supply contract with a single batch.

    N-(4-Carboxyphenyl)phthalimide also features in certain pharmaceutical intermediates. The level of trace iron and other transition metals directly impacts catalytic downstream reactions. We monitor those levels carefully—not every facility can afford to run their reactors twice to correct inefficiencies.

    Quality at Source: The Manufacturer’s Role in Long-Term Performance

    Not all N-(4-Carboxyphenyl)phthalimides act the same. Feedback from downstream users taught us long ago that stability in storage and smooth flowability make huge differences in busy production environments. We focus just as much on drying finishes and anti-clumping packaging as we do on main reaction steps. The wrong particle morphology can build up in silos or stick to feed hoppers. We calibrated our production driers to avoid this exact scenario after hearing from a partner that weeks’ worth of output sat jammed in their lines. No catalog spec captures that reality, but every experienced operator knows to ask about it.

    Handling and safety remain on our minds too. Our staff undergo dedicated in-house training so they understand not just the basics of chemical handling, but also the specific idiosyncrasies—such as sensitivity to moisture during storage or incompatibility with certain plastics. When customers call after midnight to ask about a sudden tank deposit, we answer with both lab data and hands-on suggestions, because we witness issues firsthand and document every trial.

    Comparing Competitors: In the Details, Trust Matters

    Heavy competition in specialty chemicals leads some sellers to stretch the limits of what they call “the same product.” Low-ballers might substitute starting materials or recycle spent solvents, and the resulting batch wears physical differences evolving from slight shifts in colour, inconsistent melting, or invisible impurities. Our operations never cut corners on wash water quality or crystallization time, even if it means scaling back throughput to favor consistency.

    Cost pressures run high; we see the numbers too. But every patch job on process control inevitably turns up, months down the line, at the customer’s QC bench. Decades at the manufacturing end drilled that lesson into us. High purity and repeatable performance mean running small-pilot validation runs when incoming substrates shift, instead of blindly filling drums and hoping for the best. Last year, a global shortage drove a wave of so-called “improved” substitutes that claimed the same output. Factory trials told a different story, revealing everything from filter clogging to yellowing of final films. We’ve learned to say no to opportunistic shortcuts.

    Supporting Innovation: Collaborating with Laboratories and Engineers

    Some of our most rewarding days start with calls from R&D labs — chemists who want to tweak polymers for new temperature limits, or electronics developers exploring ultra-thin insulation films for next-generation devices. We’ve run custom batches with altered particle size or varied drying times to match pilot line trials. Working hands-on with innovating companies feels different from simply box-shipping stock material.

    Direct feedback has nudged us to provide more detailed COAs, include high-resolution spectroscopy reports, and send small pre-production samples. Sometimes we pick up subtle shifts in solubility triggered by experimental additives downstream. Those moments force us to revisit how we filter or dry lots, rather than sticking to rigid templates. Innovation feeds back into our process and lets us raise the bar for the whole industry’s standards.

    Navigating Industry Standards and Regulatory Developments

    Our regulatory team constantly reviews updated standards. RoHS and REACH compliance questions trigger deep dives into trace contaminant data and third-party analytical checks. The drive to reduce residual phthalates and other flagged substances has prompted updates to our purification, including secondary filtrations. Creating an enterprise-wide understanding of changing rules minimizes headaches for every link in the supply chain and keeps us one step ahead during customer or regulatory audits.

    Some regulatory shifts arrive quickly, such as stricter dust control on loading bays or updated limits on trace organics. Changing an SOP overnight isn’t easy for large-volume flows; it means rewiring workflows and updating staff training. But putting in that effort early reduces costly disruptions later and ensures buyers receive consistent quality that meets the latest compliance expectations. Shareholders rarely see how much effort goes into keeping every lot fully compliant, but our clients do.

    How Model and Specification Impact Real-World Use

    We publish our core lot’s analytical data transparently. Instead of drown consumers in endless “high-purity,” “lab-grade,” or “industrial-grade” claims, we focus on the confirmed results: clear benchmarks on purity, moisture levels, melting range, and bulk density. Those numbers influence everything from polymer extrusion smoothness to the reactivity in further chemical syntheses.

    Drilling down to specific applications, the phthalimide structure with para-carboxy substitution brings unique reactivity for condensation reactions. Where similar products fail, often due to trace metallic residues or unreacted precursors, ours supports stable, repeatable formulations. For customers needing batch-to-batch reproducibility, this characteristic translates to less rework and fewer costly delays.

    Working with clients who require custom modifications, we often run split-lot trials. Some experiment with finer mesh sizes to aid fast dissolution; others push for tighter control over residual acidity to suit delicate intermediates. Experience from our own process trials makes us realistic about what variants are technically achievable, so we communicate timelines and possibilities directly—never overselling capabilities we haven’t validated in the plant.

    Resolving Supply Chain and Logistical Challenges

    A big part of today’s manufacturing isn’t just chemistry; it’s getting the product to customers without drama. We invest in bulk packaging resistant to physical and chemical stress, especially important for international shipments facing changes in humidity or temperature. Container liners, vacuum sealing, and controlled warehousing prevent cake-up and ensure hassle-free weighing at the customer’s site.

    A few years back, delays in global logistics prompted us to develop buffer inventory and alternate shipping lanes. Learning from those pain points, we also built stronger relationships with trusted logistics partners, prioritizing those who understand the specifics of chemical handling. Rushed deliveries cost more in lost product from mishandled loads than can ever be justified by freight savings. We choose reliability, even if it means longer lead times, because getting good material late is better than getting compromised batches fast.

    Eco-Responsibility and Sustainable Practice

    Industry trends keep pushing environmental accountability further. Our facility staff see the daily results of that: from evolving water recycling initiatives to efforts at minimizing solvents in each production pass. Direct filtration and solvent recovery reduce both cost and impact, and recycling water helps us stay within compliance while cutting emissions. Participation in green supply policies also motivates us to collaborate with downstream users aiming for lower process waste.

    On-site energy use sits under constant review. We’ve upgraded to LED lighting, motor controllers on pumps, and integrated process monitoring—all changes that incrementally reduce our carbon output. Each minor improvement may look insignificant alone, but accumulated across the year, they allow us to support suppliers and customers seeking more responsible manufacturing.

    Learning from Problems: Lessons from Production to Application

    One challenge that recurs is the occasional off-grade lot—sometimes traced back to a temporary change in upstream supply or a new equipment installation. These situations create learning moments for our team. We own those mistakes, share the breakdown with our clients, and introduce mitigation such as more robust incoming raw inspection or pilot-scale batch qualification before updating mainline output. Failures put a human face on manufacturing; users need honesty, not excuses, when a process misfires.

    We also work with customers during application missteps. One season, a major user’s polymer batch exhibited unusual yellowing. Joint investigation connected the problem to trace benzaldehyde carryover—something lab-scale tests hadn’t caught. Our intervention included both replacing affected lots and tightening post-reaction water washes. That worked because our teams stay in touch throughout the process, offering more than boilerplate replies.

    Customer Support That Goes Beyond the Shipment

    In our experience, buyers need answers at every step: initial material assessment, detailed application troubleshooting, and regular process updates. We prioritize direct communication channels and knowledge sharing instead of brushing off concerns. Sharing lessons learned—both in scaling up production and dealing with hiccups—ensures that both sides keep improving. A chemical only performs as well as the collaboration behind it.

    More than half of our new clients arrive from word-of-mouth recommendations. That level of trust only develops when your manufacturing and sales teams speak the same language, and when your laboratory doors remain open to partners. Manufacturers aren’t vendors who deal in faceless commodities: we back every drum shipped, every kilo certified, and every process refined with our direct experience.

    Looking Forward in Specialty Chemicals

    Demand for compounds like N-(4-Carboxyphenyl)phthalimide keeps evolving, both for traditional uses and emerging sectors. As raw material markets keep shifting and technology asks more from materials, we’re ready to adapt. Real-world manufacturing isn’t a straight line from specification to shipment. It takes constant listening, ongoing learning, and a willingness to keep improving both product and process.

    For industry insiders looking for more than a catalog chemical, thoughtful engagement with the actual manufacturer brings long-term results. Years of hands-on production allow us to back every claim, troubleshoot every application, and guide development with real-world fixes—so the next generation of products can keep reaching higher benchmarks.