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N-(3-Aminopropyl)-Imidazole

    • Product Name N-(3-Aminopropyl)-Imidazole
    • Alias 3-API
    • Einecs 629-041-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    251713

    Chemical Name N-(3-Aminopropyl)-Imidazole
    Molecular Formula C6H11N3
    Molecular Weight 125.17 g/mol
    Cas Number 5036-48-6
    Appearance Colorless to pale yellow liquid
    Boiling Point 142-144°C at 5 mmHg
    Density 1.087 g/cm³ at 25°C
    Melting Point -4°C
    Purity Typically ≥98%
    Solubility Miscible with water and most organic solvents
    Refractive Index n20/D 1.504
    Flash Point 122°C
    Pka Imidazole Approximately 7

    As an accredited N-(3-Aminopropyl)-Imidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 100g quantity of N-(3-Aminopropyl)-Imidazole is packaged in a sealed amber glass bottle with a secure screw cap.
    Shipping N-(3-Aminopropyl)-Imidazole is shipped in tightly sealed containers under cool, dry conditions and in compliance with chemical safety regulations. Packaging is designed to prevent leaks or contamination. The product is typically dispatched with appropriate labeling and documentation, including safety data sheets, following local and international transport guidelines for hazardous materials.
    Storage N-(3-Aminopropyl)-Imidazole should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from moisture, heat sources, and incompatible substances such as strong oxidizing agents. Store at room temperature and protect from light. Ensure containers are clearly labeled and handled with appropriate personal protective equipment to prevent contamination or accidental release.
    Application of N-(3-Aminopropyl)-Imidazole

    Applications of N-(3-Aminopropyl)-Imidazole in Industrial Manufacturing

    As a direct manufacturer of N-(3-Aminopropyl)-Imidazole, we support specialty chemical sectors by supplying consistently high-purity material for mature downstream applications. Below, we detail the focused industrial fields where this intermediate delivers critical performance in customer processes, along with exact compliance, formulation, and integration parameters tailored to each segment.

    1. Epoxy Curing Agent Systems for Industrial Coatings

    Industrial coating producers select this product chiefly for use as an efficient accelerator or latent curing component in high-solid and waterborne epoxy formulations. Its unique balance of reactivity and amine structure meets demands for extended pot-life, low color development, and controlled crosslinking under ambient or elevated temperature cure protocols for metal and concrete protection lines.

    Industry compliance standards

    • REACH (EC) No 1907/2006 for chemical safety in Europe
    • ISO 12944-6:2018 (Paints and varnishes for corrosion protection of steel structures by protective paint systems)
    • GB/T 25251-2010 (China National Epoxy Resin Coating Standard)
    • VOC content requirements per 40 CFR Part 59 (US EPA for industrial coatings)

    Typical usage ratio

    • 0.3–2.5% by weight relative to total resin solids, optimized based on desired cure speed and workability
    • Formulators may increase loadings up to 5% in ambient-cure fast-react systems

    Downstream process integration

    • Added during the grinding or mixing stage with resins; exact timing depends on heat management and catalyst package to avoid premature gelation
    • In automated systems, metered injection occurs in line with pigment and extender paste

    Final product types

    • Anticorrosive steel primers for infrastructure and marine
    • High-durability floor coatings (self-leveling, antistatic, chemical-resistant)
    • Epoxy powder coatings for industrial components
    • Protective linings for chemical storage tanks

    2. Polyurethane Catalyst Formulations for Flexible Foams

    Polyurethane manufacturers utilize this raw material as a secondary catalyst, contributing to balanced cell structure, precise reaction timing, and minimal VOC generation during the foaming process. Its dual-amine and imidazole functional groups promote efficient urea and urethane linkages, especially in demanding high-resilience (HR) and viscoelastic foam systems where fine mechanical tuning is a priority.

    Industry compliance standards

    • ISO 9001:2015 (Process Quality Systems for polyurethane plants)
    • CertiPUR/EUROPUR directives (for flexible foam in furniture and bedding)
    • GB/T 8336-2008 and ASTM D3574-17 (Specifications for polyurethane foam materials)
    • Relevant REACH Annex XVII entry for amine catalyst use

    Typical usage ratio

    • 0.05–0.25 parts per hundred polyol (php), variable depending on base polyol MW and desired gel/cream time
    • Higher loadings up to 0.4 php for rigid or fast-cure automotive foams

    Downstream process integration

    • Metered directly into the polyol blend prior to prepolymer mixing
    • In continuous slabstock lines, integrated via inline dosing units linked to reaction monitoring sensors

    Final product types

    • High-resilience (HR) seat cushions
    • Memory foam mattresses and toppers
    • Automotive interior flexible foams
    • Acoustic insulation foam sheets

    3. Corrosion Inhibitor Synthesis for Oil & Gas Pipelines

    Downstream formulators in the oilfield chemicals segment depend on this key intermediate for synthesizing custom-tailored, water-soluble imidazoline derivatives serving as film-forming corrosion inhibitors. Its specific backbone structure favors rapid interaction with metal surfaces in multiphase flow, particularly in high-salinity and acidic pipeline conditions where sulfur and CO2 exposure accelerates degradation.

    Industry compliance standards

    • NACE MR 0175/ISO 15156 (Petroleum and natural gas industries — Materials for use in H2S-containing environments)
    • API RP 552 (Transmission Pipeline Flow Line Additives)
    • Q/SH 1120 0550-2012 (Chinese Oilfield Chemical Additive Standard)
    • REACH pre-registration for downstream chemical handling

    Typical usage ratio

    • Converted to finished imidazoline inhibitor at 25–40% active ingredient; typically dosed into pipelines at 10–150 ppm depending on flow regime and corrosion analysis
    • Adjustment occurs through lab-side compatibility and efficacy testing specific to crude blend

    Downstream process integration

    • Condensed with fatty acids or tall oil derivatives using batch reactors at 150–180°C
    • Formulators neutralize and solubilize the imidazoline intermediate before blending with other additives to optimize field dosing packages

    Final product types

    • Water-soluble corrosion inhibitors for oil production pipelines
    • Gas pipeline protection additives
    • Integrated pigging fluids for maintenance operations
    • Production and gathering flow line treatments

    4. Organic Synthesis Intermediate for Active Pharmaceutical Ingredients (API)

    Pharmaceutical manufacturers engage this molecule as a building block for imidazole-containing drug structures, notably within anti-infective, antiulcer, and antifungal agent synthesis. Its reactivity enables targeted N-alkylation and side-chain modifications under controlled, GMP-compliant conditions, facilitating batch or continuous synthesis routes for heterocyclic APIs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 (US FDA GMP rules)
    • European Pharmacopoeia 11.0 monographs, where applicable
    • Chinese Pharmacopoeia (最新版) as required for local finished dose manufacture

    Typical usage ratio

    • Used as a controlled stoichiometric intermediate in multi-step synthesis; molar ratio varies from 1.0–1.5 equivalents depending on the target API pathway and scale
    • QC laboratories adjust charge ratio to optimize yield and minimize impurity risk

    Downstream process integration

    • Fed into the API synthesis chain during the ring formation or side-chain alkylation stage, usually under inert atmosphere conditions
    • Subsequent steps may include purification by distillation and re-crystallization, then integration into downstream API isolation protocols

    Final product types

    • Imidazole-based antifungal pharmaceutical actives
    • Proton pump inhibitor intermediates
    • Anti-inflammatory and anti-infective raw materials
    • Custom small-molecule building blocks for contract manufacturing organizations (CMO)

    5. Functional Additive for Electroplating Brightener Formulations

    Players in the surface finishing industry add this raw material as a brightener component to improve leveling and deposit smoothness in nickel and copper electroplating baths. Its presence controls grain refinement and enhances deposit luster, which is essential in electronics, automotive, and decorative hardware lines where plating consistency determines end-use quality standards.

    Industry compliance standards

    • ISO 4527:2014 (Nickel coatings for industrial electroplating)
    • RoHS Directive 2011/65/EU compliance for electronics substrates
    • IEC 62321 analytical standards (for restricted metals in plating chemicals)
    • GB/T 6463-2018 (China National Standard for Metal Coatings)

    Typical usage ratio

    • 10–200 mg/L bath concentration, adjusted through in-process Hull Cell testing and based on current density, temperature, and plating turnover rates
    • Fine-tuning occurs with variations in bath chemistry and target part geometry

    Downstream process integration

    • Dosed directly into the plating bath during system make-up or replenishment, followed by agitation to ensure uniform dispersion
    • Technicians may add in micro-doses during production shifts for line stability

    Final product types

    • Bright nickel-plated fasteners and fixtures
    • High-gloss copper-plated connectors and terminals
    • Decorative hardware for automotive and appliance markets
    • Electronics connectors with precision plating requirements
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    Certification & Compliance
    More Introduction

    N-(3-Aminopropyl)-Imidazole: Advancing Chemical Manufacturing and Application

    Introduction to N-(3-Aminopropyl)-Imidazole

    Tucked quietly among the specialized raw materials we produce, N-(3-Aminopropyl)-Imidazole stands out for its versatility and performance across many industrial tasks that demand reliability and precision. We synthesize this compound in-house, starting with carefully selected imidazole and guided by decades of accumulated knowledge about reaction pathways, temperature control, and batch consistency. What we have seen, year after year, is that this product gets picked up by people who know it by its utility in the lab and the plant, not just by a catalog number.

    Our Approach: Consistency and Clarity in Production

    Every batch of N-(3-Aminopropyl)-Imidazole we turn out reflects many conversations with customers and fellow chemists. We have learned that trace impurities can create downstream headaches in applications like epoxy curing, specialty coatings, textile resins, and certain pharmaceutical intermediates. Our distillation and purification steps aim for a minimum purity of 99 percent by assay (GC), ensuring reliable results whether this compound serves as a linker, a catalyst, or a synthetic precursor. Batch-to-batch consistency is not an afterthought; it is a habit that has grown from first-principles process development, with real-world application always in sight.

    Model, Physical Characteristics, and Packaging Insights

    We supply N-(3-Aminopropyl)-Imidazole in crystalline or liquid form depending on customer process needs. Our teams have extensive first-hand experience with the slight but tangible way residual moisture, storage temperature, and container selection influence product longevity and reactivity. Having seen customers run into issues with substandard product packed in inappropriate materials, we go with high-density polyethylene bottles or lined steel drums that hold up in real working environments and during long-distance transport. Weight and packaging sizes usually vary from a few kilograms for R&D and pilot trials to bulk containers for established industrial flows.

    Chemical makers set themselves apart through a transparent approach to technical support. Our own knowledge base, cultivated by direct feedback from polymer chemists, surface scientists, epoxy formulators, and resin developers, has forced us to look beyond the immediate sale. Common questions—solubility in mixed solvents, long-term storage at various humidity levels, behavior when mixed with reactive epoxies—shape our own ongoing quality checks. These regular exchanges guide incremental tweaks in handling and logistics, which ultimately reduces noise in performance data on the customer’s side.

    Where Reliability Matters: Practical Uses of N-(3-Aminopropyl)-Imidazole

    Taking a frontline view, one thing that regularly comes up is the role of N-(3-Aminopropyl)-Imidazole as a curing agent and accelerator in epoxy resin systems. Resin formulators have shared with us that this compound yields a blend of rapid cure rates and long-term mechanical stability unmatched by simpler amines. The molecule’s dual functionality – with both an imidazole ring and a flexible amine chain – lets it kick off polymerizations at moderate temperatures and reinforces the finished product with additional crosslink points. Anyone making high-performance adhesives, composite matrices, or specialty coatings recognizes the advantage right away: a quicker process, more control, and a reduction in process errors stemming from stray moisture or residual acid scavengers.

    On the electronics front, epoxy encapsulants cured with our N-(3-Aminopropyl)-Imidazole consistently report improved resistance against thermal cycling, vibration, and microcracking compared to formulations using just aliphatic or aromatic amines. The imidazole framework stands up well through baking or soldering, and feedback from PCB manufacturers often cites a lower rate of field failures when this curing system is in play. We regularly consult with engineers who debug these assemblies in real time; their reports underscore the value of attention to trace basicity, particle size, and purity in the curing agent supply chain.

    The compound steps beyond epoxies into textile and fabric treatment, where its amine functionality makes it a strong anchor point for binding specialty resins to cellulose fibers. Textile chemical engineers aiming to raise abrasion resistance, dye ability, or antimicrobial properties have looked for ways to introduce new linkages at a molecular scale. In practice, we’ve supplied N-(3-Aminopropyl)-Imidazole to pilot runs where it becomes part of a finishing bath or is grafted onto fibers, with reports often noting improved wash-fastness and fiber resilience.

    Over time, as the technology in water purification and bioprocessing advanced, N-(3-Aminopropyl)-Imidazole found a foothold as a building block in chelating resins and affinity media. Its bifunctional nature – basic nitrogen on both the imidazole ring and the aminopropyl chain – lets users tweak metal ion coordination, particularly for the separation or purification of transition metals and bioactive molecules. Having worked with teams scaling up these processes, we understand the drainage rates, swelling properties, and performance in repeated use cycles all hinge on the initial purity and molecular structure of the building block. Precision in synthesis does not just prevent product recalls; it shapes successful, long-term partnerships with the biotech and mining industries.

    Direct Comparisons: N-(3-Aminopropyl)-Imidazole and Other Amine-Based Additives

    Chemists often ask us—why choose N-(3-Aminopropyl)-Imidazole over simpler amines, basic imidazoles, or bulkier polyamines? Based on the feedback and field data, the clear distinction lies in reactivity control and product outcome. Straight-chain alkyl amines like ethylenediamine or triethylamine show strong nucleophilic power but lack the structural stability and thermal resistance brought by the imidazole ring. We’ve participated in numerous benchmarking studies where two-part epoxy systems, cured with either straight-chain amines or our compound, end up with noticeably different gel times, flexural strengths, and long-term yellowing under UV exposure.

    Some users have tried imidazole itself or 2-methylimidazole as accelerators or curing agents, typically drawn in by the lower cost or ready availability. Our process trials and customer feedback underline a key difference: N-(3-Aminopropyl)-Imidazole brings two reactive sites separated by a flexible propyl chain, giving much finer control over crosslink density and distribution. This flexibility gives formulators a unique tool for tuning glass transition temperatures in rigid laminates or improving adhesion between incompatible layers in composites and coatings. In pharmaceutical and fine chemical synthesis, the compound can act as both a base and a nucleophile, making it valuable in multi-step synthesis routes where intermediate selectivity or protection/deprotection steps matter.

    In several customer trials focused on corrosion inhibitors for oilfield and pipeline applications, N-(3-Aminopropyl)-Imidazole demonstrated a balanced affinity for both polar and non-polar environments. Where other amine-based inhibitors sometimes fall short under variable temperature or saline conditions, our compound holds its protective film longer, likely due to the combined action of imidazole ring pi electrons and the flexible aminopropyl chain anchoring to metal surfaces. Specialists using this approach have reported measurable reductions in maintenance cycles and shutdown rates in challenging field conditions.

    Supporting Modern Chemistry: Regulatory, Environmental, and Safety Considerations

    Every product’s relevance evolves with shifts in regulatory attention and environmental responsibility. Our N-(3-Aminopropyl)-Imidazole production process pays strict attention to compliance with major global frameworks—REACH, U.S. TSCA, and related chemical control statutes. Years of dialogue with environmental health and safety teams have shaped the way we control trace byproducts, manage effluent, and train staff in proper handling. No matter the intended application—curing agent, resin functionalizer, or pharmaceutical intermediate—traceability and documentation always travel with the product. We have seen firsthand how incomplete documentation from other suppliers leads to delays and complications in customs, audits, or customer certifications.

    Spills, leaks, and improper mixing remain possible risks wherever chemicals are handled. Because N-(3-Aminopropyl)-Imidazole combines strong amine reactivity with the moderately basic nature of imidazoles, we provide detailed use protocols based on both published data and in-house experiments. Our teams contribute to safety training for some of our largest customers, covering the difference between handling a neat liquid versus a blend, personal protective equipment choices, and emergency response planning adapted to the chemical’s specific reactivity. Over the last decade, we have shifted to closed-system transfer wherever possible, reducing airborne exposure and the chance of environmental release not just for ourselves but for our partners downstream.

    On the environmental front, questions about biodegradability, bioaccumulation, and aquatic toxicity govern the use of all specialty amines. Our research and customer field tests continue to monitor how small-scale spills or waste stream discharges behave in both industrial water treatment and open environments. In practice, the rapidly degradable profile of N-(3-Aminopropyl)-Imidazole in aerobic water systems, combined with our commitment to responsible disposal recommendations, lessens long-term risks. For customers in sensitive markets—water treatment, agrochemicals, and paints—we keep open dialogue lines to ensure that usage stays within evolving regulatory guardrails.

    Real-World Partnerships: Learning from Users and Hands-On Problem Solving

    Manufacturing specialty chemicals means joining a feedback loop with everyone who relies on the product. Many of the biggest gains we have made in batch reliability or impurity control stem directly from end user observations. Technical teams in high-volume resin factories have pointed out how gel time drifts with humidity or holds up under extreme temperatures; coating formulators detail subtle changes in finish under different cure atmospheres. Each claim, whether positive or critical, feeds back into our own lab routines and process optimization.

    We sit down several times a year, in person or virtually, with users testing out new applications. In one case, a developer of lightweight carbon composites suggested adjusting our drying protocol to cut trace solvent levels. After several pilot runs and iterative testing, the change increased not just the shelf life of the resin mixture but also the baseline strength of the composite after cure. Another time, a pharmaceutical research team faced difficulty removing color bodies in their intermediate, which led us to verify all solvent wash and recrystallization steps—resulting in a colorless, higher-purity batch that simplified their downstream isolation.

    Through these continued exchanges, we stay relevant by merging textbook chemistry with on-the-ground troubleshooting. Having our own analysis teams and synthesis groups in direct contact with the people using N-(3-Aminopropyl)-Imidazole for everything from adhesives to ligand synthesis helps ensure that nobody’s demand gets lost in translation. Updates to process parameters, packaging types, or impurity reporting come out of this steady cycle.

    Ongoing Innovation: Supporting the Next Generation of Applications

    From our vantage point, reliance on N-(3-Aminopropyl)-Imidazole will only deepen as complex chemical processes become more interconnected. The rise of 3D printing in electronics has drawn renewed interest in chemical settings where quick cure and high purity prevent print deformities. Green chemistry initiatives push formulators to turn to agents that perform well even in water-based or solvent-free systems—a segment where our product has demonstrated unique performance, confirmed in several pilot and scale-up trials.

    We have backed R&D projects developing new functionalized polymers and surface treatments based on this molecule, working out reactivity profiles and compatibility with other specialty monomers. Consistent feedback points to the product’s utility as both a base and a nucleophile, which speeds up certain multi-step synthetic routes and reduces the need for additional base additives.

    Pharmaceutical application spaces continue to call for ligands and linkers that combine solubility with selective reactivity—areas where N-(3-Aminopropyl)-Imidazole gives process chemists a flexible scaffold for downstream customizations. Programs aiming to make new metal chelators, affinity purification systems, or drug conjugates regularly draw on our hands-on guidance in product selection and handling.

    Industry Trends and Challenges: Navigating a Changing Market

    Over many cycles of booms and slowdowns, the chemical industry evolved its appetite for specialized amine-imidazole structures. Supply chain stability, raw material security, and regulatory pressure have reshaped sourcing and operation patterns. By focusing on in-house synthesis of N-(3-Aminopropyl)-Imidazole, we cut reliance on external intermediates vulnerable to uncertain pricing or transit disruption. Our own procurement team watches global market trends on precursor chemicals—such as chloroalkylamines and imidazole bases—so that we stay ahead of bottlenecks.

    One recurring challenge for our users remains maintaining technical advice and sourcing reliability as new certifications, auditing requirements, and sustainability reporting become the norm. For instance, partners in the electronics and coating sectors now ask for life-cycle data and environmental impact profiles alongside purity and assay sheets. To address these shifts, we invest in new analytics and reporting software that integrates chemical registration, performance analytics, and customer service into a single package. We train our staff to speak both the technical language of the laboratory and the regulatory vocabulary of compliance documentation—an approach that lightens the communication load for our customers.

    As countries expand restrictions on volatile organic compounds and mandate greener production routes, the flexibility of N-(3-Aminopropyl)-Imidazole opens up new process pathways for waterborne and low-emission applications. Our development chemists continually explore new formulation blends, focusing on how this amine-imidazole compound integrates into resin matrices, adhesives, and novel coating systems without driving up process emissions or complicating post-use processing.

    The Value of Direct Manufacturer Partnership

    Supporting our customers with N-(3-Aminopropyl)-Imidazole goes far beyond filling orders. Our team includes people who have worked on resin production lines, formulated protein purification protocols, and stood on shop floors diagnosing issues alongside plant engineers. By being involved from synthesis through post-delivery support, we create products informed by actual experience, and not theoretical optimization alone.

    The relationships we have built make a difference—whether it means rushing a fresh batch to a pilot plant testing a breakthrough process, or following up with end users to gather real performance data for the next formulation tweak. Year after year, this grounded, consistent way of working shapes how N-(3-Aminopropyl)-Imidazole earns its place in demanding, fast-changing industries. Our future improvements will keep coming from this cycle of listening, supporting, and innovating with the people who count on our product every day.