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N-(1-Cyclohexen-1-Yl)Morpholine

    • Product Name N-(1-Cyclohexen-1-Yl)Morpholine
    • Alias Morpholine cyclohexenyl
    • Einecs 629-661-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    947645

    Productname N-(1-Cyclohexen-1-Yl)Morpholine
    Casnumber 670-37-1
    Molecularformula C10H17NO
    Molecularweight 167.25
    Appearance Colorless to pale yellow liquid
    Boilingpoint 253-255°C
    Density 1.01 g/mL at 25°C
    Refractiveindex 1.501-1.503
    Flashpoint 110°C
    Solubility Soluble in organic solvents
    Purity Typically >98%
    Smiles C1CCC(=CNC2CCOCC2)CC1
    Inchikey BZNUBQXHBJWVCU-UHFFFAOYSA-N

    As an accredited N-(1-Cyclohexen-1-Yl)Morpholine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g amber glass bottle, tamper-evident cap, labeled with chemical name, hazard warnings, batch number, and manufacturer’s logo.
    Shipping N-(1-Cyclohexen-1-Yl)morpholine is shipped in tightly sealed containers under ambient conditions. Proper labeling is ensured for safety and regulatory compliance. The chemical is transported in accordance with relevant hazardous material regulations, protecting it from moisture, heat, and physical damage during transit. Shipping includes appropriate documentation and handling instructions.
    Storage N-(1-Cyclohexen-1-Yl)morpholine should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances (such as oxidizing agents and acids). Keep the container tightly closed when not in use. Store at room temperature and avoid exposure to moisture. Ensure proper labeling and follow all applicable chemical storage regulations and safety guidelines.
    Application of N-(1-Cyclohexen-1-Yl)Morpholine

    Applications of N-(1-Cyclohexen-1-Yl)Morpholine in Industrial Manufacturing

    N-(1-Cyclohexen-1-Yl)Morpholine serves as a specialized intermediate in several advanced chemical sectors. Our manufacturing clients rely on its unique cycloalkenyl and morpholine functionalities for demanding downstream syntheses where precise performance, regulatory consistency, and clean reactivity are essential. Below we outline real-world B2B application fields that utilize this compound, detailing industry compliance, practical formulation guidelines, process integration roles, and the specific finished goods produced as a result.

    1. Pharmaceutical Intermediate Synthesis

    N-(1-Cyclohexen-1-Yl)Morpholine acts as a core intermediate in the multi-step synthesis of piperidine- and morpholine-based active pharmaceutical ingredients, particularly those targeting central nervous system disorders. API manufacturers utilize its defined reactivity for cyclization and heterocycle-derivatization steps, where controlled purity and structurally consistent intermediates directly impact yield and downstream regulatory documentation. Our direct supply to top pharmaceutical sites ensures full backward traceability and batch-specific documentation for regulated process validation.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • EMA and US FDA regulations for API intermediates (21 CFR 210/211)
    • USP/Ph. Eur. for residual solvent and impurity control in process streams
    • REACH registration with toxicological dossiers for workplace safety

    Typical usage ratio

    • Ranges from 2% to 8% molar ratio relative to target intermediate, adjusted according to specific API synthetic route and batch scale

    Downstream process integration

    • Introduced during closed-vessel synthesis after initial carboxylation or amidation step; critical cyclization conducted under controlled temperature and pH for hydrolytically sensitive APIs

    Final product types

    • CNS-active ingredient intermediates
    • Morpholine/piperidine-based anti-psychotic or anti-hypertensive API precursors
    • Patent-protected small molecule leads
    • Advanced intermediates for future downstream contract manufacturing

    2. Agrochemical Synthesis

    Our customers in the crop protection sector incorporate this compound into selective insecticide and fungicide production, where ring-modified morpholine units play a decisive role in yield and eco-toxicology profiles. Process chemists rely on its reactivity in one-pot condensation strategies, minimizing side product formation and supporting efficient purification via crystallization or chromatographic techniques.

    Industry compliance standards

    • FAO/WHO specifications for technical active ingredients
    • European Union Regulation (EC) No 1107/2009 for plant protection products
    • Globally Harmonized System (GHS) Hazard Labelling
    • ISO 9001:2015 certified QC analytics for batch release

    Typical usage ratio

    • Used at 4-12% w/w in intermediate stage, adjusted based on required active moiety and downstream conversion factor to technical concentrate

    Downstream process integration

    • Feedstock addition to reaction vessel post-alkylation step; typically enters condensation sequence leading to fungicidal or insecticidal ring system finalization, with subsequent in situ workup

    Final product types

    • Morpholine-functionalized insecticide concentrates
    • Selective wheat and rice fungicides
    • Registered technical-grade crop protection APIs for seed treatment
    • Pre-formulated dispersible powders and SCs (suspension concentrates)

    3. Rubber Accelerator Production

    Chemical processors depend on N-(1-Cyclohexen-1-Yl)Morpholine as a tailored intermediate for rubber vulcanization accelerators, particularly where selectivity in cross-linking and batch repeatability are necessary for technical rubber goods manufacturers. It allows for the synthesis of novel thiazole- and sulfenamide-type accelerators with improved thermal stability and reduced nitrosamine formation, complying with current global automotive standards.

    Industry compliance standards

    • ISO 9001:2015/ISO 14001:2015 for process chemicals
    • Automotive OEM material standards (e.g., VW 50180, SAE J200)
    • EU REACH Annex XVII for restricted substances in elastomer compounding
    • US EPA SNUR (Significant New Use Rule) for process intermediates

    Typical usage ratio

    • 1.5%–5% of masterbatch weight during solution polymerization accelerator precursor preparation, variable by final rubber application (tyres, gaskets, technical elastomers)

    Downstream process integration

    • Charged directly into reaction with sulfenyl chloride source after initial aromatic amine formation; incorporated prior to final blending with sulfur and fillers in the accelerator masterbatch line

    Final product types

    • High-performance sulfenamide rubber accelerators
    • Thiazole-based process aids for tire manufacturing
    • Low-nitrosamine technical rubber compound ingredients
    • ESBR, NR, and EPDM blended rubber articles for automotive and industrial use

    4. Specialty Polymer Modification

    Manufacturers producing functionalized engineering plastics and elastomers often add cyclohexenyl morpholine derivatives during polymer backbone modification. This approach permits targeted changes to flexibility, chemical resistance, and dye absorption profiles in high-value performance resins, supporting advanced applications in automotive interiors, electrical insulation, and specialty coatings.

    Industry compliance standards

    • UL 94 Flammability Standard for Plastics
    • RoHS (Restriction of Hazardous Substances) Directive 2011/65/EU
    • EN ISO 1043 polymer nomenclature guidance
    • ASTM D638 and D257 for mechanical and electrical testing

    Typical usage ratio

    • Typically 0.5%–2.5% by weight of total monomer feed; adjusted depending on final copolymer structure targeted for specific property enhancement

    Downstream process integration

    • Injected as a co-monomer or chain modifier during melt-phase or solution polymerization; integration occurs prior to molecular weight cutoff and pelletization steps

    Final product types

    • Modified polyamides and specialty polyurethanes
    • Impact-resistant engineering thermoplastics
    • Conductive and antistatic resin formulations
    • Custom polymer elastomers for electronics and automotive interiors

    5. Advanced Organic Electronics Synthesis

    Within the organic electronics sector, qualified manufacturers deploy this compound for synthesizing precursors to certain OLED and photovoltaic polymers. The morpholine ring introduces electron-donating properties essential for modulating polymer bandgap and charge transport, directly influencing device efficiency and operational lifetime during mass production of electronic-grade materials.

    Industry compliance standards

    • IPC-4101 standards for substrate and polymer film quality
    • REACH Substances of Very High Concern (SVHC) compliance for electronics materials
    • RoHS and WEEE Directives for end-of-life management
    • Electronics-grade QC (total organic/metallic impurity thresholds)

    Typical usage ratio

    • Between 1.0%–3.5% by weight in monomer mixture, precisely metered according to target molecular design and conductivity requirements

    Downstream process integration

    • Fed into heteroatom-rich monomer synthesis for subsequent polymerization; the compound reacts with halogenated aromatics and is purified by vacuum distillation prior to spin-coating or ink formulation for device fabrication

    Final product types

    • OLED display and lighting polymer precursors
    • Organic photovoltaic active layer reactants
    • Thin film conductive coatings for smart card and sensor manufacturers
    • Electroluminescence-modified polymers for flexible device substrates
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    Certification & Compliance
    More Introduction

    N-(1-Cyclohexen-1-Yl)Morpholine: Consistency and Value from a Chemical Manufacturer

    Direct Experience with N-(1-Cyclohexen-1-Yl)Morpholine

    Working in chemical manufacturing, a few compounds challenge our production teams with their peculiarities and yet reward us with reliable end results. N-(1-Cyclohexen-1-Yl)morpholine, a specialty heterocyclic amine, has become a staple in our specialty chemicals range due to its functional reactivity profile and clear niche advantages over similar intermediates. Each batch brings tangible proof of what careful attention and tight process control can achieve. Day after day, our reactors and separation columns turn out material that meets benchmark purity and performance.

    Manufacturing at scale only works when the teams handle every step, from raw material inspection to the final filtration. Our plant has documented decades of refining the cyclohexene-morpholine pathway, investing in process improvements to enhance yield and cut down on byproducts. Years of erratic supply prompted in-house efforts to design vessel coatings and agitation rates that resist corrosion and decomposition, all to make sure clients get consistent product every shipment. No middlemen create blind spots here—every lot is traceable to a single process record, overseen by a team who understands these structures better than anyone else.

    Understanding the Chemistry: Proven Pathways, Real Results

    N-(1-Cyclohexen-1-Yl)morpholine blends the rigid cyclohexene ring system with the flexibility of morpholine’s oxygen-nitrogen motif. This combination delivers unique reactivity that downstream users have come to value, especially in custom synthesis or specialty polymer additives. In terms of physical properties, our batches typically register a pale to slightly amber liquid, depending on the precise temperature encountered during distillation. Skilled technicians monitor every drum’s olfactory signature and hue, because small shifts may signal upstream variances—a key detail from years on the production floor.

    Finished product heads to downstream users who look for good stability under storage, resistance to moisture pickup, and reliable dissolution. There is no trade-off between purity and yield because continuous feedback from analytical HPLC and GC units tells us exactly where to tune the steps. Whether for research-scale experimentation or feeding large reactors, the consistency this material brings answers the one concern that matters in a laboratory or pilot plant: Will the building block deliver the same performance every time? Our experience says yes, and the data tracked across hundreds of lots backs that up.

    The Value to Organic Synthesis and Practical Applications

    N-(1-Cyclohexen-1-Yl)morpholine attracts strong interest from process chemists because the cyclohexenyl group opens doors to selective functionalization. Our close work with customers in pharmaceutical development taught us that even small impurities or inconsistent reaction profiles can waste weeks of research. Not all amines live up to their specification sheets once inside a reaction flask, but this molecule, made under careful heat control and minimized hold-up time, retains the activity needed for key steps in amide coupling and modification of active rings.

    Feedback from advanced materials teams shows another dimension—this compound offers morpholine’s electron-donating properties but with extra hydrocarbon bulk. That makes it a favorite where precise tuning of reaction selectivity and solvent compatibility matter. We regularly help customers transition from other aminocyclohexene intermediates, and it’s clear that this molecule’s improved solubility and lessened volatility provide measurable advantages in large-scale blending and dosing.

    More than a Commodity: What Sets This Compound Apart

    Years in chemical production taught us how the smallest structural shift in a molecule can mean the difference between reactivity and stability. N-(1-Cyclohexen-1-Yl)morpholine doesn’t just sit in the middle of the morpholine and cyclohexene family—its precise bonding delivers a unique set of properties. This compound resists oxidation better than several other cyclohexenyl amines, lasting longer even in less-than-perfect atmospheric conditions. Our plant’s closed-system handling has reduced off-spec shipments to near-zero, as confirmed by long-term clients who keep coming back for reliable supply and transparent quality records.

    When lined up against other secondary amines, N-(1-Cyclohexen-1-Yl)morpholine excels in reactions where you want a moderate base and mild nucleophile without intense odors or hard-to-handle viscosity. Production-scale users tell us this single profile cuts back on the number of process steps in synthesis chains, shaving off days of development time. In contrast, simpler morpholines lack the ring structure’s extra conformational rigidity, while other cyclohexenyl amines often arrive as unstable mixtures or degrade more quickly on the shelf. Every production run emphasizes the details—right reagent addition rates, refining the distillation setup, and calibrating the sensors for tight thermal management.

    Specifications Anchored in Real Experience

    Instead of quoting certificates and generic descriptions, our teams put real-world outcomes at the center. N-(1-Cyclohexen-1-Yl)morpholine typically leaves the reactor as a clear-to-pale-amber fluid, free of visible foreign particles, and avoids water pickup through strategic storage in lined steel containers purged with dry nitrogen. Purity above 98% by GC stands as our baseline, with residual morpholine, cyclohexene, and water capped at minimal ppm levels. These numbers reflect our commitment to minimizing side products and maximizing downstream usability.

    Packaging involves more than drums and labels. Every container ships with a tamper-proof seal and a lot number tied to retained samples back in our lab. Customers can and often do request analytical runs on archived samples before taking delivery—a practice we value because it raises the bar for the whole industry. Whether the shipment serves a kilo-lab, pilot suite, or a full production floor, our teams stay in direct contact to quickly resolve any questions about the material’s handling or integration into complex syntheses.

    Listening to Customers, Improving Every Step

    Direct relationships with researchers, process engineers, and formulation chemists drive our plant’s ongoing adjustments. Repeated feedback from those in fine chemical and specialty intermediate fields called for chemical forms with less carryover from synthesis, purer morpholine signatures, and easier filtration. That’s why our latest production upgrades include high-efficiency phase separators and in-situ product stripping to reduce hold time above critical temperatures, boosting both throughput and reliability.

    Some of our longest partnerships trace back to initial troubleshooting—customers facing inconsistent batches from outside sources or grappling with unnecessary downtime switching between similar amines and morpholines. Those exchanges taught us that regular investment in technician training and analytical instrumentation gives us a direct edge. Today, process improvement at our facility involves day-shift teams pairing with R&D groups to review every lot and feed learning right back into how we stage, react, and isolate N-(1-Cyclohexen-1-Yl)morpholine.

    Supply Security Built on Vertical Integration

    So many headaches in the chemical marketplace stem from broken supply chains and poorly communicated logistics. We have solved this by keeping raw material sourcing and most intermediate reaction steps within the same campus. No overreliance on spot traders or single-source vendors means even tight global conditions rarely affect our output. When cyclohexene pricing spiked or morpholine volumes tightened in recent years, our planners drew on in-house stores and robust raw material agreements to keep regular lots rolling out, uninterrupted.

    Longtime customers tell us they count on that stability. In research environments, a single late delivery can delay whole project timelines. In production, unpredictable quality can force unscheduled shutdowns, with much higher costs as a result. Our answer, year after year, is a refocus on owning each step from chemical input to finished good, verifying every intermediate for purity, and running duplicate safety and QC checks. As a manufacturer, this style of risk management doesn’t just support our operations, it directly benefits every user who depends on timely, trustworthy shipments.

    Responding to Shifting Safety and Compliance Expectations

    Few parts of the speciality chemicals sector move as quickly as regulatory oversight. Production managers like us field inquiries from safety engineers on-site and compliance officers worldwide. N-(1-Cyclohexen-1-Yl)morpholine, though not especially hazardous by bulk chemical standards, still draws oversight for workplace exposure and environmental emission. Our policy of full transparency means we respond with recent, batch-specific analytical summaries and maintain open-door access to our production documentation.

    Every improvement in containment, air handling, and loading is a result of collaborating with downstream users who push for safer, cleaner, and more efficient operations. Whether it’s improving valve actuation speed to prevent spills or introducing better PPE for our loading crews, feedback pushes us to invest beyond minimum compliance needs. Over time, these lessons push out into end-user plants as well, supporting safer handling and less environmental concern across the supply chain.

    Side-by-Side with Other Amines and Morpholines

    Customers often ask how N-(1-Cyclohexen-1-Yl)morpholine measures up against pure morpholine or other cyclohexenyl derivatives. Experience in bulk and small-batch syntheses confirms the differences lie not just in reactivity, but in practical aspects like storage lifetime, odor, volatility, and blending. This compound brings increased chemical stability in bottles and tanks, thanks to its sterically shielded amine group—cutting down loss to air and reducing risk of unwanted side reactions during storage.

    Unlike morpholine itself, which can flex into various chemical roles but sometimes introduces excess water or strong basicity, this product tempers those features with the bulk of the cyclohexene ring. For process designers, that means tighter control through a wider pH and temperature range, plus softer handling requirements at the plant level. Compared to closely related amines, our material also avoids nuisance characteristics that plague even modestly sized cyclohexenyl species: namely, residual odor, yellowing, or tendency to degrade in open containers.

    Downstream users in pharma synthesis and material modification notice side reactions drop when switching from unstable or mixed secondary amines to our single-component material. Every time an end user reports greater lot-to-lot reproducibility, it’s a reminder that manufacturing isn’t about bullet points—it’s about day-to-day reliability, thorough communication, and the drive to solve problems as they arise. We watch every metric to keep that promise intact.

    Continuous Improvement from Plant Floor to Loading Dock

    Old habits count in chemical manufacturing, and the teams on our plant floor hold deep knowledge about every connection, valve, and reactor. It’s not just automation or batch records; it’s a culture of direct accountability for the final result. Practice and honest feedback keep our N-(1-Cyclohexen-1-Yl)morpholine shipments ahead of changing customer demands. We rotate jobs regularly, encouraging everyone from new operators to shift leads to propose ways to reduce energy use, boost recovery, or enhance purity.

    Some innovations stem from routine troubleshooting—like reconfiguring isolation to lower solvent loads or running side-by-side comparisons between filter materials. When problems sneak through, our technicians trace everything from incoming drum markings to final fill weights, digging for the root cause and coming back the next day with a better fix. Supporting this hands-on iteration, our analytics lab upgrades instrumentation as needed, not just when replacement cycles demand it but when specific lot concerns call for improved resolution or faster quantitation.

    Setting Standards for Long-Term Partnerships

    Most buyers turn to direct manufacturers not just for price or volume but for hard-earned reputation. Our credibility comes from building a record of reliability, responding directly to challenges and making improvements—whether in process yield, traceability, or on-time delivery—visible to everyone involved. N-(1-Cyclohexen-1-Yl)morpholine now supports dozens of research and industrial operations, and our teams pride themselves on answering technical questions without delay, drawing on plant history rather than marketing platitudes.

    It’s not about being perfect, but about tracking every detail that matters: temperature excursions, minor color changes, customer feedback on filtration times, downstream impurity profiles. These data points shape next week’s production run and keep our staff—some here for decades—invested in the company’s future as a trusted chemical manufacturer. Success, for us, lies in every perfect delivery, every lot that meets spec the first time, and every new insight that leads to more efficient, safer, and more sustainable production.

    Challenges and Future Directions in Specialty Amines

    Demand for N-(1-Cyclohexen-1-Yl)morpholine has grown alongside trends in custom synthesis, polymer science, and pharmaceutical innovation. Minor impurities or a missed delivery create ripple effects—so we work with each customer to forecast needs, adjust run sizes, and build redundancy into storage and shipping. Unlike trading operations, our planning stretches over years, not months.

    Supply risk management is a continuous challenge. Macro shifts in feedstock markets, regulatory changes, or advances in synthetic routes sometimes call for rapid change to our production routines. Rather than standing still, our technicians and chemists track literature for emerging reaction methodologies, monitor in-house pilot projects, and keep an open ear to what customers find as bottlenecks. Lessons from one field (such as catalysts for amination) often cut costs or improve turnaround in another.

    Continuous improvement isn’t a buzzword in our plant; it’s necessary just to keep up. Routine reviews look at waste minimization, energy use, and process water reclamation. Regular training for every shift means we notice anomalies before they escalate and respond to inquiries with clarity—a real advantage when working with partnerships that rely on agility and direct communication.

    Why Direct Manufacturing Makes a Difference

    N-(1-Cyclohexen-1-Yl)morpholine doesn’t reach its full value through paper descriptions or abstract claims. Its worth appears in real-world reaction yields, the way it helps new syntheses graduate from lab to plant, and the satisfaction of buyers who trust every drum and bottle will match the last. The journey from raw materials to packaged final product demands focus, innovation, and close attention to the needs of both internal teams and end users.

    Real-world challenges bring out the best in a responsive manufacturer. Decades of evolving with customer needs—from tighter purity specs to repeatable blending properties and improved product handling—prove that a material’s quality is shaped as much by the people making it as by the underlying chemistry. We rely on open conversations with our buyers, relentless process review, and a commitment to data-informed improvement. Every success story—a troubleshooting breakthrough, a more robust process, a new application field—cements the reasons why direct manufacturing, with all its risks and rewards, drives excellence and sets true chemical partners apart.