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Methylurea

    • Product Name Methylurea
    • Alias N-methylurea
    • Einecs 203-483-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    407565

    Chemical Name Methylurea
    Molecular Formula CH4N2O
    Molar Mass 60.06 g/mol
    Cas Number 598-50-5
    Appearance White crystalline solid
    Melting Point 106-110 °C
    Boiling Point Decomposes before boiling
    Solubility In Water Freely soluble
    Density 1.27 g/cm³
    Synonyms N-methylurea
    Odor Odorless
    Ph Value Approximately neutral (aqueous solution)
    Refractive Index 1.482 (20 °C)
    Storage Conditions Store at room temperature, in a dry place

    As an accredited Methylurea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methylurea is packaged in a sealed 25 kg fiber drum with an inner polyethylene liner, labeled with hazard and handling instructions.
    Shipping Methylurea should be shipped in tightly sealed, labeled containers, protected from moisture and incompatible substances. It is typically transported as a non-hazardous chemical under normal conditions. Follow applicable regulations, ensure proper ventilation, and avoid exposure to heat or flame during transit. Consult the Safety Data Sheet (SDS) for detailed handling and shipping instructions.
    Storage Methylurea should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and clearly labeled. Protect from moisture and direct sunlight. Use appropriate chemical-resistant containers to prevent leakage or contamination. Follow all safety guidelines and local regulations for chemical storage.
    Application of Methylurea

    Applications of Methylurea in Industrial Manufacturing

    Methylurea serves as a specialized chemical intermediate in several value-added industrial sectors. Our expertise as a direct manufacturer ensures strict quality management and traceable supply, supporting critical applications where material purity, compliance, and production consistency are essential.

    1. Pharmaceuticals: Intermediate for Antihypertensive Drug Synthesis

    Pharmaceutical manufacturers use methylurea as a key intermediate in the synthesis of several active pharmaceutical ingredients, notably in antihypertensive medications and some diuretics. Our high-purity grades comply with international pharmacopoeias to meet process validation and regulatory registration worldwide. Typical use requires control of isomer content and low levels of heavy metals, supporting large-scale API (Active Pharmaceutical Ingredient) production in batch or semi-continuous reactors.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • China Drug Master File (DMF) requirements

    Typical usage ratio

    • 0.75 to 1.2 molar equivalents relative to target API core (adjusted per route and stoichiometry)
    • Isolated process batch sizes up to several hundred kilograms

    Downstream process integration

    • Charged as an amine component in condensation or alkylation reactions
    • Introduced post-nitration or halogenation when forming complex heterocycles
    • Handled under controlled temperature with water-free conditions to maintain reactivity

    Final product types

    • Antihypertensive pharmaceuticals (finished tablets or capsules)
    • Diuretic formulations
    • Pharmaceutical intermediates for export or further synthesis

    2. Agrochemicals: Synthesis of Urea-Based Herbicides

    Producers of urea-based herbicides employ methylurea in the production of selective and non-selective weed control agents, especially where controlled release or targeted degradation is required on agricultural land. The raw material enters the process prior to ring formation and post-reaction purification requires advanced waste minimization measures due to environmental regulations.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Test Guidelines for Chemical Safety
    • REACH Regulation (EC) No 1907/2006
    • China GB2763 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • 1.0 to 1.5 mole per mole active ingredient precursor
    • Adjusted according to targeted efficacy and crop safety profile

    Downstream process integration

    • Added during early acylation or cyclization phase in herbicide backbone synthesis
    • Used in pilot reactors to evaluate environmental impact before scaling
    • Blended in closed systems to prevent operator exposure and cross-contamination

    Final product types

    • Selective urea herbicide granulars
    • Suspension concentrates for field application
    • Custom pre-emergence and post-emergence herbicides

    3. Resin Manufacturing: Modifier Component in Melamine-Formaldehyde Resins

    In high-performance coatings and laminates, methylurea modifies melamine-formaldehyde and urea-formaldehyde resins, improving flexibility, curing speed, and crosslink density. Our product supports production lines where resin flow time and formaldehyde content require precise management to maintain uniformity, adhesion, and low emission levels in the final product.

    Industry compliance standards

    • EN 13986: Emission of formaldehyde from wood-based panels
    • ASTM D5055 for MDF and Particleboard Quality
    • ISO 9001:2015 for production management
    • EPA TSCA Section 6(h) for formaldehyde emissions

    Typical usage ratio

    • 3 to 8% by mass relative to total resin solids content
    • Adjusted for target cure time and flexibility profile during R&D optimization

    Downstream process integration

    • Introduced at condensation stage, after initial melamine or urea mixing
    • Blended under vacuum to minimize formaldehyde vapor loss
    • Sampling and QC confirmation prior to resin advancement

    Final product types

    • Decorative laminates for furniture and flooring
    • Industrial wood adhesives
    • Melamine-based paints and specialized coatings

    4. Water Treatment: Additive in Boiler and Cooling Water Formulations

    Water treatment chemical manufacturers use methylurea as a conditioning additive to control scaling, fouling, and corrosion in industrial boiler and recirculating cooling systems. Proper grade selection ensures consistent solubility, and integration in concentrated blends maximizes stability and distribution within plant piping networks under dynamic flow conditions.

    Industry compliance standards

    • ANSI/ASHRAE 188-2018 for water system management
    • ISO 14001 Environmental Management for chemical manufacturers
    • FDA CFR 173.310 (for steam that contacts food, if applicable)

    Typical usage ratio

    • 10–100 ppm (parts per million) in circulating water systems
    • Field-adjusted based on water hardness and temperature

    Downstream process integration

    • Metered into water streams using programmable dosing pumps
    • Blended with phosphate, amine, or polymeric inhibitors
    • On-site titration for initial dose assessment and correction

    Final product types

    • Mixed boiler water conditioning agents
    • Cooling tower scale inhibitor blends
    • Industrial water treatment concentrate drums

    5. Specialty Chemical Synthesis: Building Block for Fine Chemical Intermediates

    Producers of custom fine chemicals utilize methylurea in the stepwise assembly of nitrogen-containing heterocycles, amides, and other specialty intermediates. Its reactivity toward carbonyls and aromatic substrates allows chemists to tailor chemical libraries for electronics, imaging, or specialty monomer applications, demanding tight specification control and documented chain of custody.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems in chemical synthesis
    • REACH Substance Evaluation for specialty intermediates
    • Custom specification agreements with customer QC labs

    Typical usage ratio

    • Varies by route, commonly 1–1.1 equivalents per coupling step
    • Fine-tuned according to target purity and yield requirements

    Downstream process integration

    • Dosed into high-purity glass or stainless vessels for structure-specific synthesis
    • Employed as a capped intermediate for further conversion
    • Purification via distillation or recrystallization as required by downstream use

    Final product types

    • Electronic chemical precursors
    • Imaging reagent intermediates
    • Specialty monomers for engineering plastics
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    Certification & Compliance
    More Introduction

    Methylurea: A Practical Solution for Industrial Chemistry

    Understanding Methylurea from the Manufacturer’s Perspective

    Here in the plant where chemistry turns to industry, methylurea proves its worth day after day. The synthesis happens by carefully controlling conditions, combining methylamine and urea to yield a compound reliable in its quality and dependable in its behavior. Each batch must meet straightforward, measurable specifications—purity above 99%, low moisture content, and minimal contaminants. These targets ensure our customers see consistency in their formulations, no matter the volume or application.

    Technical Details that Matter

    Our typical technical model of methylurea carries a molecular formula of CH4N2O. Most of our output appears as a fine, white crystalline powder. Solubility in water and simple organic solvents gives it flexibility across many reactions. Melting points land near 110–114°C, as confirmed by frequent in-house testing. This thermal window holds steady batch after batch—one sign of reliable manufacture.

    Color and odor require chemical precision, not just visual inspection. Small changes in raw material purity or process temperature alter crystal appearance and impact downstream results. We see factories that cut corners, producing yellowed or discolored methylurea. Those visual cues always forebode trouble—impurities that clog chemical processes, affect reaction yields, or end up in finished products.

    Real-World Uses that Drive Demand

    Methylurea carves out its place in both large and niche segments. One major outlet remains agricultural chemistry, where smarter fertilizers depend on methylurea’s controlled nitrogen release. We fill railcars headed to companies seeking improved crop growth and lower environmental runoff. The difference is clear in the field: methylurea’s structure slows breakdown, so nitrogen availability aligns with plant needs. Farmers avoid waste and lower groundwater contamination—not a small feat given environmental regulations tightening every year.

    In pharmaceutical circles, methylurea steps onto the production line as an intermediate. Our customers synthesize active drugs and specialty chemicals starting from methylurea because its chemical reactivity sits at a sweet spot: not too reactive to pose hazards or excessive side-reactions, yet not so inert that reaction times climb out of control. Finished pharmaceutical substances require tight impurity controls, so any slip on our part gets flagged fast by downstream quality checks. Avoiding that means repeat orders and long-term partnerships.

    We often receive requests for customized lots for research. Scientists tackling new polymer resins or surfactant blends ask for methylurea because of its versatility. The white powder serves as a backbone in polymer synthesis, enabling new materials with specific hardness or flexibility. These are not abstract applications. Customer feedback loops directly into process tweaks, especially where a slightly higher or lower water content delivers better results in pilot reactors downstream.

    The dye and pigment world puts methylurea to use as a coupling agent, offering brighter, longer-lasting color in textiles and plastics. Consistent product quality means color matches batch to batch—makers of consumer goods see the result directly in product uniformity. Textile processors report fewer batch reworks and dye failures when they insist on high-purity methylurea sourced from reputable plants, rather than generic alternatives where impurity levels sometimes spike.

    Innovation Stems from Reliable Chemistry

    Walking the production floor here means navigating between hardware and process control that modern plants have refined over decades. The core chemistry behind methylurea production rarely changes, but equipment upgrades and strict operational standards make big differences at scale. Automated dosing systems target exact ratios of methylamine and urea; onsite laboratories check every lot before it gets near a warehouse door. We maintain paper and digital records, not just for compliance, but because our own past batches tell us what tweaks lead to more efficient or safer production.

    Many customers ask about “greener” options for methylurea. We have worked with recycled feedstocks and energy recovery techniques to lower the carbon footprint. By using process condensate and minimizing waste streams, the manufacturing footprint improves. Small percentage gains matter when batches run to tons each week. Suggestions from partners, and lessons from pilot projects, often influence our next process improvement.

    Change typically arrives incrementally. Swapping solvents, reducing emissions, or recycling water loops all require trial and measurement. When a tweak works, it gets adopted across the site; when it doesn’t, quality checks catch it before the final product leaves. We learn fastest by collaborating with both customers and suppliers—sometimes raw material changes offer new paths to higher silica tolerance or greater solubility, which downstream users appreciate when scaling up.

    Comparing Methylurea to Other Ureas and Amides

    Within the urea and amide family, methylurea sets itself apart. Standard urea delivers rapid nitrogen release that doesn’t suit every application—crops, for example, can’t absorb all the available nitrogen at once, leading to waste and runoff. By adding the methyl group, methylurea shifts the breakdown timeline, allowing more gradual nitrogen supply. This single tweak to the molecule makes all the difference out in the field and in regulatory compliance reporting.

    In laboratory syntheses, methylurea offers a moderate reactivity profile compared to dimethylurea or unsubstituted urea. Dimethylurea, with two methyl groups, behaves differently in resin and pharmaceutical syntheses, introducing steric effects that alter reaction rates and sometimes block desired product formation. We remark on these differences with each technical support query. If a customer swaps urea for methylurea without changing conditions, their conversion rates may surprise them. Our technical team spends considerable time sorting out these context-driven differences and helping clients optimize usage.

    Compared to formamide, which often substitutes for low-molecular amides in certain processes, methylurea’s water solubility and handling safety offer clear upsides. Full solubility at ambient temperatures lets operators dose and mix without special conditions. Operators appreciate the lower volatility, both for workplace safety and for process control. Plant personnel in both chemical and agricultural settings report fewer complaints and fewer handling hazards when methylurea replaces alternatives, especially in high-throughput settings.

    Regular communications with our clients highlight new application challenges. Downstream processors might encounter precipitation or color changes using other amides, especially once impurities creep in. Methylurea’s stability and consistent performance often solve these problems, leading to cleaner output, easier filtration, and lower rework rates. The impact is measurable—in energy use, waste reduction, and maintenance hours saved.

    Investing in Quality Through Transparency and Rigor

    Our production mindset relies on the discipline of batch-to-batch transparency. For every lot, chemists record process times, temperature profiles, and analytical results. Quality never stands apart from process controls—the close link between frontline operators and laboratory teams ensures feedback moves quickly. By reporting deviations and making adjustments, we keep our product within strict specifications without inflating costs.

    Third-party audits and customer visits happen often here. Prospective partners want to see real operations, talk to production staff, and witness sampling methods. Our approach remains open—years of audits and customer inspections have led to process fortification rather than disruption. Inspection teams often commend the difference a single-layer process, avoiding dependency on brokers or third parties, brings in accountability.

    The demand for traceability grows year by year. Users want digital fingerprints for every shipment, so we provide certificates of analysis with production histories. Years ago, paperwork got filed away with little scrutiny. Today’s clients use these documents to compare consistency across multiple orders and even cross-check against their own process data. This feedback closes a loop, letting us refine reaction conditions and minimize deviations.

    We have found that customer returns offer learning opportunities. In more than one instance, a recurring downstream purity issue led us back to minor equipment fouling in our synthesis step. Instead of treating returns as isolated cases, our approach links plant maintenance, production control, and QA teams in a feedback loop. The best practices gained from such trace-backs often get codified into new SOPs that prevent future recurrence.

    Facing Market Challenges with Flexibility and Trust

    No chemical manufacturing story sails calm waters. Raw material volatility, shifting regulatory environments, logistics, and fluctuating demand shape weekly plans. For methylurea, the input cost of methylamine and urea reflects global price swings—sometimes squeezing margins, sometimes upending supply chains. We manage this by engaging in long-term contracts with reliable suppliers and qualifying at least two vendors per raw material. That backup plan means minor disruptions don’t grind production to a halt.

    Recently, global shipping bottlenecks draw increased attention. Customers expect reliable delivery windows and timely order fulfillment. Our logistics team monitors shipping lanes and warehouse stock so we can absorb short-term pipeline hiccups. We see real differences in customer responses—reliable forecasting and honest communication stand out as the deciding factors for long-term business, not just short-term pricing.

    Local regulations change rapidly, particularly for chemical intermediates subject to classification, environmental permitting, or transportation restrictions. Our compliance staff monitors upcoming changes, engaging with both local and regional authorities. We provide customers with clear guidance on how changes might affect their use, storage, or disposal of methylurea. Staying ahead of regulatory waves builds trust, especially as environmental and worker safety standards elevate year after year.

    We listen closely to downstream users who work in regions with evolving environmental controls. These partners sometimes struggle with legacy waste systems or noncompliant discharge methods. Sharing knowledge on best storage practices, or recommending pre-treatment systems for wastewater, gives our methylurea users practical tools to adapt without costly redesigns. In many cases, practical, field-tested input from manufacturers prevents unnecessary batch failures or fines.

    Partnerships Rooted in Experience and Progress

    From our perspective as direct producers, every ton of methylurea shipped carries the history of its manufacture—raw material traceability, reaction consistency, packaging, and delivery logistics all tied together. Customers who tour our facility, or return year after year with new projects, remind us that trust and capability grow with each solution delivered. We hear about new innovations from users—a new crop input formulation, a novel textile dye, or a more effective pharmaceutical intermediate—and evaluate how our methylurea production can fit into these solutions.

    The market often debates commodity versus specialty chemicals. In our world, what begins as a near-commodity compound can quickly transform into a premium offering through commitment and collaboration. Clients want batch consistency, technical support, and open communication. These stem not from distant offices but from the people who actually run the reactors, monitor the driers, and troubleshoot the pumps. Investing in training, cross-functional teamwork, and responsive customer support builds value and resilience in ways catalog listings or spec sheets never capture.

    Innovation never arrives from isolation. Our relationships with research institutes, process engineers, and product developers feed directly into ongoing plant upgrades. Some of these upgrades focus on efficiency—energy recovery systems, smarter process monitoring, or greener chemical inputs. Others focus on product adaptation—micro-adjustments to dry times, particle size distribution, or impurity removal that matter greatly to particular customers. The feedback cycle extends from the plant to the end-user’s application floor and back again.

    Market pressures and shifting user needs challenge us to stay nimble without sacrificing consistency. By prioritizing investments in core process improvements—better reactant control, more robust moisture management, real-time analytics—we sustain reliability at scale. Collaborative troubleshooting with users uncovers new product development paths, whether for a high-throughput agriculture complex or a laboratory-scale pharmaceutical synthesis.

    Looking Ahead: Meeting Evolving Industry Demands with Confidence

    Future directions for methylurea reflect the broader shape of global supply chains. End users seek products with lower environmental impacts, greater traceability, and flexible supply options. On our end, this means ongoing work on green chemistry initiatives, open communication about sourcing and testing, and readiness to adapt batch production to unique demands. Feedback from the factory floor and the application lab both matter equally in shaping process improvements.

    Change unfolds in stages. Sometimes customer requirements push us to tweak particle size or reduce residual moisture for specific processes. Other times, tightening environmental regulations demand new emission controls or better packaging solutions. We step forward by making these changes incrementally, building each advancement on robust feedback and technical data—never by assumption or on trend alone.

    Across all product grades—standard, high-purity, custom blends—the same core commitments apply. We stand by our methylurea: well-characterized, responsive to process improvements, and tested to clear, documented standards. Each lot leaves our warehouse backed by decades of accumulated manufacturing experience and customer feedback.

    Industry landscapes change, but the fundamental need remains for core materials that can be trusted in both process and final product. We build that trust with transparency, technical expertise, and ongoing engagement—not from a distance, but from a steady presence on the manufacturing floor and direct conversation with users. Those looking for reliable methylurea supply find more than just a chemical—they gain a partnership built on years of doing the work and learning along the way, together.