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Methylbutyric Acid

    • Product Name Methylbutyric Acid
    • Alias isovaleric-acid
    • Einecs 202-652-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    517887

    Chemical Name Methylbutyric Acid
    Molecular Formula C5H10O2
    Molar Mass 102.13 g/mol
    Cas Number 623-42-7
    Appearance Colorless liquid
    Odor Unpleasant, rancid smell
    Boiling Point 176-178°C
    Melting Point -45°C
    Density 0.94 g/cm3
    Solubility In Water Slightly soluble
    Pka 4.81
    Refractive Index 1.415
    Flash Point 74°C
    Synonyms 2-Methylbutanoic acid
    Structural Formula CH3CH2CH(CH3)COOH

    As an accredited Methylbutyric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500 mL amber glass bottle with secure screw cap, safety labeling—hazard symbols, product name “Methylbutyric Acid,” batch number, and purity.
    Shipping Methylbutyric acid should be shipped in tightly sealed, corrosion-resistant containers due to its corrosive and flammable nature. It must be labeled according to hazardous material regulations and transported in well-ventilated vehicles. Avoid contact with incompatible substances and extreme temperatures. Follow all local, national, and international shipping guidelines for chemicals.
    Storage Methylbutyric acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of heat and ignition. Keep it away from incompatible materials such as strong oxidizers and bases. Proper labeling and secondary containment are recommended to prevent leaks or spills. Avoid direct sunlight and protect from moisture to maintain stability.
    Application of Methylbutyric Acid

    Applications of Methylbutyric Acid in Industrial Manufacturing

    Methylbutyric acid serves a specialized role in several industrial sectors, where its function as a flavor precursor, feed supplement, and intermediate with distinct chemical attributes is matched with strict compliance, precise formulation controls, dedicated process steps, and defined final product characteristics. The sections below detail application-specific integration in real manufacturing scenarios.

    1. Food Flavor Formulation

    Food ingredient manufacturers use methylbutyric acid as a key component for creating dairy, cheese, and nut flavors, as it imparts authentic “aged” and “savory” notes in processed food products and seasonings. Professionals in the food flavor sector select this ingredient for natural-identical flavor synthesis, requiring both precise sensory testing and ingredient traceability. The acid is crucial where regulatory agencies mandate food-grade purity and traceability throughout the supply chain.

    Industry compliance standards

    • FCC (Food Chemicals Codex)
    • EFSA Food Flavouring Regulation (EU)
    • 21 CFR 172 (US FDA approved GRAS for flavoring)
    • FSSAI Standards (India)

    Typical usage ratio

    • 0.005–0.05% of finished flavor mixture, adjusted by final flavor intensity requirements and the presence of other acidic modifiers

    Downstream process integration

    • Added during blending of aqueous or oil-soluble phase in flavor compounding
    • Micro-batched in closed-system reactors and subsequently vacuum-stripped to remove unwanted volatiles before bulk mixing

    Final product types

    • Processed cheese flavors
    • Plant-based dairy analogues
    • Savory seasoning blends
    • Snack coatings

    2. Animal Nutrition Additives

    In animal feed manufacturing, methylbutyric acid acts as a palatability enhancer and metabolic energy source, supporting livestock intake and growth performance, especially in ruminant and swine diets. Feed formulators use it in restricted concentrations, balancing between effective intake improvement and compliance with feed additive directives to avoid off-flavors or digestive issues.

    Industry compliance standards

    • EU Regulation (EC) No 1831/2003 for feed additives
    • AAFCO (Association of American Feed Control Officials) feed ingredient definitions
    • FAMI-QS Code (Feed Additive and Premixtures Quality System)
    • China GB/T 1886.191 on feed additive purity

    Typical usage ratio

    • 30–300 mg/kg of finished feed, depending on livestock species and synergistic effect with other organic acids

    Downstream process integration

    • Premixed with mineral carriers or blended as a micro-ingredient prior to steam pelleting or extrusion processes in compound feed lines

    Final product types

    • Ruminant premixes
    • Swine starter feeds
    • Poultry growth-finish feeds
    • Liquid milk replacers for calves

    3. Pharmaceutical Intermediate for API Synthesis

    Chemical synthesis facilities use methylbutyric acid as an intermediate in the manufacture of select active pharmaceutical ingredients (APIs), such as anticonvulsants or certain branched-chain amino acid derivatives. Downstream synthesis processes require controlled release and introduction of the acid under specific temperature and pH conditions to ensure precise molecular incorporation, high purity, and predictable reaction yields to comply with pharmacopoeial monographs.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP-NF Monographs (if listed as excipient or intermediate)
    • EP (European Pharmacopoeia) API impurity standards
    • ISO 9001 for chemical manufacturing traceability

    Typical usage ratio

    • Stoichiometric ratios determined by target API synthesis; typically 0.5–1.2 mole equivalents per batch depending on reaction scale and API yield requirements

    Downstream process integration

    • Dosed directly to acylation or condensation reaction steps for side-chain building or chiral modification
    • Subjected to in-line analytical validation before next-stage purification or crystallization

    Final product types

    • Active pharmaceutical ingredient intermediates for CNS drugs
    • Branched-chain amino acid derivatives for injectable nutrition
    • Specialty pharmaceutical excipients

    4. Fragrance Chemical Synthesis

    In the fragrance industry, methylbutyric acid serves as a core raw material for esterification reactions, yielding characteristic fruity and “creamy” esters used in fine fragrance and personal care applications. Industrial perfumers focus on purity and reproducibility, as even minor process deviations affect the final ester's olfactory profile and compliance with safety and allergen restrictions stipulated by international fragrance organizations.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards
    • REACH (EC) No 1907/2006 (Registration, Evaluation, Authorisation and Restriction of Chemicals)
    • ISO 9235 for aroma chemicals
    • Cosmetic Ingredient Review (CIR) Expert Panel Guidelines (US)

    Typical usage ratio

    • Converted to esters in 1:1 molar ratio within target fragrance precursor synthesis; actual inclusion of the ester in final fragrance at 0.01–0.1% w/w depending on desired note strength

    Downstream process integration

    • Fed to esterification reactors with alcohol substrates in batch or continuous-flow manufacturing
    • Isolated, neutralized, and then introduced to master fragrance compound blending units

    Final product types

    • Fine fragrance compositions
    • Personal care fragrances (body lotions, haircare lines)
    • Room scent diffusers
    • Detergent encapsulated fragrances

    5. Specialty Organic Synthesis for Agrochemicals

    Agrochemical producers integrate methylbutyric acid as a building block for synthesizing certain branched-chain esters used as herbicide intermediates or crop growth regulators. The selection and dosage are determined by reaction specificity and environmental release restrictions, and process engineers ensure tight monitoring of purity and side-reaction control throughout multi-stage synthesis to satisfy agricultural safety and residue regulations.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EPA 40 CFR Part 180 (US pesticide residue tolerance)
    • ISO 17025 for chemical analysis and batch level QC
    • REACH Agrochemical Guidelines

    Typical usage ratio

    • Generally 0.8–1.5 mole equivalents based on intended crop protection molecule; adjusted by synthetic pathway and expected conversion yield

    Downstream process integration

    • Incorporated during the acylation stage for lactone or esterification steps within proprietary agrochemical synthetic routes

    Final product types

    • Herbicide active ingredient intermediates
    • Plant growth regulator precursor compounds
    • Agricultural adjuvant molecules
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    Certification & Compliance
    More Introduction

    Methylbutyric Acid: Real Insight from Our Manufacturing Floor

    Understanding Methylbutyric Acid’s Distinct Role

    At our plant, methylbutyric acid isn’t just another commodity chemical—it represents years of refining process knowledge and hands-on work. Our teams set out to create methylbutyric acid with a focus on real-world consistency, purity, and repeatability from batch to batch. No buzzwords—just a clear, reliable acid with predictable performance in the field. Unlike broader blends or synthesized acids, our approach focuses on prioritizing clarity of specification and chemistry you can actually see and smell; the sharp, characteristic aroma makes it quickly recognizable, helpful for both quality checks and traceability in uses like food flavoring or scent production.

    Clarity in Models and Specifications

    In-house, we’ve held a strict line around our methylbutyric acid’s specifications. We avoid ambiguity—regular bench-marked analysis tallies real purity ranges, typically high at 98% minimum by gas chromatography. We zero out the guesswork with controlled isomer separation, distinguishing between isomers, most notably the 2-methyl and 3-methylbutyric acids. Each one brings its own nuances; 2-methylbutyric acid delivers a grassier aromatic edge, handy for flavoring compounds imitating cheese or ripened fruit, while 3-methylbutyric acid adds more depth and meatiness, essential in savory applications. Every delivery undergoes tight quality checks, including water content controls of less than 0.5%. These measures aren’t window dressing—they cut down on downstream uncertainties for partners relying on safe, reproducible inputs.

    Direct Usage Beyond the Textbook

    Years of collaboration with customers—not just big-name houses, but smaller formulators as well—shape our understanding about how methylbutyric acid lands in real-world production. In food flavorings, just a touch can bring authenticity to synthetic dairy, cheese, and even whiskey notes. It’s never dosed by rote; our customers value the sensory punch this acid brings, far above mere substitutions. In animal feed, our teams learned early on the importance of keeping contaminants and aldehyde levels low, since even small traces can drive off critical feed aromas or complicate mixing.

    Fragrance is another arena where experience makes a difference. Perfume blenders prize our acid for its ability to add creamy, ripe undertones impossible to achieve using broader carboxylic acids or mixes of esters. Their feedback loops into our process—requests for sharper, less fatty profiles led us to update our purification process, moving past the old single-distillation approach. Here, we built a multi-stage stripping system that takes off-light volatiles and raises the batch reliability. Our lab team spends just as long on each batch’s odor profile as they do on analytic metrics; off-notes are immediately flagged for rework.

    Standing Apart from Other Chemical Acids

    Some buyers ask what sets our methylbutyric acid apart from standards such as isobutyric or valeric acid. The answer grounds itself in hands-on utility. Where isobutyric acid lends mostly flat, sour notes, methylbutyric acid brings richer, cheddar-like complexity. Valeric acid veers into harshness at higher inclusion levels; it overwhelms the subtle aspects of dough, cheese, or ripening fruit. Methylbutyric acid strikes a middle ground—providing depth without crossing into overpowering funk or spoilage aromas. Our regular comparison trials, run by both our team and key customers, reinforce this distinction. The unique balance, formed by precise methyl group placement in the carbon chain, ensures recognizable but refined results in finished applications.

    Supporting Partners in Scaling Production

    Our conversations with flavor specialists and feed technologists shape the way we set up each campaign batch. Scale-up always reveals hidden variables—whether it’s reaction heat management, real-time pH drifts, or the quirks of certain reactors—and our staff records these lessons for the next run. Instead of relying solely on instrumentation, on-site operators highlight subtle color shifts or evolving aromas as early warning signals for process drift. We’ve installed additional headspace sampling lines and in-line refractometry, both ideas grown out of batch troubleshooting and feedback from operators on the floor.

    For customers scaling up downstream, simple documents aren’t enough. We provide them with fresh samples from the actual run, not stockroom remnants, allowing their process engineers to run pilot batches that reflect full-scale chemistry. More than one partner flagged minor shifts in volatility at their target inclusion rates, so we supply detailed volatility curves built from our own storage and formulation data. Our team stands ready to troubleshoot on-site if real-world processing throws up any curveballs.

    Regulatory and Safety Foresight

    Methylbutyric acid finds itself under close regulatory scrutiny, especially for food and feed use. Long before finished product testing, our team takes extra steps in upstream solvent selection—rejecting common alternatives that could leave residuals or muddy the final sensory output. For every change in the supply chain, senior chemists run comprehensive impurity checks, covering metals, solvents, and even biogenic amines. We keep heavy documentation on file for end-to-end traceability, since most of our buyers need more than just a single test report.

    On the safety front, we’ve leaned into on-site training and scenario planning. The acid’s strong, piercing odor makes even minor leaks easy to spot, but it’s shipped in specialized, corrosion-resistant containers, and our teams receive regular PPE refreshers. We invest in local fire and containment drills, since strong acids always bring insurance and risk audit attention. These real efforts mean fewer surprises and smooth audits for customers during their own inspections.

    Meeting Real Manufacturing Challenges

    Consistent production of methylbutyric acid means wrestling with more than just raw chemistry. Raw material volatility and the ever-present challenge of feedstock reliability keep our planning dynamic. Sourcing butyric acid of reliable origin can change week to week based on vendor quality or logistics hiccups, so we maintain ongoing parallel supplier qualification. Our warehouse staff knows first-hand that even small impurities in incoming reagents show up downstream at the point of distillation, influencing both yield and aroma profile.

    Waste management also stands as a daily priority. Methylbutyric acid production leaves organic byproducts that need careful neutralization and responsible disposal. We have put closed-loop systems in place, capturing volatile organics and routing usable fractions back into the main reactor stream. For sandy or heavy-metal sludges, our plant sends them off to certified treatment, and our engineers keep detailed logs to spot trends before they become compliance issues.

    Pushing Product Value for Different Sectors

    Each industry segment values methylbutyric acid in its own way. In food and beverage, flavor development teams use our acid in microdosing experiments to tease out maximum character in cheese analogues, baked goods, and plant-based dairy substitutes. Their feedback led us to re-tool our packaging, switching from traditional metal drums to lined, odor-barrier containers that maintained freshness and reduced flavor cross-over during transit. In pet foods and animal feeds, the demand falls heavily on both flavor consistency and safety. Customers in these spaces rely on quick-turnaround certificates and batch-level assurance of contaminant absence—something our in-house micro-lab can deliver in a matter of hours.

    In technical applications such as polymer development, researchers look for performance instead of aroma—here, the clean profile and reliable chain structure of our methylbutyric acid wins out over blends or lower-purity grades. We collaborate with their teams on achieving fine-tuned reaction setups that maximize the acid’s reactivity without introducing unknowns. For every pound shipped, our records include trace logs and contingency plans, since project timelines can hinge on the reliability of each shipment.

    Continuous Improvement Through Practice

    Every production run is followed up by a debrief. Operators, lab techs, and logistics staff gather to share what worked, what didn’t, and what needs re-examining. This cycle led to process upgrades: tighter control loops, more precise weighing systems, and better alignment between shift teams. Correcting even small deviations earlier keeps the acid’s purity and olfactory footprint where customers expect it. These operational tweaks build on each other—our acid today reflects years of this learning-by-doing, and both our sales and QC departments know firsthand the difference it makes out in the field.

    Transparent Sourcing and Local Impact

    Community connections matter. We source a portion of our basic feedstock from regional suppliers, limiting transport time and supporting job growth locally. During global disruptions, our direct connection to these producers kept our lines moving while others faced delays. The mutual feedback loop works both ways; local suppliers see real incentives for hitting our tighter quality targets, since we share data and support long-term contracts rather than spot deals. In effect, the real value cascades to our customers, who benefit from both a lower environmental footprint and the reliability of direct shipments.

    This local integration also pays off in terms of regulatory and auditing transparency. Inspections happen with regularity, so our documentation, batch records, and chain-of-custody are constantly audited. It limits bottlenecks and makes the entire supply chain visible for customers who care about full ingredient traceability. No corners get cut; long-term relationships depend on that transparency.

    Environmental Responsibility in Action

    Nothing about producing methylbutyric acid sits outside the current push for responsible chemistry. Our waste streams face constant review; community members and regulators expect clear proof that production supports—not harms—the local ecosystem. To that end, we track water and energy usage, tweak process steps to minimize solvent use, and reclaim heat for use in ancillary utilities. Several modifications arose out of plant-wide planning workshops involving both long-tenure staff and new hires. Implementing sub-metering not only improved our efficiency, it also helped us zero in on specific process steps that could tolerate lower-energy operation.

    Broader chemical industry trends hint at ‘greener’ product streams, but the lived experience in our plant goes deeper than promotional slogans. The yearly environmental reports we prepare show impacts, improvements, and areas where more work is required—not just the success stories. Partners with sustainability targets draw value from this honest accounting, and it builds trust. Whether the batch heads to food, feed, or technical applications, our emphasis remains on responsible stewardship and minimizing off-site impact.

    Building Trust—One Batch at a Time

    Succeeding in methylbutyric acid production means balancing technical discipline, transparency, and old-fashioned reliability. Customers come back not due to fancy marketing, but because the acid they receive each time lives up to the promises made face to face, not just on digital spec sheets. Our teams trace each success or setback back to real process work: the right raw materials, carefully maintained equipment, and the collective memory of hundreds of batches behind us.

    We don’t claim infallibility. Issues can and do arise—unexpected feedstock variations, shipping mishaps, or last-minute regulatory requests. Our difference lies in meeting these head-on and keeping partners in the loop, adjusting runs or logistics as needed, and learning from the process. That openness forms the backbone of our reputation over the years, whether the end application is a fine food flavor or a critical technical material.

    What Customers Actually Value in Our Acid

    Conversations with our longtime partners confirm that consistent mouthfeel in finished food, reliability in aroma delivery for perfumers, and ease of processing in technical chemistry all benefit from our approach. The strength of the acid’s sensory profile matches its documented purity, and our willingness to roll up sleeves during troubleshooting ensures solutions when challenges appear. Customers don’t need to translate jargon—they get responsive answers and actionable guidelines direct from the engineers running the plant.

    Going forward, the future of methylbutyric acid looks promising for applications pairing flavor authenticity, supply reliability, and tighter regulatory compliance. As we continue to invest in better process controls, environmental mitigation, and customer engagement, we expect to maintain both our standards and those of the industries we serve. For us, every shipment stands as a handshake—one built on substance, not surface.