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Methyl Isonicotinate

    • Product Name Methyl Isonicotinate
    • Alias ARMONIA
    • Einecs 249-376-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    923459

    Chemical Name Methyl Isonicotinate
    Cas Number 2459-09-8
    Molecular Formula C7H7NO2
    Molar Mass 137.14 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 257 °C
    Melting Point −19 °C
    Density 1.16 g/cm3
    Solubility In Water Moderate
    Smell Slight, ester-like odor

    As an accredited Methyl Isonicotinate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 250 grams of Methyl Isonicotinate, tightly sealed with a screw cap and clearly labeled with hazard information.
    Shipping Methyl Isonicotinate is typically shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It should be packaged according to local and international regulations, including proper labeling and documentation. Handle with appropriate personal protective equipment, and ensure transportation in accordance with the applicable hazardous materials guidelines.
    Storage Methyl Isonicotinate should be stored in a cool, dry, and well-ventilated area away from heat, sparks, and open flames. Keep the container tightly closed and protected from direct sunlight. Store separately from incompatible substances such as strong oxidizing agents. Ensure containers are labeled properly and handled using suitable personal protective equipment to prevent accidental exposure.
    Application of Methyl Isonicotinate

    Applications of Methyl Isonicotinate in Industrial Manufacturing

    Methyl Isonicotinate serves as a specialized intermediate and functional agent for select industrial processes. The following application segments reflect real end use markets, drawn from practical manufacturing scenarios and established customer specifications.

    1. Insect Attractant Components for Pest Monitoring Systems

    This material is widely utilized in the production of attractants deployed in agricultural pest monitoring, especially for controlling whiteflies and thrips in open-field and greenhouse environments. Producers blend it into lures used in integrated pest management (IPM) traps to improve capture efficiency. Methyl Isonicotinate acts as a semiochemical, drawing specific insect species without toxicity, supporting regulatory and residue compliance in food-crop settings.

    Industry compliance standards

    • EU Regulation (EC) No 1107/2009 on Plant Protection Products
    • US EPA 40 CFR Part 180.1206 – Exemptions for pesticide chemicals
    • OECD Guidelines for Chemical Testing No. 213/214 – Honeybee acute toxicity
    • ISO 9001:2015 for Lure & Trap Manufacturing

    Typical usage ratio

    • 0.1–1.2% w/w in lure formulations; concentrations are adjusted to local pest pressure and environmental volatility

    Downstream process integration

    • Added during the compounding stage of lure blend production, prior to encapsulation or cartridge filling

    Final product types

    • Sticky insect traps
    • Pheromone dispensers for glasshouse crops
    • Adhesive-based monitoring cards for agriculture
    • Field-use attractant cartridges for horticulture

    2. Intermediate for Pharmaceutical Synthesis of Nicotinic Acid Derivatives

    Manufacturers employ this compound as a key building block in the synthesis of advanced nicotinic acid derivatives, which play a role in the production of vitamin B3 analogues and certain antihypertensive actives. The compound’s purity and batch reproducibility support its acceptance in regulated pharmaceutical ingredient manufacturing environments.

    Industry compliance standards

    • ICH Q7 GMP for API manufacturing
    • USP/NF monograph requirements for starting materials
    • EDQM CEP for traceability in supply chain
    • 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • Used as a limiting reagent; 0.8–1.5 molar equivalents per batch depending on target intermediate

    Downstream process integration

    • Charged to the initial condensation or esterification vessel in API synthesis routes, often prior to hydrogenation or hydrolysis steps

    Final product types

    • Nicotinamide-based pharmaceutical intermediates
    • Active pharmaceutical ingredients (APIs) for cardiovascular therapy
    • Vitamin supplement intermediates
    • Specialty building blocks for API manufacturers

    3. Synthesis Precursor in Agrochemical Active Ingredient Manufacture

    Agrochemical producers use methyl isonicotinate as a specialized precursor in the synthesis of select pyridine-based crop protection actives, such as insecticides and herbicides. Its controlled reactivity and defined impurity profile ensure consistent conversion yields in multi-step synthetic processes for regulated markets.

    Industry compliance standards

    • REACH Registration (EC 1907/2006) for raw materials
    • ISO 14001:2015 Environmental Management during chemical synthesis
    • FAO/WHO specification for technical grade actives (where applicable)
    • GLP (Good Laboratory Practice) for analytical traceability

    Typical usage ratio

    • Inputs range from 0.75–1.3 equivalents relative to the target pyridine moiety; final proportions depend on process yield optimization studies

    Downstream process integration

    • Fed into the main reaction step during active ingredient synthesis, with further processing in purification, crystallization, and formulation

    Final product types

    • Pyridine-based insecticides
    • Pyridine herbicide intermediates
    • Technical-grade crop protection molecules
    • Agrochemical formulation actives

    4. Reference Substance in Analytical Laboratories and Research

    Chemical analysis laboratories and R&D centers rely on methyl isonicotinate as a reference marker and calibration standard for chromatographic identification and quantification of pyridine derivatives and related trace residues. Its stable physical properties and certified purity facilitate analytical method validation for regulatory and forensic tests.

    Industry compliance standards

    • ISO/IEC 17025 Laboratory Accreditation
    • USP General Chapter <621> Chromatography
    • OECD GLP principles for reference materials
    • FDA 21 CFR Part 58 Good Laboratory Practice

    Typical usage ratio

    • 10–100 μg/mL as calibration standard solutions; actual usage depends on detection limits and instrumentation sensitivity

    Downstream process integration

    • Diluted in solvent at the preparation of calibration curves and quality control samples for HPLC, GC, or LC-MS/MS methods

    Final product types

    • Analytical reference standards kits
    • Certified calibration mixtures for chromatography
    • Validation standards for agrochemical and pharmaceutical analyses
    • Trace residue detection kits

    5. Modifier in Polymerization for High-Performance Films

    Some specialty polymer producers use methyl isonicotinate as a co-monomer or functional additive in the controlled polymerization of high-performance films, where targeted alteration of surface energetics or UV resistance is required. Consistent batch purity and low moisture content from the synthesis stage are essential to achieving the desired film characteristics and compliance with material safety regulations.

    Industry compliance standards

    • ASTM D882 (Standard Test Method for Tensile Properties of Thin Plastic Sheeting)
    • RoHS Directive 2011/65/EU (for restricted substance management)
    • ISO 9001:2015 for polymer compounding
    • FDA 21 CFR 177.1390 (for indirect food contact, depending on polymer)

    Typical usage ratio

    • 0.05–0.5% w/w relative to monomer feed in polymer blends, adjusted to optical and barrier property targets

    Downstream process integration

    • Metered into the reactor at initial charge or pre-polymerization stage, followed by extrusion and film casting

    Final product types

    • UV-modified packaging films
    • Specialty anti-static coatings
    • High-barrier multilayer films
    • Functional polymeric films for electronics packaging
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    Certification & Compliance
    More Introduction

    Methyl Isonicotinate – A Manufacturer’s View

    Understanding Methyl Isonicotinate

    Methyl isonicotinate holds a significant place in the toolbox of agricultural and chemical professionals. Here at our factory, we’ve spent years fine-tuning its production to deliver a product that’s both reliable and pure. The compound, which carries the molecular formula C7H7NO2, often goes by the name 4-pyridinecarboxylic acid methyl ester. It’s colorless and comes as a liquid with a distinctly noticeable odor, which users often recognize during handling. Its chemical structure lends itself to a range of uses, but our focus has always been on quality and consistency in each batch.

    Our Approach to Methyl Isonicotinate Production

    The journey of this product, from raw materials to finished goods, demands close scrutiny at each step. We utilize advanced distillation and purification techniques that keep impurities well below the stringent levels required by agrochemical formulators. Every drum or canister that leaves our site meets the specifications that large-scale farms and research institutions expect. These customers have little tolerance for variable quality, and each step in our process reflects that reality.

    Throughout the production run, the molecule’s sensitivity to heat and moisture presents challenges. Keeping the process environment dry and cool ensures the product maintains its chemical stability. Delivering a batch with GC-purity greater than 99% is not just a technical target but a point of pride for the entire team. Our technicians monitor for residual solvents, water levels, and unwanted by-products, knowing even a slight deviation can harm downstream application results. This commitment to control mirrors the standards followed across the top end of chemical manufacturing.

    Application in Agriculture

    Most people who turn to methyl isonicotinate do so for its unique effect on insect behavior. In the field, particularly with fruit crops, controlling pests is essential for both yield and product quality. Methyl isonicotinate doesn’t kill pests outright; instead, it increases their movement and makes them more vulnerable to other crop protection agents. This behavioral manipulation has practical value: combining it with insecticides helps improve how thoroughly pests come into contact with active ingredients, ensuring more effective management.

    This practical role has driven demand among growers looking for alternatives to broad-spectrum chemicals. When residues and environmental impact are a concern, this tool gives them a way to reduce reliance on higher-toxicity products. The formulation enables lower spray volumes without reducing performance, and this directly appeals to producers under pressure to show sustainable practices and achieve good market returns on their crops.

    Differences from Comparable Products

    Talking to clients and partners, we often get asked about the difference between methyl isonicotinate and related compounds, such as isonicotinic acid or some conventional crop protection agents. Many of these alternatives work through highly toxic action—knocking down pests directly. Methyl isonicotinate operates through agitation, not toxicity. That difference shapes everything from handler safety profiles to how regulatory agencies classify the product.

    Some may point to N-methyl isonicotinamide or other methylated pyridine derivatives, but their performance and regulatory pathways differ. Our product stands out because it maintains its specific chemical fingerprint through the production process. That matters to researchers and manufacturers blending their own formulations, since batch-by-batch consistency helps avoid surprises later down the line. In short, we keep the impurity levels and by-product formation much lower than seen in commodity-grade alternatives.

    Supporting Modern Agriculture’s Changing Demands

    Conversations with farm managers and agronomists give us direct insight into what end-users expect. There’s much less patience for crop losses caused by imprecise sprays and more attention on minimizing pesticide resistance. Both drivers have raised interest in behavioral modifiers like methyl isonicotinate. In regions pressured by invasive pests, a product that partners well with insecticides and improves their odds of success is hard to ignore. As a manufacturer, we’re always looking for feedback from users in the field. Their comments guide process improvements—sometimes, adding extra filtration steps or refining distillation cycles responded directly to user input about odor or residual solvent levels.

    Field trials show another benefit: as more growers adopt integrated pest management strategies, they need every tool available. Methyl isonicotinate offers a mode of action that plugs gaps between chemical applications, cultural controls, and biological techniques. A tank mix that spreads evenly and enhances activity across a broad pest population reflects modern pest management strategies that were rare just a decade ago. The fact that methyl isonicotinate fits easily into such approaches points to its practical, results-oriented value.

    Quality Control and Specification

    Our product range includes technical-grade and formulation-grade methyl isonicotinate, each suited for different downstream uses. Careful monitoring during the batch process allows us to maintain purity standards above most regional requirements. Final GC analyses usually demonstrate a purity level of over 99%, with water and acid numbers kept exceptionally low. For researchers or specialty applications, a higher grade is available that reduces trace by-product content below the usual detection limits. This added assurance supports customers developing proprietary blends for overseas markets or registration trials.

    Direct feedback from users told us long ago that stability matters more in some settings than raw purity numbers alone. Users storing or transporting large volumes prefer a product whose performance won’t slip over time, often due to hidden degradation. That’s why all shipments leave protected in tamper-evident packaging and with clear lab results attached. Our attention to moisture control, storage temperatures during distribution, and batch traceability reflects hard lessons learned over years of working closely with farmers and warehouse managers.

    Common Questions and Field Insights

    Many clients ask not just what’s in the drum, but how it behaves in real-world spraying conditions. Some worry about compatibility with other tank additives, or whether methyl isonicotinate might affect equipment or labor safety. Years of collaborating with formulation chemists and mechanized sprayer operators gave us valuable answers. Test results confirm that methyl isonicotinate holds up under the mixing, pumping, and spraying stresses encountered in global field conditions. It remains chemically stable without clumping or precipitating, even after standing in diluted form for hours—a feature especially important to large-scale users who mix big batches.

    Another frequent question centers on odor. While the compound carries a characteristic pyridine-like smell, careful refining and filtering steps in our process minimize any residual sharpness. Some early lots sent out before we made these process adjustments brought justified complaints, as odor lingers in protective gear and even harvest bins. Improved fractional distillation and vacuum stripping helped resolve this. The result: a finished product that performs its role without leaving a lasting impact on tools or harvest equipment.

    Handled with Care and Experience

    Each team member here knows the importance of chemical safety in daily operations. Methyl isonicotinate doesn’t call for the same level of hardened containment as more hazardous actives. Standard PPE, ventilation, and handling procedures all meet regulatory requirements without overcomplicating the workflow. We document best practices at each step, from bulk storage to transport, and train all staff on updated handling guides. These habits reflect a culture built on preventing near-misses and minimizing spills, not just ticking off boxes for compliance checks.

    We picked up early that shipping this particular product during warmer months needed special precautions. Supply chain planners and drivers all share their experience with customs stops, transit times, and regional climate, so we can adjust how we store and move loads near ports. This focus on real-world logistics reduces spoilage and product loss—hard-won knowledge after seeing rejected shipments or batches degraded by exposure. With methyl isonicotinate, attention to detail pays off far better than chasing volume through quick but risky shortcuts.

    What End-Users Gain from Direct Manufacturer Contact

    One of the main differences between dealing with us versus buying from brokers or repackagers sits in getting reliable, traceable supply. Customers who come to the factory can discuss their needs, get supporting documents quickly, and request custom packaging. That’s possible because we oversee all traceability records from raw material receipt to finished goods out the door. In cases where end-users wanted validation of performance for specific crops or geographies, our technical staff supported them with samples, additional analysis, and real-world data.

    Often, partnerships with research teams let us learn about shifting regulations and special project needs early. That collaboration gives our clients an edge, since small runs or modified batches can be arranged when standard products fall short. The experience lets us spot trends and offer advice based on real case studies, not generic product sheets.

    Responsibility Towards Long-Term Sustainability

    As a direct manufacturer, the responsibility doesn’t end at the factory gate. Chemical production has an impact on people and the planet, and that motivates us to make choices grounded in environmental stewardship. Efforts in our facility focus on minimizing waste and emissions, keeping solvents in tightly managed loops, and reducing water usage wherever process design allows. Every improvement in yield, every reduction in scrap or off-grade product supports both our bottom line and the communities near us.

    Modern agriculture expects tools that work with nature, not against it. Methyl isonicotinate answers that need by offering reliable support to well-designed Integrated Pest Management strategies. It helps minimize the ecological footprint by making crop protection more targeted and less reliant on brute force chemistry. Our work is far from finished—there’s always room to refine, whether it’s applying newer green chemistry methods or engaging with farming partners to improve use instructions and product stewardship.

    Looking Ahead: Methyl Isonicotinate and Future Needs

    We often talk with crop advisors, regulatory officers, and formulation scientists about where the next improvements will come from. Resistance management, tank mix flexibility, and application efficiency top the list. Methyl isonicotinate promises a long runway for innovation—it's structurally robust but open to formulation tweaks, so new delivery systems can use it without large investments.

    Feedback loops run tight in this segment. Users pass along field data, efficacy observations, and compatibility notes. Those form the basis for next-generation product improvements: reducing odor, improving shelf life, and fine-tuning the balance between volatility and persistence. Our own research facility tracks advances in analytical instrumentation, letting us refine what we make and how we document performance. The future looks bright for those willing to listen closely, invest in skills, and commit to factual, transparent operation.

    Final Thoughts from the Production Floor

    Making and supplying methyl isonicotinate isn’t glamorous, but it gives meaningful support to people who make food security possible. Our entire process—from sourcing vetted raw materials, through careful synthesis, to tested final product—reflects decades of accumulated experience. In every batch, what counts most is the confidence growers, formulators, and researchers place in our consistency.

    We continue improving, based on evidence and the lived reality of our partners in the field. Each season brings new demands, whether in tightening quality controls or listening to the subtle impacts an impurity level can have on application success. Through all these changes, the team’s commitment holds steady: learn from every lesson, improve with every cycle, and deliver a methyl isonicotinate that meets needs both today and into the future.