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Methyl Isoeugenol

    • Product Name Methyl Isoeugenol
    • Alias isomethyleugenol
    • Einecs 219-239-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    704948

    Cas Number 93-16-3
    Molecular Formula C11H14O2
    Molecular Weight 178.23 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Sweet, spicy, clove-like
    Density 1.036 g/cm3
    Boiling Point 265-267°C
    Melting Point -18°C
    Solubility Insoluble in water; soluble in ethanol and oils
    Refractive Index 1.538–1.540
    Flash Point 117°C
    Purity Typically ≥98%

    As an accredited Methyl Isoeugenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of Methyl Isoeugenol, sealed with a screw cap, labeled with hazard warnings and product details.
    Shipping Methyl Isoeugenol is typically shipped in tightly sealed, chemical-resistant containers to prevent leakage and contamination. It should be transported under cool, dry conditions away from sources of ignition or incompatible substances. Ensure proper labeling and documentation as required by transportation regulations for hazardous chemicals. Handle with appropriate safety precautions during shipping.
    Storage Methyl isoeugenol should be stored in a tightly sealed container, away from light, heat, and sources of ignition. Keep it in a cool, dry, and well-ventilated area, separated from incompatible substances such as strong oxidizers and acids. Ensure proper labeling and restrict access to trained personnel. Store at room temperature and avoid prolonged exposure to air to prevent degradation.
    Application of Methyl Isoeugenol

    Applications of Methyl Isoeugenol in Industrial Manufacturing

    Methyl Isoeugenol serves as a specialized aromatic and chemical intermediate across several regulated manufacturing sectors. As a direct producer, we supply this material to industrial users who require strict batch consistency, traceability, and technical documentation for advanced formulations and processes.

    1. Fragrance Ingredients for Fine and Functional Perfumes

    Perfume compounders utilize Methyl Isoeugenol as a soft-spicy, floral note in fragrance accords for both fine fragrances and household scent formulations. The raw material enters bases requiring delicate modulation of character, and its use remains tightly regulated regarding allergenic potential. Manufacturers perform rigorous analytical testing for trace purities and allergen profiling. Legislative limits under various perfume regulations control allowable dosage, necessitating supply lots accompanied by validated COAs and IFRA conformity documents.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards, current amendments (product type restrictions and maximum allowed content)
    • REACH Annex XVII and CLP Regulation (EC) No 1272/2008 for labeling and safety data
    • EU Cosmetics Regulation (EC) No 1223/2009 for cosmetic ingredient limits and labelling
    • Good Manufacturing Practice ISO 22716 for manufacturing control

    Typical usage ratio

    • Ranged from 0.01% up to 0.2% in fine fragrance compounds, adjusted below IFRA limits as per finished product exposure category
    • Functional fragrancing (soaps, cleaners) typically uses <0.05%, modulation based on desired intensity and regulatory maximums

    Downstream process integration

    • Added during the mixing of fragrance bases in compounding vessels
    • Quality assurance includes allergen content analysis, GC-MS impurity checks, and batch sample retention
    • Integrated within both bulk concentrate and ready-to-use dilution charging

    Final product types

    • Eau de toilette and parfum oils
    • Household air care products (aerosol sprays, diffusers)
    • Creams and personal wash items with fragranced content
    • Industrial cleaning agents featuring floral or spicy notes

    2. Flavor Formulation in Non-food Applications

    Flavor houses incorporate Methyl Isoeugenol primarily in oral care compounds, such as toothpastes and mouthwashes that do not fall under food use regulations. Here, the material acts as a flavor enhancer and modulator in clove, floral, and spiced profiles, often requiring close sensory evaluation and toxicological assessment to validate compliance with authorities. Formulators apply raw material only in product classes where relevant flavor guidelines and consumer safety standards permit its presence.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009 for oral care composition ingredient restrictions
    • US FDA 21 CFR 700 subpart B for permissible ingredients in dentifrices and oral hygiene
    • ISO 16128 for guidelines on the definition and technical criteria for natural and organic oral care formulation
    • IFRA notifications if used in rinse-off aromatic preparations

    Typical usage ratio

    • 0.005%–0.05% in paste and gel bases—sensory attributes balanced against regulatory limits and risk of oral mucosa irritation
    • Flavor concentrate blends may contain up to 0.2% in intermediate flavor oils

    Downstream process integration

    • Pre-mixing with other flavor actives prior to emulsion or gel base addition
    • QC includes quantitative GC-FID traceability, supported by batch toxicity and stability data
    • Full audit trails maintained for batch-to-batch consistency and declaration audits

    Final product types

    • Toothpastes and tooth powders
    • Alcohol-free mouthrinses with herbal profiles
    • Chewable non-food dental products
    • Flavor concentrates for cosmetic oral hygiene

    3. Synthesis Intermediate for Pharmaceutical and Agrochemical Compounds

    In synthesis operations, Methyl Isoeugenol functions as an intermediate or blocking group in the multi-step preparation of active compounds, mainly for pharmaceuticals and selected crop protection actives. Pharmaceutical CMOs and agrochemical formulators demand consistent reactivity and minimal impurity profiles. Traceability is maintained using 21 CFR and ICH Q7 GMP criteria, with focus on secondary metabolite risk minimization and documented cleaning validation for interchangeable reaction lines.

    Industry compliance standards

    • ICH Q7 and EU GMP Annex 1 for active pharmaceutical ingredient intermediate production
    • 21 CFR Part 211 for process documentation and impurity control in the U.S. market
    • FAO WHO Specifications on agrochemical technical materials
    • REACH registration and reporting for North America and EU chemical intermediates

    Typical usage ratio

    • Determined by synthesis stoichiometry—commonly 85–95% purity processed in batch quantities from several kilograms to metric tons, as dictated by target compound yield
    • Excess may be added as a reactivity control reagent, then removed by distillation or extraction in line with process validation protocols

    Downstream process integration

    • Charged into reaction vessels as a starting intermediate or methylating agent during the core step
    • Composition and impurity controls at incoming QC, intermediate holding, and reaction purge stages
    • Dedicated or validated shared lines to prevent cross-contamination with other actives

    Final product types

    • API intermediates and specialty amines (e.g., anti-inflammatory agents, certain antiviral classes)
    • Synthetic pyrethroid agrochemical precursors
    • Fine chemical synthesis standards for contract manufacturing
    • Potential use in semi-synthetic alkaloid derivatives

    4. Stabilizing Agent in Polymer and Resin Additive Manufacturing

    Technical compounders in plastics and resin industries select Methyl Isoeugenol for its mild stabilization properties, particularly where color and fragrance retention is important in consumer and specialty polymer applications. Its antioxidant mechanism helps slow down degradation of sensitive resin systems during processing and short-term storage. Strict QC ensures the absence of regulatory impurities and odoriferous byproducts. Suppliers deliver detailed origin, batch analytics, and documentation for use in products requiring high consumer safety standards.

    Industry compliance standards

    • EU Regulation (EC) No 1907/2006 (REACH) on chemical substances in articles
    • US FDA 21 CFR 177.2600 for indirect food contact polymer materials (only when supported by safety assessment)
    • RoHS Directive 2011/65/EU for electronic and electrical equipment additives
    • ISO 9001:2015 certification for process control in additive manufacturing

    Typical usage ratio

    • 0.01%–0.1% by weight for functional resin or masterbatch stabilization, adjusted based on color retention and volatilization test results
    • Lower end of range typical for non-contact packaging and decorative plastics

    Downstream process integration

    • Incorporated by melt blending during extrusion or pelletization
    • Stability and migration testing as per client specification, especially for contact-sensitive applications
    • Outgoing QA reports for each batch integrating chromatographic purity, odor threshold, and residual content

    Final product types

    • Aromatic plastic films for decorative application
    • Perfumed polymer beads used in air freshening products
    • Resin castings and consumer plastic ware with retained fragrance characteristics
    • Non-food contact colored polymeric packaging

    5. Reference Standard in Analytical and Sensory Laboratories

    Qualified laboratories employ Methyl Isoeugenol as a calibration and identification standard, particularly for sensory evaluation and forensic analysis of essential oil authenticity. The material enables accurate GC-FID and GC-MS calibration curves for quantifying homologous aromatics and verifying the purity and botanical origin of batch essential oils. Reference-standard level traceability is mandatory, and the raw material is supplied in highly characterized lots, supporting both guideline conformance and metadata traceability.

    Industry compliance standards

    • ISO 17025 for testing and calibration laboratory management
    • Pharmacopoeial monographs (USP, Ph. Eur.) for analytical standards in herbal extracts
    • AOAC Official Methods for spice and herbal composition analysis
    • Consignment lot traceability and documentation for reference materials

    Typical usage ratio

    • Used at <1 ppm up to 100 ppm levels for calibration standards depending on matrix and detection limits
    • Lab protocol determines spike levels, generally from 0.01% to 0.1% in calibration mixtures

    Downstream process integration

    • Prepared in analytical grade solvent as calibration curves or internal reference for GC, LC, or sensory panel training
    • QC includes note-to-note purity assessment, retention index logging, and storage under controlled temperature
    • Produced and dispatched with full analytical and impurity profile certificates

    Final product types

    • GC-FID, GC-MS calibration standards
    • Sensory panel training reference kits
    • Quality control protocols for essential oil or aroma concentrate validation
    • Authenticity and adulteration detection solution standards
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    Certification & Compliance
    More Introduction

    Methyl Isoeugenol: Perspective from the Manufacturer's Floor

    Among specialty aroma chemicals, Methyl Isoeugenol stands apart for professionals who actually work at the intersection of natural extraction and synthetic precision. As chemical manufacturers who run the reactors, check the yields, and make sure every drum measures up, we pay attention to details others might miss. This product doesn’t come from abstract optimization or market buzz. It comes from measured synthesis, years of batch-to-batch adjustments, and plenty of honest talk in the plant about what customers actually see in their applications.

    What Drives Our Interest in Methyl Isoeugenol

    Few chemicals offer such versatility for fragrance blenders and flavor chemists. In our plant, Methyl Isoeugenol—derived through methylation steps from Isoeugenol—gives a warm, spicy-sweet base note that doesn’t drown out subtler top notes or clash with other ingredients. Real experience with this molecule shows it lets perfumers extend floral or woody bases without the overly cloying impact of its parent isoeugenol. Over years, we’ve seen demand not just from large brands but also from makers searching for an alternative to vanilla-heavy or overtly synthetic-smelling bases.

    Every batch tells its own story. Some customers ask for sharply defined, high-purity material (over 98%), with GC-MS reports as proof. Others want a technical grade for lower-tier formulations where cost and stability trump everything. We’ve learned to control reaction time, temperature, and post-synthesis purification, all because real-world use leaves little room for guesswork. End users don’t care about theorized methods—they want the fragrance to last, the notes to blend, and no off-notes under real conditions.

    Our Manufacturing Mindset: Getting the Details Right

    For us, synthesis of Methyl Isoeugenol runs best on controlled methylation, typically of Isoeugenol sourced from clove or basil. Set temperatures and the right timing make or break the selectivity. Get sloppy with methanol ratio or catalyst choice, you risk forming too many byproducts that customers pick out as “medicinal” or “off.” Recovery of the product, stripping out unreacted starting material, passes through vacuum distillation more than once to secure a high-purity result. Our standard model follows the trans isomer, since it presents greater stability and a cleaner scent—this matters to anyone formulating for shelf life or heat exposure.

    Much of our equipment has seen upgrades over the years because scaling up for multi-ton annual output means resolving heat transfer problems and agitation rates. The solvent recapture system isn’t just for cost: Reusing solvents reduces impurities in subsequent batches, which cuts down on variability across months and years. Many fragrance companies call us about color, and we've learned: fresh drums off the still are pale yellow, but if handling gets sloppy, color deepens and customers get suspicious. Details make the difference between consistent orders and “one-time” transactions.

    Specifications Built on Reality, Not Guesswork

    We list assay, boiling range, and isomer ratio because customers told us they found wild variation between suppliers. Ours consistently measures at over 98% GC purity, tailored sometimes to 99% if buyers ask for highly transparent base notes. The boiling point centers around 265°C at atmospheric pressure, but most blending happens below this in working formulas. Moisture content rarely poses a problem, as our drying post-distillation is rigorous. Marketers like to focus on color, but after years of shipments, we know what really matters is batch repeatability and shelf stability.

    Heavy metals, residual solvents, or cloudiness sometimes show up in improperly handled imports. We run extra quality checks, using analytical data from real batches—not marketing copy—to confirm product meets user requirements. Our GC-MS and HPLC data comes from calibrated labs staffed by chemists, not just high-throughput testing for compliance only. Whether our client is a craft fragrance producer or a multinational, trust builds when specs mean what we say. Traceability matters; we show full batch histories to key buyers.

    Where Customers Use Methyl Isoeugenol: Not Just Theory

    Ask the operators or the lab staff in charge of sample approvals, and they’ll tell you: Perfumery dominates the client base for Methyl Isoeugenol. It lands in wood, spice, herb, and, more quietly, food flavorings, where allowed. Unlike Isoeugenol or Eugenol themselves, the methyl derivative offers a subtlety, helping build complexity in finished scents. Floral, powder, and amber bases all benefit from its role as an enhancer, where it rounds off sharp edges from cheaper artificial ingredients.

    In practical use, this molecule rarely acts alone. It gets blended with tonka, coumarin, or heliotropine to drive warmth and lift in finished products—soap, candles, household fragrances. Users value its fixative properties. Our feedback loop with end users made clear: too much of the parent isoeugenol risks creeping bitterness; too little Methyl Isoeugenol causes the blend to lose backbone and complexity. The manufacturers making up the bulk of orders care less about the origin story and more about how their bulk liquid or solid form will perform in actual runs, exposed to high shear, heat, or challenging bases.

    A staple of soap, detergent, and air care, Methyl Isoeugenol survives many processing environments. During pilot testing, we noticed it holds up in saponification better than several other spice notes—this translates into fewer complaints about loss of scent after curing or aging, an issue that haunts lower-cost blends. Its performance in candles also gets industry attention: volatility stays lower, so the scent lasts through the burning life. End-use feedback shapes every batch we tweak.

    Differences that Matter: Methyl Isoeugenol versus Other Choices

    Plenty of buyers still confuse Methyl Isoeugenol with the broader eugenol family or with completely different materials like Vanillin. Years of troubleshooting customer complaints taught us these nuances matter. Eugenol brings a sharper, more medicinal note and oxidizes more quickly under air and light. Isoeugenol, both cis and trans, leans into intense clove and herbal aspects, giving problems in high concentration for delicate blends.

    Methyl Isoeugenol, with its methyl ether group, softens these sharper edges, provides increased oxidative stability, and delivers a more rounded olfactory profile. Customers intent on recreating classic floral or spicy accords—for instance, in lily, carnation, or allspice notes—benefit from this profile shift. Its long dry-down distinguishes it from the fleeting nature of lower molecular weight aroma chemicals. We’ve tested dozens of dozens of blends in application labs: those using Methyl Isoeugenol at 1-3% generally get better lasting power and acceptance scores on consumer testing than those relying solely on more volatile spices.

    Another point of difference: regulatory acceptance and labeling. Whereas many companies face EU and North American restrictions on isoeugenol or eugenol for consumer products, methylation often allows use in broader categories or at higher concentrations—though this is shifting, and we keep an eye on proposed IFRA limits. For every blend shipped, we provide up-to-date compliance documentation, knowing that rules change on allergen labeling and trace levels.

    Raw material cost fluctuates far less for Methyl Isoeugenol than for naturally extracted eugenol, which rises and falls with clove harvests and weather events in source countries. Our experience in sourcing synthetic precursors means less downtime and stockouts, another reason larger users turned toward methyl derivatives in the last decade. Still, we maintain access to both synthetic and naturally derived sources, depending on customer preference or regulatory requirements.

    Challenges on the Production Line

    Manufacturing reality doesn’t always align with white-paper promises. Consistency in quality comes from troubleshooting, minor re-tooling, and honest admission of occasional missteps. Impurities can sneak in if feedstock purity dips or if distillation columns run too hot. Even workers who’ve spent decades in chemical plants know that making a “standard” product year after year demands vigilance. We log deviations and track seasonal variability in raw aromatics, sharing transparent QA trails for the most demanding buyers.

    Odor control is an overlooked part of our own business. Large-scale synthesis carries risks—overheating, minor leaks, and pressure blips can affect final olfactory signature. The finished aroma points to a well-run operation or reveals unseen process hiccups. After batch failures or customer returns, we set up better in-line controls for temperature spikes and improved nitrogen blanketing to arrest oxidation. Real responses, driven by loss prevention, matter far more than boilerplate “quality initiatives.”

    Worker safety governs all our choices, not just to meet standards but from lived experience of what an accident means both for families and operations. By investing in better closed systems and ongoing HAZOP reviews, we keep up compliance—but it’s the direct reporting from operators that flags most real-world risks before they escalate. Chemical manufacturing isn’t theory, it’s lived process, and we pass that accountable approach on in every batch shipped.

    Looking Forward: What Industry Change Means for Methyl Isoeugenol

    Demand for sustainable sourcing pushes even synthetic manufacturers to reevaluate process flows and environmental impact. In our experience, shifting to greener methylating agents and recycling strategies accomplishes more than greenwashing badge claims. Solvent recapture, minimized waste, and more efficient catalysis help us reduce both emissions and costs.

    Traceability is no longer a niche concern. Brands and regulators ask for data trails—batch by batch, drum by drum. Scalable chemical systems must allow for this level of detail without ballooning costs or stalling lines. Digital batch records were seen as a hassle years ago, but we found they increased customer trust, sped up incident investigations, and give buyers peace of mind that can’t be faked with marketing.

    Application-wise, we see increased formulation with “cleaner” base chemicals. Methyl Isoeugenol delivers because of its stable profile and multi-industry reputation. As more clients prepare for regulatory scrutiny on allergens, they value our transparency on origin, isomer ratio, and minor impurity tracking. We collaborate with technical teams to forecast supply and keep analytical packages ready for audits or certifications.

    In Summary: Decades of Tangible Experience

    Methyl Isoeugenol succeeds because chemical manufacturers listen to users, probe for details, and support every drum shipped with concrete technical readiness. Comparing it to its chemical cousins does little justice—the real world of fragrance, air care, and food formulations shows its worth in subtlety, longevity, and flexibility. Our history running these reactions, adjusting flows and refining purification, anchors the value we offer.

    The future for this molecule remains strong as long as manufacturers keep an ear to the ground. Regulation, sourcing, and customer needs keep shifting, but careful handling, rigorous testing, and open feedback ensure every shipment stays up to our line standards. Methyl Isoeugenol isn’t just a catalog entry—it’s a product shaped by experience, real production know-how, and ongoing collaboration with seasoned users who recognize its place in memorable fragrances and flavors.