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Methyl Glycolate

    • Product Name Methyl Glycolate
    • Alias methyl-glycolate
    • Einecs 210-279-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    477551

    Chemical Name Methyl Glycolate
    Cas Number 96-35-5
    Molecular Formula C3H6O3
    Molecular Weight 90.08 g/mol
    Appearance Colorless liquid
    Boiling Point 155-157 °C
    Melting Point -27 °C
    Density 1.208 g/cm3 at 20 °C
    Solubility In Water Miscible
    Refractive Index 1.411
    Flash Point 85 °C
    Odor Mild, fruity
    Purity Typically ≥99%
    Storage Conditions Store in a cool, dry place, tightly closed
    Synonyms Glycolic acid methyl ester

    As an accredited Methyl Glycolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methyl Glycolate is packaged in a 500 mL amber glass bottle with a secure screw cap and safety hazard labeling.
    Shipping Methyl Glycolate is typically shipped in tightly sealed, corrosion-resistant containers such as drums or bottles to prevent leakage and contamination. It should be stored and transported in cool, dry, well-ventilated areas, away from incompatible substances. Handling must comply with local regulations regarding hazardous chemicals to ensure safe delivery and storage.
    Storage Methyl glycolate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible substances such as strong oxidizers. Store it in tightly closed, properly labeled containers made of compatible material. Protect from moisture and direct sunlight. Keep the storage area equipped with appropriate spill containment and fire-fighting equipment.
    Application of Methyl Glycolate

    Applications of Methyl Glycolate in Industrial Manufacturing

    Methyl Glycolate is a key chemical intermediate employed by various industrial sectors due to its valuable reactivity and solubility profile. Below, we present detailed application segments representing authentic and specialized downstream uses in manufacturing.

    1. Production of Herbicide Active Ingredients

    Methyl Glycolate acts as a critical building block in the synthesis of several post-emergence herbicide molecules, particularly in the fabrication of Dimethyl Glycine Derivatives such as the main component for clethodim and quizalofop-based herbicides. The compound contributes to side-chain construction during the acylation step, delivering precise methyl groups required for high weed selectivity and environmental stability. Manufacturers adjust reaction parameters based on desired crop safety and local environmental restrictions, typically operating under controlled pH and temperature to ensure selectivity and yield in the final active ingredient.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for agrochemical intermediates
    • Regulation (EC) No 1107/2009 for plant protection products (Europe)
    • US EPA Tolerances for Pesticide Chemical Residues
    • FAO Specifications for Agricultural Pesticides

    Typical usage ratio

    • 10–25% of total reaction mass during acylation step, with adjustments based on active molecular yield targets and impurity limits

    Downstream process integration

    • Charged into reaction vessels after the completion of base esterification; directly involved in condensation or side-chain installation for herbicide core formation

    Final product types

    • Clethodim technical grade
    • Quizalofop-p-ethyl technical
    • Fenoxaprop-p-ethyl active ingredients
    • Emulsifiable concentrate and suspension concentrate herbicide formulations

    2. Synthesis of Pharmaceutical Intermediates

    Methyl Glycolate serves as a strategic intermediate in the multistep synthesis of specific non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular medications. It provides a methyl ester function necessary for selective amidation and subsequent downstream chiral transformations, ensuring pharmaceutical intermediates meet rigorous impurity profiles and batch reproducibility. EU and US pharmacopeia dictate the permitted excipient and impurity carryover, requiring manufacturers to validate the removal or full conversion of starting esters from final APIs.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP/NF (United States Pharmacopeia/National Formulary) standards for intermediates
    • EDQM CEP/COS for raw material traceability (Europe)
    • 21 CFR Part 211 - US cGMP for Finished Pharmaceuticals

    Typical usage ratio

    • 5–18% w/w in intermediate reaction mixtures; ratio set per molecule and conversion efficiency, with close control on residual methyl content

    Downstream process integration

    • Introduced at early-stage amidation or alkylation steps in multi-stage syntheses, purified after initial coupling reactions, then further processed to yield final pharmaceutical intermediates

    Final product types

    • Naproxen side-chain intermediates
    • Indomethacin intermediates
    • Statin precursor compounds
    • Chiral building blocks for custom APIs

    3. High-Purity Polyethylene Terephthalate (PET) Additive Manufacturing

    Methyl Glycolate modifies the polymer chain length and end-group structure in PET resin production, increasing product clarity, mechanical strength, and crystallinity control. The compound functions as a reactive chain transfer agent, especially in applications targeting food-contact grades and optical films. PET producers conduct strict monitoring of glycolate content, as excessive addition can lead to chain scission or altered melting points, with compliance lab testing for food safety in every batch.

    Industry compliance standards

    • FDA 21 CFR 177.1630 for PET polymers (U.S. food contact)
    • EU Regulation (EU) No 10/2011 for plastic food contact materials
    • EN ISO 22000:2018 for food safety management
    • China GB 4806.6-2016 for food-contact plastics

    Typical usage ratio

    • 0.15–0.8% of total monomer mass, with ratio tailored for target intrinsic viscosity and film clarity

    Downstream process integration

    • Dosed continuously after initial ethylene glycol/polyester melt step, directly before polycondensation; monitored via in-line FTIR or HPLC detection to control functional group distribution

    Final product types

    • Food-grade PET chips and pellets
    • Optical-grade PET films
    • High-clarity beverage bottles
    • Pharmaceutical blister packaging sheets

    4. Industrial Solvent and Cleaning Agent Formulations

    The product is utilized as a biodegradable ester solvent in heavy-duty cleaning, degreasing, and metal surface preparation. Methyl Glycolate’s ester functionality provides effective solvency for various polar and non-polar contaminants while maintaining rapid hydrolysis profiles with minimal VOC release compared to other glycol-based solvents. End users validate final formulation using standard residue and emulsion break parameters aligned with global cleaning agent regulations.

    Industry compliance standards

    • OECD 301B Biodegradability Standard
    • EU REACH Annex XVII restrictions on solvent use
    • US EPA Safer Choice Program (for formulations seeking listing)
    • ISO 14001:2015 Environmental Management certification

    Typical usage ratio

    • 15–40% in solvent-based cleaning formulations; proportion varies per cleaning strength required, with higher content in industrial degreasing

    Downstream process integration

    • Dosed to mixing tanks with other co-solvents and surfactants during liquid or gel concentrate formulation; performance tuning occurs in pilot-scale batch testing before scale-up

    Final product types

    • Heavy-duty industrial cleaning agents
    • Machinery and engine degreasing solvents
    • Metal surface pre-treatment washes
    • Paint and ink remover blends

    5. Flavor and Fragrance Ester Synthesis

    Methyl Glycolate enables the manufacture of select flavor and fragrance esters, particularly where rapid, controlled transesterification and reduced hydrolysis byproducts are desired. Perfume and food flavor manufacturers employ strict food grade quality benchmarks, making use of the compound’s clean decomposition profile and manageable reactivity to create aromatic alcohol esters with consistent olfactory impact and safety. Raw material suppliers certify every batch for absence of residual methanol and high-purity standards prior to use in FDA-regulated flavor synthesis.

    Industry compliance standards

    • FCC (Food Chemicals Codex) for food additive quality
    • European Food Safety Authority (EFSA) Flavoring Regulation (EC) No 1334/2008
    • IFRA Standards for regulated fragrance ingredients
    • FDA 21 CFR Part 172 Subpart F for flavoring agents

    Typical usage ratio

    • 2–10% of the reaction mass; scaled based on target yield and final ester purity, with adjustment for food or fragrance certification requirements

    Downstream process integration

    • Reacted with fatty acids or aromatic alcohols under acid catalysis, typically before distillation or solvent extraction of the final ester fraction

    Final product types

    • Fruit and floral ester components for flavors
    • Perfume base notes and fixatives
    • Vanilla and dairy mimic flavors
    • Low-odor carrier solvents in fragrance oil blends
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    Certification & Compliance
    More Introduction

    Methyl Glycolate: A Perspective from the Production Floor

    Looking at Methyl Glycolate through a Manufacturer’s Eyes

    Walking through the reactor halls, the scent of methyl glycolate at different stages gives away more than its chemical footprint. This molecule—known for its clarity, faint odor, and stability—has earned a regular spot in our daily batch schedules. The value of methyl glycolate doesn’t just surface in its formula; it shows up when resin manufacturers accelerate the reaction to hit their targets, or when coatings mixers need that precise base for dispersions.

    We produce methyl glycolate with repeated distillation and dedicated water removal, ensuring a content of at least 98.5% by GC, measured off each batch before packing. Some end users ask for higher purity, targeting next-gen flavor intermediates or safer solvents, but for polyester, coatings, and adhesives, the standard spec provides real chemical performance. Viscosity and moisture matter. We keep water content tightly below 0.1% with careful control during fractionation and final tank sampling. Once a year, someone calls for a higher boiling impurity profile; for 99.5% and up we switch to molecular sieve drying and finer cuts. For most production partners, 98.5% balances value, cost, and reactivity, with glycolic esters present well below 1%.

    Synonymous terms float between countries—methyl hydroxyacetate in some places, methyl 2-hydroxyacetate elsewhere—but the molecule stays the same. Our own output consistently shows a density near 1.18 g/cm³ at 25°C, and a boiling range at around 173°C under atmospheric pressure. As a team that weighs incoming raw materials every day, we treat these numbers as more than reference points, since they determine loading points, drum and IBC selection, and even valve choice during bulk fill-outs.

    Meeting the Specifics: Why Purity and Handling Define Usability

    Not all methyl glycolate is equal. There’s material that smells sharp, arrives off-color, or leaves residue after simple evaporation. Often, that’s down to byproduct glycolic acid, shop-floor contamination, or imprecise temperature ramps during synthesis. These differences matter once you pour into reactors or weigh out for fine chemical preparations. We track every tank and batch through real retention samples, because even slight variations in acidity or color shift rheological properties downstream.

    Our regular partners in lamination adhesives flag off-odor and water content faster than an internal audit, while players in electronics care about trace ions and color. That’s relatable from a manufacturing view; we’ve witnessed whole reactors stall or foams surge simply from shortcutting a drying step. Bulk methyl glycolate sets a base for specialty chemicals, but without tighter control on storage, packing, and transfer, even minor slip-ups affect performance.

    Some competitors push recycled or blended grades under cost pressure. That route delivers lower per-ton numbers, but too often we’ve heard complaints about inconsistent polymerization in polyester chains, shortened shelf stability, or issues with reactive diluents. Instead of mixing, we maintain single-source methanol and glycolic acid stocks, run standard pressure-esterification, then finish each batch through vacuum distillation. A fixed sequence and audit trail may feel slow or conservative, but it keeps complaints minimal.

    How Methyl Glycolate Stands apart from Conventional Solvent Esters

    It’s easy to overlook the quirks separating methyl glycolate from its bulkier cousins. Compared to ethyl glycolate or methyl lactate, methyl glycolate pulls ahead in water solubility, making it easier for formulators driving water-based polyesters or adhesives. In practical use, it interacts more predictably with amine hardeners, so crosslinkers and coatings give steadier backbone growth. When polyester resins require a faster-reacting, less hazardous alternative to PVC plasticizers, methyl glycolate takes the spot based on lower toxicity profiles and emissions.

    Looking over our product line, methyl glycolate holds a lower molecular weight than butyl glycolate or methyl lactate. Viscosity checks read lower at room temperature, which benefits users metering large volumes or balancing thinner runs in reactors where temperature control and feed pump tolerance set the production pace. In field use, this makes faster mixing and less residue inside tanks—attributes operators mention often. Cleanup becomes quicker, and line transitions require less intervention—a saving both measurable and appreciated in both energy and man-hours.

    Sometimes, the books stack methyl glycolate next to general-purpose esters. It wins out for those who need faster hydrolysis in recycling applications. Instead of slow breakdown into acids and alcohols, methyl glycolate degrades gently in alkaline conditions, making industrial process water handling manageable. Downstream, we’ve had clients shift from bulk methyl acetate or ethyl lactate, chasing cost and performance, then land on methyl glycolate for its straightforward chemical characteristics.

    A point most literature skips: methyl glycolate’s tendency to resist peroxide formation, even after extended open handling or air exposure. For plants wary of dangerous peroxide build-up, especially in older tanks, that’s a quiet but real safety edge. It’s something we highlight for long-haul shipments and storage, knowing that material stability lowers risk in operations and enables longer shelf life for received product.

    Application Stories from the Plant Level

    Resin suppliers often call us before upscaling, seeking input on the best ratios for methyl glycolate in their polyester modification steps. We’ve watched benches and pilot reactors adjust ratios, keeping within safe exotherm limits, and found that methyl glycolate allows a tighter control on molecular weight distribution. That means higher conversion in shorter cycle times for polyesters.

    Coating manufacturers, who need reproducibility on gloss and drying times, note methyl glycolate’s influence on leveling and flexibility without shifting color or blocking performance. By tuning glycolate content, they’ve sharpened the edge on film toughness, increasing end-use options for construction and automotive finishes. These are areas where substitution with related esters fell short: excess yellowing from methyl lactate, or softening from less polar esters.

    We have dealt with customers running into repeated foaming or viscosity drift when using multi-component ester blends. Switching to a higher-purity methyl glycolate cut batch defects, brought down reject rates, and ultimately reduced raw material consumption over a production month. Even minor improvements add up when scaling to several hundred tons yearly; supply reliability is only part of the equation.

    Ink and coating lines, especially those producing for direct food contact, push for materials without undesirable migration or contamination risk. Methyl glycolate—certified under key compliance checks and packed via lined drums to avoid cross-contact—has kept returns low for years, supporting stringent audit demands. Most regulatory reviews pass on first submission, saving time and money for everyone downstream.

    Key Details We Track in our Own Operations

    Raw materials come in, weighed and sampled, then pass through our continuous esterification reactors. Temperature, pressure, catalyst selection, and residence time influence conversion rates, but drying steps after neutralization shape the final purity. Each batch is measured for water and acid values, with retention samples set aside every run. These checks catch deviations before anything ships.

    We run stability tests on stored material, especially during hot months or when customer pipelines slow. Over time, methyl glycolate stays clear and stable, rarely showing color shift or acid increase. On moving material, our logistics team loads straight into lined drums or food-grade IBCs, always avoiding contamination with older esters or raw glycolic stocks. Lines and pumps get double-checked with water flushes, keeping each batch free from back-contamination.

    Few products respond as clearly to incremental process changes as methyl glycolate. A few degrees shift in the main reactor or a lazy drying sequence show up right away in the acid value or color index. That simplicity helps, both in troubleshooting and in keeping customer complaints down.

    Comparing Footprints: Environmental and Health Points from the Shop Floor

    Handling safety often shapes how partners view a molecule. Methyl glycolate, unlike conventional glycolates or more volatile esters like methyl acetate, gives off a milder vapor, less irritating to operators. Respiratory complaints are rare here when all handling follows usual PPE, but even without exhaust, release to air and odor issues are much lower than with alternatives.

    We have reviewed multiple LCA (life cycle assessment) statements with customers keen on lowering emissions. Methyl glycolate scores better than longer-chain esters on downstream aquatic breakdown, with lower toxicity to aquatic life. These advantages flow from its simple structure and higher water solubility, enabling easier removal in wastewater treatment plants. Less hazardous waste builds up—an operational saving for users facing tougher environmental audits.

    From a worker’s perspective, material splashes still matter, and we keep showers and eyewash stations close but we haven’t had a methyl glycolate incident in years that exceeded minor irritation. Downstream, audits focusing on SVHC (substance of very high concern) lists skip methyl glycolate, easing regulatory pressure on import and storage. Users in sensitive applications like flavors, fragrances, and certain medical intermediates report peace of mind with these lower regulatory hurdles.

    Managing Quality: How a Manufacturer Guarantees Each Ton

    Process control shapes finished chemical property. Real-world variation creeps into every production run, so our team samples at every buffer tank, monitors end-point titrations, and double-checks color on calibrated photometers. Before approval for shipment, every drum is barcoded and traced to batch, with backup samples stored six months minimum.

    Every year, a run or two produces out-of-spec off-color or acid values; those get rejected before loading. Most issues stem from minor feedstock impurity, occasional catalyst imbalance, or even condensate returning to the reactor in humid seasons. We don’t double batch or cut corners: rejected product gets reprocessed, not blended away. That straightforward approach keeps recurring quality claims off our desk.

    Following production, we store in clean, temperature-shielded tanks, warehouse every packed lot indoors, and ship under sealed conditions. We mark each drum with shipping date, batch, and spec—tracking never lapses, because one slip means potential off-spec product at the user end. We have shipped thousands of tons across the years, and this commitment drives repeat business.

    Handling and Logistics: Firsthand Obstacles and Real Solutions

    Bulk methyl glycolate can pick up water if stored in unsealed containers. Open drums or exposed transfer lines translate to more hydrolysis, sometimes increasing acidity or causing slight color change. To combat this, we only use airtight drums and IBCs for shipment, and store our inventory under nitrogen blanketed tanks whenever possible.

    Drum and IBC cleaning follows specific standards here. Even trace residues of glycolic acid or past batch byproducts cloud up the next fill. We pressure-wash and dry each container, using dedicated lines for methyl glycolate to prevent cross-ester contamination. This discipline has meant that our returns due to shipping flaws fall below industry averages year after year.

    Long-distance and export buyers ask about low temperature stability, with some worried about crystallization or viscosity increase in winter shipments. Methyl glycolate stays liquid and pourable through most shipping climates, down to minus 20°C. Packed carefully, risk of physical or chemical change is limited, and customers receive material ready for immediate use.

    Cost, Supply Chain, and Market Trends: Insights from Continuous Supply

    Feedstock volatility is one reality for any methyl glycolate producer. Methanol and glycolic acid both trade on open commodities markets, regularly shifting either due to supply demand or feedstock disruption. Having fixed contracts for both inputs, and redundant supply lines, shields our costs and enables stable bulk pricing for our customers—even during sharp market spikes.

    From our view, price stability counts for as much as technical quality. A sudden spike in methanol doesn’t just raise cost; it pushes buyers to experiment away from methyl glycolate, sometimes at the expense of product quality or process stability. We share pricing models openly with contract buyers, giving longer term commitment in exchange for forecasted demand, which in turn helps smooth our production scheduling.

    Over the last few years, steady growth in polyester intermediates and advanced coatings has supported rising demand for higher-purity methyl glycolate. Major expansions in Asia-based specialty chemical plants and surging downstream applications in electronics and automotive sectors push capacities higher. This drives investment in new distillation and reactor lines at our facilities, enabling us to keep pace and avoid allocation issues that lead to missed shipments.

    Why Methyl Glycolate Remains a Go-To for Modern Industry

    In practice, methyl glycolate blends technical reliability, clean supply, and straightforward regulatory compliance. From the eyes of the production crew to the QA team releasing final drums, we see how every stage—raw feedstock control, process discipline, sample retention, and logistics—affects end use. Customers come back not just for the specs, but for the batch-to-batch consistency, responsive handling of unique purity profiles, and minimal supply disruption.

    Over the decades, we’ve refined production to meet evolving needs, resisting the temptation to cut corners that may mean downtime or product returns for our users. We take pride in every drum and tank that leaves our gates, knowing it plays a small but critical role in creating safer coatings, sturdier resins, and better-performing adhesives worldwide.

    Methyl glycolate’s utility arises from these tangible differences—realized in clean runs, safer operations, and robust finished products. Our daily experience in manufacturing proves that the details matter, and we commit every day to keeping those details right, ensuring that our customers enjoy dependable chemical performance from every ton we produce.